Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ76_LEIBR

TriTrypDb:

LbrM.35.5880 , LBRM2903_350070100

Length:

558

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	237	239	PF00675	0.436
CLV_NRD_NRD_1	35	37	PF00675	0.598
CLV_NRD_NRD_1	368	370	PF00675	0.574
CLV_NRD_NRD_1	380	382	PF00675	0.489
CLV_NRD_NRD_1	440	442	PF00675	0.536
CLV_NRD_NRD_1	70	72	PF00675	0.763
CLV_NRD_NRD_1	74	76	PF00675	0.769
CLV_PCSK_KEX2_1	237	239	PF00082	0.436
CLV_PCSK_KEX2_1	34	36	PF00082	0.622
CLV_PCSK_KEX2_1	368	370	PF00082	0.518
CLV_PCSK_KEX2_1	380	382	PF00082	0.567
CLV_PCSK_KEX2_1	440	442	PF00082	0.536
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.687
CLV_PCSK_PC7_1	30	36	PF00082	0.674
CLV_PCSK_SKI1_1	11	15	PF00082	0.472
CLV_PCSK_SKI1_1	157	161	PF00082	0.697
CLV_PCSK_SKI1_1	200	204	PF00082	0.518
CLV_PCSK_SKI1_1	238	242	PF00082	0.474
CLV_PCSK_SKI1_1	265	269	PF00082	0.772
CLV_PCSK_SKI1_1	325	329	PF00082	0.322
CLV_PCSK_SKI1_1	346	350	PF00082	0.480
CLV_PCSK_SKI1_1	371	375	PF00082	0.486
CLV_PCSK_SKI1_1	477	481	PF00082	0.514
CLV_PCSK_SKI1_1	496	500	PF00082	0.478
DEG_APCC_DBOX_1	236	244	PF00400	0.501
DEG_SCF_FBW7_1	267	274	PF00400	0.482
DEG_SPOP_SBC_1	163	167	PF00917	0.653
DEG_SPOP_SBC_1	248	252	PF00917	0.454
DEG_SPOP_SBC_1	430	434	PF00917	0.287
DEG_SPOP_SBC_1	516	520	PF00917	0.582
DEG_SPOP_SBC_1	82	86	PF00917	0.578
DOC_CDC14_PxL_1	40	48	PF14671	0.518
DOC_CKS1_1	16	21	PF01111	0.732
DOC_CKS1_1	268	273	PF01111	0.486
DOC_CYCLIN_RxL_1	235	245	PF00134	0.603
DOC_CYCLIN_yCln2_LP_2	191	194	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	276	282	PF00134	0.486
DOC_CYCLIN_yCln2_LP_2	420	426	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	470	476	PF00134	0.517
DOC_MAPK_DCC_7	179	188	PF00069	0.534
DOC_MAPK_gen_1	177	185	PF00069	0.790
DOC_MAPK_gen_1	440	447	PF00069	0.437
DOC_MAPK_gen_1	496	506	PF00069	0.493
DOC_MAPK_MEF2A_6	179	188	PF00069	0.534
DOC_MAPK_MEF2A_6	325	334	PF00069	0.282
DOC_MAPK_NFAT4_5	325	333	PF00069	0.282
DOC_PP2B_LxvP_1	160	163	PF13499	0.771
DOC_PP2B_LxvP_1	191	194	PF13499	0.539
DOC_PP2B_LxvP_1	470	473	PF13499	0.518
DOC_PP4_MxPP_1	192	195	PF00568	0.542
DOC_SPAK_OSR1_1	179	183	PF12202	0.750
DOC_USP7_MATH_1	155	159	PF00917	0.682
DOC_USP7_MATH_1	163	167	PF00917	0.726
DOC_USP7_MATH_1	45	49	PF00917	0.596
DOC_USP7_MATH_1	535	539	PF00917	0.674
DOC_USP7_MATH_1	70	74	PF00917	0.584
DOC_USP7_MATH_1	83	87	PF00917	0.529
DOC_USP7_UBL2_3	346	350	PF12436	0.445
DOC_USP7_UBL2_3	477	481	PF12436	0.510
DOC_USP7_UBL2_3	72	76	PF12436	0.748
DOC_WW_Pin1_4	15	20	PF00397	0.657
DOC_WW_Pin1_4	267	272	PF00397	0.677
DOC_WW_Pin1_4	380	385	PF00397	0.710
DOC_WW_Pin1_4	60	65	PF00397	0.663
DOC_WW_Pin1_4	88	93	PF00397	0.730
DOC_WW_Pin1_4	99	104	PF00397	0.758
LIG_14-3-3_CanoR_1	197	206	PF00244	0.701
LIG_14-3-3_CanoR_1	249	257	PF00244	0.693
LIG_14-3-3_CanoR_1	353	357	PF00244	0.464
LIG_14-3-3_CanoR_1	71	78	PF00244	0.638
LIG_Actin_WH2_2	483	498	PF00022	0.501
LIG_BRCT_BRCA1_1	104	108	PF00533	0.543
LIG_BRCT_BRCA1_1	414	418	PF00533	0.482
LIG_BRCT_BRCA1_1	511	515	PF00533	0.485
LIG_CSL_BTD_1	16	19	PF09270	0.718
LIG_EH1_1	321	329	PF00400	0.546
LIG_eIF4E_1	322	328	PF01652	0.415
LIG_FHA_1	116	122	PF00498	0.568
LIG_FHA_1	343	349	PF00498	0.531
LIG_FHA_1	398	404	PF00498	0.628
LIG_FHA_1	459	465	PF00498	0.526
LIG_FHA_1	546	552	PF00498	0.586
LIG_FHA_1	83	89	PF00498	0.580
LIG_FHA_2	249	255	PF00498	0.525
LIG_NRBOX	326	332	PF00104	0.461
LIG_OCRL_FandH_1	145	157	PF00620	0.482
LIG_Pex14_1	17	21	PF04695	0.602
LIG_RPA_C_Fungi	31	43	PF08784	0.694
LIG_SH2_CRK	316	320	PF00017	0.509
LIG_SH2_NCK_1	218	222	PF00017	0.532
LIG_SH2_NCK_1	544	548	PF00017	0.644
LIG_SH2_SRC	544	547	PF00017	0.648
LIG_SH2_STAT5	21	24	PF00017	0.621
LIG_SH2_STAT5	283	286	PF00017	0.546
LIG_SH3_3	149	155	PF00018	0.732
LIG_SH3_3	187	193	PF00018	0.725
LIG_SH3_3	470	476	PF00018	0.631
LIG_SH3_3	89	95	PF00018	0.633
LIG_SUMO_SIM_par_1	292	301	PF11976	0.452
LIG_SUMO_SIM_par_1	449	455	PF11976	0.435
LIG_TRAF2_1	409	412	PF00917	0.564
LIG_TRAF2_1	463	466	PF00917	0.376
LIG_TYR_ITIM	314	319	PF00017	0.500
LIG_TYR_ITIM	542	547	PF00017	0.469
LIG_WRC_WIRS_1	444	449	PF05994	0.335
LIG_WW_3	194	198	PF00397	0.781
LIG_WW_3	68	72	PF00397	0.576
MOD_CDK_SPK_2	15	20	PF00069	0.733
MOD_CDK_SPxK_1	60	66	PF00069	0.588
MOD_CK1_1	102	108	PF00069	0.571
MOD_CK1_1	131	137	PF00069	0.781
MOD_CK1_1	167	173	PF00069	0.635
MOD_CK1_1	60	66	PF00069	0.675
MOD_CK1_1	84	90	PF00069	0.791
MOD_CK2_1	248	254	PF00069	0.610
MOD_CK2_1	320	326	PF00069	0.374
MOD_CK2_1	552	558	PF00069	0.493
MOD_CK2_1	74	80	PF00069	0.794
MOD_Cter_Amidation	32	35	PF01082	0.732
MOD_GlcNHglycan	146	149	PF01048	0.689
MOD_GlcNHglycan	166	169	PF01048	0.648
MOD_GlcNHglycan	170	173	PF01048	0.731
MOD_GlcNHglycan	219	222	PF01048	0.616
MOD_GlcNHglycan	271	274	PF01048	0.698
MOD_GlcNHglycan	521	524	PF01048	0.570
MOD_GlcNHglycan	532	536	PF01048	0.673
MOD_GlcNHglycan	555	558	PF01048	0.753
MOD_GSK3_1	124	131	PF00069	0.670
MOD_GSK3_1	163	170	PF00069	0.785
MOD_GSK3_1	200	207	PF00069	0.567
MOD_GSK3_1	243	250	PF00069	0.525
MOD_GSK3_1	267	274	PF00069	0.684
MOD_GSK3_1	342	349	PF00069	0.537
MOD_GSK3_1	352	359	PF00069	0.500
MOD_GSK3_1	429	436	PF00069	0.521
MOD_GSK3_1	515	522	PF00069	0.511
MOD_GSK3_1	531	538	PF00069	0.672
MOD_GSK3_1	56	63	PF00069	0.791
MOD_GSK3_1	70	77	PF00069	0.654
MOD_GSK3_1	84	91	PF00069	0.745
MOD_GSK3_1	95	102	PF00069	0.755
MOD_NEK2_1	1	6	PF00069	0.559
MOD_NEK2_1	108	113	PF00069	0.780
MOD_NEK2_1	198	203	PF00069	0.622
MOD_NEK2_1	217	222	PF00069	0.518
MOD_NEK2_1	243	248	PF00069	0.610
MOD_NEK2_1	281	286	PF00069	0.418
MOD_NEK2_1	314	319	PF00069	0.573
MOD_NEK2_1	352	357	PF00069	0.465
MOD_NEK2_1	431	436	PF00069	0.450
MOD_NEK2_1	46	51	PF00069	0.688
MOD_NEK2_1	488	493	PF00069	0.569
MOD_NEK2_1	515	520	PF00069	0.507
MOD_NEK2_1	9	14	PF00069	0.439
MOD_PIKK_1	115	121	PF00454	0.489
MOD_PIKK_1	128	134	PF00454	0.786
MOD_PIKK_1	314	320	PF00454	0.578
MOD_PKA_1	71	77	PF00069	0.591
MOD_PKA_2	248	254	PF00069	0.473
MOD_PKA_2	352	358	PF00069	0.464
MOD_PKA_2	70	76	PF00069	0.626
MOD_Plk_1	204	210	PF00069	0.481
MOD_Plk_1	531	537	PF00069	0.562
MOD_Plk_2-3	124	130	PF00069	0.660
MOD_Plk_4	352	358	PF00069	0.512
MOD_Plk_4	443	449	PF00069	0.318
MOD_ProDKin_1	15	21	PF00069	0.659
MOD_ProDKin_1	267	273	PF00069	0.672
MOD_ProDKin_1	380	386	PF00069	0.720
MOD_ProDKin_1	60	66	PF00069	0.664
MOD_ProDKin_1	88	94	PF00069	0.733
MOD_ProDKin_1	99	105	PF00069	0.755
MOD_SUMO_rev_2	219	229	PF00179	0.538
TRG_DiLeu_BaEn_1	224	229	PF01217	0.566
TRG_DiLeu_BaEn_1	326	331	PF01217	0.341
TRG_DiLeu_BaEn_2	420	426	PF01217	0.451
TRG_DiLeu_BaEn_2	481	487	PF01217	0.556
TRG_DiLeu_BaEn_4	411	417	PF01217	0.566
TRG_ENDOCYTIC_2	143	146	PF00928	0.553
TRG_ENDOCYTIC_2	316	319	PF00928	0.445
TRG_ENDOCYTIC_2	544	547	PF00928	0.594
TRG_ER_diArg_1	177	180	PF00400	0.671
TRG_ER_diArg_1	236	238	PF00400	0.484
TRG_ER_diArg_1	35	38	PF00400	0.708
TRG_ER_diArg_1	368	371	PF00400	0.589
TRG_ER_diArg_1	440	442	PF00400	0.421
TRG_NLS_MonoExtC_3	33	38	PF00514	0.726

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMS8	Leptomonas seymouri	44%	94%
A0A3Q8IJU5	Leishmania donovani	73%	99%
A4IDX4	Leishmania infantum	73%	99%
E9ATZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	99%
Q4Q0K1	Leishmania major	72%	100%
V5BNQ7	Trypanosoma cruzi	27%	100%