LeishMANIAdb
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NERD domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
NERD domain-containing protein
Gene product:
Nuclease-related domain containing protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HQ77_LEIBR
TriTrypDb:
LbrM.35.5890 , LBRM2903_350070200 *
Length:
439

Annotations

LeishMANIAdb annotations

A conserved signal-anchored protein family of obscure function also found in plants and bacteria.. Some of the Leishmaniid proteins might have 3 TM segments instead of 1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4HQ77
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ77

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 166 170 PF00656 0.523
CLV_C14_Caspase3-7 184 188 PF00656 0.459
CLV_NRD_NRD_1 132 134 PF00675 0.355
CLV_NRD_NRD_1 156 158 PF00675 0.234
CLV_NRD_NRD_1 163 165 PF00675 0.234
CLV_NRD_NRD_1 313 315 PF00675 0.412
CLV_NRD_NRD_1 376 378 PF00675 0.452
CLV_NRD_NRD_1 48 50 PF00675 0.427
CLV_NRD_NRD_1 74 76 PF00675 0.321
CLV_NRD_NRD_1 86 88 PF00675 0.235
CLV_PCSK_KEX2_1 134 136 PF00082 0.300
CLV_PCSK_KEX2_1 156 158 PF00082 0.234
CLV_PCSK_KEX2_1 163 165 PF00082 0.234
CLV_PCSK_KEX2_1 189 191 PF00082 0.316
CLV_PCSK_KEX2_1 313 315 PF00082 0.412
CLV_PCSK_KEX2_1 371 373 PF00082 0.397
CLV_PCSK_KEX2_1 376 378 PF00082 0.441
CLV_PCSK_KEX2_1 48 50 PF00082 0.427
CLV_PCSK_KEX2_1 85 87 PF00082 0.235
CLV_PCSK_PC1ET2_1 134 136 PF00082 0.307
CLV_PCSK_PC1ET2_1 189 191 PF00082 0.349
CLV_PCSK_PC1ET2_1 371 373 PF00082 0.418
CLV_PCSK_PC1ET2_1 376 378 PF00082 0.471
CLV_PCSK_PC7_1 372 378 PF00082 0.443
CLV_PCSK_PC7_1 44 50 PF00082 0.447
CLV_PCSK_SKI1_1 189 193 PF00082 0.372
CLV_PCSK_SKI1_1 229 233 PF00082 0.375
CLV_PCSK_SKI1_1 267 271 PF00082 0.496
CLV_PCSK_SKI1_1 313 317 PF00082 0.402
CLV_PCSK_SKI1_1 353 357 PF00082 0.458
CLV_PCSK_SKI1_1 36 40 PF00082 0.269
CLV_PCSK_SKI1_1 372 376 PF00082 0.324
CLV_PCSK_SKI1_1 44 48 PF00082 0.283
DEG_APCC_DBOX_1 132 140 PF00400 0.423
DEG_APCC_DBOX_1 333 341 PF00400 0.541
DEG_APCC_KENBOX_2 398 402 PF00400 0.567
DEG_Nend_UBRbox_3 1 3 PF02207 0.367
DEG_SPOP_SBC_1 277 281 PF00917 0.555
DOC_CYCLIN_RxL_1 350 359 PF00134 0.552
DOC_CYCLIN_RxL_1 40 51 PF00134 0.608
DOC_MAPK_DCC_7 205 213 PF00069 0.537
DOC_MAPK_gen_1 131 141 PF00069 0.537
DOC_MAPK_gen_1 343 351 PF00069 0.537
DOC_MAPK_MEF2A_6 205 213 PF00069 0.469
DOC_MAPK_MEF2A_6 334 342 PF00069 0.482
DOC_MAPK_RevD_3 216 229 PF00069 0.608
DOC_MAPK_RevD_3 363 377 PF00069 0.583
DOC_PP2B_PxIxI_1 105 111 PF00149 0.537
DOC_PP4_FxxP_1 213 216 PF00568 0.496
DOC_USP7_MATH_1 253 257 PF00917 0.668
DOC_USP7_MATH_1 258 262 PF00917 0.695
DOC_USP7_MATH_1 277 281 PF00917 0.609
DOC_USP7_UBL2_3 197 201 PF12436 0.546
DOC_USP7_UBL2_3 371 375 PF12436 0.623
DOC_USP7_UBL2_3 376 380 PF12436 0.671
DOC_USP7_UBL2_3 394 398 PF12436 0.487
LIG_14-3-3_CanoR_1 190 194 PF00244 0.539
LIG_14-3-3_CanoR_1 262 266 PF00244 0.686
LIG_14-3-3_CanoR_1 424 428 PF00244 0.510
LIG_BRCT_BRCA1_1 30 34 PF00533 0.565
LIG_CaM_IQ_9 61 77 PF13499 0.537
LIG_eIF4E_1 332 338 PF01652 0.538
LIG_FHA_1 17 23 PF00498 0.276
LIG_FHA_1 302 308 PF00498 0.553
LIG_FHA_1 315 321 PF00498 0.569
LIG_FHA_1 355 361 PF00498 0.553
LIG_FHA_1 409 415 PF00498 0.527
LIG_FHA_1 9 15 PF00498 0.265
LIG_FHA_2 182 188 PF00498 0.494
LIG_GBD_Chelix_1 307 315 PF00786 0.385
LIG_LIR_Gen_1 10 21 PF02991 0.331
LIG_LIR_Gen_1 138 149 PF02991 0.439
LIG_LIR_Gen_1 304 311 PF02991 0.464
LIG_LIR_Gen_1 400 409 PF02991 0.543
LIG_LIR_Nem_3 10 16 PF02991 0.331
LIG_LIR_Nem_3 138 144 PF02991 0.445
LIG_LIR_Nem_3 235 240 PF02991 0.494
LIG_LIR_Nem_3 264 269 PF02991 0.669
LIG_LIR_Nem_3 304 308 PF02991 0.459
LIG_LIR_Nem_3 327 332 PF02991 0.583
LIG_NRBOX 306 312 PF00104 0.573
LIG_PCNA_yPIPBox_3 292 303 PF02747 0.504
LIG_Pex14_1 305 309 PF04695 0.472
LIG_Pex14_1 79 83 PF04695 0.445
LIG_RPA_C_Fungi 81 93 PF08784 0.414
LIG_SH2_PTP2 13 16 PF00017 0.313
LIG_SH2_STAT3 332 335 PF00017 0.258
LIG_SH2_STAT5 13 16 PF00017 0.364
LIG_SH2_STAT5 158 161 PF00017 0.425
LIG_SH2_STAT5 230 233 PF00017 0.412
LIG_SH2_STAT5 309 312 PF00017 0.352
LIG_SH2_STAT5 403 406 PF00017 0.406
LIG_SH3_2 392 397 PF14604 0.528
LIG_SH3_3 162 168 PF00018 0.364
LIG_SH3_3 389 395 PF00018 0.406
LIG_SH3_4 394 401 PF00018 0.318
LIG_SUMO_SIM_anti_2 362 369 PF11976 0.475
LIG_SUMO_SIM_anti_2 415 421 PF11976 0.248
LIG_SUMO_SIM_anti_2 98 103 PF11976 0.270
LIG_SUMO_SIM_par_1 106 112 PF11976 0.274
LIG_SUMO_SIM_par_1 14 20 PF11976 0.204
LIG_SUMO_SIM_par_1 208 214 PF11976 0.285
LIG_SUMO_SIM_par_1 3 11 PF11976 0.572
LIG_SUMO_SIM_par_1 321 327 PF11976 0.430
LIG_SUMO_SIM_par_1 415 421 PF11976 0.339
LIG_SxIP_EBH_1 265 274 PF03271 0.587
LIG_UBA3_1 61 69 PF00899 0.197
LIG_WRC_WIRS_1 234 239 PF05994 0.369
LIG_WRPW_2 266 269 PF00400 0.445
MOD_CK1_1 236 242 PF00069 0.411
MOD_CK1_1 256 262 PF00069 0.672
MOD_CK1_1 279 285 PF00069 0.461
MOD_CK1_1 359 365 PF00069 0.516
MOD_CMANNOS 263 266 PF00535 0.665
MOD_Cter_Amidation 187 190 PF01082 0.469
MOD_GlcNHglycan 255 258 PF01048 0.559
MOD_GlcNHglycan 326 329 PF01048 0.444
MOD_GSK3_1 275 282 PF00069 0.547
MOD_GSK3_1 56 63 PF00069 0.368
MOD_NEK2_1 119 124 PF00069 0.443
MOD_NEK2_1 16 21 PF00069 0.364
MOD_NEK2_1 276 281 PF00069 0.525
MOD_NEK2_1 28 33 PF00069 0.386
MOD_NEK2_1 351 356 PF00069 0.416
MOD_NEK2_1 365 370 PF00069 0.364
MOD_NEK2_1 408 413 PF00069 0.464
MOD_NEK2_1 60 65 PF00069 0.434
MOD_NEK2_1 8 13 PF00069 0.524
MOD_PKA_1 189 195 PF00069 0.339
MOD_PKA_2 189 195 PF00069 0.409
MOD_PKA_2 261 267 PF00069 0.474
MOD_PKA_2 423 429 PF00069 0.370
MOD_PKB_1 133 141 PF00069 0.339
MOD_Plk_1 8 14 PF00069 0.348
MOD_Plk_4 17 23 PF00069 0.214
MOD_Plk_4 189 195 PF00069 0.285
MOD_Plk_4 3 9 PF00069 0.518
MOD_Plk_4 351 357 PF00069 0.486
MOD_Plk_4 56 62 PF00069 0.523
MOD_SUMO_rev_2 183 191 PF00179 0.324
MOD_SUMO_rev_2 63 70 PF00179 0.394
TRG_DiLeu_BaEn_1 400 405 PF01217 0.426
TRG_DiLeu_BaLyEn_6 311 316 PF01217 0.493
TRG_ENDOCYTIC_2 13 16 PF00928 0.364
TRG_ENDOCYTIC_2 403 406 PF00928 0.432
TRG_ER_diArg_1 133 136 PF00400 0.401
TRG_ER_diArg_1 155 157 PF00400 0.270
TRG_ER_diArg_1 163 165 PF00400 0.270
TRG_ER_diArg_1 313 315 PF00400 0.507
TRG_ER_diArg_1 47 49 PF00400 0.521
TRG_ER_diArg_1 84 87 PF00400 0.311
TRG_Pf-PMV_PEXEL_1 314 319 PF00026 0.249
TRG_Pf-PMV_PEXEL_1 429 433 PF00026 0.455

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDN0 Leptomonas seymouri 73% 99%
A0A0S4J7E4 Bodo saltans 35% 100%
A0A1X0P0I4 Trypanosomatidae 40% 100%
A0A3R7R7J3 Trypanosoma rangeli 43% 100%
A0A3S7XC13 Leishmania donovani 87% 85%
A4IDX5 Leishmania infantum 86% 81%
D0A437 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9ATZ5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 84%
Q4Q0K0 Leishmania major 85% 100%
V5B3M2 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS