Progestin and adipoQ receptor family member 4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HQ63_LEIBR

TriTrypDb:

LbrM.35.5740 , LBRM2903_350069100

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

A4HQ63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.441
CLV_NRD_NRD_1	50	52	PF00675	0.417
CLV_PCSK_KEX2_1	12	14	PF00082	0.461
CLV_PCSK_KEX2_1	18	20	PF00082	0.481
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.363
CLV_PCSK_SKI1_1	12	16	PF00082	0.337
CLV_PCSK_SKI1_1	150	154	PF00082	0.323
CLV_PCSK_SKI1_1	19	23	PF00082	0.321
DEG_APCC_DBOX_1	160	168	PF00400	0.123
DOC_AGCK_PIF_1	169	174	PF00069	0.187
DOC_CYCLIN_RxL_1	9	17	PF00134	0.534
DOC_MAPK_DCC_7	161	169	PF00069	0.123
DOC_MAPK_gen_1	147	157	PF00069	0.123
DOC_MAPK_gen_1	161	169	PF00069	0.222
DOC_MAPK_MEF2A_6	161	169	PF00069	0.123
DOC_USP7_MATH_2	41	47	PF00917	0.460
DOC_WW_Pin1_4	21	26	PF00397	0.742
LIG_14-3-3_CanoR_1	30	35	PF00244	0.576
LIG_APCC_ABBA_1	104	109	PF00400	0.400
LIG_BRCT_BRCA1_1	182	186	PF00533	0.138
LIG_BRCT_BRCA1_1	193	197	PF00533	0.329
LIG_EH1_1	206	214	PF00400	0.307
LIG_eIF4E_1	206	212	PF01652	0.281
LIG_FHA_1	108	114	PF00498	0.418
LIG_FHA_1	130	136	PF00498	0.296
LIG_FHA_1	208	214	PF00498	0.295
LIG_FHA_1	65	71	PF00498	0.396
LIG_FHA_1	99	105	PF00498	0.514
LIG_LIR_Gen_1	173	181	PF02991	0.277
LIG_LIR_Gen_1	183	193	PF02991	0.257
LIG_LIR_Gen_1	195	206	PF02991	0.407
LIG_LIR_LC3C_4	210	214	PF02991	0.152
LIG_LIR_Nem_3	173	177	PF02991	0.232
LIG_LIR_Nem_3	183	189	PF02991	0.290
LIG_LIR_Nem_3	205	209	PF02991	0.249
LIG_LIR_Nem_3	216	220	PF02991	0.267
LIG_Pex14_1	231	235	PF04695	0.148
LIG_SH2_STAP1	207	211	PF00017	0.129
LIG_SH2_STAT5	139	142	PF00017	0.217
LIG_SH2_STAT5	79	82	PF00017	0.438
LIG_SH2_STAT5	85	88	PF00017	0.445
LIG_SH2_STAT5	94	97	PF00017	0.462
LIG_SH3_3	35	41	PF00018	0.559
LIG_SUMO_SIM_anti_2	210	216	PF11976	0.319
LIG_SUMO_SIM_par_1	210	216	PF11976	0.206
LIG_TYR_ITIM	204	209	PF00017	0.247
LIG_WRC_WIRS_1	186	191	PF05994	0.373
LIG_WRC_WIRS_1	214	219	PF05994	0.247
MOD_CK1_1	33	39	PF00069	0.529
MOD_GlcNHglycan	157	160	PF01048	0.403
MOD_GlcNHglycan	182	185	PF01048	0.270
MOD_GlcNHglycan	30	33	PF01048	0.492
MOD_GlcNHglycan	35	38	PF01048	0.426
MOD_GSK3_1	155	162	PF00069	0.123
MOD_N-GLC_1	107	112	PF02516	0.207
MOD_N-GLC_1	148	153	PF02516	0.323
MOD_NEK2_1	172	177	PF00069	0.320
MOD_NEK2_1	180	185	PF00069	0.184
MOD_NEK2_1	44	49	PF00069	0.551
MOD_PIKK_1	129	135	PF00454	0.241
MOD_Plk_1	107	113	PF00069	0.415
MOD_Plk_1	64	70	PF00069	0.577
MOD_Plk_4	185	191	PF00069	0.190
MOD_Plk_4	213	219	PF00069	0.250
MOD_Plk_4	99	105	PF00069	0.512
MOD_ProDKin_1	21	27	PF00069	0.742
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.534
TRG_ENDOCYTIC_2	198	201	PF00928	0.384
TRG_ENDOCYTIC_2	206	209	PF00928	0.129
TRG_ER_diArg_1	161	164	PF00400	0.123

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I909	Leptomonas seymouri	36%	70%
A0A0S4J8V2	Bodo saltans	40%	79%
A0A0S4JWI8	Bodo saltans	40%	89%
A0A0S4KIQ2	Bodo saltans	35%	70%
A0A1X0P1D6	Trypanosomatidae	33%	73%
A0A1X0P1Q2	Trypanosomatidae	42%	68%
A0A3R7L1Y6	Trypanosoma rangeli	48%	70%
A0A3S5ISE8	Trypanosoma rangeli	25%	70%
A0A3S7XC05	Leishmania donovani	37%	70%
A4HQ68	Leishmania braziliensis	36%	70%
A4IDW6	Leishmania infantum	37%	70%
D0A450	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	77%
D0A451	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	68%
E9ATY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	70%
Q4Q0K9	Leishmania major	35%	70%
Q6TCG8	Mus musculus	35%	76%
Q6TCH7	Homo sapiens	35%	76%
Q753H5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	31%	74%
Q93ZH9	Arabidopsis thaliana	29%	71%
Q9ZUH8	Arabidopsis thaliana	32%	69%
V5BJ57	Trypanosoma cruzi	31%	76%
V5BXS6	Trypanosoma cruzi	21%	69%
V5DK49	Trypanosoma cruzi	45%	69%