Putative aminopeptidase P1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MG, Family M24

Species:

Leishmania braziliensis

UniProt:

A4HQ72_LEIBR

TriTrypDb:

LbrM.35.5830 , LBRM2903_350069700

Length:

825

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQ72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ72

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004177	aminopeptidase activity	5	7
GO:0005488	binding	1	7
GO:0008233	peptidase activity	3	7
GO:0008235	metalloexopeptidase activity	5	7
GO:0008237	metallopeptidase activity	4	7
GO:0008238	exopeptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0030145	manganese ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0070006	metalloaminopeptidase activity	6	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	324	328	PF00656	0.450
CLV_C14_Caspase3-7	369	373	PF00656	0.561
CLV_C14_Caspase3-7	471	475	PF00656	0.400
CLV_C14_Caspase3-7	713	717	PF00656	0.384
CLV_NRD_NRD_1	13	15	PF00675	0.566
CLV_NRD_NRD_1	185	187	PF00675	0.579
CLV_NRD_NRD_1	419	421	PF00675	0.278
CLV_NRD_NRD_1	44	46	PF00675	0.306
CLV_NRD_NRD_1	524	526	PF00675	0.336
CLV_NRD_NRD_1	560	562	PF00675	0.312
CLV_NRD_NRD_1	93	95	PF00675	0.285
CLV_PCSK_FUR_1	44	48	PF00082	0.364
CLV_PCSK_KEX2_1	12	14	PF00082	0.570
CLV_PCSK_KEX2_1	152	154	PF00082	0.327
CLV_PCSK_KEX2_1	185	187	PF00082	0.579
CLV_PCSK_KEX2_1	419	421	PF00082	0.261
CLV_PCSK_KEX2_1	44	46	PF00082	0.312
CLV_PCSK_KEX2_1	560	562	PF00082	0.328
CLV_PCSK_KEX2_1	93	95	PF00082	0.285
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.327
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.231
CLV_PCSK_PC7_1	89	95	PF00082	0.327
CLV_PCSK_SKI1_1	124	128	PF00082	0.361
CLV_PCSK_SKI1_1	14	18	PF00082	0.460
CLV_PCSK_SKI1_1	152	156	PF00082	0.327
CLV_PCSK_SKI1_1	186	190	PF00082	0.568
CLV_PCSK_SKI1_1	297	301	PF00082	0.433
CLV_PCSK_SKI1_1	419	423	PF00082	0.276
CLV_PCSK_SKI1_1	46	50	PF00082	0.464
CLV_PCSK_SKI1_1	525	529	PF00082	0.312
CLV_PCSK_SKI1_1	561	565	PF00082	0.338
CLV_PCSK_SKI1_1	745	749	PF00082	0.391
DEG_APCC_DBOX_1	524	532	PF00400	0.312
DEG_APCC_DBOX_1	642	650	PF00400	0.312
DEG_APCC_DBOX_1	744	752	PF00400	0.258
DEG_Nend_Nbox_1	1	3	PF02207	0.628
DEG_ODPH_VHL_1	96	109	PF01847	0.388
DEG_SPOP_SBC_1	206	210	PF00917	0.509
DEG_SPOP_SBC_1	269	273	PF00917	0.617
DOC_ANK_TNKS_1	499	506	PF00023	0.312
DOC_ANK_TNKS_1	528	535	PF00023	0.225
DOC_CYCLIN_yClb1_LxF_4	745	751	PF00134	0.417
DOC_MAPK_MEF2A_6	529	537	PF00069	0.225
DOC_MAPK_MEF2A_6	814	823	PF00069	0.329
DOC_PP2B_LxvP_1	127	130	PF13499	0.312
DOC_PP2B_LxvP_1	293	296	PF13499	0.402
DOC_PP2B_LxvP_1	671	674	PF13499	0.370
DOC_PP2B_LxvP_1	96	99	PF13499	0.352
DOC_PP4_FxxP_1	275	278	PF00568	0.445
DOC_USP7_MATH_1	314	318	PF00917	0.501
DOC_USP7_MATH_1	53	57	PF00917	0.388
DOC_USP7_MATH_1	533	537	PF00917	0.388
DOC_USP7_MATH_1	563	567	PF00917	0.380
DOC_USP7_MATH_1	63	67	PF00917	0.285
DOC_USP7_MATH_1	730	734	PF00917	0.458
DOC_USP7_MATH_1	764	768	PF00917	0.398
DOC_USP7_MATH_1	795	799	PF00917	0.413
DOC_USP7_MATH_1	802	806	PF00917	0.369
DOC_WW_Pin1_4	161	166	PF00397	0.771
DOC_WW_Pin1_4	207	212	PF00397	0.526
DOC_WW_Pin1_4	286	291	PF00397	0.479
DOC_WW_Pin1_4	327	332	PF00397	0.573
DOC_WW_Pin1_4	347	352	PF00397	0.492
DOC_WW_Pin1_4	507	512	PF00397	0.276
DOC_WW_Pin1_4	672	677	PF00397	0.541
DOC_WW_Pin1_4	717	722	PF00397	0.368
LIG_14-3-3_CanoR_1	108	112	PF00244	0.183
LIG_14-3-3_CanoR_1	13	17	PF00244	0.550
LIG_14-3-3_CanoR_1	24	30	PF00244	0.407
LIG_14-3-3_CanoR_1	256	261	PF00244	0.506
LIG_14-3-3_CanoR_1	270	275	PF00244	0.372
LIG_14-3-3_CanoR_1	408	415	PF00244	0.315
LIG_14-3-3_CanoR_1	419	429	PF00244	0.326
LIG_14-3-3_CanoR_1	561	571	PF00244	0.366
LIG_14-3-3_CanoR_1	643	647	PF00244	0.225
LIG_14-3-3_CanoR_1	7	12	PF00244	0.578
LIG_14-3-3_CanoR_1	755	759	PF00244	0.256
LIG_14-3-3_CanoR_1	89	93	PF00244	0.231
LIG_APCC_ABBA_1	591	596	PF00400	0.312
LIG_BIR_III_2	160	164	PF00653	0.510
LIG_Clathr_ClatBox_1	646	650	PF01394	0.388
LIG_CtBP_PxDLS_1	572	576	PF00389	0.231
LIG_deltaCOP1_diTrp_1	79	86	PF00928	0.312
LIG_FHA_1	102	108	PF00498	0.349
LIG_FHA_1	121	127	PF00498	0.319
LIG_FHA_1	172	178	PF00498	0.608
LIG_FHA_1	21	27	PF00498	0.616
LIG_FHA_1	263	269	PF00498	0.579
LIG_FHA_1	287	293	PF00498	0.416
LIG_FHA_1	328	334	PF00498	0.517
LIG_FHA_1	335	341	PF00498	0.592
LIG_FHA_1	360	366	PF00498	0.653
LIG_FHA_1	372	378	PF00498	0.688
LIG_FHA_1	420	426	PF00498	0.231
LIG_FHA_1	497	503	PF00498	0.318
LIG_FHA_1	546	552	PF00498	0.312
LIG_FHA_1	6	12	PF00498	0.502
LIG_FHA_1	718	724	PF00498	0.345
LIG_FHA_1	807	813	PF00498	0.335
LIG_FHA_2	171	177	PF00498	0.535
LIG_FHA_2	422	428	PF00498	0.390
LIG_FHA_2	469	475	PF00498	0.388
LIG_LIR_Apic_2	272	278	PF02991	0.467
LIG_LIR_Gen_1	322	331	PF02991	0.471
LIG_LIR_Gen_1	384	391	PF02991	0.624
LIG_LIR_Gen_1	411	421	PF02991	0.331
LIG_LIR_Gen_1	80	90	PF02991	0.312
LIG_LIR_Nem_3	149	154	PF02991	0.327
LIG_LIR_Nem_3	235	240	PF02991	0.438
LIG_LIR_Nem_3	280	286	PF02991	0.419
LIG_LIR_Nem_3	322	326	PF02991	0.469
LIG_LIR_Nem_3	384	390	PF02991	0.629
LIG_LIR_Nem_3	411	417	PF02991	0.312
LIG_LIR_Nem_3	453	458	PF02991	0.248
LIG_LIR_Nem_3	510	516	PF02991	0.404
LIG_LIR_Nem_3	79	85	PF02991	0.312
LIG_LIR_Nem_3	798	803	PF02991	0.409
LIG_MYND_1	331	335	PF01753	0.629
LIG_PCNA_yPIPBox_3	186	200	PF02747	0.361
LIG_PCNA_yPIPBox_3	312	320	PF02747	0.453
LIG_Pex14_1	82	86	PF04695	0.312
LIG_Pex14_2	585	589	PF04695	0.388
LIG_Pex14_2	654	658	PF04695	0.327
LIG_PTB_Apo_2	780	787	PF02174	0.510
LIG_PTB_Phospho_1	780	786	PF10480	0.499
LIG_SH2_CRK	151	155	PF00017	0.327
LIG_SH2_CRK	803	807	PF00017	0.340
LIG_SH2_NCK_1	323	327	PF00017	0.601
LIG_SH2_PTP2	455	458	PF00017	0.312
LIG_SH2_PTP2	513	516	PF00017	0.388
LIG_SH2_SRC	455	458	PF00017	0.312
LIG_SH2_SRC	637	640	PF00017	0.388
LIG_SH2_SRC	786	789	PF00017	0.406
LIG_SH2_STAP1	387	391	PF00017	0.511
LIG_SH2_STAP1	68	72	PF00017	0.312
LIG_SH2_STAP1	803	807	PF00017	0.340
LIG_SH2_STAT3	240	243	PF00017	0.468
LIG_SH2_STAT5	329	332	PF00017	0.459
LIG_SH2_STAT5	455	458	PF00017	0.339
LIG_SH2_STAT5	513	516	PF00017	0.388
LIG_SH2_STAT5	637	640	PF00017	0.388
LIG_SH2_STAT5	692	695	PF00017	0.462
LIG_SH2_STAT5	700	703	PF00017	0.351
LIG_SH2_STAT5	786	789	PF00017	0.406
LIG_SH3_3	55	61	PF00018	0.388
LIG_SH3_3	633	639	PF00018	0.388
LIG_SH3_3	688	694	PF00018	0.492
LIG_SH3_3	778	784	PF00018	0.418
LIG_SH3_3	787	793	PF00018	0.426
LIG_SH3_4	395	402	PF00018	0.309
LIG_SUMO_SIM_anti_2	56	61	PF11976	0.312
LIG_SUMO_SIM_anti_2	667	675	PF11976	0.312
LIG_SUMO_SIM_anti_2	815	820	PF11976	0.423
LIG_SUMO_SIM_par_1	667	675	PF11976	0.388
LIG_SUMO_SIM_par_1	722	729	PF11976	0.406
LIG_TRAF2_1	37	40	PF00917	0.509
LIG_TRAF2_1	565	568	PF00917	0.326
LIG_TRAF2_1	685	688	PF00917	0.491
LIG_UBA3_1	520	526	PF00899	0.388
MOD_CDK_SPK_2	161	166	PF00069	0.545
MOD_CDK_SPK_2	347	352	PF00069	0.685
MOD_CDK_SPxxK_3	347	354	PF00069	0.601
MOD_CK1_1	101	107	PF00069	0.348
MOD_CK1_1	15	21	PF00069	0.568
MOD_CK1_1	164	170	PF00069	0.571
MOD_CK1_1	336	342	PF00069	0.531
MOD_CK1_1	359	365	PF00069	0.808
MOD_CK1_1	366	372	PF00069	0.686
MOD_CK1_1	507	513	PF00069	0.222
MOD_CK1_1	538	544	PF00069	0.231
MOD_CK1_1	598	604	PF00069	0.364
MOD_CK1_1	66	72	PF00069	0.388
MOD_CK2_1	170	176	PF00069	0.545
MOD_CK2_1	34	40	PF00069	0.435
MOD_CK2_1	421	427	PF00069	0.417
MOD_CK2_1	533	539	PF00069	0.231
MOD_CK2_1	562	568	PF00069	0.253
MOD_CK2_1	682	688	PF00069	0.490
MOD_CK2_1	693	699	PF00069	0.286
MOD_GlcNHglycan	100	103	PF01048	0.388
MOD_GlcNHglycan	135	138	PF01048	0.231
MOD_GlcNHglycan	286	289	PF01048	0.526
MOD_GlcNHglycan	323	326	PF01048	0.548
MOD_GlcNHglycan	365	368	PF01048	0.699
MOD_GlcNHglycan	405	408	PF01048	0.325
MOD_GlcNHglycan	452	455	PF01048	0.381
MOD_GlcNHglycan	460	463	PF01048	0.255
MOD_GlcNHglycan	598	601	PF01048	0.243
MOD_GlcNHglycan	611	615	PF01048	0.195
MOD_GSK3_1	12	19	PF00069	0.623
MOD_GSK3_1	131	138	PF00069	0.440
MOD_GSK3_1	256	263	PF00069	0.533
MOD_GSK3_1	282	289	PF00069	0.430
MOD_GSK3_1	336	343	PF00069	0.558
MOD_GSK3_1	356	363	PF00069	0.625
MOD_GSK3_1	391	398	PF00069	0.309
MOD_GSK3_1	403	410	PF00069	0.315
MOD_GSK3_1	419	426	PF00069	0.323
MOD_GSK3_1	559	566	PF00069	0.334
MOD_GSK3_1	682	689	PF00069	0.482
MOD_GSK3_1	719	726	PF00069	0.560
MOD_GSK3_1	802	809	PF00069	0.498
MOD_N-GLC_1	20	25	PF02516	0.452
MOD_NEK2_1	282	287	PF00069	0.445
MOD_NEK2_1	321	326	PF00069	0.583
MOD_NEK2_1	360	365	PF00069	0.560
MOD_NEK2_1	551	556	PF00069	0.263
MOD_NEK2_1	575	580	PF00069	0.388
MOD_NEK2_1	649	654	PF00069	0.262
MOD_NEK2_1	723	728	PF00069	0.453
MOD_NEK2_1	808	813	PF00069	0.340
MOD_NEK2_1	88	93	PF00069	0.233
MOD_NEK2_2	63	68	PF00069	0.388
MOD_PIKK_1	340	346	PF00454	0.533
MOD_PIKK_1	395	401	PF00454	0.387
MOD_PIKK_1	545	551	PF00454	0.231
MOD_PIKK_1	563	569	PF00454	0.192
MOD_PIKK_1	598	604	PF00454	0.324
MOD_PK_1	270	276	PF00069	0.419
MOD_PK_1	7	13	PF00069	0.477
MOD_PKA_1	12	18	PF00069	0.466
MOD_PKA_1	419	425	PF00069	0.231
MOD_PKA_2	107	113	PF00069	0.292
MOD_PKA_2	12	18	PF00069	0.561
MOD_PKA_2	269	275	PF00069	0.432
MOD_PKA_2	391	397	PF00069	0.389
MOD_PKA_2	407	413	PF00069	0.312
MOD_PKA_2	419	425	PF00069	0.255
MOD_PKA_2	463	469	PF00069	0.312
MOD_PKA_2	559	565	PF00069	0.291
MOD_PKA_2	617	623	PF00069	0.236
MOD_PKA_2	642	648	PF00069	0.225
MOD_PKA_2	754	760	PF00069	0.255
MOD_PKA_2	88	94	PF00069	0.450
MOD_PKB_1	252	260	PF00069	0.472
MOD_Plk_1	20	26	PF00069	0.453
MOD_Plk_1	34	40	PF00069	0.353
MOD_Plk_1	371	377	PF00069	0.579
MOD_Plk_1	53	59	PF00069	0.365
MOD_Plk_1	538	544	PF00069	0.231
MOD_Plk_1	63	69	PF00069	0.265
MOD_Plk_1	686	692	PF00069	0.450
MOD_Plk_2-3	176	182	PF00069	0.384
MOD_Plk_2-3	34	40	PF00069	0.354
MOD_Plk_2-3	682	688	PF00069	0.490
MOD_Plk_4	135	141	PF00069	0.342
MOD_Plk_4	232	238	PF00069	0.432
MOD_Plk_4	270	276	PF00069	0.492
MOD_Plk_4	314	320	PF00069	0.603
MOD_Plk_4	336	342	PF00069	0.624
MOD_Plk_4	356	362	PF00069	0.511
MOD_Plk_4	509	515	PF00069	0.388
MOD_Plk_4	53	59	PF00069	0.388
MOD_Plk_4	63	69	PF00069	0.356
MOD_Plk_4	642	648	PF00069	0.247
MOD_Plk_4	719	725	PF00069	0.485
MOD_Plk_4	77	83	PF00069	0.235
MOD_Plk_4	776	782	PF00069	0.454
MOD_Plk_4	802	808	PF00069	0.378
MOD_ProDKin_1	161	167	PF00069	0.770
MOD_ProDKin_1	207	213	PF00069	0.532
MOD_ProDKin_1	286	292	PF00069	0.481
MOD_ProDKin_1	327	333	PF00069	0.572
MOD_ProDKin_1	347	353	PF00069	0.490
MOD_ProDKin_1	507	513	PF00069	0.276
MOD_ProDKin_1	672	678	PF00069	0.553
MOD_ProDKin_1	717	723	PF00069	0.358
MOD_SUMO_rev_2	144	154	PF00179	0.291
TRG_DiLeu_BaEn_1	150	155	PF01217	0.231
TRG_DiLeu_BaEn_1	547	552	PF01217	0.312
TRG_DiLeu_BaEn_1	667	672	PF01217	0.312
TRG_DiLeu_BaEn_3	182	188	PF01217	0.363
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.653
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.430
TRG_DiLeu_LyEn_5	150	155	PF01217	0.231
TRG_ENDOCYTIC_2	151	154	PF00928	0.327
TRG_ENDOCYTIC_2	323	326	PF00928	0.590
TRG_ENDOCYTIC_2	387	390	PF00928	0.454
TRG_ENDOCYTIC_2	455	458	PF00928	0.312
TRG_ENDOCYTIC_2	513	516	PF00928	0.331
TRG_ENDOCYTIC_2	517	520	PF00928	0.294
TRG_ENDOCYTIC_2	803	806	PF00928	0.345
TRG_ENDOCYTIC_2	83	86	PF00928	0.312
TRG_ER_diArg_1	11	14	PF00400	0.558
TRG_ER_diArg_1	184	186	PF00400	0.580
TRG_ER_diArg_1	251	254	PF00400	0.689
TRG_ER_diArg_1	351	354	PF00400	0.649
TRG_ER_diArg_1	418	420	PF00400	0.275
TRG_ER_diArg_1	44	47	PF00400	0.312
TRG_ER_diArg_1	559	561	PF00400	0.312
TRG_ER_diArg_1	92	94	PF00400	0.285
TRG_NES_CRM1_1	27	40	PF08389	0.390
TRG_NLS_MonoExtC_3	44	50	PF00514	0.231
TRG_NLS_MonoExtN_4	44	49	PF00514	0.231
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	749	754	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P918	Leptomonas seymouri	47%	96%
A0A3Q8IHX0	Leishmania donovani	75%	98%
A4IDX0	Leishmania infantum	75%	98%
E9ATZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q0K5	Leishmania major	74%	100%