Integral membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ84_LEIBR

TriTrypDb:

LbrM.35.5960 , LBRM2903_350070900

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HQ84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ84

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	97	99	PF00675	0.305
CLV_PCSK_KEX2_1	97	99	PF00082	0.333
CLV_PCSK_SKI1_1	87	91	PF00082	0.439
DEG_APCC_DBOX_1	69	77	PF00400	0.467
DEG_ODPH_VHL_1	127	139	PF01847	0.478
DOC_CKS1_1	132	137	PF01111	0.542
DOC_MAPK_gen_1	83	91	PF00069	0.439
DOC_MAPK_MEF2A_6	200	208	PF00069	0.439
DOC_MAPK_MEF2A_6	85	93	PF00069	0.399
DOC_PP4_FxxP_1	126	129	PF00568	0.542
DOC_PP4_FxxP_1	74	77	PF00568	0.585
DOC_USP7_MATH_1	46	50	PF00917	0.712
DOC_USP7_MATH_1	75	79	PF00917	0.448
DOC_USP7_UBL2_3	109	113	PF12436	0.354
DOC_WW_Pin1_4	131	136	PF00397	0.553
DOC_WW_Pin1_4	154	159	PF00397	0.351
DOC_WW_Pin1_4	185	190	PF00397	0.419
LIG_14-3-3_CanoR_1	153	158	PF00244	0.543
LIG_14-3-3_CanoR_1	98	106	PF00244	0.501
LIG_APCC_ABBA_1	141	146	PF00400	0.565
LIG_BIR_II_1	1	5	PF00653	0.584
LIG_BRCT_BRCA1_1	116	120	PF00533	0.587
LIG_eIF4E_1	174	180	PF01652	0.427
LIG_FHA_1	132	138	PF00498	0.438
LIG_FHA_1	154	160	PF00498	0.460
LIG_FHA_1	21	27	PF00498	0.512
LIG_FHA_2	106	112	PF00498	0.458
LIG_GBD_Chelix_1	26	34	PF00786	0.546
LIG_LIR_Gen_1	197	206	PF02991	0.399
LIG_LIR_Gen_1	28	34	PF02991	0.502
LIG_LIR_Nem_3	116	121	PF02991	0.568
LIG_LIR_Nem_3	171	177	PF02991	0.338
LIG_LIR_Nem_3	197	201	PF02991	0.388
LIG_LIR_Nem_3	205	211	PF02991	0.406
LIG_LIR_Nem_3	28	32	PF02991	0.509
LIG_Pex14_2	140	144	PF04695	0.455
LIG_Pex14_2	216	220	PF04695	0.465
LIG_Pex14_2	25	29	PF04695	0.495
LIG_REV1ctd_RIR_1	138	146	PF16727	0.531
LIG_SH2_CRK	118	122	PF00017	0.561
LIG_SH2_CRK	177	181	PF00017	0.300
LIG_SH2_CRK	69	73	PF00017	0.500
LIG_SH2_STAT3	214	217	PF00017	0.416
LIG_SH2_STAT5	138	141	PF00017	0.494
LIG_SH2_STAT5	209	212	PF00017	0.464
LIG_SH2_STAT5	227	230	PF00017	0.594
LIG_SH3_1	69	75	PF00018	0.472
LIG_SH3_3	130	136	PF00018	0.530
LIG_SH3_3	69	75	PF00018	0.472
LIG_TYR_ITSM	114	121	PF00017	0.323
LIG_WW_1	135	138	PF00397	0.439
MOD_CK1_1	170	176	PF00069	0.340
MOD_CK1_1	20	26	PF00069	0.498
MOD_CK2_1	105	111	PF00069	0.468
MOD_CK2_1	219	225	PF00069	0.514
MOD_DYRK1A_RPxSP_1	185	189	PF00069	0.510
MOD_GlcNHglycan	19	22	PF01048	0.503
MOD_GlcNHglycan	211	214	PF01048	0.445
MOD_GSK3_1	154	161	PF00069	0.349
MOD_GSK3_1	3	10	PF00069	0.610
MOD_NEK2_1	114	119	PF00069	0.564
MOD_NEK2_1	179	184	PF00069	0.371
MOD_NEK2_1	34	39	PF00069	0.551
MOD_PIKK_1	34	40	PF00454	0.551
MOD_Plk_1	170	176	PF00069	0.445
MOD_Plk_1	196	202	PF00069	0.550
MOD_Plk_4	11	17	PF00069	0.534
MOD_ProDKin_1	131	137	PF00069	0.549
MOD_ProDKin_1	154	160	PF00069	0.354
MOD_ProDKin_1	185	191	PF00069	0.416
MOD_SUMO_rev_2	104	114	PF00179	0.514
TRG_ENDOCYTIC_2	118	121	PF00928	0.443
TRG_ENDOCYTIC_2	123	126	PF00928	0.472
TRG_ENDOCYTIC_2	138	141	PF00928	0.378
TRG_ENDOCYTIC_2	177	180	PF00928	0.301
TRG_ER_diArg_1	152	155	PF00400	0.472
TRG_ER_diArg_1	97	99	PF00400	0.306
TRG_NES_CRM1_1	17	28	PF08389	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P911	Leptomonas seymouri	78%	100%
A0A0S4J1S1	Bodo saltans	48%	98%
A0A1X0P1B4	Trypanosomatidae	66%	100%
A0A3Q8IGN5	Leishmania donovani	92%	100%
A0A422NSE3	Trypanosoma rangeli	65%	100%
A4IDY2	Leishmania infantum	91%	100%
D0A428	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AU02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q0J3	Leishmania major	89%	100%
V5BJ65	Trypanosoma cruzi	66%	100%