Putative G-actin binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adenylyl cyclase-associated protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ75_LEIBR

TriTrypDb:

LbrM.35.5860 , LBRM2903_350070000

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQ75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ75

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	7
GO:0007010	cytoskeleton organization	5	7
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0071840	cellular component organization or biogenesis	2	9
GO:0007015	actin filament organization	5	2
GO:0097435	supramolecular fiber organization	4	2

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	9
GO:0005488	binding	1	9
GO:0005515	protein binding	2	9
GO:0008092	cytoskeletal protein binding	3	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.288
CLV_NRD_NRD_1	211	213	PF00675	0.237
CLV_NRD_NRD_1	72	74	PF00675	0.574
CLV_NRD_NRD_1	81	83	PF00675	0.567
CLV_PCSK_KEX2_1	108	110	PF00082	0.338
CLV_PCSK_KEX2_1	81	83	PF00082	0.557
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.338
CLV_PCSK_SKI1_1	48	52	PF00082	0.569
DEG_SPOP_SBC_1	219	223	PF00917	0.438
DOC_ANK_TNKS_1	89	96	PF00023	0.507
DOC_CKS1_1	97	102	PF01111	0.237
DOC_MAPK_MEF2A_6	197	205	PF00069	0.430
DOC_PP2B_PxIxI_1	190	196	PF00149	0.477
DOC_PP4_MxPP_1	1	4	PF00568	0.614
DOC_USP7_MATH_1	219	223	PF00917	0.363
DOC_USP7_MATH_1	263	267	PF00917	0.575
DOC_USP7_UBL2_3	254	258	PF12436	0.507
DOC_WW_Pin1_4	115	120	PF00397	0.372
DOC_WW_Pin1_4	96	101	PF00397	0.563
LIG_14-3-3_CanoR_1	197	202	PF00244	0.438
LIG_14-3-3_CanoR_1	48	57	PF00244	0.571
LIG_FHA_1	147	153	PF00498	0.391
LIG_FHA_1	190	196	PF00498	0.338
LIG_FHA_1	212	218	PF00498	0.361
LIG_FHA_1	221	227	PF00498	0.325
LIG_FHA_1	245	251	PF00498	0.419
LIG_FHA_1	42	48	PF00498	0.574
LIG_FHA_1	97	103	PF00498	0.386
LIG_FHA_2	89	95	PF00498	0.686
LIG_PDZ_Class_3	262	267	PF00595	0.494
LIG_Pex14_1	110	114	PF04695	0.363
LIG_PROFILIN_1	2	8	PF00235	0.605
LIG_PROFILIN_1	9	15	PF00235	0.603
LIG_SH2_PTP2	145	148	PF00017	0.398
LIG_SH2_STAT5	145	148	PF00017	0.369
LIG_SH2_STAT5	204	207	PF00017	0.394
LIG_SH3_3	1	7	PF00018	0.632
LIG_SH3_3	223	229	PF00018	0.363
LIG_SH3_3	8	14	PF00018	0.598
LIG_SH3_3	94	100	PF00018	0.597
LIG_SUMO_SIM_anti_2	154	159	PF11976	0.338
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.340
LIG_SUMO_SIM_par_1	123	128	PF11976	0.344
LIG_SUMO_SIM_par_1	191	196	PF11976	0.438
LIG_SUMO_SIM_par_1	99	105	PF11976	0.466
LIG_TRAF2_1	77	80	PF00917	0.670
MOD_CK1_1	21	27	PF00069	0.566
MOD_CK2_1	115	121	PF00069	0.355
MOD_CK2_1	169	175	PF00069	0.394
MOD_CK2_1	66	72	PF00069	0.604
MOD_CK2_1	88	94	PF00069	0.714
MOD_GlcNHglycan	21	24	PF01048	0.684
MOD_GlcNHglycan	91	94	PF01048	0.609
MOD_GSK3_1	166	173	PF00069	0.243
MOD_GSK3_1	211	218	PF00069	0.388
MOD_GSK3_1	244	251	PF00069	0.414
MOD_N-GLC_1	41	46	PF02516	0.541
MOD_PIKK_1	184	190	PF00454	0.237
MOD_PK_1	151	157	PF00069	0.363
MOD_PK_1	197	203	PF00069	0.361
MOD_PKA_2	196	202	PF00069	0.438
MOD_PKA_2	211	217	PF00069	0.438
MOD_PKA_2	89	95	PF00069	0.638
MOD_PKB_1	46	54	PF00069	0.575
MOD_Plk_4	153	159	PF00069	0.352
MOD_Plk_4	166	172	PF00069	0.150
MOD_ProDKin_1	115	121	PF00069	0.372
MOD_ProDKin_1	96	102	PF00069	0.364
MOD_SUMO_rev_2	52	56	PF00179	0.560
MOD_SUMO_rev_2	67	76	PF00179	0.490
TRG_ENDOCYTIC_2	145	148	PF00928	0.369
TRG_ER_diArg_1	81	83	PF00400	0.696
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P914	Leptomonas seymouri	72%	97%
A0A1X0P0T3	Trypanosomatidae	55%	93%
A0A3Q8IRQ9	Leishmania donovani	86%	99%
A0A3R7NFV7	Trypanosoma rangeli	56%	97%
A4IDX3	Leishmania infantum	86%	99%
D0A444	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	99%
Q4Q0K2	Leishmania major	84%	100%