PCIF1_WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphorylated CTD interacting factor 1 WW domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ69_LEIBR

TriTrypDb:

LbrM.35.5800 , LBRM2903_350069400

Length:

659

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ69

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000993	RNA polymerase II complex binding	5	10
GO:0001098	basal transcription machinery binding	3	10
GO:0001099	basal RNA polymerase II transcription machinery binding	4	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0008168	methyltransferase activity	4	10
GO:0008173	RNA methyltransferase activity	4	10
GO:0008174	mRNA methyltransferase activity	5	10
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	10
GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	6	10
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10
GO:0019899	enzyme binding	3	10
GO:0043175	RNA polymerase core enzyme binding	5	10
GO:0070063	RNA polymerase binding	4	10
GO:0099122	RNA polymerase II C-terminal domain binding	6	10
GO:0140098	catalytic activity, acting on RNA	3	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.403
CLV_C14_Caspase3-7	264	268	PF00656	0.507
CLV_C14_Caspase3-7	352	356	PF00656	0.322
CLV_C14_Caspase3-7	477	481	PF00656	0.475
CLV_NRD_NRD_1	198	200	PF00675	0.417
CLV_NRD_NRD_1	216	218	PF00675	0.239
CLV_NRD_NRD_1	585	587	PF00675	0.628
CLV_NRD_NRD_1	82	84	PF00675	0.443
CLV_PCSK_KEX2_1	198	200	PF00082	0.416
CLV_PCSK_KEX2_1	585	587	PF00082	0.615
CLV_PCSK_KEX2_1	591	593	PF00082	0.653
CLV_PCSK_KEX2_1	82	84	PF00082	0.443
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.416
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.659
CLV_PCSK_PC7_1	581	587	PF00082	0.593
CLV_PCSK_SKI1_1	12	16	PF00082	0.394
CLV_PCSK_SKI1_1	148	152	PF00082	0.441
CLV_PCSK_SKI1_1	174	178	PF00082	0.565
CLV_PCSK_SKI1_1	223	227	PF00082	0.364
CLV_PCSK_SKI1_1	363	367	PF00082	0.443
CLV_PCSK_SKI1_1	38	42	PF00082	0.407
CLV_PCSK_SKI1_1	422	426	PF00082	0.341
CLV_Separin_Metazoa	582	586	PF03568	0.506
CLV_Separin_Metazoa	7	11	PF03568	0.336
DEG_APCC_DBOX_1	103	111	PF00400	0.427
DEG_Nend_UBRbox_3	1	3	PF02207	0.461
DEG_SPOP_SBC_1	94	98	PF00917	0.475
DOC_CKS1_1	149	154	PF01111	0.434
DOC_CYCLIN_RxL_1	170	178	PF00134	0.440
DOC_CYCLIN_yCln2_LP_2	160	166	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	326	332	PF00134	0.376
DOC_MAPK_gen_1	10	17	PF00069	0.383
DOC_MAPK_gen_1	23	31	PF00069	0.333
DOC_MAPK_gen_1	325	334	PF00069	0.244
DOC_MAPK_gen_1	82	90	PF00069	0.502
DOC_MAPK_HePTP_8	322	334	PF00069	0.375
DOC_MAPK_JIP1_4	238	244	PF00069	0.423
DOC_MAPK_MEF2A_6	174	181	PF00069	0.410
DOC_MAPK_MEF2A_6	238	246	PF00069	0.439
DOC_MAPK_MEF2A_6	325	334	PF00069	0.414
DOC_MAPK_MEF2A_6	72	81	PF00069	0.376
DOC_MAPK_NFAT4_5	174	182	PF00069	0.416
DOC_PP2B_LxvP_1	297	300	PF13499	0.467
DOC_PP2B_LxvP_1	326	329	PF13499	0.371
DOC_PP4_FxxP_1	414	417	PF00568	0.276
DOC_USP7_MATH_1	351	355	PF00917	0.391
DOC_USP7_MATH_1	435	439	PF00917	0.485
DOC_USP7_MATH_1	459	463	PF00917	0.431
DOC_USP7_MATH_1	483	487	PF00917	0.514
DOC_USP7_MATH_1	59	63	PF00917	0.463
DOC_USP7_MATH_1	653	657	PF00917	0.469
DOC_WW_Pin1_4	135	140	PF00397	0.531
DOC_WW_Pin1_4	148	153	PF00397	0.373
DOC_WW_Pin1_4	29	34	PF00397	0.474
DOC_WW_Pin1_4	400	405	PF00397	0.348
DOC_WW_Pin1_4	413	418	PF00397	0.233
DOC_WW_Pin1_4	457	462	PF00397	0.530
LIG_14-3-3_CanoR_1	12	18	PF00244	0.252
LIG_14-3-3_CanoR_1	140	145	PF00244	0.435
LIG_14-3-3_CanoR_1	199	205	PF00244	0.390
LIG_14-3-3_CanoR_1	223	228	PF00244	0.408
LIG_14-3-3_CanoR_1	296	300	PF00244	0.488
LIG_14-3-3_CanoR_1	327	333	PF00244	0.396
LIG_14-3-3_CanoR_1	556	562	PF00244	0.438
LIG_APCC_ABBA_1	31	36	PF00400	0.358
LIG_APCC_ABBA_1	426	431	PF00400	0.341
LIG_BIR_III_4	36	40	PF00653	0.421
LIG_BRCT_BRCA1_1	191	195	PF00533	0.355
LIG_BRCT_BRCA1_1	353	357	PF00533	0.272
LIG_CaM_NSCaTE_8	180	187	PF13499	0.411
LIG_Clathr_ClatBox_1	494	498	PF01394	0.425
LIG_deltaCOP1_diTrp_1	287	294	PF00928	0.485
LIG_deltaCOP1_diTrp_1	66	74	PF00928	0.367
LIG_FHA_1	270	276	PF00498	0.426
LIG_FHA_1	338	344	PF00498	0.400
LIG_FHA_1	406	412	PF00498	0.444
LIG_FHA_2	14	20	PF00498	0.375
LIG_FHA_2	262	268	PF00498	0.389
LIG_FHA_2	466	472	PF00498	0.477
LIG_FHA_2	475	481	PF00498	0.460
LIG_LIR_Apic_2	412	417	PF02991	0.276
LIG_LIR_Apic_2	71	77	PF02991	0.392
LIG_LIR_Gen_1	285	295	PF02991	0.474
LIG_LIR_Gen_1	313	324	PF02991	0.381
LIG_LIR_Gen_1	612	619	PF02991	0.369
LIG_LIR_Nem_3	208	214	PF02991	0.385
LIG_LIR_Nem_3	285	291	PF02991	0.475
LIG_LIR_Nem_3	293	297	PF02991	0.465
LIG_LIR_Nem_3	313	319	PF02991	0.250
LIG_LIR_Nem_3	433	439	PF02991	0.393
LIG_LIR_Nem_3	612	616	PF02991	0.363
LIG_MYND_3	161	165	PF01753	0.463
LIG_NRBOX	360	366	PF00104	0.393
LIG_NRBOX	4	10	PF00104	0.310
LIG_PCNA_yPIPBox_3	114	122	PF02747	0.275
LIG_PCNA_yPIPBox_3	2	12	PF02747	0.253
LIG_Pex14_2	414	418	PF04695	0.444
LIG_Pex14_2	425	429	PF04695	0.326
LIG_PTB_Apo_2	497	504	PF02174	0.276
LIG_SH2_CRK	368	372	PF00017	0.276
LIG_SH2_SRC	568	571	PF00017	0.276
LIG_SH2_STAT5	112	115	PF00017	0.460
LIG_SH2_STAT5	211	214	PF00017	0.439
LIG_SH2_STAT5	342	345	PF00017	0.571
LIG_SH2_STAT5	568	571	PF00017	0.276
LIG_SH3_3	117	123	PF00018	0.477
LIG_SH3_3	133	139	PF00018	0.649
LIG_SH3_3	27	33	PF00018	0.460
LIG_SH3_3	383	389	PF00018	0.288
LIG_SH3_3	401	407	PF00018	0.190
LIG_SH3_3	485	491	PF00018	0.539
LIG_SUMO_SIM_anti_2	331	336	PF11976	0.292
LIG_SUMO_SIM_anti_2	529	538	PF11976	0.298
LIG_SUMO_SIM_anti_2	620	628	PF11976	0.335
LIG_SUMO_SIM_par_1	407	412	PF11976	0.341
LIG_SUMO_SIM_par_1	529	538	PF11976	0.397
LIG_TRAF2_1	16	19	PF00917	0.420
LIG_TRAF2_1	4	7	PF00917	0.382
LIG_TYR_ITIM	366	371	PF00017	0.276
LIG_UBA3_1	176	183	PF00899	0.413
LIG_WW_3	561	565	PF00397	0.199
MOD_CDC14_SPxK_1	403	406	PF00782	0.286
MOD_CDK_SPK_2	135	140	PF00069	0.379
MOD_CDK_SPxK_1	400	406	PF00069	0.286
MOD_CDK_SPxxK_3	457	464	PF00069	0.364
MOD_CK1_1	138	144	PF00069	0.554
MOD_CK1_1	269	275	PF00069	0.423
MOD_CK1_1	298	304	PF00069	0.589
MOD_CK1_1	32	38	PF00069	0.399
MOD_CK1_1	486	492	PF00069	0.484
MOD_CK1_1	521	527	PF00069	0.474
MOD_CK1_1	617	623	PF00069	0.307
MOD_CK1_1	648	654	PF00069	0.480
MOD_CK1_1	93	99	PF00069	0.501
MOD_CK2_1	13	19	PF00069	0.352
MOD_CK2_1	245	251	PF00069	0.316
MOD_CK2_1	309	315	PF00069	0.618
MOD_CK2_1	465	471	PF00069	0.473
MOD_CK2_1	544	550	PF00069	0.409
MOD_GlcNHglycan	2	5	PF01048	0.431
MOD_GlcNHglycan	258	261	PF01048	0.499
MOD_GlcNHglycan	267	271	PF01048	0.635
MOD_GlcNHglycan	297	300	PF01048	0.604
MOD_GlcNHglycan	351	354	PF01048	0.278
MOD_GlcNHglycan	379	382	PF01048	0.344
MOD_GlcNHglycan	476	480	PF01048	0.580
MOD_GlcNHglycan	520	523	PF01048	0.464
MOD_GlcNHglycan	655	658	PF01048	0.562
MOD_GSK3_1	131	138	PF00069	0.674
MOD_GSK3_1	203	210	PF00069	0.439
MOD_GSK3_1	279	286	PF00069	0.569
MOD_GSK3_1	305	312	PF00069	0.693
MOD_GSK3_1	465	472	PF00069	0.474
MOD_GSK3_1	48	55	PF00069	0.508
MOD_GSK3_1	648	655	PF00069	0.467
MOD_GSK3_1	90	97	PF00069	0.536
MOD_N-GLC_1	418	423	PF02516	0.300
MOD_NEK2_1	179	184	PF00069	0.466
MOD_NEK2_1	191	196	PF00069	0.408
MOD_NEK2_1	295	300	PF00069	0.642
MOD_NEK2_1	418	423	PF00069	0.300
MOD_NEK2_1	424	429	PF00069	0.298
MOD_NEK2_1	52	57	PF00069	0.669
MOD_NEK2_1	526	531	PF00069	0.199
MOD_NEK2_2	53	58	PF00069	0.390
MOD_PIKK_1	229	235	PF00454	0.547
MOD_PIKK_1	486	492	PF00454	0.527
MOD_PIKK_1	535	541	PF00454	0.225
MOD_PIKK_1	645	651	PF00454	0.261
MOD_PK_1	140	146	PF00069	0.463
MOD_PK_1	544	550	PF00069	0.199
MOD_PKA_1	198	204	PF00069	0.300
MOD_PKA_2	198	204	PF00069	0.359
MOD_PKA_2	295	301	PF00069	0.419
MOD_PKA_2	405	411	PF00069	0.401
MOD_PKA_2	593	599	PF00069	0.649
MOD_Plk_1	207	213	PF00069	0.548
MOD_Plk_1	314	320	PF00069	0.538
MOD_Plk_1	470	476	PF00069	0.492
MOD_Plk_1	549	555	PF00069	0.277
MOD_Plk_4	207	213	PF00069	0.440
MOD_Plk_4	405	411	PF00069	0.471
MOD_Plk_4	526	532	PF00069	0.278
MOD_Plk_4	609	615	PF00069	0.410
MOD_ProDKin_1	135	141	PF00069	0.521
MOD_ProDKin_1	148	154	PF00069	0.375
MOD_ProDKin_1	29	35	PF00069	0.469
MOD_ProDKin_1	400	406	PF00069	0.348
MOD_ProDKin_1	413	419	PF00069	0.233
MOD_ProDKin_1	457	463	PF00069	0.542
TRG_DiLeu_BaEn_4	19	25	PF01217	0.292
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.300
TRG_DiLeu_BaLyEn_6	360	365	PF01217	0.341
TRG_ENDOCYTIC_2	368	371	PF00928	0.324
TRG_ER_diArg_1	104	107	PF00400	0.530
TRG_ER_diArg_1	324	327	PF00400	0.383
TRG_ER_diArg_1	584	586	PF00400	0.652
TRG_ER_diArg_1	81	83	PF00400	0.493
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	546	550	PF00026	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P0J4	Trypanosomatidae	31%	100%
A0A3Q8IGM5	Leishmania donovani	78%	100%
A0A422NKA3	Trypanosoma rangeli	33%	100%
A4IDW7	Leishmania infantum	78%	100%
E9ATY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q0K8	Leishmania major	77%	99%
V5BF31	Trypanosoma cruzi	27%	95%
V5BTB5	Trypanosoma cruzi	32%	100%