Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ62_LEIBR

TriTrypDb:

LbrM.35.5730 , LBRM2903_350068800

Length:

817

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ62

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.777
CLV_NRD_NRD_1	125	127	PF00675	0.545
CLV_NRD_NRD_1	200	202	PF00675	0.601
CLV_NRD_NRD_1	286	288	PF00675	0.748
CLV_NRD_NRD_1	289	291	PF00675	0.728
CLV_NRD_NRD_1	30	32	PF00675	0.467
CLV_NRD_NRD_1	35	37	PF00675	0.499
CLV_NRD_NRD_1	403	405	PF00675	0.477
CLV_NRD_NRD_1	492	494	PF00675	0.589
CLV_NRD_NRD_1	623	625	PF00675	0.554
CLV_NRD_NRD_1	65	67	PF00675	0.623
CLV_NRD_NRD_1	682	684	PF00675	0.681
CLV_NRD_NRD_1	85	87	PF00675	0.435
CLV_NRD_NRD_1	96	98	PF00675	0.366
CLV_PCSK_FUR_1	287	291	PF00082	0.760
CLV_PCSK_FUR_1	621	625	PF00082	0.531
CLV_PCSK_KEX2_1	200	202	PF00082	0.616
CLV_PCSK_KEX2_1	286	288	PF00082	0.768
CLV_PCSK_KEX2_1	289	291	PF00082	0.714
CLV_PCSK_KEX2_1	30	32	PF00082	0.467
CLV_PCSK_KEX2_1	35	37	PF00082	0.499
CLV_PCSK_KEX2_1	403	405	PF00082	0.477
CLV_PCSK_KEX2_1	492	494	PF00082	0.536
CLV_PCSK_KEX2_1	623	625	PF00082	0.549
CLV_PCSK_KEX2_1	64	66	PF00082	0.617
CLV_PCSK_KEX2_1	682	684	PF00082	0.687
CLV_PCSK_KEX2_1	69	71	PF00082	0.564
CLV_PCSK_KEX2_1	95	97	PF00082	0.492
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.608
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.756
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.729
CLV_PCSK_PC7_1	31	37	PF00082	0.501
CLV_PCSK_PC7_1	65	71	PF00082	0.489
CLV_PCSK_SKI1_1	10	14	PF00082	0.410
CLV_PCSK_SKI1_1	155	159	PF00082	0.449
CLV_PCSK_SKI1_1	31	35	PF00082	0.607
CLV_PCSK_SKI1_1	451	455	PF00082	0.530
CLV_PCSK_SKI1_1	97	101	PF00082	0.609
CLV_Separin_Metazoa	542	546	PF03568	0.543
DEG_APCC_DBOX_1	154	162	PF00400	0.469
DEG_APCC_DBOX_1	9	17	PF00400	0.555
DEG_SCF_FBW7_1	268	273	PF00400	0.538
DEG_SCF_FBW7_1	354	361	PF00400	0.445
DEG_SPOP_SBC_1	260	264	PF00917	0.512
DOC_ANK_TNKS_1	171	178	PF00023	0.586
DOC_ANK_TNKS_1	491	498	PF00023	0.628
DOC_CKS1_1	359	364	PF01111	0.767
DOC_CKS1_1	592	597	PF01111	0.682
DOC_CYCLIN_RxL_1	28	38	PF00134	0.568
DOC_CYCLIN_RxL_1	7	14	PF00134	0.382
DOC_MAPK_gen_1	286	296	PF00069	0.626
DOC_MAPK_gen_1	468	477	PF00069	0.605
DOC_MAPK_gen_1	64	76	PF00069	0.470
DOC_MAPK_gen_1	95	105	PF00069	0.352
DOC_MAPK_MEF2A_6	155	163	PF00069	0.487
DOC_MAPK_MEF2A_6	424	431	PF00069	0.372
DOC_MAPK_MEF2A_6	69	76	PF00069	0.480
DOC_PP1_RVXF_1	291	297	PF00149	0.564
DOC_PP2B_LxvP_1	258	261	PF13499	0.743
DOC_PP2B_LxvP_1	325	328	PF13499	0.522
DOC_PP4_FxxP_1	320	323	PF00568	0.404
DOC_PP4_FxxP_1	571	574	PF00568	0.479
DOC_SPAK_OSR1_1	186	190	PF12202	0.626
DOC_USP7_MATH_1	192	196	PF00917	0.616
DOC_USP7_MATH_1	204	208	PF00917	0.622
DOC_USP7_MATH_1	212	216	PF00917	0.429
DOC_USP7_MATH_1	270	274	PF00917	0.727
DOC_USP7_MATH_1	309	313	PF00917	0.458
DOC_USP7_MATH_1	316	320	PF00917	0.398
DOC_USP7_MATH_1	469	473	PF00917	0.625
DOC_USP7_MATH_1	551	555	PF00917	0.545
DOC_USP7_MATH_1	6	10	PF00917	0.602
DOC_USP7_MATH_1	635	639	PF00917	0.614
DOC_USP7_MATH_1	714	718	PF00917	0.517
DOC_WW_Pin1_4	2	7	PF00397	0.745
DOC_WW_Pin1_4	266	271	PF00397	0.730
DOC_WW_Pin1_4	354	359	PF00397	0.673
DOC_WW_Pin1_4	360	365	PF00397	0.669
DOC_WW_Pin1_4	410	415	PF00397	0.762
DOC_WW_Pin1_4	591	596	PF00397	0.625
LIG_14-3-3_CanoR_1	107	111	PF00244	0.486
LIG_14-3-3_CanoR_1	113	123	PF00244	0.384
LIG_14-3-3_CanoR_1	126	130	PF00244	0.312
LIG_14-3-3_CanoR_1	186	192	PF00244	0.558
LIG_14-3-3_CanoR_1	235	239	PF00244	0.781
LIG_14-3-3_CanoR_1	276	282	PF00244	0.765
LIG_14-3-3_CanoR_1	293	297	PF00244	0.743
LIG_14-3-3_CanoR_1	44	52	PF00244	0.550
LIG_14-3-3_CanoR_1	458	465	PF00244	0.590
LIG_14-3-3_CanoR_1	470	475	PF00244	0.447
LIG_14-3-3_CanoR_1	552	560	PF00244	0.559
LIG_14-3-3_CanoR_1	564	573	PF00244	0.483
LIG_14-3-3_CanoR_1	691	698	PF00244	0.721
LIG_14-3-3_CanoR_1	86	92	PF00244	0.439
LIG_deltaCOP1_diTrp_1	49	59	PF00928	0.562
LIG_FHA_1	129	135	PF00498	0.473
LIG_FHA_1	302	308	PF00498	0.564
LIG_FHA_1	312	318	PF00498	0.475
LIG_FHA_1	459	465	PF00498	0.617
LIG_FHA_1	531	537	PF00498	0.393
LIG_FHA_1	539	545	PF00498	0.342
LIG_FHA_1	555	561	PF00498	0.493
LIG_FHA_1	574	580	PF00498	0.366
LIG_FHA_1	598	604	PF00498	0.587
LIG_FHA_1	641	647	PF00498	0.432
LIG_FHA_1	792	798	PF00498	0.496
LIG_FHA_1	801	807	PF00498	0.468
LIG_FHA_2	219	225	PF00498	0.742
LIG_FHA_2	262	268	PF00498	0.591
LIG_FHA_2	410	416	PF00498	0.517
LIG_FHA_2	591	597	PF00498	0.667
LIG_FHA_2	648	654	PF00498	0.496
LIG_FHA_2	89	95	PF00498	0.367
LIG_IRF3_LxIS_1	581	588	PF10401	0.545
LIG_LIR_Apic_2	319	323	PF02991	0.402
LIG_LIR_Apic_2	569	574	PF02991	0.498
LIG_LIR_Gen_1	248	258	PF02991	0.676
LIG_LIR_Gen_1	49	60	PF02991	0.557
LIG_LIR_Nem_3	248	254	PF02991	0.627
LIG_LIR_Nem_3	452	457	PF02991	0.483
LIG_LIR_Nem_3	49	55	PF02991	0.550
LIG_LIR_Nem_3	614	620	PF02991	0.513
LIG_NRBOX	119	125	PF00104	0.520
LIG_NRBOX	18	24	PF00104	0.531
LIG_NRBOX	445	451	PF00104	0.524
LIG_NRBOX	754	760	PF00104	0.472
LIG_PDZ_Class_2	812	817	PF00595	0.686
LIG_Pex14_2	55	59	PF04695	0.564
LIG_RPA_C_Fungi	680	692	PF08784	0.730
LIG_SH2_SRC	174	177	PF00017	0.613
LIG_SH2_STAT5	174	177	PF00017	0.572
LIG_SH2_STAT5	498	501	PF00017	0.551
LIG_SH3_3	186	192	PF00018	0.615
LIG_SH3_3	533	539	PF00018	0.331
LIG_SH3_3	592	598	PF00018	0.682
LIG_Sin3_3	712	719	PF02671	0.516
LIG_SUMO_SIM_anti_2	101	107	PF11976	0.362
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.486
LIG_SUMO_SIM_anti_2	145	151	PF11976	0.593
LIG_SUMO_SIM_anti_2	605	611	PF11976	0.468
LIG_SUMO_SIM_anti_2	79	86	PF11976	0.533
LIG_SUMO_SIM_par_1	312	319	PF11976	0.459
LIG_SUMO_SIM_par_1	351	357	PF11976	0.525
LIG_SUMO_SIM_par_1	532	537	PF11976	0.338
LIG_SUMO_SIM_par_1	599	605	PF11976	0.526
LIG_TRAF2_1	25	28	PF00917	0.574
LIG_TRAF2_1	602	605	PF00917	0.572
LIG_TRAF2_1	91	94	PF00917	0.365
LIG_UBA3_1	453	460	PF00899	0.621
LIG_WRC_WIRS_1	149	154	PF05994	0.506
LIG_WRC_WIRS_1	317	322	PF05994	0.385
MOD_CDK_SPxK_1	410	416	PF00069	0.653
MOD_CK1_1	114	120	PF00069	0.424
MOD_CK1_1	128	134	PF00069	0.432
MOD_CK1_1	190	196	PF00069	0.553
MOD_CK1_1	206	212	PF00069	0.613
MOD_CK1_1	263	269	PF00069	0.634
MOD_CK1_1	537	543	PF00069	0.339
MOD_CK1_1	554	560	PF00069	0.538
MOD_CK1_1	684	690	PF00069	0.619
MOD_CK1_1	708	714	PF00069	0.617
MOD_CK1_1	733	739	PF00069	0.701
MOD_CK1_1	740	746	PF00069	0.590
MOD_CK2_1	218	224	PF00069	0.717
MOD_CK2_1	22	28	PF00069	0.567
MOD_CK2_1	403	409	PF00069	0.715
MOD_CK2_1	590	596	PF00069	0.534
MOD_CK2_1	599	605	PF00069	0.521
MOD_CK2_1	647	653	PF00069	0.492
MOD_CK2_1	88	94	PF00069	0.486
MOD_Cter_Amidation	490	493	PF01082	0.579
MOD_Cter_Amidation	67	70	PF01082	0.551
MOD_GlcNHglycan	116	119	PF01048	0.403
MOD_GlcNHglycan	142	145	PF01048	0.549
MOD_GlcNHglycan	208	211	PF01048	0.654
MOD_GlcNHglycan	214	217	PF01048	0.702
MOD_GlcNHglycan	272	275	PF01048	0.645
MOD_GlcNHglycan	279	282	PF01048	0.736
MOD_GlcNHglycan	350	353	PF01048	0.320
MOD_GlcNHglycan	441	444	PF01048	0.336
MOD_GlcNHglycan	446	449	PF01048	0.513
MOD_GlcNHglycan	45	48	PF01048	0.347
MOD_GlcNHglycan	566	569	PF01048	0.666
MOD_GlcNHglycan	587	590	PF01048	0.589
MOD_GlcNHglycan	630	633	PF01048	0.461
MOD_GlcNHglycan	687	690	PF01048	0.606
MOD_GlcNHglycan	732	735	PF01048	0.662
MOD_GSK3_1	140	147	PF00069	0.445
MOD_GSK3_1	192	199	PF00069	0.494
MOD_GSK3_1	2	9	PF00069	0.642
MOD_GSK3_1	206	213	PF00069	0.512
MOD_GSK3_1	218	225	PF00069	0.688
MOD_GSK3_1	259	266	PF00069	0.724
MOD_GSK3_1	354	361	PF00069	0.661
MOD_GSK3_1	370	377	PF00069	0.457
MOD_GSK3_1	405	412	PF00069	0.768
MOD_GSK3_1	530	537	PF00069	0.548
MOD_GSK3_1	587	594	PF00069	0.396
MOD_GSK3_1	681	688	PF00069	0.607
MOD_GSK3_1	733	740	PF00069	0.650
MOD_N-GLC_1	798	803	PF02516	0.354
MOD_NEK2_1	1	6	PF00069	0.590
MOD_NEK2_1	106	111	PF00069	0.456
MOD_NEK2_1	125	130	PF00069	0.498
MOD_NEK2_1	161	166	PF00069	0.397
MOD_NEK2_1	187	192	PF00069	0.557
MOD_NEK2_1	254	259	PF00069	0.532
MOD_NEK2_1	342	347	PF00069	0.437
MOD_NEK2_1	374	379	PF00069	0.470
MOD_NEK2_1	381	386	PF00069	0.440
MOD_NEK2_1	444	449	PF00069	0.569
MOD_NEK2_1	523	528	PF00069	0.564
MOD_NEK2_1	534	539	PF00069	0.517
MOD_NEK2_1	585	590	PF00069	0.517
MOD_NEK2_1	628	633	PF00069	0.602
MOD_NEK2_1	681	686	PF00069	0.582
MOD_NEK2_1	705	710	PF00069	0.643
MOD_NEK2_1	769	774	PF00069	0.554
MOD_NEK2_1	798	803	PF00069	0.511
MOD_PIKK_1	210	216	PF00454	0.697
MOD_PIKK_1	705	711	PF00454	0.419
MOD_PIKK_1	776	782	PF00454	0.606
MOD_PKA_1	403	409	PF00069	0.507
MOD_PKA_2	106	112	PF00069	0.546
MOD_PKA_2	125	131	PF00069	0.321
MOD_PKA_2	234	240	PF00069	0.652
MOD_PKA_2	275	281	PF00069	0.579
MOD_PKA_2	292	298	PF00069	0.517
MOD_PKA_2	403	409	PF00069	0.736
MOD_PKA_2	43	49	PF00069	0.562
MOD_PKA_2	469	475	PF00069	0.568
MOD_PKA_2	551	557	PF00069	0.380
MOD_PKA_2	635	641	PF00069	0.600
MOD_PKA_2	681	687	PF00069	0.676
MOD_PKA_2	85	91	PF00069	0.497
MOD_PKB_1	683	691	PF00069	0.688
MOD_Plk_1	144	150	PF00069	0.611
MOD_Plk_1	233	239	PF00069	0.741
MOD_Plk_1	370	376	PF00069	0.506
MOD_Plk_1	381	387	PF00069	0.569
MOD_Plk_1	676	682	PF00069	0.632
MOD_Plk_1	728	734	PF00069	0.616
MOD_Plk_4	101	107	PF00069	0.477
MOD_Plk_4	125	131	PF00069	0.546
MOD_Plk_4	144	150	PF00069	0.433
MOD_Plk_4	218	224	PF00069	0.527
MOD_Plk_4	292	298	PF00069	0.685
MOD_Plk_4	316	322	PF00069	0.481
MOD_Plk_4	326	332	PF00069	0.462
MOD_Plk_4	470	476	PF00069	0.505
MOD_Plk_4	499	505	PF00069	0.541
MOD_Plk_4	611	617	PF00069	0.436
MOD_ProDKin_1	2	8	PF00069	0.729
MOD_ProDKin_1	266	272	PF00069	0.729
MOD_ProDKin_1	354	360	PF00069	0.687
MOD_ProDKin_1	410	416	PF00069	0.753
MOD_ProDKin_1	591	597	PF00069	0.628
TRG_DiLeu_BaEn_1	542	547	PF01217	0.540
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.510
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.474
TRG_DiLeu_BaLyEn_6	615	620	PF01217	0.538
TRG_DiLeu_LyEn_5	542	547	PF01217	0.540
TRG_ER_diArg_1	287	290	PF00400	0.747
TRG_ER_diArg_1	34	36	PF00400	0.576
TRG_ER_diArg_1	402	404	PF00400	0.466
TRG_ER_diArg_1	620	623	PF00400	0.487
TRG_ER_diArg_1	63	66	PF00400	0.650
TRG_ER_diArg_1	634	637	PF00400	0.676
TRG_ER_diArg_1	681	683	PF00400	0.680
TRG_ER_diArg_1	95	97	PF00400	0.497
TRG_NES_CRM1_1	787	800	PF08389	0.545
TRG_NLS_MonoCore_2	285	290	PF00514	0.763
TRG_NLS_MonoExtC_3	285	290	PF00514	0.763
TRG_NLS_MonoExtN_4	286	292	PF00514	0.734
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	564	569	PF00026	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9D8	Leptomonas seymouri	50%	79%
A0A1X0P0U5	Trypanosomatidae	29%	91%
A0A3Q8IPQ0	Leishmania donovani	75%	84%
A0A3R7KDM9	Trypanosoma rangeli	30%	95%
A4IDW1	Leishmania infantum	75%	84%
D0A455	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	96%
E9ATY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	85%
Q4Q0L4	Leishmania major	74%	100%