DAO domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FAD dependent oxidoreductase, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ82_LEIBR

TriTrypDb:

LbrM.35.5940 , LBRM2903_350070700

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQ82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ82

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0000166	nucleotide binding	3	1
GO:0004497	monooxygenase activity	3	1
GO:0005488	binding	1	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.642
CLV_C14_Caspase3-7	372	376	PF00656	0.559
CLV_C14_Caspase3-7	650	654	PF00656	0.560
CLV_C14_Caspase3-7	70	74	PF00656	0.211
CLV_NRD_NRD_1	313	315	PF00675	0.621
CLV_NRD_NRD_1	533	535	PF00675	0.547
CLV_NRD_NRD_1	554	556	PF00675	0.675
CLV_NRD_NRD_1	586	588	PF00675	0.608
CLV_NRD_NRD_1	618	620	PF00675	0.631
CLV_NRD_NRD_1	62	64	PF00675	0.411
CLV_NRD_NRD_1	656	658	PF00675	0.650
CLV_NRD_NRD_1	706	708	PF00675	0.615
CLV_PCSK_KEX2_1	312	314	PF00082	0.611
CLV_PCSK_KEX2_1	533	535	PF00082	0.516
CLV_PCSK_KEX2_1	617	619	PF00082	0.642
CLV_PCSK_KEX2_1	62	64	PF00082	0.411
CLV_PCSK_KEX2_1	698	700	PF00082	0.743
CLV_PCSK_KEX2_1	706	708	PF00082	0.590
CLV_PCSK_KEX2_1	714	716	PF00082	0.493
CLV_PCSK_PC1ET2_1	698	700	PF00082	0.743
CLV_PCSK_PC1ET2_1	714	716	PF00082	0.493
CLV_PCSK_SKI1_1	304	308	PF00082	0.402
CLV_PCSK_SKI1_1	460	464	PF00082	0.440
CLV_PCSK_SKI1_1	542	546	PF00082	0.452
CLV_PCSK_SKI1_1	588	592	PF00082	0.654
CLV_PCSK_SKI1_1	689	693	PF00082	0.500
CLV_PCSK_SKI1_1	709	713	PF00082	0.686
CLV_PCSK_SKI1_1	89	93	PF00082	0.506
CLV_PCSK_SKI1_1	98	102	PF00082	0.462
CLV_Separin_Metazoa	95	99	PF03568	0.525
DEG_APCC_DBOX_1	71	79	PF00400	0.540
DEG_SPOP_SBC_1	362	366	PF00917	0.420
DOC_CKS1_1	11	16	PF01111	0.524
DOC_CKS1_1	390	395	PF01111	0.543
DOC_CKS1_1	672	677	PF01111	0.710
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.590
DOC_MAPK_DCC_7	72	80	PF00069	0.539
DOC_MAPK_gen_1	428	437	PF00069	0.463
DOC_MAPK_MEF2A_6	72	80	PF00069	0.539
DOC_PP1_RVXF_1	50	56	PF00149	0.408
DOC_PP1_RVXF_1	540	546	PF00149	0.300
DOC_PP2B_LxvP_1	29	32	PF13499	0.577
DOC_PP4_FxxP_1	171	174	PF00568	0.582
DOC_USP7_MATH_1	244	248	PF00917	0.468
DOC_USP7_MATH_1	266	270	PF00917	0.487
DOC_USP7_MATH_1	302	306	PF00917	0.487
DOC_USP7_MATH_1	318	322	PF00917	0.719
DOC_USP7_MATH_1	362	366	PF00917	0.589
DOC_USP7_MATH_1	380	384	PF00917	0.770
DOC_USP7_MATH_1	436	440	PF00917	0.624
DOC_USP7_UBL2_3	498	502	PF12436	0.403
DOC_WW_Pin1_4	10	15	PF00397	0.756
DOC_WW_Pin1_4	17	22	PF00397	0.700
DOC_WW_Pin1_4	320	325	PF00397	0.676
DOC_WW_Pin1_4	340	345	PF00397	0.300
DOC_WW_Pin1_4	389	394	PF00397	0.640
DOC_WW_Pin1_4	460	465	PF00397	0.399
DOC_WW_Pin1_4	527	532	PF00397	0.673
DOC_WW_Pin1_4	592	597	PF00397	0.651
DOC_WW_Pin1_4	648	653	PF00397	0.446
DOC_WW_Pin1_4	671	676	PF00397	0.734
LIG_14-3-3_CanoR_1	131	139	PF00244	0.546
LIG_14-3-3_CanoR_1	26	32	PF00244	0.648
LIG_14-3-3_CanoR_1	533	541	PF00244	0.569
LIG_14-3-3_CanoR_1	555	560	PF00244	0.605
LIG_14-3-3_CanoR_1	667	676	PF00244	0.608
LIG_14-3-3_CanoR_1	699	708	PF00244	0.642
LIG_Actin_WH2_2	284	302	PF00022	0.552
LIG_BRCT_BRCA1_1	73	77	PF00533	0.502
LIG_Clathr_ClatBox_1	401	405	PF01394	0.473
LIG_deltaCOP1_diTrp_1	635	642	PF00928	0.640
LIG_FHA_1	143	149	PF00498	0.410
LIG_FHA_1	199	205	PF00498	0.410
LIG_FHA_1	22	28	PF00498	0.669
LIG_FHA_1	234	240	PF00498	0.540
LIG_FHA_1	270	276	PF00498	0.484
LIG_FHA_1	344	350	PF00498	0.504
LIG_FHA_1	410	416	PF00498	0.632
LIG_FHA_1	524	530	PF00498	0.656
LIG_FHA_2	103	109	PF00498	0.409
LIG_FHA_2	390	396	PF00498	0.660
LIG_FHA_2	440	446	PF00498	0.681
LIG_FHA_2	533	539	PF00498	0.506
LIG_FHA_2	558	564	PF00498	0.673
LIG_FHA_2	56	62	PF00498	0.335
LIG_FHA_2	609	615	PF00498	0.611
LIG_FHA_2	690	696	PF00498	0.768
LIG_FHA_2	700	706	PF00498	0.556
LIG_IBAR_NPY_1	575	577	PF08397	0.557
LIG_Integrin_RGD_1	63	65	PF01839	0.479
LIG_LIR_Apic_2	566	572	PF02991	0.468
LIG_LIR_Apic_2	670	675	PF02991	0.703
LIG_LIR_Gen_1	113	124	PF02991	0.477
LIG_LIR_Gen_1	134	144	PF02991	0.427
LIG_LIR_Gen_1	257	266	PF02991	0.467
LIG_LIR_Gen_1	476	485	PF02991	0.450
LIG_LIR_Gen_1	579	590	PF02991	0.614
LIG_LIR_Gen_1	639	646	PF02991	0.626
LIG_LIR_Nem_3	113	119	PF02991	0.509
LIG_LIR_Nem_3	134	139	PF02991	0.441
LIG_LIR_Nem_3	225	231	PF02991	0.522
LIG_LIR_Nem_3	257	262	PF02991	0.448
LIG_LIR_Nem_3	424	429	PF02991	0.454
LIG_LIR_Nem_3	476	480	PF02991	0.463
LIG_LIR_Nem_3	521	525	PF02991	0.647
LIG_LIR_Nem_3	74	80	PF02991	0.497
LIG_LYPXL_yS_3	163	166	PF13949	0.466
LIG_NRBOX	397	403	PF00104	0.498
LIG_PAM2_1	313	325	PF00658	0.508
LIG_PCNA_yPIPBox_3	121	133	PF02747	0.535
LIG_PCNA_yPIPBox_3	89	101	PF02747	0.361
LIG_SH2_CRK	259	263	PF00017	0.473
LIG_SH2_GRB2like	144	147	PF00017	0.399
LIG_SH2_STAP1	144	148	PF00017	0.394
LIG_SH2_STAP1	259	263	PF00017	0.494
LIG_SH2_STAT3	212	215	PF00017	0.540
LIG_SH2_STAT5	144	147	PF00017	0.399
LIG_SH2_STAT5	228	231	PF00017	0.547
LIG_SH2_STAT5	359	362	PF00017	0.533
LIG_SH2_STAT5	426	429	PF00017	0.458
LIG_SH2_STAT5	458	461	PF00017	0.427
LIG_SH3_1	243	249	PF00018	0.605
LIG_SH3_3	238	244	PF00018	0.583
LIG_SH3_3	289	295	PF00018	0.540
LIG_SH3_3	8	14	PF00018	0.714
LIG_SUMO_SIM_anti_2	137	143	PF11976	0.292
LIG_SUMO_SIM_anti_2	260	265	PF11976	0.398
LIG_SUMO_SIM_anti_2	346	352	PF11976	0.461
LIG_SUMO_SIM_par_1	191	196	PF11976	0.425
LIG_SUMO_SIM_par_1	345	352	PF11976	0.392
LIG_SUMO_SIM_par_1	400	407	PF11976	0.535
LIG_TRAF2_1	604	607	PF00917	0.454
LIG_UBA3_1	401	409	PF00899	0.590
LIG_WRC_WIRS_1	437	442	PF05994	0.374
MOD_CDC14_SPxK_1	530	533	PF00782	0.639
MOD_CDK_SPxK_1	527	533	PF00069	0.663
MOD_CDK_SPxxK_3	527	534	PF00069	0.655
MOD_CK1_1	134	140	PF00069	0.491
MOD_CK1_1	149	155	PF00069	0.179
MOD_CK1_1	235	241	PF00069	0.593
MOD_CK1_1	269	275	PF00069	0.549
MOD_CK1_1	286	292	PF00069	0.338
MOD_CK1_1	352	358	PF00069	0.452
MOD_CK1_1	363	369	PF00069	0.601
MOD_CK1_1	403	409	PF00069	0.529
MOD_CK1_1	438	444	PF00069	0.672
MOD_CK1_1	527	533	PF00069	0.663
MOD_CK1_1	690	696	PF00069	0.616
MOD_CK2_1	134	140	PF00069	0.500
MOD_CK2_1	244	250	PF00069	0.477
MOD_CK2_1	439	445	PF00069	0.669
MOD_CK2_1	532	538	PF00069	0.475
MOD_CK2_1	55	61	PF00069	0.354
MOD_CK2_1	557	563	PF00069	0.710
MOD_CK2_1	608	614	PF00069	0.584
MOD_CK2_1	667	673	PF00069	0.738
MOD_CK2_1	689	695	PF00069	0.763
MOD_CK2_1	699	705	PF00069	0.562
MOD_DYRK1A_RPxSP_1	460	464	PF00069	0.416
MOD_GlcNHglycan	285	288	PF01048	0.492
MOD_GlcNHglycan	315	318	PF01048	0.667
MOD_GlcNHglycan	32	35	PF01048	0.495
MOD_GlcNHglycan	329	332	PF01048	0.503
MOD_GlcNHglycan	378	381	PF01048	0.769
MOD_GlcNHglycan	545	548	PF01048	0.326
MOD_GSK3_1	142	149	PF00069	0.447
MOD_GSK3_1	17	24	PF00069	0.687
MOD_GSK3_1	235	242	PF00069	0.498
MOD_GSK3_1	267	274	PF00069	0.433
MOD_GSK3_1	313	320	PF00069	0.717
MOD_GSK3_1	348	355	PF00069	0.467
MOD_GSK3_1	357	364	PF00069	0.536
MOD_GSK3_1	376	383	PF00069	0.449
MOD_GSK3_1	400	407	PF00069	0.466
MOD_GSK3_1	431	438	PF00069	0.545
MOD_GSK3_1	439	446	PF00069	0.603
MOD_GSK3_1	523	530	PF00069	0.655
MOD_GSK3_1	551	558	PF00069	0.636
MOD_GSK3_1	559	566	PF00069	0.681
MOD_GSK3_1	667	674	PF00069	0.653
MOD_GSK3_1	687	694	PF00069	0.689
MOD_GSK3_1	83	90	PF00069	0.559
MOD_N-GLC_1	146	151	PF02516	0.413
MOD_N-GLC_1	21	26	PF02516	0.679
MOD_NEK2_1	115	120	PF00069	0.527
MOD_NEK2_1	142	147	PF00069	0.407
MOD_NEK2_1	222	227	PF00069	0.324
MOD_NEK2_1	27	32	PF00069	0.428
MOD_NEK2_1	283	288	PF00069	0.489
MOD_NEK2_1	349	354	PF00069	0.517
MOD_NEK2_1	374	379	PF00069	0.786
MOD_NEK2_1	384	389	PF00069	0.662
MOD_NEK2_1	404	409	PF00069	0.314
MOD_NEK2_1	524	529	PF00069	0.670
MOD_NEK2_1	543	548	PF00069	0.233
MOD_NEK2_1	55	60	PF00069	0.335
MOD_NEK2_1	87	92	PF00069	0.604
MOD_NEK2_2	302	307	PF00069	0.552
MOD_NMyristoyl	1	7	PF02799	0.665
MOD_PIKK_1	667	673	PF00454	0.720
MOD_PKA_1	313	319	PF00069	0.507
MOD_PKA_1	555	561	PF00069	0.731
MOD_PKA_2	239	245	PF00069	0.479
MOD_PKA_2	25	31	PF00069	0.671
MOD_PKA_2	3	9	PF00069	0.750
MOD_PKA_2	313	319	PF00069	0.546
MOD_PKA_2	447	453	PF00069	0.626
MOD_PKA_2	532	538	PF00069	0.494
MOD_PKA_2	71	77	PF00069	0.449
MOD_Plk_1	146	152	PF00069	0.410
MOD_Plk_1	687	693	PF00069	0.673
MOD_Plk_4	115	121	PF00069	0.546
MOD_Plk_4	151	157	PF00069	0.478
MOD_Plk_4	224	230	PF00069	0.513
MOD_Plk_4	352	358	PF00069	0.509
MOD_Plk_4	380	386	PF00069	0.728
MOD_Plk_4	422	428	PF00069	0.541
MOD_Plk_4	55	61	PF00069	0.335
MOD_Plk_4	565	571	PF00069	0.707
MOD_Plk_4	636	642	PF00069	0.500
MOD_ProDKin_1	10	16	PF00069	0.753
MOD_ProDKin_1	17	23	PF00069	0.697
MOD_ProDKin_1	320	326	PF00069	0.672
MOD_ProDKin_1	340	346	PF00069	0.287
MOD_ProDKin_1	389	395	PF00069	0.621
MOD_ProDKin_1	460	466	PF00069	0.403
MOD_ProDKin_1	527	533	PF00069	0.663
MOD_ProDKin_1	592	598	PF00069	0.650
MOD_ProDKin_1	648	654	PF00069	0.443
MOD_ProDKin_1	671	677	PF00069	0.736
MOD_SUMO_for_1	408	411	PF00179	0.639
MOD_SUMO_rev_2	673	682	PF00179	0.706
TRG_DiLeu_BaEn_1	411	416	PF01217	0.378
TRG_DiLeu_BaEn_1	539	544	PF01217	0.511
TRG_DiLeu_LyEn_5	539	544	PF01217	0.311
TRG_ENDOCYTIC_2	125	128	PF00928	0.512
TRG_ENDOCYTIC_2	163	166	PF00928	0.466
TRG_ENDOCYTIC_2	211	214	PF00928	0.519
TRG_ENDOCYTIC_2	259	262	PF00928	0.500
TRG_ENDOCYTIC_2	426	429	PF00928	0.458
TRG_ER_diArg_1	311	314	PF00400	0.601
TRG_ER_diArg_1	453	456	PF00400	0.507
TRG_ER_diArg_1	616	619	PF00400	0.658
TRG_ER_diArg_1	706	709	PF00400	0.726
TRG_NES_CRM1_1	49	61	PF08389	0.335
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I902	Leptomonas seymouri	57%	97%
A0A0S4IXS1	Bodo saltans	27%	100%
A0A1X0P069	Trypanosomatidae	35%	100%
A0A3Q8IK10	Leishmania donovani	82%	100%
A4IDY0	Leishmania infantum	82%	100%
D0A430	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AU00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q0J5	Leishmania major	82%	100%
V5DK61	Trypanosoma cruzi	36%	100%