CUE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ86_LEIBR

TriTrypDb:

LbrM.35.5980 , LBRM2903_350071100

Length:

790

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ86

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	365	369	PF00656	0.559
CLV_C14_Caspase3-7	371	375	PF00656	0.524
CLV_C14_Caspase3-7	4	8	PF00656	0.525
CLV_C14_Caspase3-7	439	443	PF00656	0.554
CLV_C14_Caspase3-7	515	519	PF00656	0.510
CLV_C14_Caspase3-7	582	586	PF00656	0.666
CLV_C14_Caspase3-7	662	666	PF00656	0.708
CLV_C14_Caspase3-7	684	688	PF00656	0.726
CLV_NRD_NRD_1	105	107	PF00675	0.566
CLV_NRD_NRD_1	254	256	PF00675	0.488
CLV_NRD_NRD_1	404	406	PF00675	0.342
CLV_PCSK_KEX2_1	105	107	PF00082	0.527
CLV_PCSK_KEX2_1	254	256	PF00082	0.490
CLV_PCSK_KEX2_1	404	406	PF00082	0.342
CLV_PCSK_KEX2_1	731	733	PF00082	0.624
CLV_PCSK_KEX2_1	736	738	PF00082	0.616
CLV_PCSK_PC1ET2_1	731	733	PF00082	0.614
CLV_PCSK_PC1ET2_1	736	738	PF00082	0.603
CLV_PCSK_PC7_1	732	738	PF00082	0.698
CLV_PCSK_SKI1_1	124	128	PF00082	0.477
CLV_PCSK_SKI1_1	255	259	PF00082	0.540
CLV_PCSK_SKI1_1	405	409	PF00082	0.340
CLV_PCSK_SKI1_1	481	485	PF00082	0.516
CLV_PCSK_SKI1_1	779	783	PF00082	0.608
CLV_PCSK_SKI1_1	95	99	PF00082	0.416
CLV_Separin_Metazoa	390	394	PF03568	0.586
DEG_SCF_FBW7_2	81	86	PF00400	0.325
DEG_SPOP_SBC_1	447	451	PF00917	0.719
DEG_SPOP_SBC_1	455	459	PF00917	0.597
DOC_CYCLIN_RxL_1	121	130	PF00134	0.473
DOC_CYCLIN_yClb1_LxF_4	122	127	PF00134	0.262
DOC_CYCLIN_yCln2_LP_2	125	131	PF00134	0.314
DOC_CYCLIN_yCln2_LP_2	507	513	PF00134	0.629
DOC_MAPK_FxFP_2	339	342	PF00069	0.365
DOC_MAPK_gen_1	225	234	PF00069	0.487
DOC_MAPK_gen_1	380	389	PF00069	0.432
DOC_MAPK_MEF2A_6	124	133	PF00069	0.518
DOC_MAPK_MEF2A_6	225	234	PF00069	0.376
DOC_MAPK_MEF2A_6	353	362	PF00069	0.590
DOC_MAPK_MEF2A_6	382	391	PF00069	0.427
DOC_MAPK_MEF2A_6	54	62	PF00069	0.492
DOC_MAPK_MEF2A_6	88	96	PF00069	0.504
DOC_PP1_RVXF_1	122	128	PF00149	0.512
DOC_PP4_FxxP_1	339	342	PF00568	0.462
DOC_USP7_MATH_1	139	143	PF00917	0.457
DOC_USP7_MATH_1	144	148	PF00917	0.411
DOC_USP7_MATH_1	15	19	PF00917	0.472
DOC_USP7_MATH_1	287	291	PF00917	0.468
DOC_USP7_MATH_1	434	438	PF00917	0.721
DOC_USP7_MATH_1	445	449	PF00917	0.694
DOC_USP7_MATH_1	455	459	PF00917	0.577
DOC_USP7_MATH_1	535	539	PF00917	0.770
DOC_USP7_MATH_1	549	553	PF00917	0.688
DOC_USP7_MATH_1	615	619	PF00917	0.503
DOC_USP7_MATH_1	69	73	PF00917	0.432
DOC_USP7_MATH_1	773	777	PF00917	0.680
DOC_USP7_UBL2_3	763	767	PF12436	0.673
DOC_WW_Pin1_4	235	240	PF00397	0.381
DOC_WW_Pin1_4	249	254	PF00397	0.441
DOC_WW_Pin1_4	448	453	PF00397	0.741
DOC_WW_Pin1_4	541	546	PF00397	0.755
DOC_WW_Pin1_4	714	719	PF00397	0.749
DOC_WW_Pin1_4	79	84	PF00397	0.364
LIG_14-3-3_CanoR_1	116	120	PF00244	0.460
LIG_14-3-3_CanoR_1	260	265	PF00244	0.537
LIG_14-3-3_CanoR_1	289	299	PF00244	0.637
LIG_14-3-3_CanoR_1	314	322	PF00244	0.538
LIG_14-3-3_CanoR_1	405	415	PF00244	0.467
LIG_14-3-3_CanoR_1	681	691	PF00244	0.554
LIG_AP2alpha_1	560	564	PF02296	0.729
LIG_APCC_ABBAyCdc20_2	393	399	PF00400	0.566
LIG_BIR_II_1	1	5	PF00653	0.488
LIG_BIR_III_2	7	11	PF00653	0.512
LIG_BIR_III_4	11	15	PF00653	0.543
LIG_BIR_III_4	660	664	PF00653	0.672
LIG_BRCT_BRCA1_1	17	21	PF00533	0.468
LIG_BRCT_BRCA1_1	342	346	PF00533	0.361
LIG_BRCT_BRCA1_1	368	372	PF00533	0.545
LIG_BRCT_BRCA1_1	617	621	PF00533	0.720
LIG_BRCT_BRCA1_1	698	702	PF00533	0.733
LIG_Clathr_ClatBox_1	386	390	PF01394	0.450
LIG_EH1_1	126	134	PF00400	0.501
LIG_eIF4E_1	296	302	PF01652	0.323
LIG_FHA_1	144	150	PF00498	0.394
LIG_FHA_1	156	162	PF00498	0.417
LIG_FHA_1	176	182	PF00498	0.245
LIG_FHA_1	202	208	PF00498	0.474
LIG_FHA_1	42	48	PF00498	0.474
LIG_FHA_1	421	427	PF00498	0.524
LIG_FHA_1	455	461	PF00498	0.701
LIG_FHA_1	551	557	PF00498	0.621
LIG_FHA_1	743	749	PF00498	0.692
LIG_FHA_1	751	757	PF00498	0.727
LIG_FHA_2	163	169	PF00498	0.498
LIG_FHA_2	406	412	PF00498	0.435
LIG_FHA_2	434	440	PF00498	0.792
LIG_FHA_2	457	463	PF00498	0.675
LIG_FHA_2	48	54	PF00498	0.480
LIG_FHA_2	510	516	PF00498	0.666
LIG_FHA_2	580	586	PF00498	0.650
LIG_FHA_2	607	613	PF00498	0.784
LIG_FHA_2	62	68	PF00498	0.383
LIG_FHA_2	80	86	PF00498	0.462
LIG_FHA_2	96	102	PF00498	0.459
LIG_FXI_DFP_1	557	561	PF00024	0.747
LIG_GBD_Chelix_1	113	121	PF00786	0.486
LIG_HP1_1	463	467	PF01393	0.585
LIG_LIR_Apic_2	293	299	PF02991	0.565
LIG_LIR_Apic_2	526	532	PF02991	0.525
LIG_LIR_Gen_1	165	175	PF02991	0.474
LIG_LIR_Gen_1	18	26	PF02991	0.480
LIG_LIR_Gen_1	195	203	PF02991	0.463
LIG_LIR_Gen_1	218	227	PF02991	0.461
LIG_LIR_Gen_1	305	313	PF02991	0.435
LIG_LIR_Gen_1	332	341	PF02991	0.288
LIG_LIR_Gen_1	44	53	PF02991	0.450
LIG_LIR_Gen_1	576	585	PF02991	0.583
LIG_LIR_Nem_3	165	170	PF02991	0.512
LIG_LIR_Nem_3	18	24	PF02991	0.475
LIG_LIR_Nem_3	195	200	PF02991	0.466
LIG_LIR_Nem_3	218	223	PF02991	0.444
LIG_LIR_Nem_3	28	34	PF02991	0.358
LIG_LIR_Nem_3	305	309	PF02991	0.440
LIG_LIR_Nem_3	332	336	PF02991	0.277
LIG_LIR_Nem_3	42	48	PF02991	0.346
LIG_LIR_Nem_3	470	475	PF02991	0.573
LIG_LIR_Nem_3	576	581	PF02991	0.608
LIG_MLH1_MIPbox_1	17	21	PF16413	0.481
LIG_Pex14_1	123	127	PF04695	0.510
LIG_Pex14_2	162	166	PF04695	0.490
LIG_Pex14_2	560	564	PF04695	0.729
LIG_PTB_Apo_2	149	156	PF02174	0.363
LIG_PTB_Apo_2	300	307	PF02174	0.545
LIG_PTB_Apo_2	327	334	PF02174	0.308
LIG_PTB_Phospho_1	149	155	PF10480	0.364
LIG_PTB_Phospho_1	300	306	PF10480	0.543
LIG_SH2_CRK	220	224	PF00017	0.451
LIG_SH2_CRK	296	300	PF00017	0.486
LIG_SH2_GRB2like	487	490	PF00017	0.455
LIG_SH2_GRB2like	759	762	PF00017	0.741
LIG_SH2_NCK_1	475	479	PF00017	0.305
LIG_SH2_STAP1	487	491	PF00017	0.560
LIG_SH2_STAP1	639	643	PF00017	0.600
LIG_SH2_STAT3	282	285	PF00017	0.586
LIG_SH2_STAT5	155	158	PF00017	0.383
LIG_SH2_STAT5	282	285	PF00017	0.367
LIG_SH2_STAT5	296	299	PF00017	0.384
LIG_SH2_STAT5	590	593	PF00017	0.586
LIG_SH3_3	116	122	PF00018	0.487
LIG_SH3_3	158	164	PF00018	0.288
LIG_SH3_3	233	239	PF00018	0.488
LIG_SH3_3	250	256	PF00018	0.551
LIG_SH3_3	457	463	PF00018	0.659
LIG_SUMO_SIM_anti_2	130	135	PF11976	0.319
LIG_SUMO_SIM_anti_2	146	152	PF11976	0.370
LIG_SUMO_SIM_anti_2	332	338	PF11976	0.397
LIG_SUMO_SIM_anti_2	385	390	PF11976	0.436
LIG_SUMO_SIM_par_1	232	238	PF11976	0.368
LIG_SUMO_SIM_par_1	358	363	PF11976	0.558
LIG_SUMO_SIM_par_1	385	390	PF11976	0.436
LIG_TRAF2_1	522	525	PF00917	0.655
LIG_UBA3_1	359	364	PF00899	0.600
LIG_WRC_WIRS_1	194	199	PF05994	0.503
MOD_CDK_SPK_2	249	254	PF00069	0.586
MOD_CDK_SPxK_1	249	255	PF00069	0.583
MOD_CDK_SPxxK_3	541	548	PF00069	0.799
MOD_CK1_1	290	296	PF00069	0.407
MOD_CK1_1	332	338	PF00069	0.359
MOD_CK1_1	418	424	PF00069	0.573
MOD_CK1_1	437	443	PF00069	0.591
MOD_CK1_1	448	454	PF00069	0.726
MOD_CK1_1	514	520	PF00069	0.688
MOD_CK1_1	544	550	PF00069	0.677
MOD_CK1_1	71	77	PF00069	0.562
MOD_CK1_1	750	756	PF00069	0.503
MOD_CK2_1	192	198	PF00069	0.551
MOD_CK2_1	405	411	PF00069	0.448
MOD_CK2_1	433	439	PF00069	0.776
MOD_CK2_1	509	515	PF00069	0.626
MOD_GlcNHglycan	136	139	PF01048	0.456
MOD_GlcNHglycan	273	276	PF01048	0.466
MOD_GlcNHglycan	342	345	PF01048	0.505
MOD_GlcNHglycan	423	426	PF01048	0.636
MOD_GlcNHglycan	436	439	PF01048	0.634
MOD_GlcNHglycan	475	478	PF01048	0.562
MOD_GlcNHglycan	537	540	PF01048	0.739
MOD_GlcNHglycan	659	664	PF01048	0.597
MOD_GlcNHglycan	697	701	PF01048	0.756
MOD_GSK3_1	139	146	PF00069	0.395
MOD_GSK3_1	15	22	PF00069	0.437
MOD_GSK3_1	162	169	PF00069	0.400
MOD_GSK3_1	215	222	PF00069	0.459
MOD_GSK3_1	256	263	PF00069	0.433
MOD_GSK3_1	360	367	PF00069	0.503
MOD_GSK3_1	420	427	PF00069	0.586
MOD_GSK3_1	433	440	PF00069	0.657
MOD_GSK3_1	659	666	PF00069	0.775
MOD_GSK3_1	681	688	PF00069	0.817
MOD_LATS_1	312	318	PF00433	0.319
MOD_N-GLC_1	270	275	PF02516	0.519
MOD_N-GLC_1	302	307	PF02516	0.534
MOD_N-GLC_1	329	334	PF02516	0.557
MOD_NEK2_1	1	6	PF00069	0.488
MOD_NEK2_1	134	139	PF00069	0.478
MOD_NEK2_1	278	283	PF00069	0.419
MOD_NEK2_1	742	747	PF00069	0.661
MOD_PIKK_1	281	287	PF00454	0.575
MOD_PIKK_1	685	691	PF00454	0.551
MOD_PK_1	260	266	PF00069	0.494
MOD_PKA_1	762	768	PF00069	0.650
MOD_PKA_2	115	121	PF00069	0.479
MOD_PKA_2	134	140	PF00069	0.344
MOD_PKA_2	175	181	PF00069	0.453
MOD_PKA_2	201	207	PF00069	0.455
MOD_PKB_1	679	687	PF00069	0.554
MOD_Plk_1	302	308	PF00069	0.500
MOD_Plk_1	41	47	PF00069	0.456
MOD_Plk_1	418	424	PF00069	0.515
MOD_Plk_1	496	502	PF00069	0.516
MOD_Plk_1	560	566	PF00069	0.717
MOD_Plk_4	115	121	PF00069	0.473
MOD_Plk_4	127	133	PF00069	0.299
MOD_Plk_4	144	150	PF00069	0.257
MOD_Plk_4	16	22	PF00069	0.416
MOD_Plk_4	162	168	PF00069	0.265
MOD_Plk_4	260	266	PF00069	0.455
MOD_Plk_4	329	335	PF00069	0.461
MOD_Plk_4	708	714	PF00069	0.547
MOD_ProDKin_1	235	241	PF00069	0.377
MOD_ProDKin_1	249	255	PF00069	0.438
MOD_ProDKin_1	448	454	PF00069	0.738
MOD_ProDKin_1	541	547	PF00069	0.757
MOD_ProDKin_1	714	720	PF00069	0.749
MOD_ProDKin_1	79	85	PF00069	0.354
MOD_SUMO_rev_2	622	629	PF00179	0.663
TRG_ENDOCYTIC_2	220	223	PF00928	0.477
TRG_ENDOCYTIC_2	306	309	PF00928	0.418
TRG_ENDOCYTIC_2	570	573	PF00928	0.602
TRG_ENDOCYTIC_2	578	581	PF00928	0.550
TRG_ER_diArg_1	104	106	PF00400	0.588
TRG_ER_diArg_1	183	186	PF00400	0.567
TRG_ER_diArg_1	253	255	PF00400	0.591
TRG_ER_diArg_1	380	383	PF00400	0.429
TRG_ER_diArg_1	404	406	PF00400	0.342
TRG_ER_diArg_1	672	675	PF00400	0.768
TRG_NES_CRM1_1	235	250	PF08389	0.456
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	575	579	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	632	636	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3W0	Leptomonas seymouri	62%	99%
A0A1X0P037	Trypanosomatidae	37%	100%
A0A3S7XBW7	Leishmania donovani	80%	100%
A0A422NSD1	Trypanosoma rangeli	40%	100%
A4IDY4	Leishmania infantum	79%	100%
D0A425	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AU04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q0J1	Leishmania major	79%	100%
V5BTA0	Trypanosoma cruzi	40%	100%