Defective in cullin neddylation protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cullin binding, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ87_LEIBR

TriTrypDb:

LbrM.35.5990 , LBRM2903_350071200

Length:

265

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HQ87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ87

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031396	regulation of protein ubiquitination	8	1
GO:0031398	positive regulation of protein ubiquitination	9	1
GO:0031399	regulation of protein modification process	6	1
GO:0031401	positive regulation of protein modification process	7	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044093	positive regulation of molecular function	3	1
GO:0044238	primary metabolic process	2	1
GO:0045116	protein neddylation	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0051338	regulation of transferase activity	4	1
GO:0051347	positive regulation of transferase activity	5	1
GO:0051438	regulation of ubiquitin-protein transferase activity	5	1
GO:0051443	positive regulation of ubiquitin-protein transferase activity	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1903320	regulation of protein modification by small protein conjugation or removal	7	1
GO:1903322	positive regulation of protein modification by small protein conjugation or removal	8	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0031624	ubiquitin conjugating enzyme binding	5	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0044390	ubiquitin-like protein conjugating enzyme binding	4	1
GO:0097602	cullin family protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.331
CLV_NRD_NRD_1	134	136	PF00675	0.306
CLV_NRD_NRD_1	256	258	PF00675	0.406
CLV_PCSK_KEX2_1	134	136	PF00082	0.408
CLV_PCSK_KEX2_1	74	76	PF00082	0.520
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.435
DEG_APCC_KENBOX_2	103	107	PF00400	0.382
DOC_MAPK_gen_1	178	187	PF00069	0.357
DOC_USP7_MATH_1	90	94	PF00917	0.394
DOC_USP7_UBL2_3	74	78	PF12436	0.440
DOC_WW_Pin1_4	165	170	PF00397	0.390
DOC_WW_Pin1_4	9	14	PF00397	0.503
LIG_14-3-3_CanoR_1	178	188	PF00244	0.331
LIG_BRCT_BRCA1_1	161	165	PF00533	0.386
LIG_deltaCOP1_diTrp_1	159	165	PF00928	0.255
LIG_deltaCOP1_diTrp_1	222	230	PF00928	0.255
LIG_deltaCOP1_diTrp_1	240	252	PF00928	0.266
LIG_FHA_1	180	186	PF00498	0.368
LIG_FHA_1	223	229	PF00498	0.331
LIG_FHA_2	229	235	PF00498	0.259
LIG_FHA_2	246	252	PF00498	0.456
LIG_LIR_Gen_1	159	169	PF02991	0.334
LIG_LIR_Gen_1	182	190	PF02991	0.311
LIG_LIR_Gen_1	195	204	PF02991	0.271
LIG_LIR_Gen_1	20	30	PF02991	0.373
LIG_LIR_Gen_1	222	230	PF02991	0.294
LIG_LIR_Gen_1	38	46	PF02991	0.455
LIG_LIR_Nem_3	105	111	PF02991	0.370
LIG_LIR_Nem_3	159	164	PF02991	0.255
LIG_LIR_Nem_3	182	187	PF02991	0.268
LIG_LIR_Nem_3	195	199	PF02991	0.227
LIG_LIR_Nem_3	20	25	PF02991	0.332
LIG_LIR_Nem_3	222	227	PF02991	0.294
LIG_LIR_Nem_3	231	236	PF02991	0.294
LIG_LIR_Nem_3	250	255	PF02991	0.261
LIG_LIR_Nem_3	38	43	PF02991	0.462
LIG_MLH1_MIPbox_1	161	165	PF16413	0.386
LIG_Pex14_1	161	165	PF04695	0.255
LIG_Pex14_2	139	143	PF04695	0.255
LIG_Pex14_2	22	26	PF04695	0.217
LIG_SH2_CRK	108	112	PF00017	0.384
LIG_SH2_CRK	137	141	PF00017	0.255
LIG_SH2_STAT5	184	187	PF00017	0.386
LIG_SH2_STAT5	24	27	PF00017	0.397
LIG_SH2_STAT5	255	258	PF00017	0.355
LIG_SH2_STAT5	63	66	PF00017	0.351
LIG_SH3_3	167	173	PF00018	0.431
LIG_SH3_3	182	188	PF00018	0.377
LIG_SUMO_SIM_anti_2	195	202	PF11976	0.270
LIG_SUMO_SIM_par_1	118	125	PF11976	0.174
LIG_TRAF2_1	173	176	PF00917	0.390
MOD_CDK_SPK_2	9	14	PF00069	0.377
MOD_CK1_1	217	223	PF00069	0.397
MOD_CK2_1	153	159	PF00069	0.338
MOD_GlcNHglycan	155	158	PF01048	0.392
MOD_GlcNHglycan	165	168	PF01048	0.337
MOD_GlcNHglycan	208	211	PF01048	0.390
MOD_GlcNHglycan	215	219	PF01048	0.381
MOD_GSK3_1	122	129	PF00069	0.174
MOD_GSK3_1	159	166	PF00069	0.387
MOD_GSK3_1	202	209	PF00069	0.357
MOD_GSK3_1	241	248	PF00069	0.434
MOD_N-GLC_1	122	127	PF02516	0.331
MOD_N-GLC_1	206	211	PF02516	0.174
MOD_N-GLC_1	50	55	PF02516	0.223
MOD_N-GLC_1	9	14	PF02516	0.575
MOD_N-GLC_2	142	144	PF02516	0.386
MOD_NEK2_1	122	127	PF00069	0.416
MOD_NEK2_1	214	219	PF00069	0.268
MOD_NEK2_1	228	233	PF00069	0.143
MOD_NEK2_1	259	264	PF00069	0.446
MOD_NEK2_1	4	9	PF00069	0.612
MOD_PIKK_1	222	228	PF00454	0.386
MOD_PKA_2	126	132	PF00069	0.217
MOD_Plk_1	122	128	PF00069	0.331
MOD_Plk_1	241	247	PF00069	0.413
MOD_Plk_1	50	56	PF00069	0.331
MOD_Plk_1	58	64	PF00069	0.281
MOD_Plk_4	58	64	PF00069	0.287
MOD_ProDKin_1	165	171	PF00069	0.390
MOD_ProDKin_1	9	15	PF00069	0.490
TRG_ENDOCYTIC_2	108	111	PF00928	0.391
TRG_ENDOCYTIC_2	137	140	PF00928	0.255
TRG_ENDOCYTIC_2	184	187	PF00928	0.255
TRG_ER_diArg_1	134	136	PF00400	0.257
TRG_ER_diLys_1	261	265	PF00400	0.421
TRG_NES_CRM1_1	47	59	PF08389	0.310

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC74	Leptomonas seymouri	63%	98%
A0A0S4IZZ0	Bodo saltans	22%	100%
A0A1X0P053	Trypanosomatidae	29%	100%
A0A3Q8ILQ1	Leishmania donovani	83%	100%
A0A422NSC3	Trypanosoma rangeli	25%	100%
A4IDY5	Leishmania infantum	83%	100%
D0A424	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AU05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
P0CN06	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	24%	95%
P0CN07	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	24%	95%
Q4Q0J0	Leishmania major	83%	100%
V5DK31	Trypanosoma cruzi	27%	100%