Adiponectin receptor protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adiponectin receptor protein 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ64_LEIBR

TriTrypDb:

LbrM.35.5750 , LBRM2903_350069200

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14

Expansion

Sequence features

A4HQ64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ64

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0038023	signaling receptor activity	2	2
GO:0060089	molecular transducer activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.725
CLV_NRD_NRD_1	203	205	PF00675	0.529
CLV_NRD_NRD_1	217	219	PF00675	0.470
CLV_PCSK_KEX2_1	202	204	PF00082	0.598
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.595
CLV_PCSK_PC7_1	199	205	PF00082	0.401
CLV_PCSK_SKI1_1	266	270	PF00082	0.316
CLV_PCSK_SKI1_1	28	32	PF00082	0.445
CLV_PCSK_SKI1_1	302	306	PF00082	0.492
CLV_PCSK_SKI1_1	343	347	PF00082	0.330
DEG_ODPH_VHL_1	421	433	PF01847	0.336
DEG_SIAH_1	48	56	PF03145	0.596
DEG_SPOP_SBC_1	132	136	PF00917	0.692
DOC_CKS1_1	436	441	PF01111	0.198
DOC_MAPK_gen_1	199	207	PF00069	0.610
DOC_MAPK_gen_1	21	31	PF00069	0.654
DOC_MAPK_gen_1	227	235	PF00069	0.507
DOC_MAPK_MEF2A_6	350	358	PF00069	0.467
DOC_MAPK_MEF2A_6	409	418	PF00069	0.405
DOC_PP4_FxxP_1	364	367	PF00568	0.343
DOC_USP7_MATH_1	132	136	PF00917	0.752
DOC_USP7_MATH_1	169	173	PF00917	0.757
DOC_USP7_MATH_1	41	45	PF00917	0.690
DOC_USP7_MATH_1	424	428	PF00917	0.440
DOC_USP7_MATH_1	47	51	PF00917	0.647
DOC_WW_Pin1_4	171	176	PF00397	0.737
DOC_WW_Pin1_4	177	182	PF00397	0.745
DOC_WW_Pin1_4	190	195	PF00397	0.723
DOC_WW_Pin1_4	435	440	PF00397	0.198
LIG_14-3-3_CanoR_1	203	208	PF00244	0.687
LIG_14-3-3_CanoR_1	256	265	PF00244	0.529
LIG_14-3-3_CanoR_1	343	351	PF00244	0.530
LIG_14-3-3_CanoR_1	409	413	PF00244	0.471
LIG_AP2alpha_2	137	139	PF02296	0.593
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_deltaCOP1_diTrp_1	404	413	PF00928	0.398
LIG_deltaCOP1_diTrp_1	472	481	PF00928	0.538
LIG_eIF4E_1	382	388	PF01652	0.403
LIG_FHA_1	148	154	PF00498	0.751
LIG_FHA_1	161	167	PF00498	0.784
LIG_FHA_1	230	236	PF00498	0.634
LIG_FHA_1	273	279	PF00498	0.481
LIG_FHA_1	290	296	PF00498	0.346
LIG_FHA_1	355	361	PF00498	0.346
LIG_FHA_1	378	384	PF00498	0.333
LIG_FHA_1	389	395	PF00498	0.298
LIG_FHA_1	88	94	PF00498	0.655
LIG_FHA_2	132	138	PF00498	0.600
LIG_FHA_2	7	13	PF00498	0.787
LIG_FHA_2	98	104	PF00498	0.669
LIG_GBD_Chelix_1	81	89	PF00786	0.379
LIG_HCF-1_HBM_1	195	198	PF13415	0.617
LIG_LIR_Apic_2	362	367	PF02991	0.348
LIG_LIR_Gen_1	136	147	PF02991	0.678
LIG_LIR_Gen_1	284	293	PF02991	0.376
LIG_LIR_Gen_1	400	410	PF02991	0.484
LIG_LIR_Nem_3	136	142	PF02991	0.764
LIG_LIR_Nem_3	253	258	PF02991	0.569
LIG_LIR_Nem_3	284	288	PF02991	0.376
LIG_LIR_Nem_3	330	336	PF02991	0.422
LIG_LIR_Nem_3	341	345	PF02991	0.498
LIG_LIR_Nem_3	352	356	PF02991	0.344
LIG_LIR_Nem_3	404	410	PF02991	0.514
LIG_LIR_Nem_3	411	416	PF02991	0.323
LIG_NRBOX	441	447	PF00104	0.206
LIG_PCNA_PIPBox_1	487	496	PF02747	0.206
LIG_PCNA_yPIPBox_3	329	343	PF02747	0.403
LIG_Pex14_1	398	402	PF04695	0.538
LIG_Pex14_2	265	269	PF04695	0.460
LIG_SH2_CRK	296	300	PF00017	0.403
LIG_SH2_CRK	342	346	PF00017	0.398
LIG_SH2_GRB2like	493	496	PF00017	0.252
LIG_SH2_PTP2	353	356	PF00017	0.206
LIG_SH2_STAP1	259	263	PF00017	0.510
LIG_SH2_STAP1	279	283	PF00017	0.176
LIG_SH2_STAP1	296	300	PF00017	0.469
LIG_SH2_STAP1	403	407	PF00017	0.398
LIG_SH2_STAT3	259	262	PF00017	0.494
LIG_SH2_STAT5	250	253	PF00017	0.567
LIG_SH2_STAT5	259	262	PF00017	0.523
LIG_SH2_STAT5	296	299	PF00017	0.380
LIG_SH2_STAT5	353	356	PF00017	0.250
LIG_SH2_STAT5	369	372	PF00017	0.385
LIG_SH2_STAT5	382	385	PF00017	0.343
LIG_SH2_STAT5	451	454	PF00017	0.380
LIG_SH2_STAT5	458	461	PF00017	0.319
LIG_SH2_STAT5	493	496	PF00017	0.362
LIG_SH3_3	433	439	PF00018	0.263
LIG_SH3_3	89	95	PF00018	0.712
LIG_SUMO_SIM_anti_2	357	363	PF11976	0.354
LIG_SUMO_SIM_anti_2	384	391	PF11976	0.403
LIG_SUMO_SIM_anti_2	427	432	PF11976	0.484
LIG_SUMO_SIM_par_1	356	363	PF11976	0.356
LIG_SUMO_SIM_par_1	384	391	PF11976	0.403
LIG_SxIP_EBH_1	45	54	PF03271	0.603
LIG_TYR_ITIM	294	299	PF00017	0.403
LIG_TYR_ITIM	351	356	PF00017	0.363
LIG_Vh1_VBS_1	377	395	PF01044	0.276
LIG_WRC_WIRS_1	282	287	PF05994	0.403
LIG_WRC_WIRS_1	361	366	PF05994	0.346
LIG_WW_1	366	369	PF00397	0.343
MOD_CDK_SPxxK_3	171	178	PF00069	0.614
MOD_CK1_1	116	122	PF00069	0.688
MOD_CK1_1	177	183	PF00069	0.668
MOD_CK1_1	33	39	PF00069	0.737
MOD_CK2_1	85	91	PF00069	0.696
MOD_CK2_1	97	103	PF00069	0.749
MOD_GlcNHglycan	115	118	PF01048	0.524
MOD_GlcNHglycan	167	170	PF01048	0.499
MOD_GlcNHglycan	309	312	PF01048	0.568
MOD_GlcNHglycan	418	421	PF01048	0.346
MOD_GlcNHglycan	452	455	PF01048	0.389
MOD_GlcNHglycan	49	52	PF01048	0.463
MOD_GlcNHglycan	75	78	PF01048	0.493
MOD_GSK3_1	113	120	PF00069	0.689
MOD_GSK3_1	153	160	PF00069	0.690
MOD_GSK3_1	161	168	PF00069	0.763
MOD_GSK3_1	20	27	PF00069	0.657
MOD_GSK3_1	203	210	PF00069	0.610
MOD_GSK3_1	246	253	PF00069	0.547
MOD_GSK3_1	277	284	PF00069	0.395
MOD_GSK3_1	294	301	PF00069	0.309
MOD_GSK3_1	305	312	PF00069	0.288
MOD_GSK3_1	377	384	PF00069	0.414
MOD_GSK3_1	43	50	PF00069	0.609
MOD_LATS_1	71	77	PF00433	0.619
MOD_N-GLC_1	272	277	PF02516	0.298
MOD_N-GLC_1	328	333	PF02516	0.354
MOD_N-GLC_1	36	41	PF02516	0.461
MOD_N-GLC_1	71	76	PF02516	0.433
MOD_N-GLC_2	113	115	PF02516	0.396
MOD_NEK2_1	106	111	PF00069	0.615
MOD_NEK2_1	207	212	PF00069	0.582
MOD_NEK2_1	289	294	PF00069	0.360
MOD_NEK2_1	295	300	PF00069	0.335
MOD_NEK2_1	309	314	PF00069	0.176
MOD_NEK2_1	327	332	PF00069	0.345
MOD_NEK2_1	359	364	PF00069	0.333
MOD_NEK2_1	416	421	PF00069	0.371
MOD_NEK2_1	450	455	PF00069	0.418
MOD_NEK2_1	457	462	PF00069	0.371
MOD_NEK2_1	483	488	PF00069	0.378
MOD_NEK2_1	85	90	PF00069	0.602
MOD_NEK2_2	264	269	PF00069	0.443
MOD_OFUCOSY	57	62	PF10250	0.417
MOD_PIKK_1	118	124	PF00454	0.669
MOD_PIKK_1	157	163	PF00454	0.647
MOD_PIKK_1	30	36	PF00454	0.698
MOD_PKA_1	203	209	PF00069	0.686
MOD_PKA_2	203	209	PF00069	0.686
MOD_PKA_2	408	414	PF00069	0.476
MOD_PKB_1	227	235	PF00069	0.507
MOD_Plk_1	229	235	PF00069	0.648
MOD_Plk_1	24	30	PF00069	0.671
MOD_Plk_1	272	278	PF00069	0.515
MOD_Plk_1	328	334	PF00069	0.354
MOD_Plk_1	36	42	PF00069	0.736
MOD_Plk_1	6	12	PF00069	0.655
MOD_Plk_4	203	209	PF00069	0.593
MOD_Plk_4	246	252	PF00069	0.560
MOD_Plk_4	264	270	PF00069	0.647
MOD_Plk_4	281	287	PF00069	0.262
MOD_Plk_4	295	301	PF00069	0.300
MOD_Plk_4	320	326	PF00069	0.381
MOD_Plk_4	328	334	PF00069	0.403
MOD_Plk_4	360	366	PF00069	0.346
MOD_Plk_4	408	414	PF00069	0.476
MOD_Plk_4	426	432	PF00069	0.352
MOD_Plk_4	495	501	PF00069	0.365
MOD_ProDKin_1	171	177	PF00069	0.737
MOD_ProDKin_1	190	196	PF00069	0.722
MOD_ProDKin_1	435	441	PF00069	0.198
MOD_SUMO_rev_2	185	194	PF00179	0.658
MOD_SUMO_rev_2	38	47	PF00179	0.613
TRG_DiLeu_BaEn_2	102	108	PF01217	0.700
TRG_ENDOCYTIC_2	255	258	PF00928	0.511
TRG_ENDOCYTIC_2	279	282	PF00928	0.331
TRG_ENDOCYTIC_2	296	299	PF00928	0.336
TRG_ENDOCYTIC_2	316	319	PF00928	0.391
TRG_ENDOCYTIC_2	333	336	PF00928	0.496
TRG_ENDOCYTIC_2	342	345	PF00928	0.538
TRG_ENDOCYTIC_2	353	356	PF00928	0.298
TRG_ENDOCYTIC_2	369	372	PF00928	0.368
TRG_ENDOCYTIC_2	403	406	PF00928	0.479
TRG_ER_diArg_1	203	205	PF00400	0.743
TRG_NLS_MonoExtN_4	199	206	PF00514	0.643
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I280	Leptomonas seymouri	35%	100%
A0A0N1PEB9	Leptomonas seymouri	50%	95%
A0A1X0P1Q2	Trypanosomatidae	37%	100%
A0A3S7XBT4	Leishmania donovani	36%	100%
A0A3S7XBU6	Leishmania donovani	67%	100%
A4HQ67	Leishmania braziliensis	36%	100%
A4IDW4	Leishmania infantum	36%	100%
A4IDW5	Leishmania infantum	68%	100%
E9ATY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9ATY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4Q0L0	Leishmania major	68%	98%
Q4Q0L1	Leishmania major	37%	100%