PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ65_LEIBR

TriTrypDb:

LbrM.35.5760 , LBRM2903_350068900

Length:

650

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQ65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.563
CLV_NRD_NRD_1	285	287	PF00675	0.572
CLV_NRD_NRD_1	292	294	PF00675	0.514
CLV_PCSK_KEX2_1	285	287	PF00082	0.572
CLV_PCSK_KEX2_1	292	294	PF00082	0.514
CLV_PCSK_KEX2_1	300	302	PF00082	0.447
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.527
CLV_PCSK_SKI1_1	390	394	PF00082	0.566
CLV_PCSK_SKI1_1	607	611	PF00082	0.552
DEG_Nend_UBRbox_2	1	3	PF02207	0.724
DEG_SCF_FBW7_2	70	77	PF00400	0.573
DOC_CKS1_1	40	45	PF01111	0.588
DOC_CKS1_1	559	564	PF01111	0.664
DOC_CKS1_1	71	76	PF01111	0.574
DOC_MAPK_FxFP_2	21	24	PF00069	0.534
DOC_MAPK_FxFP_2	55	58	PF00069	0.570
DOC_MAPK_gen_1	297	304	PF00069	0.525
DOC_MAPK_MEF2A_6	165	172	PF00069	0.588
DOC_PP1_RVXF_1	298	305	PF00149	0.370
DOC_PP2B_LxvP_1	568	571	PF13499	0.624
DOC_PP2B_LxvP_1	611	614	PF13499	0.686
DOC_PP2B_LxvP_1	640	643	PF13499	0.512
DOC_PP4_FxxP_1	21	24	PF00568	0.685
DOC_PP4_FxxP_1	236	239	PF00568	0.643
DOC_PP4_FxxP_1	55	58	PF00568	0.570
DOC_USP7_MATH_1	119	123	PF00917	0.688
DOC_USP7_MATH_1	210	214	PF00917	0.485
DOC_USP7_MATH_1	247	251	PF00917	0.659
DOC_USP7_MATH_1	32	36	PF00917	0.650
DOC_USP7_MATH_1	367	371	PF00917	0.515
DOC_USP7_MATH_1	425	429	PF00917	0.580
DOC_USP7_MATH_1	433	437	PF00917	0.566
DOC_USP7_MATH_1	519	523	PF00917	0.621
DOC_USP7_MATH_1	58	62	PF00917	0.573
DOC_USP7_MATH_1	612	616	PF00917	0.528
DOC_WW_Pin1_4	159	164	PF00397	0.526
DOC_WW_Pin1_4	234	239	PF00397	0.643
DOC_WW_Pin1_4	28	33	PF00397	0.585
DOC_WW_Pin1_4	350	355	PF00397	0.382
DOC_WW_Pin1_4	39	44	PF00397	0.578
DOC_WW_Pin1_4	486	491	PF00397	0.611
DOC_WW_Pin1_4	558	563	PF00397	0.663
DOC_WW_Pin1_4	570	575	PF00397	0.559
DOC_WW_Pin1_4	70	75	PF00397	0.668
DOC_WW_Pin1_4	78	83	PF00397	0.601
LIG_14-3-3_CanoR_1	126	133	PF00244	0.612
LIG_14-3-3_CanoR_1	186	190	PF00244	0.490
LIG_14-3-3_CanoR_1	318	326	PF00244	0.520
LIG_14-3-3_CanoR_1	607	612	PF00244	0.549
LIG_Actin_WH2_2	174	192	PF00022	0.462
LIG_BRCT_BRCA1_1	17	21	PF00533	0.595
LIG_BRCT_BRCA1_1	61	65	PF00533	0.573
LIG_BRCT_BRCA1_2	61	67	PF00533	0.574
LIG_Clathr_ClatBox_1	169	173	PF01394	0.457
LIG_CSL_BTD_1	351	354	PF09270	0.388
LIG_CtBP_PxDLS_1	534	538	PF00389	0.535
LIG_FHA_1	133	139	PF00498	0.644
LIG_FHA_1	17	23	PF00498	0.571
LIG_FHA_1	186	192	PF00498	0.515
LIG_FHA_1	335	341	PF00498	0.456
LIG_FHA_1	35	41	PF00498	0.731
LIG_FHA_1	387	393	PF00498	0.569
LIG_FHA_1	530	536	PF00498	0.557
LIG_FHA_2	145	151	PF00498	0.619
LIG_FHA_2	153	159	PF00498	0.567
LIG_FHA_2	198	204	PF00498	0.540
LIG_FHA_2	293	299	PF00498	0.513
LIG_FHA_2	361	367	PF00498	0.524
LIG_FHA_2	391	397	PF00498	0.407
LIG_FHA_2	4	10	PF00498	0.564
LIG_FHA_2	40	46	PF00498	0.587
LIG_FHA_2	619	625	PF00498	0.658
LIG_LIR_Apic_2	18	24	PF02991	0.675
LIG_LIR_Apic_2	233	239	PF02991	0.580
LIG_LIR_Apic_2	466	472	PF02991	0.551
LIG_LIR_Gen_1	399	406	PF02991	0.528
LIG_LIR_Gen_1	62	72	PF02991	0.568
LIG_LIR_Gen_1	621	628	PF02991	0.682
LIG_LIR_Nem_3	20	26	PF02991	0.534
LIG_LIR_Nem_3	372	378	PF02991	0.520
LIG_LIR_Nem_3	399	405	PF02991	0.525
LIG_LIR_Nem_3	575	581	PF02991	0.688
LIG_LIR_Nem_3	621	625	PF02991	0.682
LIG_LIR_Nem_3	630	636	PF02991	0.573
LIG_LIR_Nem_3	637	641	PF02991	0.508
LIG_LYPXL_yS_3	542	545	PF13949	0.671
LIG_LYPXL_yS_3	638	641	PF13949	0.672
LIG_Pex14_2	172	176	PF04695	0.471
LIG_Pex14_2	23	27	PF04695	0.531
LIG_RPA_C_Fungi	301	313	PF08784	0.502
LIG_SH2_CRK	402	406	PF00017	0.527
LIG_SH2_CRK	633	637	PF00017	0.670
LIG_SH2_NCK_1	402	406	PF00017	0.527
LIG_SH2_NCK_1	497	501	PF00017	0.686
LIG_SH2_NCK_1	76	80	PF00017	0.578
LIG_SH2_SRC	633	636	PF00017	0.520
LIG_SH2_STAP1	402	406	PF00017	0.527
LIG_SH2_STAP1	463	467	PF00017	0.550
LIG_SH2_STAT3	481	484	PF00017	0.571
LIG_SH2_STAT3	504	507	PF00017	0.695
LIG_SH2_STAT3	57	60	PF00017	0.729
LIG_SH2_STAT5	270	273	PF00017	0.608
LIG_SH2_STAT5	303	306	PF00017	0.660
LIG_SH2_STAT5	342	345	PF00017	0.600
LIG_SH2_STAT5	402	405	PF00017	0.372
LIG_SH2_STAT5	463	466	PF00017	0.697
LIG_SH2_STAT5	481	484	PF00017	0.541
LIG_SH2_STAT5	497	500	PF00017	0.619
LIG_SH2_STAT5	504	507	PF00017	0.625
LIG_SH2_STAT5	580	583	PF00017	0.700
LIG_SH3_2	562	567	PF14604	0.617
LIG_SH3_3	100	106	PF00018	0.707
LIG_SH3_3	500	506	PF00018	0.678
LIG_SH3_3	537	543	PF00018	0.681
LIG_SH3_3	556	562	PF00018	0.497
LIG_SH3_3	568	574	PF00018	0.574
LIG_SH3_3	614	620	PF00018	0.655
LIG_SH3_3	633	639	PF00018	0.501
LIG_SUMO_SIM_par_1	167	173	PF11976	0.460
LIG_SUMO_SIM_par_1	35	42	PF11976	0.602
LIG_SUMO_SIM_par_1	637	644	PF11976	0.517
LIG_TRAF2_1	393	396	PF00917	0.409
LIG_TRFH_1	497	501	PF08558	0.686
LIG_TYR_ITIM	400	405	PF00017	0.521
LIG_TYR_ITIM	540	545	PF00017	0.674
LIG_TYR_ITIM	636	641	PF00017	0.669
LIG_TYR_ITSM	574	581	PF00017	0.559
MOD_CDC14_SPxK_1	162	165	PF00782	0.457
MOD_CDC14_SPxK_1	81	84	PF00782	0.713
MOD_CDK_SPxK_1	159	165	PF00069	0.495
MOD_CDK_SPxK_1	78	84	PF00069	0.719
MOD_CK1_1	149	155	PF00069	0.560
MOD_CK1_1	250	256	PF00069	0.579
MOD_CK1_1	3	9	PF00069	0.675
MOD_CK1_1	39	45	PF00069	0.599
MOD_CK1_1	486	492	PF00069	0.636
MOD_CK1_1	521	527	PF00069	0.547
MOD_CK1_1	573	579	PF00069	0.553
MOD_CK1_1	590	596	PF00069	0.576
MOD_CK1_1	96	102	PF00069	0.701
MOD_CK2_1	144	150	PF00069	0.618
MOD_CK2_1	152	158	PF00069	0.572
MOD_CK2_1	197	203	PF00069	0.538
MOD_CK2_1	3	9	PF00069	0.566
MOD_CK2_1	39	45	PF00069	0.608
MOD_CK2_1	390	396	PF00069	0.420
MOD_CK2_1	455	461	PF00069	0.536
MOD_CK2_1	618	624	PF00069	0.657
MOD_GlcNHglycan	121	124	PF01048	0.587
MOD_GlcNHglycan	182	185	PF01048	0.615
MOD_GlcNHglycan	211	215	PF01048	0.338
MOD_GlcNHglycan	249	252	PF01048	0.589
MOD_GlcNHglycan	328	331	PF01048	0.471
MOD_GlcNHglycan	34	37	PF01048	0.648
MOD_GlcNHglycan	343	346	PF01048	0.347
MOD_GlcNHglycan	427	430	PF01048	0.618
MOD_GlcNHglycan	435	438	PF01048	0.573
MOD_GlcNHglycan	465	468	PF01048	0.658
MOD_GlcNHglycan	549	552	PF01048	0.525
MOD_GlcNHglycan	583	586	PF01048	0.594
MOD_GlcNHglycan	589	592	PF01048	0.632
MOD_GlcNHglycan	61	64	PF01048	0.572
MOD_GlcNHglycan	643	646	PF01048	0.507
MOD_GlcNHglycan	98	101	PF01048	0.676
MOD_GSK3_1	105	112	PF00069	0.618
MOD_GSK3_1	246	253	PF00069	0.792
MOD_GSK3_1	264	271	PF00069	0.430
MOD_GSK3_1	28	35	PF00069	0.668
MOD_GSK3_1	3	10	PF00069	0.690
MOD_GSK3_1	341	348	PF00069	0.347
MOD_GSK3_1	386	393	PF00069	0.567
MOD_GSK3_1	433	440	PF00069	0.587
MOD_GSK3_1	480	487	PF00069	0.566
MOD_GSK3_1	521	528	PF00069	0.612
MOD_GSK3_1	529	536	PF00069	0.525
MOD_GSK3_1	570	577	PF00069	0.612
MOD_GSK3_1	590	597	PF00069	0.575
MOD_GSK3_1	643	650	PF00069	0.593
MOD_LATS_1	409	415	PF00433	0.601
MOD_N-GLC_1	144	149	PF02516	0.624
MOD_N-GLC_1	159	164	PF02516	0.475
MOD_N-GLC_1	32	37	PF02516	0.712
MOD_N-GLC_1	334	339	PF02516	0.342
MOD_NEK2_1	1	6	PF00069	0.719
MOD_NEK2_1	185	190	PF00069	0.583
MOD_NEK2_1	263	268	PF00069	0.665
MOD_NEK2_1	360	365	PF00069	0.510
MOD_NEK2_1	386	391	PF00069	0.579
MOD_NEK2_1	495	500	PF00069	0.621
MOD_PIKK_1	345	351	PF00454	0.535
MOD_PIKK_1	437	443	PF00454	0.730
MOD_PIKK_1	480	486	PF00454	0.621
MOD_PIKK_1	525	531	PF00454	0.624
MOD_PIKK_1	590	596	PF00454	0.604
MOD_PK_1	114	120	PF00069	0.543
MOD_PKA_1	292	298	PF00069	0.513
MOD_PKA_2	185	191	PF00069	0.492
MOD_PKA_2	292	298	PF00069	0.513
MOD_Plk_1	1	7	PF00069	0.719
MOD_Plk_1	149	155	PF00069	0.560
MOD_Plk_1	210	216	PF00069	0.483
MOD_Plk_1	334	340	PF00069	0.336
MOD_Plk_1	574	580	PF00069	0.532
MOD_Plk_4	17	23	PF00069	0.533
MOD_Plk_4	204	210	PF00069	0.471
MOD_Plk_4	321	327	PF00069	0.422
MOD_Plk_4	360	366	PF00069	0.542
MOD_Plk_4	533	539	PF00069	0.686
MOD_Plk_4	574	580	PF00069	0.558
MOD_Plk_4	601	607	PF00069	0.693
MOD_Plk_4	618	624	PF00069	0.533
MOD_ProDKin_1	159	165	PF00069	0.510
MOD_ProDKin_1	234	240	PF00069	0.645
MOD_ProDKin_1	28	34	PF00069	0.588
MOD_ProDKin_1	350	356	PF00069	0.382
MOD_ProDKin_1	39	45	PF00069	0.578
MOD_ProDKin_1	486	492	PF00069	0.609
MOD_ProDKin_1	558	564	PF00069	0.665
MOD_ProDKin_1	570	576	PF00069	0.557
MOD_ProDKin_1	70	76	PF00069	0.670
MOD_ProDKin_1	78	84	PF00069	0.601
TRG_DiLeu_BaEn_3	395	401	PF01217	0.385
TRG_ENDOCYTIC_2	402	405	PF00928	0.522
TRG_ENDOCYTIC_2	542	545	PF00928	0.671
TRG_ENDOCYTIC_2	578	581	PF00928	0.698
TRG_ENDOCYTIC_2	633	636	PF00928	0.671
TRG_ENDOCYTIC_2	638	641	PF00928	0.622
TRG_ER_diArg_1	284	286	PF00400	0.569
TRG_ER_diArg_1	291	293	PF00400	0.519
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	318	323	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJZ7	Leishmania donovani	68%	97%
A4IDW2	Leishmania infantum	68%	98%
E9ATY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	98%
Q4Q0L3	Leishmania major	69%	100%