Coiled-coil domain-containing protein 52

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ90_LEIBR

TriTrypDb:

LbrM.35.6020 , LBRM2903_350071500

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ90

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.654
CLV_NRD_NRD_1	113	115	PF00675	0.607
CLV_NRD_NRD_1	211	213	PF00675	0.632
CLV_NRD_NRD_1	263	265	PF00675	0.785
CLV_NRD_NRD_1	301	303	PF00675	0.614
CLV_NRD_NRD_1	99	101	PF00675	0.800
CLV_PCSK_FUR_1	107	111	PF00082	0.724
CLV_PCSK_KEX2_1	109	111	PF00082	0.649
CLV_PCSK_KEX2_1	113	115	PF00082	0.586
CLV_PCSK_KEX2_1	211	213	PF00082	0.593
CLV_PCSK_KEX2_1	262	264	PF00082	0.777
CLV_PCSK_KEX2_1	351	353	PF00082	0.684
CLV_PCSK_KEX2_1	99	101	PF00082	0.779
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.585
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.819
CLV_PCSK_SKI1_1	316	320	PF00082	0.596
CLV_PCSK_SKI1_1	72	76	PF00082	0.670
DEG_Nend_Nbox_1	1	3	PF02207	0.590
DEG_SPOP_SBC_1	443	447	PF00917	0.835
DOC_CDC14_PxL_1	379	387	PF14671	0.546
DOC_CKS1_1	469	474	PF01111	0.544
DOC_CKS1_1	590	595	PF01111	0.595
DOC_MAPK_gen_1	211	218	PF00069	0.597
DOC_MAPK_MEF2A_6	425	433	PF00069	0.586
DOC_MAPK_MEF2A_6	474	481	PF00069	0.537
DOC_PP2B_LxvP_1	330	333	PF13499	0.565
DOC_PP4_FxxP_1	554	557	PF00568	0.848
DOC_USP7_MATH_1	115	119	PF00917	0.717
DOC_USP7_MATH_1	127	131	PF00917	0.630
DOC_USP7_MATH_1	139	143	PF00917	0.826
DOC_USP7_MATH_1	170	174	PF00917	0.823
DOC_USP7_MATH_1	179	183	PF00917	0.627
DOC_USP7_MATH_1	199	203	PF00917	0.525
DOC_USP7_MATH_1	236	240	PF00917	0.838
DOC_USP7_MATH_1	283	287	PF00917	0.676
DOC_USP7_MATH_1	347	351	PF00917	0.778
DOC_USP7_MATH_1	361	365	PF00917	0.568
DOC_USP7_MATH_1	381	385	PF00917	0.625
DOC_USP7_MATH_1	443	447	PF00917	0.802
DOC_USP7_MATH_1	495	499	PF00917	0.687
DOC_USP7_MATH_1	536	540	PF00917	0.845
DOC_USP7_MATH_1	55	59	PF00917	0.658
DOC_USP7_MATH_1	578	582	PF00917	0.585
DOC_USP7_MATH_1	586	590	PF00917	0.685
DOC_USP7_MATH_1	596	600	PF00917	0.807
DOC_USP7_MATH_1	627	631	PF00917	0.691
DOC_USP7_MATH_1	677	681	PF00917	0.539
DOC_USP7_UBL2_3	275	279	PF12436	0.576
DOC_WW_Pin1_4	123	128	PF00397	0.668
DOC_WW_Pin1_4	131	136	PF00397	0.671
DOC_WW_Pin1_4	158	163	PF00397	0.650
DOC_WW_Pin1_4	175	180	PF00397	0.810
DOC_WW_Pin1_4	202	207	PF00397	0.598
DOC_WW_Pin1_4	288	293	PF00397	0.639
DOC_WW_Pin1_4	343	348	PF00397	0.741
DOC_WW_Pin1_4	385	390	PF00397	0.800
DOC_WW_Pin1_4	407	412	PF00397	0.831
DOC_WW_Pin1_4	468	473	PF00397	0.799
DOC_WW_Pin1_4	489	494	PF00397	0.616
DOC_WW_Pin1_4	514	519	PF00397	0.580
DOC_WW_Pin1_4	589	594	PF00397	0.750
DOC_WW_Pin1_4	625	630	PF00397	0.685
DOC_WW_Pin1_4	637	642	PF00397	0.556
DOC_WW_Pin1_4	682	687	PF00397	0.693
LIG_14-3-3_CanoR_1	172	179	PF00244	0.762
LIG_14-3-3_CanoR_1	211	218	PF00244	0.811
LIG_14-3-3_CanoR_1	26	34	PF00244	0.722
LIG_14-3-3_CanoR_1	294	304	PF00244	0.610
LIG_14-3-3_CanoR_1	316	325	PF00244	0.585
LIG_14-3-3_CanoR_1	342	348	PF00244	0.697
LIG_14-3-3_CanoR_1	430	440	PF00244	0.582
LIG_14-3-3_CanoR_1	482	488	PF00244	0.811
LIG_14-3-3_CanoR_1	587	594	PF00244	0.850
LIG_BIR_III_2	626	630	PF00653	0.708
LIG_CSL_BTD_1	408	411	PF09270	0.573
LIG_FHA_1	158	164	PF00498	0.688
LIG_FHA_1	211	217	PF00498	0.596
LIG_FHA_1	526	532	PF00498	0.744
LIG_FHA_2	221	227	PF00498	0.808
LIG_FHA_2	447	453	PF00498	0.851
LIG_FHA_2	590	596	PF00498	0.590
LIG_FHA_2	92	98	PF00498	0.622
LIG_LIR_Apic_2	384	389	PF02991	0.791
LIG_LIR_Apic_2	410	416	PF02991	0.577
LIG_LIR_Apic_2	551	557	PF02991	0.722
LIG_LIR_Nem_3	569	575	PF02991	0.828
LIG_LIR_Nem_3	606	610	PF02991	0.669
LIG_LIR_Nem_3	69	74	PF02991	0.669
LIG_MYND_1	532	536	PF01753	0.590
LIG_SH2_CRK	327	331	PF00017	0.606
LIG_SH2_CRK	379	383	PF00017	0.799
LIG_SH2_CRK	386	390	PF00017	0.684
LIG_SH2_CRK	71	75	PF00017	0.418
LIG_SH2_NCK_1	386	390	PF00017	0.703
LIG_SH2_NCK_1	575	579	PF00017	0.582
LIG_SH2_STAP1	575	579	PF00017	0.835
LIG_SH2_STAT3	610	613	PF00017	0.654
LIG_SH2_STAT5	266	269	PF00017	0.791
LIG_SH3_3	156	162	PF00018	0.591
LIG_SH3_3	46	52	PF00018	0.586
LIG_SH3_3	478	484	PF00018	0.546
LIG_SH3_3	590	596	PF00018	0.842
LIG_SUMO_SIM_par_1	483	489	PF11976	0.814
LIG_TRAF2_1	222	225	PF00917	0.853
LIG_TRAF2_1	309	312	PF00917	0.853
LIG_TRAF2_1	421	424	PF00917	0.630
LIG_TRAF2_1	449	452	PF00917	0.736
LIG_TRAF2_1	631	634	PF00917	0.565
MOD_CDC14_SPxK_1	178	181	PF00782	0.608
MOD_CDC14_SPxK_1	291	294	PF00782	0.594
MOD_CDK_SPK_2	131	136	PF00069	0.594
MOD_CDK_SPxK_1	175	181	PF00069	0.608
MOD_CDK_SPxK_1	288	294	PF00069	0.598
MOD_CDK_SPxK_1	468	474	PF00069	0.800
MOD_CDK_SPxxK_3	131	138	PF00069	0.598
MOD_CK1_1	103	109	PF00069	0.612
MOD_CK1_1	118	124	PF00069	0.685
MOD_CK1_1	125	131	PF00069	0.671
MOD_CK1_1	134	140	PF00069	0.631
MOD_CK1_1	161	167	PF00069	0.630
MOD_CK1_1	173	179	PF00069	0.826
MOD_CK1_1	202	208	PF00069	0.606
MOD_CK1_1	214	220	PF00069	0.590
MOD_CK1_1	252	258	PF00069	0.774
MOD_CK1_1	346	352	PF00069	0.647
MOD_CK1_1	354	360	PF00069	0.710
MOD_CK1_1	434	440	PF00069	0.834
MOD_CK1_1	444	450	PF00069	0.682
MOD_CK1_1	486	492	PF00069	0.827
MOD_CK1_1	496	502	PF00069	0.617
MOD_CK1_1	538	544	PF00069	0.738
MOD_CK1_1	546	552	PF00069	0.850
MOD_CK1_1	581	587	PF00069	0.812
MOD_CK1_1	589	595	PF00069	0.613
MOD_CK1_1	628	634	PF00069	0.780
MOD_CK1_1	651	657	PF00069	0.748
MOD_CK1_1	678	684	PF00069	0.801
MOD_CK2_1	214	220	PF00069	0.779
MOD_CK2_1	253	259	PF00069	0.698
MOD_CK2_1	306	312	PF00069	0.837
MOD_CK2_1	317	323	PF00069	0.587
MOD_CK2_1	418	424	PF00069	0.595
MOD_CK2_1	446	452	PF00069	0.843
MOD_CK2_1	628	634	PF00069	0.565
MOD_CK2_1	91	97	PF00069	0.531
MOD_GlcNHglycan	11	16	PF01048	0.624
MOD_GlcNHglycan	127	130	PF01048	0.646
MOD_GlcNHglycan	141	144	PF01048	0.530
MOD_GlcNHglycan	201	204	PF01048	0.692
MOD_GlcNHglycan	213	216	PF01048	0.730
MOD_GlcNHglycan	238	242	PF01048	0.652
MOD_GlcNHglycan	251	254	PF01048	0.693
MOD_GlcNHglycan	279	282	PF01048	0.598
MOD_GlcNHglycan	295	298	PF01048	0.682
MOD_GlcNHglycan	330	333	PF01048	0.662
MOD_GlcNHglycan	379	382	PF01048	0.625
MOD_GlcNHglycan	433	436	PF01048	0.650
MOD_GlcNHglycan	57	60	PF01048	0.798
MOD_GlcNHglycan	650	653	PF01048	0.575
MOD_GlcNHglycan	88	91	PF01048	0.502
MOD_GSK3_1	11	18	PF00069	0.418
MOD_GSK3_1	114	121	PF00069	0.708
MOD_GSK3_1	123	130	PF00069	0.677
MOD_GSK3_1	139	146	PF00069	0.744
MOD_GSK3_1	157	164	PF00069	0.609
MOD_GSK3_1	170	177	PF00069	0.857
MOD_GSK3_1	210	217	PF00069	0.709
MOD_GSK3_1	249	256	PF00069	0.768
MOD_GSK3_1	269	276	PF00069	0.780
MOD_GSK3_1	277	284	PF00069	0.690
MOD_GSK3_1	293	300	PF00069	0.766
MOD_GSK3_1	306	313	PF00069	0.659
MOD_GSK3_1	343	350	PF00069	0.681
MOD_GSK3_1	361	368	PF00069	0.547
MOD_GSK3_1	377	384	PF00069	0.637
MOD_GSK3_1	385	392	PF00069	0.670
MOD_GSK3_1	395	402	PF00069	0.516
MOD_GSK3_1	405	412	PF00069	0.495
MOD_GSK3_1	442	449	PF00069	0.817
MOD_GSK3_1	451	458	PF00069	0.685
MOD_GSK3_1	464	471	PF00069	0.602
MOD_GSK3_1	489	496	PF00069	0.742
MOD_GSK3_1	51	58	PF00069	0.810
MOD_GSK3_1	521	528	PF00069	0.632
MOD_GSK3_1	538	545	PF00069	0.793
MOD_GSK3_1	546	553	PF00069	0.594
MOD_GSK3_1	573	580	PF00069	0.676
MOD_GSK3_1	581	588	PF00069	0.716
MOD_GSK3_1	612	619	PF00069	0.766
MOD_GSK3_1	625	632	PF00069	0.560
MOD_GSK3_1	644	651	PF00069	0.493
MOD_GSK3_1	653	660	PF00069	0.648
MOD_GSK3_1	677	684	PF00069	0.785
MOD_GSK3_1	99	106	PF00069	0.590
MOD_LATS_1	566	572	PF00433	0.831
MOD_N-GLC_1	268	273	PF02516	0.794
MOD_N-GLC_1	377	382	PF02516	0.799
MOD_N-GLC_1	441	446	PF02516	0.587
MOD_N-GLC_1	573	578	PF02516	0.734
MOD_NEK2_1	149	154	PF00069	0.792
MOD_NEK2_1	174	179	PF00069	0.778
MOD_NEK2_1	237	242	PF00069	0.679
MOD_NEK2_1	257	262	PF00069	0.819
MOD_NEK2_1	268	273	PF00069	0.698
MOD_NEK2_1	395	400	PF00069	0.561
MOD_NEK2_1	431	436	PF00069	0.837
MOD_NEK2_1	612	617	PF00069	0.772
MOD_NEK2_1	635	640	PF00069	0.719
MOD_NEK2_1	644	649	PF00069	0.674
MOD_NEK2_1	650	655	PF00069	0.594
MOD_NEK2_2	115	120	PF00069	0.587
MOD_OFUCOSY	119	124	PF10250	0.590
MOD_PIKK_1	220	226	PF00454	0.613
MOD_PIKK_1	25	31	PF00454	0.693
MOD_PIKK_1	273	279	PF00454	0.576
MOD_PIKK_1	317	323	PF00454	0.587
MOD_PIKK_1	578	584	PF00454	0.841
MOD_PIKK_1	586	592	PF00454	0.663
MOD_PIKK_1	596	602	PF00454	0.795
MOD_PIKK_1	629	635	PF00454	0.654
MOD_PIKK_1	675	681	PF00454	0.749
MOD_PK_1	657	663	PF00069	0.536
MOD_PKA_1	211	217	PF00069	0.635
MOD_PKA_1	351	357	PF00069	0.822
MOD_PKA_1	99	105	PF00069	0.678
MOD_PKA_2	210	216	PF00069	0.843
MOD_PKA_2	25	31	PF00069	0.679
MOD_PKA_2	293	299	PF00069	0.704
MOD_PKA_2	341	347	PF00069	0.626
MOD_PKA_2	351	357	PF00069	0.702
MOD_PKA_2	541	547	PF00069	0.661
MOD_PKA_2	567	573	PF00069	0.708
MOD_PKA_2	586	592	PF00069	0.861
MOD_PKA_2	99	105	PF00069	0.680
MOD_Plk_1	15	21	PF00069	0.419
MOD_Plk_1	268	274	PF00069	0.791
MOD_Plk_1	377	383	PF00069	0.798
MOD_Plk_1	395	401	PF00069	0.516
MOD_Plk_1	418	424	PF00069	0.595
MOD_Plk_1	550	556	PF00069	0.679
MOD_Plk_1	568	574	PF00069	0.674
MOD_Plk_4	180	186	PF00069	0.705
MOD_Plk_4	365	371	PF00069	0.804
MOD_Plk_4	381	387	PF00069	0.533
MOD_Plk_4	464	470	PF00069	0.681
MOD_ProDKin_1	123	129	PF00069	0.671
MOD_ProDKin_1	131	137	PF00069	0.673
MOD_ProDKin_1	158	164	PF00069	0.648
MOD_ProDKin_1	175	181	PF00069	0.813
MOD_ProDKin_1	202	208	PF00069	0.598
MOD_ProDKin_1	288	294	PF00069	0.641
MOD_ProDKin_1	343	349	PF00069	0.740
MOD_ProDKin_1	385	391	PF00069	0.802
MOD_ProDKin_1	407	413	PF00069	0.832
MOD_ProDKin_1	468	474	PF00069	0.800
MOD_ProDKin_1	489	495	PF00069	0.618
MOD_ProDKin_1	514	520	PF00069	0.582
MOD_ProDKin_1	589	595	PF00069	0.751
MOD_ProDKin_1	625	631	PF00069	0.685
MOD_ProDKin_1	637	643	PF00069	0.556
MOD_ProDKin_1	682	688	PF00069	0.691
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.505
TRG_ENDOCYTIC_2	2	5	PF00928	0.665
TRG_ENDOCYTIC_2	327	330	PF00928	0.580
TRG_ENDOCYTIC_2	379	382	PF00928	0.801
TRG_ENDOCYTIC_2	71	74	PF00928	0.672
TRG_ER_diArg_1	110	113	PF00400	0.690
TRG_ER_diArg_1	135	138	PF00400	0.597
TRG_ER_diArg_1	19	22	PF00400	0.645
TRG_ER_diArg_1	191	194	PF00400	0.601
TRG_ER_diArg_1	262	264	PF00400	0.788
TRG_NLS_Bipartite_1	99	113	PF00514	0.572
TRG_NLS_MonoExtC_3	108	113	PF00514	0.585
TRG_NLS_MonoExtN_4	107	113	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XBV2	Leishmania donovani	52%	95%
A4IDY8	Leishmania infantum	52%	95%
E9AU08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
Q4Q0I7	Leishmania major	53%	100%