LeishMANIAdb
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Phosphoprotein lepp12

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoprotein lepp12
Gene product:
phosphoprotein lepp12
Species:
Leishmania braziliensis
UniProt:
A4HQ88_LEIBR
TriTrypDb:
LbrM.35.6000 , LBRM2903_350071300
Length:
88

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ88
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ88

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 12 14 PF00675 0.557
CLV_NRD_NRD_1 21 23 PF00675 0.490
CLV_NRD_NRD_1 62 64 PF00675 0.552
CLV_PCSK_KEX2_1 12 14 PF00082 0.566
CLV_PCSK_KEX2_1 3 5 PF00082 0.610
CLV_PCSK_KEX2_1 33 35 PF00082 0.518
CLV_PCSK_KEX2_1 75 77 PF00082 0.598
CLV_PCSK_PC1ET2_1 12 14 PF00082 0.566
CLV_PCSK_PC1ET2_1 3 5 PF00082 0.610
CLV_PCSK_PC1ET2_1 33 35 PF00082 0.518
CLV_PCSK_PC1ET2_1 75 77 PF00082 0.582
CLV_PCSK_SKI1_1 22 26 PF00082 0.511
CLV_PCSK_SKI1_1 56 60 PF00082 0.635
CLV_PCSK_SKI1_1 83 87 PF00082 0.691
DEG_APCC_DBOX_1 33 41 PF00400 0.533
DOC_MAPK_gen_1 63 69 PF00069 0.428
DOC_PP1_RVXF_1 41 48 PF00149 0.658
DOC_USP7_UBL2_3 10 14 PF12436 0.554
DOC_USP7_UBL2_3 23 27 PF12436 0.362
DOC_USP7_UBL2_3 29 33 PF12436 0.477
DOC_USP7_UBL2_3 3 7 PF12436 0.588
DOC_WW_Pin1_4 5 10 PF00397 0.455
LIG_14-3-3_CanoR_1 22 30 PF00244 0.577
LIG_14-3-3_CanoR_1 43 48 PF00244 0.630
LIG_Integrin_RGD_1 34 36 PF01839 0.517
LIG_SH2_STAT5 84 87 PF00017 0.708
MOD_CDK_SPK_2 5 10 PF00069 0.455
MOD_CDK_SPxxK_3 5 12 PF00069 0.455
MOD_Cter_Amidation 1 4 PF01082 0.610
MOD_GSK3_1 39 46 PF00069 0.656
MOD_N-GLC_1 43 48 PF02516 0.702
MOD_NEK2_1 39 44 PF00069 0.642
MOD_PKA_1 22 28 PF00069 0.509
MOD_PKB_1 20 28 PF00069 0.483
MOD_Plk_1 43 49 PF00069 0.638
MOD_ProDKin_1 5 11 PF00069 0.456
TRG_ER_diArg_1 81 84 PF00400 0.644
TRG_NLS_MonoExtC_3 2 7 PF00514 0.556
TRG_NLS_MonoExtN_4 9 16 PF00514 0.566

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4J235 Bodo saltans 73% 81%
A0A3Q8IL65 Leishmania donovani 93% 100%
A0A6L0XUA8 Leishmania infantum 93% 100%
C9ZT84 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 65% 100%
E9AU06 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q9N861 Leishmania major 92% 100%
V5BJ70 Trypanosoma cruzi 77% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS