Zeta_toxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphoseryl-tRNA Kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ70_LEIBR

TriTrypDb:

LbrM.35.5810 , LBRM2903_350069500

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ70

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	1
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.346
CLV_NRD_NRD_1	200	202	PF00675	0.412
CLV_NRD_NRD_1	332	334	PF00675	0.680
CLV_NRD_NRD_1	381	383	PF00675	0.481
CLV_NRD_NRD_1	46	48	PF00675	0.462
CLV_NRD_NRD_1	89	91	PF00675	0.538
CLV_PCSK_FUR_1	330	334	PF00082	0.702
CLV_PCSK_KEX2_1	102	104	PF00082	0.486
CLV_PCSK_KEX2_1	200	202	PF00082	0.429
CLV_PCSK_KEX2_1	330	332	PF00082	0.650
CLV_PCSK_PC7_1	98	104	PF00082	0.451
CLV_PCSK_SKI1_1	186	190	PF00082	0.393
CLV_PCSK_SKI1_1	37	41	PF00082	0.484
CLV_PCSK_SKI1_1	98	102	PF00082	0.434
DEG_APCC_DBOX_1	396	404	PF00400	0.351
DEG_Nend_UBRbox_1	1	4	PF02207	0.607
DOC_CKS1_1	187	192	PF01111	0.401
DOC_CKS1_1	372	377	PF01111	0.361
DOC_CKS1_1	450	455	PF01111	0.474
DOC_CYCLIN_RxL_1	434	444	PF00134	0.281
DOC_CYCLIN_RxL_1	98	110	PF00134	0.447
DOC_MAPK_DCC_7	125	135	PF00069	0.380
DOC_MAPK_MEF2A_6	186	195	PF00069	0.425
DOC_PP4_FxxP_1	187	190	PF00568	0.447
DOC_SPAK_OSR1_1	395	399	PF12202	0.326
DOC_USP7_MATH_1	169	173	PF00917	0.685
DOC_USP7_MATH_1	213	217	PF00917	0.589
DOC_USP7_MATH_1	26	30	PF00917	0.393
DOC_WW_Pin1_4	161	166	PF00397	0.566
DOC_WW_Pin1_4	186	191	PF00397	0.385
DOC_WW_Pin1_4	371	376	PF00397	0.603
DOC_WW_Pin1_4	4	9	PF00397	0.743
DOC_WW_Pin1_4	449	454	PF00397	0.461
DOC_WW_Pin1_4	90	95	PF00397	0.454
LIG_14-3-3_CanoR_1	59	64	PF00244	0.346
LIG_CSL_BTD_1	217	220	PF09270	0.472
LIG_FHA_1	115	121	PF00498	0.543
LIG_FHA_1	236	242	PF00498	0.617
LIG_FHA_1	268	274	PF00498	0.441
LIG_FHA_1	366	372	PF00498	0.583
LIG_FHA_1	409	415	PF00498	0.627
LIG_FHA_1	99	105	PF00498	0.423
LIG_FHA_2	162	168	PF00498	0.440
LIG_HCF-1_HBM_1	232	235	PF13415	0.498
LIG_LIR_Apic_2	184	190	PF02991	0.432
LIG_LIR_Apic_2	215	221	PF02991	0.605
LIG_LIR_LC3C_4	428	431	PF02991	0.266
LIG_LIR_Nem_3	260	266	PF02991	0.454
LIG_LIR_Nem_3	276	282	PF02991	0.646
LIG_LIR_Nem_3	289	293	PF02991	0.304
LIG_LIR_Nem_3	89	95	PF02991	0.373
LIG_NRBOX	15	21	PF00104	0.243
LIG_PCNA_PIPBox_1	435	444	PF02747	0.338
LIG_PCNA_yPIPBox_3	435	443	PF02747	0.331
LIG_PCNA_yPIPBox_3	55	64	PF02747	0.420
LIG_Pex14_2	179	183	PF04695	0.373
LIG_Rb_pABgroove_1	225	233	PF01858	0.438
LIG_RPA_C_Fungi	327	339	PF08784	0.396
LIG_SH2_STAT3	160	163	PF00017	0.530
LIG_SH3_1	2	8	PF00018	0.512
LIG_SH3_1	80	86	PF00018	0.455
LIG_SH3_3	2	8	PF00018	0.765
LIG_SH3_3	216	222	PF00018	0.507
LIG_SH3_3	80	86	PF00018	0.550
LIG_SUMO_SIM_anti_2	14	21	PF11976	0.248
LIG_SUMO_SIM_par_1	103	108	PF11976	0.434
LIG_SUMO_SIM_par_1	131	137	PF11976	0.265
LIG_SUMO_SIM_par_1	14	21	PF11976	0.245
LIG_SUMO_SIM_par_1	411	417	PF11976	0.569
LIG_SxIP_EBH_1	16	28	PF03271	0.407
LIG_TRAF2_1	388	391	PF00917	0.419
LIG_UBA3_1	19	28	PF00899	0.263
MOD_CK1_1	168	174	PF00069	0.655
MOD_CK1_1	370	376	PF00069	0.446
MOD_CK1_1	7	13	PF00069	0.590
MOD_CK2_1	140	146	PF00069	0.476
MOD_GlcNHglycan	109	112	PF01048	0.478
MOD_GlcNHglycan	13	16	PF01048	0.442
MOD_GlcNHglycan	171	174	PF01048	0.514
MOD_GlcNHglycan	215	218	PF01048	0.512
MOD_GSK3_1	107	114	PF00069	0.518
MOD_GSK3_1	161	168	PF00069	0.590
MOD_GSK3_1	3	10	PF00069	0.640
MOD_GSK3_1	367	374	PF00069	0.580
MOD_N-GLC_1	43	48	PF02516	0.401
MOD_NEK2_1	105	110	PF00069	0.492
MOD_NEK2_1	18	23	PF00069	0.425
MOD_NEK2_1	381	386	PF00069	0.326
MOD_PIKK_1	105	111	PF00454	0.481
MOD_PIKK_1	257	263	PF00454	0.516
MOD_PIKK_1	267	273	PF00454	0.547
MOD_PIKK_1	355	361	PF00454	0.301
MOD_PK_1	59	65	PF00069	0.343
MOD_PKA_2	381	387	PF00069	0.476
MOD_Plk_1	275	281	PF00069	0.470
MOD_Plk_4	27	33	PF00069	0.462
MOD_Plk_4	286	292	PF00069	0.565
MOD_Plk_4	367	373	PF00069	0.640
MOD_Plk_4	59	65	PF00069	0.431
MOD_ProDKin_1	161	167	PF00069	0.575
MOD_ProDKin_1	186	192	PF00069	0.394
MOD_ProDKin_1	371	377	PF00069	0.595
MOD_ProDKin_1	4	10	PF00069	0.729
MOD_ProDKin_1	449	455	PF00069	0.464
MOD_ProDKin_1	90	96	PF00069	0.444
MOD_SUMO_for_1	388	391	PF00179	0.523
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.418
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.432
TRG_ENDOCYTIC_2	141	144	PF00928	0.374
TRG_ENDOCYTIC_2	148	151	PF00928	0.344
TRG_ER_diArg_1	102	104	PF00400	0.431
TRG_ER_diArg_1	330	333	PF00400	0.675
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	401	406	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFJ4	Leptomonas seymouri	36%	98%
A0A1X0P061	Trypanosomatidae	23%	100%
A0A3Q8ILN7	Leishmania donovani	73%	100%
A0A422NKD5	Trypanosoma rangeli	26%	100%
A4IDW8	Leishmania infantum	73%	100%
E9ATY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q0K7	Leishmania major	71%	100%