Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ85_LEIBR

TriTrypDb:

LbrM.35.5970 , LBRM2903_350071000

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ85

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.444
CLV_C14_Caspase3-7	98	102	PF00656	0.591
CLV_NRD_NRD_1	291	293	PF00675	0.492
CLV_NRD_NRD_1	300	302	PF00675	0.514
CLV_NRD_NRD_1	39	41	PF00675	0.646
CLV_NRD_NRD_1	61	63	PF00675	0.444
CLV_PCSK_KEX2_1	215	217	PF00082	0.363
CLV_PCSK_KEX2_1	228	230	PF00082	0.406
CLV_PCSK_KEX2_1	281	283	PF00082	0.559
CLV_PCSK_KEX2_1	300	302	PF00082	0.390
CLV_PCSK_KEX2_1	39	41	PF00082	0.646
CLV_PCSK_KEX2_1	61	63	PF00082	0.445
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.363
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.406
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.512
CLV_PCSK_PC7_1	211	217	PF00082	0.391
CLV_PCSK_SKI1_1	143	147	PF00082	0.338
CLV_PCSK_SKI1_1	292	296	PF00082	0.541
CLV_PCSK_SKI1_1	3	7	PF00082	0.550
CLV_PCSK_SKI1_1	306	310	PF00082	0.496
CLV_PCSK_SKI1_1	85	89	PF00082	0.548
DEG_APCC_DBOX_1	38	46	PF00400	0.731
DEG_Nend_UBRbox_3	1	3	PF02207	0.668
DOC_CYCLIN_RxL_1	137	150	PF00134	0.351
DOC_MAPK_gen_1	259	266	PF00069	0.342
DOC_MAPK_MEF2A_6	118	125	PF00069	0.514
DOC_PP2B_LxvP_1	246	249	PF13499	0.543
DOC_PP2B_LxvP_1	309	312	PF13499	0.565
DOC_PP4_FxxP_1	286	289	PF00568	0.546
DOC_PP4_FxxP_1	295	298	PF00568	0.588
DOC_USP7_MATH_1	22	26	PF00917	0.604
DOC_USP7_MATH_1	233	237	PF00917	0.570
DOC_USP7_UBL2_3	143	147	PF12436	0.471
DOC_USP7_UBL2_3	54	58	PF12436	0.490
DOC_WW_Pin1_4	18	23	PF00397	0.637
DOC_WW_Pin1_4	30	35	PF00397	0.663
LIG_14-3-3_CanoR_1	232	240	PF00244	0.612
LIG_14-3-3_CanoR_1	52	57	PF00244	0.494
LIG_APCC_ABBA_1	161	166	PF00400	0.517
LIG_FHA_1	105	111	PF00498	0.504
LIG_FHA_1	86	92	PF00498	0.514
LIG_FHA_2	248	254	PF00498	0.574
LIG_LIR_Apic_2	284	289	PF02991	0.548
LIG_LIR_Gen_1	150	158	PF02991	0.358
LIG_LIR_Gen_1	173	183	PF02991	0.414
LIG_LIR_Gen_1	250	258	PF02991	0.362
LIG_LIR_Nem_3	173	178	PF02991	0.417
LIG_LIR_Nem_3	250	254	PF02991	0.511
LIG_OCRL_FandH_1	250	262	PF00620	0.360
LIG_Pex14_2	63	67	PF04695	0.510
LIG_SH2_CRK	53	57	PF00017	0.622
LIG_SH2_NCK_1	75	79	PF00017	0.635
LIG_SH2_STAT5	103	106	PF00017	0.574
LIG_SH2_STAT5	285	288	PF00017	0.470
LIG_SH3_3	309	315	PF00018	0.514
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.314
LIG_SUMO_SIM_anti_2	88	98	PF11976	0.420
LIG_SUMO_SIM_par_1	121	128	PF11976	0.457
MOD_CK1_1	18	24	PF00069	0.611
MOD_CK1_1	33	39	PF00069	0.682
MOD_CK2_1	247	253	PF00069	0.491
MOD_Cter_Amidation	213	216	PF01082	0.385
MOD_GlcNHglycan	235	238	PF01048	0.592
MOD_GlcNHglycan	24	27	PF01048	0.690
MOD_GSK3_1	18	25	PF00069	0.620
MOD_GSK3_1	183	190	PF00069	0.288
MOD_GSK3_1	249	256	PF00069	0.580
MOD_LATS_1	50	56	PF00433	0.582
MOD_LATS_1	83	89	PF00433	0.509
MOD_NEK2_1	185	190	PF00069	0.347
MOD_NEK2_1	28	33	PF00069	0.553
MOD_OFUCOSY	182	189	PF10250	0.281
MOD_PIKK_1	183	189	PF00454	0.287
MOD_PK_1	300	306	PF00069	0.393
MOD_PKA_1	300	306	PF00069	0.393
MOD_PKA_1	61	67	PF00069	0.486
MOD_PKA_2	300	306	PF00069	0.393
MOD_PKA_2	61	67	PF00069	0.538
MOD_Plk_1	217	223	PF00069	0.432
MOD_Plk_4	121	127	PF00069	0.403
MOD_Plk_4	171	177	PF00069	0.379
MOD_Plk_4	52	58	PF00069	0.494
MOD_ProDKin_1	18	24	PF00069	0.630
MOD_ProDKin_1	30	36	PF00069	0.660
MOD_SUMO_rev_2	236	244	PF00179	0.694
TRG_ENDOCYTIC_2	53	56	PF00928	0.624
TRG_ENDOCYTIC_2	75	78	PF00928	0.550
TRG_ER_diArg_1	289	292	PF00400	0.532
TRG_ER_diArg_1	299	301	PF00400	0.551
TRG_ER_diArg_1	61	63	PF00400	0.426
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGJ4	Leptomonas seymouri	75%	99%
A0A0S4IS55	Bodo saltans	50%	100%
A0A1X0P0I2	Trypanosomatidae	61%	100%
A0A3R7M3K5	Trypanosoma rangeli	56%	100%
A0A3S7XBV5	Leishmania donovani	86%	100%
A4IDY3	Leishmania infantum	85%	100%
D0A426	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AU03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q0J2	Leishmania major	85%	100%