DUF5726 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ74_LEIBR

TriTrypDb:

LbrM.35.5850 , LBRM2903_350069900

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ74

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.505
CLV_C14_Caspase3-7	148	152	PF00656	0.660
CLV_C14_Caspase3-7	73	77	PF00656	0.511
CLV_NRD_NRD_1	113	115	PF00675	0.505
CLV_NRD_NRD_1	119	121	PF00675	0.566
CLV_NRD_NRD_1	12	14	PF00675	0.511
CLV_NRD_NRD_1	189	191	PF00675	0.666
CLV_NRD_NRD_1	29	31	PF00675	0.361
CLV_NRD_NRD_1	47	49	PF00675	0.397
CLV_PCSK_KEX2_1	113	115	PF00082	0.585
CLV_PCSK_KEX2_1	119	121	PF00082	0.624
CLV_PCSK_KEX2_1	12	14	PF00082	0.424
CLV_PCSK_KEX2_1	189	191	PF00082	0.662
CLV_PCSK_KEX2_1	29	31	PF00082	0.488
CLV_PCSK_KEX2_1	305	307	PF00082	0.570
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.594
CLV_PCSK_SKI1_1	189	193	PF00082	0.788
CLV_PCSK_SKI1_1	252	256	PF00082	0.489
DEG_APCC_DBOX_1	29	37	PF00400	0.446
DEG_SPOP_SBC_1	143	147	PF00917	0.686
DEG_SPOP_SBC_1	181	185	PF00917	0.758
DOC_CDC14_PxL_1	130	138	PF14671	0.503
DOC_CKS1_1	102	107	PF01111	0.353
DOC_CKS1_1	136	141	PF01111	0.657
DOC_CYCLIN_RxL_1	45	53	PF00134	0.521
DOC_MAPK_MEF2A_6	207	215	PF00069	0.530
DOC_MIT_MIM_1	7	17	PF04212	0.432
DOC_PP2B_LxvP_1	215	218	PF13499	0.408
DOC_USP7_MATH_1	143	147	PF00917	0.783
DOC_USP7_MATH_1	181	185	PF00917	0.757
DOC_USP7_MATH_1	345	349	PF00917	0.465
DOC_WW_Pin1_4	101	106	PF00397	0.594
DOC_WW_Pin1_4	135	140	PF00397	0.678
LIG_14-3-3_CanoR_1	189	194	PF00244	0.774
LIG_14-3-3_CanoR_1	237	243	PF00244	0.430
LIG_14-3-3_CanoR_1	252	262	PF00244	0.406
LIG_14-3-3_CanoR_1	29	34	PF00244	0.476
LIG_14-3-3_CanoR_1	38	47	PF00244	0.427
LIG_14-3-3_CanoR_1	48	53	PF00244	0.395
LIG_APCC_ABBA_1	324	329	PF00400	0.634
LIG_BIR_II_1	1	5	PF00653	0.506
LIG_BRCT_BRCA1_1	296	300	PF00533	0.587
LIG_BRCT_BRCA1_1	317	321	PF00533	0.611
LIG_BRCT_BRCA1_2	296	302	PF00533	0.464
LIG_FHA_1	186	192	PF00498	0.791
LIG_FHA_1	224	230	PF00498	0.527
LIG_FHA_1	351	357	PF00498	0.513
LIG_FHA_1	97	103	PF00498	0.490
LIG_FHA_2	104	110	PF00498	0.505
LIG_FHA_2	174	180	PF00498	0.686
LIG_FHA_2	349	355	PF00498	0.683
LIG_GBD_Chelix_1	10	18	PF00786	0.304
LIG_LIR_Gen_1	158	166	PF02991	0.713
LIG_LIR_Gen_1	269	279	PF02991	0.436
LIG_LIR_Gen_1	318	327	PF02991	0.648
LIG_LIR_Nem_3	158	162	PF02991	0.719
LIG_LIR_Nem_3	269	275	PF02991	0.439
LIG_LIR_Nem_3	297	303	PF02991	0.663
LIG_LIR_Nem_3	318	324	PF02991	0.599
LIG_MLH1_MIPbox_1	296	300	PF16413	0.587
LIG_NRBOX	13	19	PF00104	0.310
LIG_Pex14_2	254	258	PF04695	0.515
LIG_Pex14_2	360	364	PF04695	0.667
LIG_REV1ctd_RIR_1	296	306	PF16727	0.460
LIG_SH2_CRK	159	163	PF00017	0.712
LIG_SH2_GRB2like	272	275	PF00017	0.540
LIG_SH2_NCK_1	327	331	PF00017	0.426
LIG_SH2_NCK_1	87	91	PF00017	0.473
LIG_SH2_SRC	272	275	PF00017	0.518
LIG_SH2_SRC	87	90	PF00017	0.468
LIG_SH2_STAP1	159	163	PF00017	0.712
LIG_SH2_STAP1	242	246	PF00017	0.433
LIG_SH2_STAP1	272	276	PF00017	0.540
LIG_SH2_STAT5	228	231	PF00017	0.578
LIG_SH2_STAT5	242	245	PF00017	0.518
LIG_SH2_STAT5	309	312	PF00017	0.534
LIG_SH2_STAT5	56	59	PF00017	0.396
LIG_SH3_3	102	108	PF00018	0.363
LIG_SH3_3	193	199	PF00018	0.511
LIG_SUMO_SIM_anti_2	167	173	PF11976	0.745
LIG_SUMO_SIM_anti_2	6	12	PF11976	0.429
LIG_SUMO_SIM_anti_2	63	69	PF11976	0.435
LIG_SUMO_SIM_anti_2	99	104	PF11976	0.547
LIG_SUMO_SIM_par_1	76	83	PF11976	0.519
LIG_SUMO_SIM_par_1	96	104	PF11976	0.247
LIG_WW_3	138	142	PF00397	0.498
MOD_CDK_SPxK_1	135	141	PF00069	0.625
MOD_CK1_1	170	176	PF00069	0.718
MOD_CK1_1	182	188	PF00069	0.736
MOD_CK1_1	312	318	PF00069	0.406
MOD_CK1_1	348	354	PF00069	0.566
MOD_CK1_1	96	102	PF00069	0.542
MOD_CK2_1	142	148	PF00069	0.783
MOD_CK2_1	173	179	PF00069	0.672
MOD_CK2_1	224	230	PF00069	0.502
MOD_GlcNHglycan	172	175	PF01048	0.754
MOD_GlcNHglycan	246	249	PF01048	0.529
MOD_GlcNHglycan	255	258	PF01048	0.495
MOD_GlcNHglycan	277	280	PF01048	0.528
MOD_GlcNHglycan	311	314	PF01048	0.647
MOD_GlcNHglycan	347	350	PF01048	0.596
MOD_GSK3_1	181	188	PF00069	0.687
MOD_GSK3_1	238	245	PF00069	0.534
MOD_GSK3_1	290	297	PF00069	0.600
MOD_GSK3_1	301	308	PF00069	0.599
MOD_GSK3_1	345	352	PF00069	0.620
MOD_N-GLC_1	290	295	PF02516	0.632
MOD_N-GLC_1	331	336	PF02516	0.580
MOD_NEK2_1	149	154	PF00069	0.775
MOD_NEK2_1	180	185	PF00069	0.669
MOD_NEK2_1	223	228	PF00069	0.514
MOD_NEK2_1	240	245	PF00069	0.448
MOD_NEK2_1	294	299	PF00069	0.683
MOD_NEK2_1	320	325	PF00069	0.559
MOD_PIKK_1	94	100	PF00454	0.575
MOD_PKA_1	189	195	PF00069	0.748
MOD_PKA_1	29	35	PF00069	0.460
MOD_PKA_1	305	311	PF00069	0.583
MOD_PKA_1	48	54	PF00069	0.392
MOD_PKA_2	189	195	PF00069	0.747
MOD_PKA_2	29	35	PF00069	0.442
MOD_PKA_2	305	311	PF00069	0.559
MOD_PKA_2	40	46	PF00069	0.388
MOD_Plk_1	224	230	PF00069	0.549
MOD_Plk_1	290	296	PF00069	0.622
MOD_Plk_1	331	337	PF00069	0.532
MOD_Plk_1	6	12	PF00069	0.522
MOD_Plk_4	167	173	PF00069	0.746
MOD_Plk_4	209	215	PF00069	0.403
MOD_Plk_4	224	230	PF00069	0.350
MOD_Plk_4	294	300	PF00069	0.616
MOD_Plk_4	305	311	PF00069	0.475
MOD_Plk_4	320	326	PF00069	0.509
MOD_Plk_4	6	12	PF00069	0.522
MOD_ProDKin_1	101	107	PF00069	0.591
MOD_ProDKin_1	135	141	PF00069	0.683
TRG_DiLeu_BaEn_1	53	58	PF01217	0.429
TRG_DiLeu_BaEn_1	63	68	PF01217	0.379
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.529
TRG_ENDOCYTIC_2	159	162	PF00928	0.714
TRG_ENDOCYTIC_2	272	275	PF00928	0.540
TRG_ER_diArg_1	11	13	PF00400	0.527
TRG_ER_diArg_1	112	114	PF00400	0.498
TRG_ER_diArg_1	119	121	PF00400	0.485
TRG_ER_diArg_1	189	191	PF00400	0.666
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	48	53	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9D5	Leptomonas seymouri	70%	97%
A0A1X0P057	Trypanosomatidae	31%	100%
A0A3R7RKF3	Trypanosoma rangeli	36%	100%
A0A3S7XBW0	Leishmania donovani	81%	98%
A4IDX2	Leishmania infantum	82%	98%
D0A445	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ATZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	98%
Q4Q0K3	Leishmania major	81%	100%
V5B3M7	Trypanosoma cruzi	35%	100%