DUF3456 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ81_LEIBR

TriTrypDb:

LbrM.35.5930 , LBRM2903_350070600

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 0
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQ81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ81

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.542
CLV_C14_Caspase3-7	225	229	PF00656	0.520
CLV_C14_Caspase3-7	289	293	PF00656	0.408
CLV_NRD_NRD_1	36	38	PF00675	0.669
CLV_PCSK_SKI1_1	136	140	PF00082	0.309
CLV_PCSK_SKI1_1	269	273	PF00082	0.557
DEG_APCC_DBOX_1	276	284	PF00400	0.393
DEG_SCF_FBW7_2	199	204	PF00400	0.309
DOC_CYCLIN_yCln2_LP_2	42	48	PF00134	0.583
DOC_MAPK_gen_1	145	155	PF00069	0.521
DOC_MAPK_gen_1	37	44	PF00069	0.464
DOC_MAPK_MEF2A_6	132	139	PF00069	0.584
DOC_MAPK_MEF2A_6	37	44	PF00069	0.498
DOC_MAPK_NFAT4_5	37	45	PF00069	0.410
DOC_PIKK_1	86	93	PF02985	0.308
DOC_PP2B_LxvP_1	42	45	PF13499	0.495
DOC_PP2B_LxvP_1	96	99	PF13499	0.264
DOC_PP4_FxxP_1	100	103	PF00568	0.283
DOC_PP4_FxxP_1	196	199	PF00568	0.505
DOC_USP7_MATH_1	123	127	PF00917	0.439
DOC_USP7_MATH_2	232	238	PF00917	0.384
DOC_WW_Pin1_4	197	202	PF00397	0.460
LIG_14-3-3_CanoR_1	108	113	PF00244	0.276
LIG_14-3-3_CanoR_1	6	16	PF00244	0.586
LIG_Actin_WH2_2	210	226	PF00022	0.598
LIG_BRCT_BRCA1_1	189	193	PF00533	0.313
LIG_FHA_1	10	16	PF00498	0.635
LIG_FHA_1	123	129	PF00498	0.437
LIG_FHA_1	150	156	PF00498	0.487
LIG_FHA_2	289	295	PF00498	0.603
LIG_LIR_Apic_2	194	199	PF02991	0.561
LIG_LIR_Gen_1	190	201	PF02991	0.445
LIG_LIR_Gen_1	292	302	PF02991	0.532
LIG_LIR_Nem_3	167	172	PF02991	0.311
LIG_LIR_Nem_3	190	196	PF02991	0.568
LIG_LIR_Nem_3	292	298	PF02991	0.530
LIG_LYPXL_yS_3	46	49	PF13949	0.539
LIG_PDZ_Class_3	322	327	PF00595	0.753
LIG_Rb_LxCxE_1	151	168	PF01857	0.287
LIG_SH2_STAT5	172	175	PF00017	0.301
LIG_SH2_STAT5	301	304	PF00017	0.575
LIG_SH2_STAT5	69	72	PF00017	0.358
LIG_SH2_STAT5	8	11	PF00017	0.605
LIG_SH3_3	42	48	PF00018	0.554
LIG_SUMO_SIM_anti_2	151	159	PF11976	0.522
LIG_SUMO_SIM_par_1	25	31	PF11976	0.437
LIG_TRAF2_1	184	187	PF00917	0.345
LIG_TRAF2_1	306	309	PF00917	0.545
LIG_TYR_ITIM	44	49	PF00017	0.302
LIG_Vh1_VBS_1	15	33	PF01044	0.371
LIG_WRC_WIRS_1	58	63	PF05994	0.430
MOD_CK1_1	293	299	PF00069	0.382
MOD_CK1_1	319	325	PF00069	0.784
MOD_CK1_1	7	13	PF00069	0.650
MOD_CK2_1	123	129	PF00069	0.678
MOD_CK2_1	181	187	PF00069	0.540
MOD_CK2_1	258	264	PF00069	0.551
MOD_CK2_1	288	294	PF00069	0.552
MOD_CK2_1	319	325	PF00069	0.532
MOD_GlcNHglycan	178	181	PF01048	0.374
MOD_GlcNHglycan	189	192	PF01048	0.454
MOD_GlcNHglycan	207	210	PF01048	0.283
MOD_GlcNHglycan	255	258	PF01048	0.666
MOD_GlcNHglycan	34	37	PF01048	0.570
MOD_GSK3_1	187	194	PF00069	0.365
MOD_GSK3_1	211	218	PF00069	0.595
MOD_GSK3_1	28	35	PF00069	0.531
MOD_GSK3_1	315	322	PF00069	0.521
MOD_GSK3_1	4	11	PF00069	0.636
MOD_N-GLC_1	181	186	PF02516	0.500
MOD_N-GLC_2	57	59	PF02516	0.247
MOD_NEK2_1	161	166	PF00069	0.416
MOD_PIKK_1	191	197	PF00454	0.305
MOD_PIKK_1	75	81	PF00454	0.351
MOD_PIKK_1	9	15	PF00454	0.412
MOD_PKA_2	247	253	PF00069	0.617
MOD_PKA_2	315	321	PF00069	0.737
MOD_Plk_1	123	129	PF00069	0.576
MOD_Plk_1	161	167	PF00069	0.551
MOD_Plk_1	293	299	PF00069	0.576
MOD_Plk_2-3	234	240	PF00069	0.607
MOD_Plk_4	123	129	PF00069	0.678
MOD_Plk_4	161	167	PF00069	0.418
MOD_Plk_4	168	174	PF00069	0.480
MOD_Plk_4	57	63	PF00069	0.408
MOD_ProDKin_1	197	203	PF00069	0.457
MOD_SUMO_for_1	235	238	PF00179	0.561
MOD_SUMO_rev_2	111	119	PF00179	0.331
MOD_SUMO_rev_2	228	237	PF00179	0.382
MOD_SUMO_rev_2	278	283	PF00179	0.535
TRG_ENDOCYTIC_2	46	49	PF00928	0.546
TRG_NES_CRM1_1	88	102	PF08389	0.544
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P915	Leptomonas seymouri	48%	100%
A0A0S4IVP5	Bodo saltans	28%	100%
A0A1X0P0S9	Trypanosomatidae	33%	100%
A0A3R7NVI0	Trypanosoma rangeli	29%	100%
A0A3S7XC03	Leishmania donovani	65%	100%
A4IDX9	Leishmania infantum	65%	100%
D0A431	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ATZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	99%
Q4Q0J6	Leishmania major	63%	100%
V5DK35	Trypanosoma cruzi	33%	99%