SWIM-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ79_LEIBR

TriTrypDb:

LbrM.35.5910 , LBRM2903_350070400

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0097196	Shu complex	2	1

Expansion

Sequence features

A4HQ79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ79

Function

Biological processes
Term	Name	Level	Count
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0008270	zinc ion binding	6	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0046914	transition metal ion binding	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.699
CLV_PCSK_FUR_1	118	122	PF00082	0.679
CLV_PCSK_KEX2_1	120	122	PF00082	0.739
CLV_PCSK_SKI1_1	193	197	PF00082	0.371
CLV_PCSK_SKI1_1	21	25	PF00082	0.548
CLV_PCSK_SKI1_1	68	72	PF00082	0.429
DEG_Nend_UBRbox_2	1	3	PF02207	0.512
DEG_SPOP_SBC_1	126	130	PF00917	0.751
DOC_MAPK_MEF2A_6	193	202	PF00069	0.353
DOC_MAPK_NFAT4_5	193	201	PF00069	0.355
DOC_PP4_FxxP_1	15	18	PF00568	0.350
DOC_USP7_MATH_1	126	130	PF00917	0.663
DOC_USP7_MATH_1	146	150	PF00917	0.734
DOC_USP7_MATH_1	180	184	PF00917	0.566
DOC_USP7_MATH_1	91	95	PF00917	0.493
DOC_WW_Pin1_4	147	152	PF00397	0.642
DOC_WW_Pin1_4	167	172	PF00397	0.393
LIG_14-3-3_CanoR_1	217	227	PF00244	0.370
LIG_deltaCOP1_diTrp_1	5	15	PF00928	0.460
LIG_FHA_1	128	134	PF00498	0.638
LIG_FHA_1	18	24	PF00498	0.480
LIG_FHA_2	1	7	PF00498	0.494
LIG_FHA_2	102	108	PF00498	0.764
LIG_FHA_2	110	116	PF00498	0.694
LIG_LIR_Apic_2	13	18	PF02991	0.596
LIG_LIR_Apic_2	170	175	PF02991	0.437
LIG_LIR_Gen_1	221	232	PF02991	0.459
LIG_LIR_Nem_3	167	172	PF02991	0.548
LIG_LIR_Nem_3	221	227	PF02991	0.482
LIG_LIR_Nem_3	25	30	PF02991	0.455
LIG_LIR_Nem_3	6	12	PF02991	0.649
LIG_MAD2	10	18	PF02301	0.405
LIG_SH2_CRK	181	185	PF00017	0.487
LIG_SH2_SRC	30	33	PF00017	0.464
LIG_SH2_SRC	87	90	PF00017	0.349
LIG_SH2_STAP1	224	228	PF00017	0.515
LIG_SH2_STAP1	27	31	PF00017	0.418
LIG_SH2_STAT3	179	182	PF00017	0.455
LIG_SH2_STAT5	173	176	PF00017	0.400
LIG_SH2_STAT5	30	33	PF00017	0.482
LIG_SH2_STAT5	87	90	PF00017	0.473
LIG_SH3_3	145	151	PF00018	0.494
LIG_TRAF2_1	3	6	PF00917	0.488
LIG_TRAF2_1	54	57	PF00917	0.511
MOD_CK1_1	129	135	PF00069	0.505
MOD_CK1_1	35	41	PF00069	0.634
MOD_CK2_1	102	108	PF00069	0.616
MOD_CK2_1	217	223	PF00069	0.498
MOD_CK2_1	51	57	PF00069	0.502
MOD_CK2_1	93	99	PF00069	0.596
MOD_GlcNHglycan	143	146	PF01048	0.749
MOD_GlcNHglycan	176	179	PF01048	0.495
MOD_GlcNHglycan	220	223	PF01048	0.295
MOD_GlcNHglycan	71	74	PF01048	0.413
MOD_GlcNHglycan	89	92	PF01048	0.432
MOD_GSK3_1	109	116	PF00069	0.621
MOD_GSK3_1	125	132	PF00069	0.771
MOD_GSK3_1	228	235	PF00069	0.581
MOD_GSK3_1	31	38	PF00069	0.446
MOD_GSK3_1	87	94	PF00069	0.599
MOD_N-GLC_1	35	40	PF02516	0.463
MOD_NEK2_1	127	132	PF00069	0.501
MOD_NEK2_1	228	233	PF00069	0.313
MOD_NEK2_2	164	169	PF00069	0.517
MOD_PIKK_1	134	140	PF00454	0.773
MOD_PIKK_1	207	213	PF00454	0.336
MOD_Plk_1	109	115	PF00069	0.546
MOD_Plk_1	164	170	PF00069	0.538
MOD_Plk_4	164	170	PF00069	0.503
MOD_Plk_4	80	86	PF00069	0.356
MOD_ProDKin_1	147	153	PF00069	0.640
MOD_ProDKin_1	167	173	PF00069	0.399
TRG_DiLeu_BaEn_1	223	228	PF01217	0.479
TRG_ENDOCYTIC_2	181	184	PF00928	0.465
TRG_ENDOCYTIC_2	224	227	PF00928	0.515
TRG_ER_diArg_1	118	121	PF00400	0.701

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I274	Leptomonas seymouri	53%	95%
A0A0S4J7F5	Bodo saltans	30%	95%
A0A1X0P068	Trypanosomatidae	34%	100%
A0A3R7L646	Trypanosoma rangeli	37%	100%
A0A3S7XBY1	Leishmania donovani	68%	100%
A4IDX7	Leishmania infantum	69%	100%
D0A433	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ATZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q0J8	Leishmania major	69%	100%
V5BTC7	Trypanosoma cruzi	37%	100%