RAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ89_LEIBR

TriTrypDb:

LbrM.35.6010 , LBRM2903_350071400

Length:

669

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ89

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.404
CLV_NRD_NRD_1	23	25	PF00675	0.454
CLV_NRD_NRD_1	377	379	PF00675	0.488
CLV_NRD_NRD_1	391	393	PF00675	0.497
CLV_NRD_NRD_1	436	438	PF00675	0.438
CLV_NRD_NRD_1	634	636	PF00675	0.411
CLV_PCSK_KEX2_1	158	160	PF00082	0.489
CLV_PCSK_KEX2_1	23	25	PF00082	0.429
CLV_PCSK_KEX2_1	377	379	PF00082	0.506
CLV_PCSK_KEX2_1	391	393	PF00082	0.480
CLV_PCSK_KEX2_1	436	438	PF00082	0.438
CLV_PCSK_KEX2_1	475	477	PF00082	0.413
CLV_PCSK_KEX2_1	634	636	PF00082	0.413
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.413
CLV_PCSK_SKI1_1	234	238	PF00082	0.335
CLV_PCSK_SKI1_1	383	387	PF00082	0.503
CLV_PCSK_SKI1_1	428	432	PF00082	0.418
CLV_PCSK_SKI1_1	605	609	PF00082	0.553
CLV_PCSK_SKI1_1	625	629	PF00082	0.394
DEG_APCC_DBOX_1	233	241	PF00400	0.329
DEG_APCC_DBOX_1	38	46	PF00400	0.482
DEG_APCC_DBOX_1	624	632	PF00400	0.396
DOC_CDC14_PxL_1	511	519	PF14671	0.553
DOC_CKS1_1	350	355	PF01111	0.382
DOC_CYCLIN_RxL_1	123	131	PF00134	0.515
DOC_CYCLIN_RxL_1	377	388	PF00134	0.458
DOC_CYCLIN_RxL_1	535	544	PF00134	0.438
DOC_CYCLIN_RxL_1	658	668	PF00134	0.388
DOC_MAPK_DCC_7	39	47	PF00069	0.515
DOC_MAPK_FxFP_2	202	205	PF00069	0.515
DOC_MAPK_gen_1	158	165	PF00069	0.281
DOC_MAPK_gen_1	179	187	PF00069	0.403
DOC_MAPK_gen_1	23	30	PF00069	0.500
DOC_MAPK_gen_1	473	480	PF00069	0.285
DOC_MAPK_JIP1_4	181	187	PF00069	0.412
DOC_MAPK_MEF2A_6	158	167	PF00069	0.269
DOC_MAPK_MEF2A_6	322	330	PF00069	0.346
DOC_MAPK_MEF2A_6	39	47	PF00069	0.518
DOC_MAPK_MEF2A_6	521	528	PF00069	0.327
DOC_PP1_RVXF_1	659	666	PF00149	0.433
DOC_PP4_FxxP_1	202	205	PF00568	0.515
DOC_WW_Pin1_4	144	149	PF00397	0.560
DOC_WW_Pin1_4	349	354	PF00397	0.470
DOC_WW_Pin1_4	367	372	PF00397	0.594
DOC_WW_Pin1_4	574	579	PF00397	0.483
LIG_14-3-3_CanoR_1	115	121	PF00244	0.411
LIG_14-3-3_CanoR_1	181	186	PF00244	0.374
LIG_14-3-3_CanoR_1	234	243	PF00244	0.406
LIG_14-3-3_CanoR_1	441	450	PF00244	0.468
LIG_14-3-3_CanoR_1	467	471	PF00244	0.463
LIG_14-3-3_CanoR_1	529	535	PF00244	0.471
LIG_14-3-3_CanoR_1	552	559	PF00244	0.622
LIG_14-3-3_CanoR_1	568	574	PF00244	0.591
LIG_14-3-3_CanoR_1	64	70	PF00244	0.298
LIG_14-3-3_CanoR_1	651	660	PF00244	0.556
LIG_Actin_WH2_2	471	488	PF00022	0.288
LIG_Actin_WH2_2	539	554	PF00022	0.537
LIG_Actin_WH2_2	56	73	PF00022	0.459
LIG_APCC_ABBA_1	72	77	PF00400	0.280
LIG_CtBP_PxDLS_1	463	467	PF00389	0.526
LIG_EH1_1	494	502	PF00400	0.392
LIG_eIF4E_1	495	501	PF01652	0.443
LIG_FHA_1	150	156	PF00498	0.615
LIG_FHA_1	160	166	PF00498	0.370
LIG_FHA_1	182	188	PF00498	0.353
LIG_FHA_1	192	198	PF00498	0.314
LIG_FHA_1	380	386	PF00498	0.457
LIG_FHA_1	541	547	PF00498	0.392
LIG_FHA_2	441	447	PF00498	0.493
LIG_FHA_2	456	462	PF00498	0.503
LIG_LIR_Apic_2	400	406	PF02991	0.496
LIG_LIR_Apic_2	553	559	PF02991	0.377
LIG_LIR_Gen_1	162	172	PF02991	0.359
LIG_LIR_Gen_1	530	539	PF02991	0.496
LIG_LIR_Nem_3	162	167	PF02991	0.307
LIG_LIR_Nem_3	530	534	PF02991	0.520
LIG_NRBOX	109	115	PF00104	0.385
LIG_NRBOX	606	612	PF00104	0.535
LIG_Pex14_1	632	636	PF04695	0.451
LIG_Pex14_2	160	164	PF04695	0.264
LIG_PTB_Apo_2	340	347	PF02174	0.494
LIG_Rb_LxCxE_1	639	658	PF01857	0.292
LIG_RPA_C_Fungi	10	22	PF08784	0.398
LIG_SH2_CRK	502	506	PF00017	0.505
LIG_SH2_CRK	615	619	PF00017	0.448
LIG_SH2_PTP2	403	406	PF00017	0.539
LIG_SH2_PTP2	410	413	PF00017	0.424
LIG_SH2_SRC	410	413	PF00017	0.429
LIG_SH2_SRC	75	78	PF00017	0.516
LIG_SH2_STAP1	263	267	PF00017	0.338
LIG_SH2_STAP1	75	79	PF00017	0.283
LIG_SH2_STAT5	403	406	PF00017	0.479
LIG_SH2_STAT5	410	413	PF00017	0.303
LIG_SH2_STAT5	495	498	PF00017	0.503
LIG_SH2_STAT5	502	505	PF00017	0.462
LIG_SH2_STAT5	615	618	PF00017	0.335
LIG_SH3_3	506	512	PF00018	0.432
LIG_SH3_3	575	581	PF00018	0.409
LIG_SUMO_SIM_anti_2	183	189	PF11976	0.350
LIG_SUMO_SIM_par_1	126	131	PF11976	0.435
LIG_SUMO_SIM_par_1	183	189	PF11976	0.461
LIG_SUMO_SIM_par_1	537	544	PF11976	0.455
LIG_TRAF2_1	458	461	PF00917	0.519
LIG_TRAF2_1	577	580	PF00917	0.548
LIG_TRFH_1	403	407	PF08558	0.524
LIG_TYR_ITIM	500	505	PF00017	0.490
LIG_TYR_ITIM	73	78	PF00017	0.463
LIG_UBA3_1	127	132	PF00899	0.306
LIG_UBA3_1	603	608	PF00899	0.408
MOD_CDK_SPxxK_3	349	356	PF00069	0.374
MOD_CK1_1	116	122	PF00069	0.284
MOD_CK1_1	142	148	PF00069	0.671
MOD_CK1_1	186	192	PF00069	0.371
MOD_CK1_1	367	373	PF00069	0.611
MOD_CK1_1	65	71	PF00069	0.292
MOD_CK2_1	116	122	PF00069	0.425
MOD_CK2_1	186	192	PF00069	0.377
MOD_CK2_1	236	242	PF00069	0.329
MOD_CK2_1	306	312	PF00069	0.431
MOD_CK2_1	440	446	PF00069	0.446
MOD_CK2_1	455	461	PF00069	0.363
MOD_CK2_1	574	580	PF00069	0.678
MOD_Cter_Amidation	632	635	PF01082	0.334
MOD_GlcNHglycan	371	374	PF01048	0.691
MOD_GlcNHglycan	559	562	PF01048	0.578
MOD_GlcNHglycan	594	597	PF01048	0.391
MOD_GSK3_1	109	116	PF00069	0.356
MOD_GSK3_1	128	135	PF00069	0.450
MOD_GSK3_1	142	149	PF00069	0.622
MOD_GSK3_1	159	166	PF00069	0.466
MOD_GSK3_1	253	260	PF00069	0.449
MOD_GSK3_1	363	370	PF00069	0.695
MOD_GSK3_1	428	435	PF00069	0.413
MOD_LATS_1	303	309	PF00433	0.374
MOD_N-GLC_1	245	250	PF02516	0.409
MOD_N-GLC_1	268	273	PF02516	0.450
MOD_NEK2_1	113	118	PF00069	0.420
MOD_NEK2_1	128	133	PF00069	0.412
MOD_NEK2_1	191	196	PF00069	0.367
MOD_NEK2_1	236	241	PF00069	0.439
MOD_NEK2_1	257	262	PF00069	0.398
MOD_NEK2_1	306	311	PF00069	0.372
MOD_NEK2_1	385	390	PF00069	0.421
MOD_NEK2_1	466	471	PF00069	0.424
MOD_NEK2_1	527	532	PF00069	0.484
MOD_NEK2_1	551	556	PF00069	0.556
MOD_NEK2_1	603	608	PF00069	0.516
MOD_NEK2_1	613	618	PF00069	0.460
MOD_NEK2_1	62	67	PF00069	0.319
MOD_NEK2_1	87	92	PF00069	0.343
MOD_OFUCOSY	363	369	PF10250	0.489
MOD_PIKK_1	274	280	PF00454	0.422
MOD_PIKK_1	281	287	PF00454	0.341
MOD_PKA_2	142	148	PF00069	0.630
MOD_PKA_2	180	186	PF00069	0.424
MOD_PKA_2	432	438	PF00069	0.439
MOD_PKA_2	440	446	PF00069	0.428
MOD_PKA_2	466	472	PF00069	0.459
MOD_PKA_2	551	557	PF00069	0.546
MOD_PKB_1	179	187	PF00069	0.403
MOD_Plk_1	11	17	PF00069	0.368
MOD_Plk_4	109	115	PF00069	0.367
MOD_Plk_4	159	165	PF00069	0.490
MOD_Plk_4	183	189	PF00069	0.347
MOD_Plk_4	210	216	PF00069	0.410
MOD_Plk_4	306	312	PF00069	0.359
MOD_Plk_4	65	71	PF00069	0.311
MOD_ProDKin_1	144	150	PF00069	0.558
MOD_ProDKin_1	349	355	PF00069	0.475
MOD_ProDKin_1	367	373	PF00069	0.593
MOD_ProDKin_1	574	580	PF00069	0.480
TRG_DiLeu_BaEn_1	33	38	PF01217	0.403
TRG_DiLeu_BaEn_1	446	451	PF01217	0.399
TRG_DiLeu_BaEn_1	639	644	PF01217	0.600
TRG_DiLeu_BaEn_1	658	663	PF01217	0.341
TRG_DiLeu_BaEn_4	579	585	PF01217	0.502
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.476
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.443
TRG_DiLeu_LyEn_5	658	663	PF01217	0.308
TRG_ENDOCYTIC_2	410	413	PF00928	0.369
TRG_ENDOCYTIC_2	427	430	PF00928	0.300
TRG_ENDOCYTIC_2	502	505	PF00928	0.494
TRG_ENDOCYTIC_2	75	78	PF00928	0.470
TRG_ER_diArg_1	157	159	PF00400	0.423
TRG_ER_diArg_1	634	636	PF00400	0.384
TRG_NES_CRM1_1	319	333	PF08389	0.324
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMS6	Leptomonas seymouri	64%	98%
A0A0S4IXA8	Bodo saltans	27%	94%
A0A1X0NNB6	Trypanosomatidae	41%	100%
A0A3Q8IHX9	Leishmania donovani	80%	100%
A4IDY7	Leishmania infantum	80%	100%
D0A422	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AU07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q0I8	Leishmania major	82%	100%
V5B3L6	Trypanosoma cruzi	41%	100%