Cyclin_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cyclin 12, L-type

Species:

Leishmania braziliensis

UniProt:

A4HQ80_LEIBR

TriTrypDb:

LbrM.35.5920 , LBRM2903_350070500

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQ80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ80

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	12
GO:0006357	regulation of transcription by RNA polymerase II	7	12
GO:0009889	regulation of biosynthetic process	4	12
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051252	regulation of RNA metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0080090	regulation of primary metabolic process	4	12
GO:1903506	regulation of nucleic acid-templated transcription	7	12
GO:2001141	regulation of RNA biosynthetic process	6	12
GO:0000365	mRNA trans splicing, via spliceosome	9	1
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045291	mRNA trans splicing, SL addition	10	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	5	12
GO:0019207	kinase regulator activity	3	12
GO:0019887	protein kinase regulator activity	4	12
GO:0030234	enzyme regulator activity	2	12
GO:0098772	molecular function regulator activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	397	401	PF00656	0.421
CLV_NRD_NRD_1	180	182	PF00675	0.457
CLV_NRD_NRD_1	294	296	PF00675	0.532
CLV_NRD_NRD_1	352	354	PF00675	0.496
CLV_NRD_NRD_1	451	453	PF00675	0.671
CLV_NRD_NRD_1	463	465	PF00675	0.657
CLV_NRD_NRD_1	474	476	PF00675	0.682
CLV_NRD_NRD_1	482	484	PF00675	0.669
CLV_NRD_NRD_1	485	487	PF00675	0.749
CLV_PCSK_FUR_1	292	296	PF00082	0.523
CLV_PCSK_FUR_1	483	487	PF00082	0.762
CLV_PCSK_KEX2_1	180	182	PF00082	0.454
CLV_PCSK_KEX2_1	294	296	PF00082	0.544
CLV_PCSK_KEX2_1	352	354	PF00082	0.554
CLV_PCSK_KEX2_1	450	452	PF00082	0.682
CLV_PCSK_KEX2_1	470	472	PF00082	0.762
CLV_PCSK_KEX2_1	474	476	PF00082	0.709
CLV_PCSK_KEX2_1	484	486	PF00082	0.813
CLV_PCSK_KEX2_1	72	74	PF00082	0.650
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.716
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.587
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.650
CLV_PCSK_PC7_1	176	182	PF00082	0.419
CLV_PCSK_PC7_1	480	486	PF00082	0.667
CLV_PCSK_SKI1_1	226	230	PF00082	0.467
CLV_PCSK_SKI1_1	294	298	PF00082	0.515
CLV_PCSK_SKI1_1	332	336	PF00082	0.530
CLV_PCSK_SKI1_1	352	356	PF00082	0.310
CLV_PCSK_SKI1_1	384	388	PF00082	0.458
CLV_PCSK_SKI1_1	390	394	PF00082	0.451
CLV_PCSK_SKI1_1	399	403	PF00082	0.391
DEG_APCC_DBOX_1	119	127	PF00400	0.610
DEG_APCC_DBOX_1	72	80	PF00400	0.655
DEG_SPOP_SBC_1	343	347	PF00917	0.322
DEG_SPOP_SBC_1	80	84	PF00917	0.677
DOC_CYCLIN_yCln2_LP_2	129	135	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	297	303	PF00134	0.523
DOC_MAPK_DCC_7	120	129	PF00069	0.600
DOC_MAPK_gen_1	118	126	PF00069	0.645
DOC_MAPK_gen_1	166	173	PF00069	0.427
DOC_MAPK_gen_1	292	299	PF00069	0.502
DOC_MAPK_gen_1	72	78	PF00069	0.655
DOC_MAPK_HePTP_8	117	129	PF00069	0.640
DOC_MAPK_MEF2A_6	120	129	PF00069	0.589
DOC_MAPK_MEF2A_6	159	167	PF00069	0.452
DOC_MAPK_MEF2A_6	168	175	PF00069	0.386
DOC_MAPK_MEF2A_6	226	234	PF00069	0.383
DOC_MAPK_RevD_3	165	181	PF00069	0.325
DOC_PP2B_LxvP_1	129	132	PF13499	0.539
DOC_PP2B_LxvP_1	297	300	PF13499	0.541
DOC_PP2B_LxvP_1	317	320	PF13499	0.251
DOC_PP2B_LxvP_1	58	61	PF13499	0.648
DOC_PP2B_PxIxI_1	162	168	PF00149	0.301
DOC_PP4_FxxP_1	423	426	PF00568	0.751
DOC_USP7_MATH_1	410	414	PF00917	0.659
DOC_USP7_MATH_1	453	457	PF00917	0.540
DOC_USP7_MATH_1	80	84	PF00917	0.561
DOC_WW_Pin1_4	181	186	PF00397	0.572
DOC_WW_Pin1_4	220	225	PF00397	0.447
DOC_WW_Pin1_4	25	30	PF00397	0.413
DOC_WW_Pin1_4	402	407	PF00397	0.633
DOC_WW_Pin1_4	408	413	PF00397	0.637
DOC_WW_Pin1_4	422	427	PF00397	0.571
LIG_14-3-3_CanoR_1	176	180	PF00244	0.502
LIG_14-3-3_CanoR_1	362	370	PF00244	0.634
LIG_14-3-3_CanoR_1	452	462	PF00244	0.659
LIG_Actin_WH2_2	11	28	PF00022	0.439
LIG_Actin_WH2_2	164	182	PF00022	0.542
LIG_BRCT_BRCA1_1	323	327	PF00533	0.524
LIG_BRCT_BRCA1_1	35	39	PF00533	0.437
LIG_deltaCOP1_diTrp_1	321	327	PF00928	0.444
LIG_eIF4E_1	33	39	PF01652	0.371
LIG_FHA_1	119	125	PF00498	0.600
LIG_FHA_1	18	24	PF00498	0.428
LIG_FHA_1	353	359	PF00498	0.611
LIG_FHA_1	364	370	PF00498	0.443
LIG_FHA_2	156	162	PF00498	0.458
LIG_FHA_2	217	223	PF00498	0.402
LIG_FHA_2	241	247	PF00498	0.447
LIG_FHA_2	316	322	PF00498	0.552
LIG_FHA_2	370	376	PF00498	0.542
LIG_LIR_Apic_2	108	112	PF02991	0.505
LIG_LIR_Apic_2	422	426	PF02991	0.748
LIG_LIR_Gen_1	36	46	PF02991	0.454
LIG_LIR_Nem_3	222	228	PF02991	0.448
LIG_LIR_Nem_3	338	344	PF02991	0.523
LIG_LIR_Nem_3	36	42	PF02991	0.445
LIG_LIR_Nem_3	8	13	PF02991	0.407
LIG_LYPXL_SIV_4	224	232	PF13949	0.487
LIG_NRBOX	231	237	PF00104	0.294
LIG_Pex14_1	323	327	PF04695	0.403
LIG_SH2_CRK	225	229	PF00017	0.394
LIG_SH2_CRK	370	374	PF00017	0.579
LIG_SH2_GRB2like	231	234	PF00017	0.504
LIG_SH2_PTP2	227	230	PF00017	0.498
LIG_SH2_STAT3	307	310	PF00017	0.481
LIG_SH2_STAT5	10	13	PF00017	0.433
LIG_SH2_STAT5	109	112	PF00017	0.498
LIG_SH2_STAT5	135	138	PF00017	0.434
LIG_SH2_STAT5	148	151	PF00017	0.300
LIG_SH2_STAT5	227	230	PF00017	0.498
LIG_SH2_STAT5	231	234	PF00017	0.504
LIG_SH2_STAT5	54	57	PF00017	0.652
LIG_SH3_3	218	224	PF00018	0.374
LIG_SH3_3	266	272	PF00018	0.612
LIG_SxIP_EBH_1	362	373	PF03271	0.357
LIG_TRAF2_1	239	242	PF00917	0.421
LIG_TRAF2_1	428	431	PF00917	0.688
LIG_TRAF2_2	453	458	PF00917	0.542
LIG_TYR_ITIM	229	234	PF00017	0.511
LIG_WRC_WIRS_1	217	222	PF05994	0.409
MOD_CDC14_SPxK_1	223	226	PF00782	0.444
MOD_CDK_SPxK_1	220	226	PF00069	0.454
MOD_CK1_1	240	246	PF00069	0.607
MOD_CK1_1	262	268	PF00069	0.635
MOD_CK1_1	312	318	PF00069	0.371
MOD_CK1_1	345	351	PF00069	0.589
MOD_CK1_1	422	428	PF00069	0.574
MOD_CK1_1	439	445	PF00069	0.704
MOD_CK1_1	45	51	PF00069	0.541
MOD_CK1_1	82	88	PF00069	0.666
MOD_CK2_1	155	161	PF00069	0.372
MOD_CK2_1	216	222	PF00069	0.413
MOD_CK2_1	369	375	PF00069	0.555
MOD_CK2_1	425	431	PF00069	0.668
MOD_CK2_1	453	459	PF00069	0.656
MOD_CK2_1	463	469	PF00069	0.754
MOD_DYRK1A_RPxSP_1	181	185	PF00069	0.521
MOD_GlcNHglycan	181	184	PF01048	0.597
MOD_GlcNHglycan	246	250	PF01048	0.650
MOD_GlcNHglycan	281	284	PF01048	0.445
MOD_GlcNHglycan	347	350	PF01048	0.583
MOD_GlcNHglycan	395	399	PF01048	0.630
MOD_GlcNHglycan	414	417	PF01048	0.679
MOD_GSK3_1	175	182	PF00069	0.546
MOD_GSK3_1	216	223	PF00069	0.476
MOD_GSK3_1	24	31	PF00069	0.454
MOD_GSK3_1	245	252	PF00069	0.553
MOD_GSK3_1	344	351	PF00069	0.602
MOD_GSK3_1	390	397	PF00069	0.559
MOD_GSK3_1	402	409	PF00069	0.572
MOD_GSK3_1	45	52	PF00069	0.558
MOD_GSK3_1	79	86	PF00069	0.599
MOD_GSK3_1	91	98	PF00069	0.651
MOD_N-GLC_1	476	481	PF02516	0.548
MOD_N-GLC_2	172	174	PF02516	0.482
MOD_NEK2_1	155	160	PF00069	0.429
MOD_NEK2_1	17	22	PF00069	0.369
MOD_NEK2_1	175	180	PF00069	0.543
MOD_NEK2_1	24	29	PF00069	0.405
MOD_NEK2_1	369	374	PF00069	0.577
MOD_NEK2_1	79	84	PF00069	0.649
MOD_PIKK_1	274	280	PF00454	0.529
MOD_PIKK_1	49	55	PF00454	0.628
MOD_PKA_1	352	358	PF00069	0.630
MOD_PKA_2	175	181	PF00069	0.524
MOD_PKA_2	33	39	PF00069	0.403
MOD_PKA_2	352	358	PF00069	0.504
MOD_PKA_2	453	459	PF00069	0.756
MOD_PKA_2	463	469	PF00069	0.627
MOD_PKA_2	479	485	PF00069	0.699
MOD_Plk_1	315	321	PF00069	0.526
MOD_Plk_1	42	48	PF00069	0.515
MOD_Plk_2-3	237	243	PF00069	0.526
MOD_Plk_4	190	196	PF00069	0.350
MOD_Plk_4	216	222	PF00069	0.413
MOD_Plk_4	28	34	PF00069	0.445
MOD_ProDKin_1	181	187	PF00069	0.574
MOD_ProDKin_1	220	226	PF00069	0.454
MOD_ProDKin_1	25	31	PF00069	0.405
MOD_ProDKin_1	402	408	PF00069	0.635
MOD_ProDKin_1	422	428	PF00069	0.565
MOD_SUMO_rev_2	193	202	PF00179	0.483
MOD_SUMO_rev_2	68	74	PF00179	0.631
TRG_DiLeu_BaEn_1	431	436	PF01217	0.699
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.512
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.535
TRG_ENDOCYTIC_2	197	200	PF00928	0.407
TRG_ENDOCYTIC_2	225	228	PF00928	0.386
TRG_ENDOCYTIC_2	231	234	PF00928	0.390
TRG_ENDOCYTIC_2	370	373	PF00928	0.527
TRG_ER_diArg_1	165	168	PF00400	0.402
TRG_ER_diArg_1	179	181	PF00400	0.464
TRG_ER_diArg_1	291	294	PF00400	0.486
TRG_ER_diArg_1	450	452	PF00400	0.701
TRG_ER_diArg_1	483	486	PF00400	0.731
TRG_NLS_Bipartite_1	450	468	PF00514	0.652
TRG_NLS_Bipartite_1	470	488	PF00514	0.545
TRG_NLS_MonoCore_2	482	487	PF00514	0.784
TRG_NLS_MonoExtC_3	463	469	PF00514	0.736
TRG_NLS_MonoExtN_4	480	487	PF00514	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDY9	Leptomonas seymouri	59%	100%
A0A0S4IZS7	Bodo saltans	26%	86%
A0A1X0P050	Trypanosomatidae	40%	71%
A0A3S7XBU2	Leishmania donovani	83%	99%
A0A422NSB3	Trypanosoma rangeli	35%	100%
A4IDX8	Leishmania infantum	84%	99%
D0A432	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	77%
E9ATZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4Q0J7	Leishmania major	82%	100%
V5BNQ3	Trypanosoma cruzi	42%	81%