Adiponectin receptor protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Haemolysin-III related, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ67_LEIBR

TriTrypDb:

LbrM.35.5780 , LBRM2903_350069100

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 30
NetGPI	no	yes: 0, no: 30

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	31
GO:0110165	cellular anatomical entity	1	31

Expansion

Sequence features

A4HQ67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ67

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0038023	signaling receptor activity	2	3
GO:0060089	molecular transducer activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.578
CLV_NRD_NRD_1	50	52	PF00675	0.390
CLV_PCSK_KEX2_1	12	14	PF00082	0.481
CLV_PCSK_KEX2_1	18	20	PF00082	0.579
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.474
CLV_PCSK_SKI1_1	12	16	PF00082	0.366
CLV_PCSK_SKI1_1	150	154	PF00082	0.427
CLV_PCSK_SKI1_1	19	23	PF00082	0.575
CLV_PCSK_SKI1_1	264	268	PF00082	0.324
CLV_PCSK_SKI1_1	296	300	PF00082	0.525
DEG_APCC_DBOX_1	160	168	PF00400	0.141
DOC_AGCK_PIF_1	169	174	PF00069	0.208
DOC_CYCLIN_RxL_1	293	300	PF00134	0.325
DOC_CYCLIN_RxL_1	9	17	PF00134	0.558
DOC_MAPK_DCC_7	161	169	PF00069	0.141
DOC_MAPK_gen_1	147	157	PF00069	0.341
DOC_MAPK_gen_1	161	169	PF00069	0.177
DOC_MAPK_MEF2A_6	161	169	PF00069	0.333
DOC_PP1_RVXF_1	261	268	PF00149	0.474
DOC_PP2B_PxIxI_1	277	283	PF00149	0.237
DOC_PP4_FxxP_1	314	317	PF00568	0.468
DOC_USP7_MATH_2	41	47	PF00917	0.511
DOC_WW_Pin1_4	21	26	PF00397	0.677
DOC_WW_Pin1_4	318	323	PF00397	0.391
LIG_14-3-3_CanoR_1	253	260	PF00244	0.461
LIG_14-3-3_CanoR_1	30	35	PF00244	0.707
LIG_APCC_ABBA_1	104	109	PF00400	0.416
LIG_BRCT_BRCA1_1	182	186	PF00533	0.241
LIG_BRCT_BRCA1_1	193	197	PF00533	0.408
LIG_BRCT_BRCA1_1	256	260	PF00533	0.480
LIG_EH1_1	206	214	PF00400	0.258
LIG_EH1_1	241	249	PF00400	0.216
LIG_eIF4E_1	206	212	PF01652	0.337
LIG_FHA_1	108	114	PF00498	0.429
LIG_FHA_1	130	136	PF00498	0.360
LIG_FHA_1	208	214	PF00498	0.305
LIG_FHA_1	260	266	PF00498	0.453
LIG_FHA_1	277	283	PF00498	0.271
LIG_FHA_1	65	71	PF00498	0.538
LIG_FHA_1	99	105	PF00498	0.502
LIG_IRF3_LxIS_1	286	291	PF10401	0.333
LIG_LIR_Gen_1	173	181	PF02991	0.253
LIG_LIR_Gen_1	183	193	PF02991	0.217
LIG_LIR_Gen_1	195	206	PF02991	0.420
LIG_LIR_Gen_1	345	355	PF02991	0.318
LIG_LIR_LC3C_4	210	214	PF02991	0.294
LIG_LIR_Nem_3	173	177	PF02991	0.273
LIG_LIR_Nem_3	183	189	PF02991	0.306
LIG_LIR_Nem_3	205	209	PF02991	0.286
LIG_LIR_Nem_3	216	220	PF02991	0.303
LIG_LIR_Nem_3	240	245	PF02991	0.239
LIG_LIR_Nem_3	324	328	PF02991	0.491
LIG_LIR_Nem_3	345	351	PF02991	0.318
LIG_PDZ_Class_2	358	363	PF00595	0.276
LIG_Pex14_1	231	235	PF04695	0.236
LIG_Pex14_2	251	255	PF04695	0.444
LIG_Pex14_2	310	314	PF04695	0.302
LIG_Pex14_2	325	329	PF04695	0.414
LIG_REV1ctd_RIR_1	249	257	PF16727	0.300
LIG_SH2_CRK	348	352	PF00017	0.218
LIG_SH2_GRB2like	354	357	PF00017	0.209
LIG_SH2_NCK_1	348	352	PF00017	0.218
LIG_SH2_STAP1	207	211	PF00017	0.147
LIG_SH2_STAP1	312	316	PF00017	0.265
LIG_SH2_STAT5	139	142	PF00017	0.283
LIG_SH2_STAT5	235	238	PF00017	0.278
LIG_SH2_STAT5	268	271	PF00017	0.204
LIG_SH2_STAT5	294	297	PF00017	0.245
LIG_SH2_STAT5	328	331	PF00017	0.436
LIG_SH2_STAT5	354	357	PF00017	0.283
LIG_SH2_STAT5	79	82	PF00017	0.499
LIG_SH2_STAT5	85	88	PF00017	0.500
LIG_SH2_STAT5	94	97	PF00017	0.481
LIG_SH3_3	35	41	PF00018	0.580
LIG_SUMO_SIM_anti_2	210	216	PF11976	0.272
LIG_SUMO_SIM_par_1	210	216	PF11976	0.235
LIG_SUMO_SIM_par_1	286	291	PF11976	0.339
LIG_TYR_ITIM	204	209	PF00017	0.288
LIG_WRC_WIRS_1	186	191	PF05994	0.482
LIG_WRC_WIRS_1	214	219	PF05994	0.291
LIG_WRC_WIRS_1	239	244	PF05994	0.375
MOD_CK1_1	237	243	PF00069	0.292
MOD_CK1_1	321	327	PF00069	0.547
MOD_CK1_1	33	39	PF00069	0.651
MOD_GlcNHglycan	157	160	PF01048	0.505
MOD_GlcNHglycan	182	185	PF01048	0.304
MOD_GlcNHglycan	273	276	PF01048	0.278
MOD_GlcNHglycan	289	293	PF01048	0.434
MOD_GlcNHglycan	30	33	PF01048	0.569
MOD_GlcNHglycan	35	38	PF01048	0.532
MOD_GSK3_1	155	162	PF00069	0.283
MOD_GSK3_1	234	241	PF00069	0.352
MOD_GSK3_1	276	283	PF00069	0.314
MOD_N-GLC_1	107	112	PF02516	0.238
MOD_N-GLC_1	148	153	PF02516	0.509
MOD_N-GLC_1	64	69	PF02516	0.372
MOD_NEK2_1	172	177	PF00069	0.281
MOD_NEK2_1	180	185	PF00069	0.227
MOD_NEK2_1	238	243	PF00069	0.288
MOD_NEK2_1	271	276	PF00069	0.283
MOD_NEK2_1	288	293	PF00069	0.276
MOD_NEK2_1	327	332	PF00069	0.450
MOD_NEK2_1	44	49	PF00069	0.557
MOD_PIKK_1	129	135	PF00454	0.348
MOD_PIKK_1	280	286	PF00454	0.423
MOD_PKA_2	356	362	PF00069	0.342
MOD_Plk_1	107	113	PF00069	0.454
MOD_Plk_1	64	70	PF00069	0.601
MOD_Plk_4	185	191	PF00069	0.281
MOD_Plk_4	213	219	PF00069	0.283
MOD_Plk_4	234	240	PF00069	0.265
MOD_Plk_4	297	303	PF00069	0.334
MOD_Plk_4	356	362	PF00069	0.305
MOD_Plk_4	99	105	PF00069	0.545
MOD_ProDKin_1	21	27	PF00069	0.673
MOD_ProDKin_1	318	324	PF00069	0.391
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.733
TRG_ENDOCYTIC_2	198	201	PF00928	0.442
TRG_ENDOCYTIC_2	206	209	PF00928	0.210
TRG_ENDOCYTIC_2	235	238	PF00928	0.297
TRG_ENDOCYTIC_2	268	271	PF00928	0.278
TRG_ENDOCYTIC_2	348	351	PF00928	0.295
TRG_ER_diArg_1	161	164	PF00400	0.141

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I280	Leptomonas seymouri	64%	100%
A0A0N1I909	Leptomonas seymouri	37%	100%
A0A0N1PEB9	Leptomonas seymouri	37%	67%
A0A0S4J7T5	Bodo saltans	37%	98%
A0A0S4J8V2	Bodo saltans	42%	100%
A0A0S4JQM0	Bodo saltans	42%	100%
A0A0S4JWI8	Bodo saltans	37%	100%
A0A0S4KIQ2	Bodo saltans	36%	100%
A0A1X0P1D6	Trypanosomatidae	34%	100%
A0A1X0P1Q2	Trypanosomatidae	47%	100%
A0A3R7L1Y6	Trypanosoma rangeli	49%	100%
A0A3S5ISE8	Trypanosoma rangeli	21%	100%
A0A3S7XBT4	Leishmania donovani	79%	100%
A0A3S7XBU6	Leishmania donovani	35%	71%
A0A3S7XC05	Leishmania donovani	37%	100%
A4HQ64	Leishmania braziliensis	36%	71%
A4HQ68	Leishmania braziliensis	36%	100%
A4IDW4	Leishmania infantum	79%	100%
A4IDW5	Leishmania infantum	35%	71%
A4IDW6	Leishmania infantum	37%	100%
B7F9G7	Oryza sativa subsp. japonica	29%	97%
D0A450	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
D0A451	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ATY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9ATY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	73%
E9ATY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q03419	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q07959	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	67%
Q09749	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q09910	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	82%
Q12442	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q4Q0K9	Leishmania major	38%	100%
Q4Q0L0	Leishmania major	35%	72%
Q4Q0L1	Leishmania major	77%	100%
Q6DC77	Danio rerio	26%	100%
Q6TCG5	Mus musculus	28%	100%
Q6TCG8	Mus musculus	31%	100%
Q6TCH4	Homo sapiens	27%	100%
Q6TCH7	Homo sapiens	31%	100%
Q6ZVX9	Homo sapiens	26%	96%
Q753H5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	100%
Q75F81	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	87%
Q801D8	Cynoscion nebulosus	24%	100%
Q84N34	Arabidopsis thaliana	30%	100%
Q86V24	Homo sapiens	32%	94%
Q8BQS5	Mus musculus	32%	94%
Q91VH1	Mus musculus	32%	97%
Q93ZH9	Arabidopsis thaliana	29%	100%
Q94177	Caenorhabditis elegans	30%	84%
Q96A54	Homo sapiens	32%	97%
Q9JJE4	Mus musculus	26%	100%
Q9SVF3	Arabidopsis thaliana	30%	97%
Q9SZG0	Arabidopsis thaliana	30%	94%
Q9VCY8	Drosophila melanogaster	32%	82%
Q9ZUH8	Arabidopsis thaliana	30%	100%
V5BJ57	Trypanosoma cruzi	33%	100%
V5DK49	Trypanosoma cruzi	51%	100%