DAO domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ61_LEIBR

TriTrypDb:

LbrM.35.5720 , LBRM2903_350068700

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQ61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ61

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0003973	(S)-2-hydroxy-acid oxidase activity	5	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	2
GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	4	1
GO:0047545	2-hydroxyglutarate dehydrogenase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	424	428	PF00656	0.262
CLV_NRD_NRD_1	28	30	PF00675	0.534
CLV_NRD_NRD_1	330	332	PF00675	0.386
CLV_NRD_NRD_1	346	348	PF00675	0.254
CLV_NRD_NRD_1	406	408	PF00675	0.250
CLV_NRD_NRD_1	53	55	PF00675	0.453
CLV_NRD_NRD_1	75	77	PF00675	0.286
CLV_PCSK_KEX2_1	28	30	PF00082	0.534
CLV_PCSK_KEX2_1	296	298	PF00082	0.364
CLV_PCSK_KEX2_1	330	332	PF00082	0.202
CLV_PCSK_KEX2_1	346	348	PF00082	0.254
CLV_PCSK_KEX2_1	406	408	PF00082	0.330
CLV_PCSK_KEX2_1	53	55	PF00082	0.453
CLV_PCSK_KEX2_1	82	84	PF00082	0.272
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.337
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.330
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.272
CLV_PCSK_SKI1_1	209	213	PF00082	0.272
CLV_PCSK_SKI1_1	265	269	PF00082	0.386
CLV_PCSK_SKI1_1	296	300	PF00082	0.303
CLV_PCSK_SKI1_1	407	411	PF00082	0.277
CLV_PCSK_SKI1_1	83	87	PF00082	0.272
DEG_APCC_DBOX_1	208	216	PF00400	0.272
DEG_APCC_DBOX_1	314	322	PF00400	0.173
DEG_SCF_FBW7_1	311	316	PF00400	0.173
DOC_CKS1_1	310	315	PF01111	0.330
DOC_CYCLIN_RxL_1	293	303	PF00134	0.173
DOC_MAPK_gen_1	330	337	PF00069	0.386
DOC_MAPK_gen_1	346	353	PF00069	0.254
DOC_MAPK_gen_1	53	61	PF00069	0.398
DOC_MAPK_JIP1_4	488	494	PF00069	0.359
DOC_MAPK_MEF2A_6	330	339	PF00069	0.276
DOC_MAPK_RevD_3	333	347	PF00069	0.254
DOC_PP4_FxxP_1	110	113	PF00568	0.386
DOC_PP4_FxxP_1	451	454	PF00568	0.374
DOC_USP7_MATH_1	284	288	PF00917	0.284
DOC_USP7_MATH_1	313	317	PF00917	0.173
DOC_USP7_MATH_1	502	506	PF00917	0.246
DOC_USP7_MATH_1	515	519	PF00917	0.326
DOC_USP7_UBL2_3	78	82	PF12436	0.333
DOC_WW_Pin1_4	193	198	PF00397	0.254
DOC_WW_Pin1_4	239	244	PF00397	0.305
DOC_WW_Pin1_4	309	314	PF00397	0.330
DOC_WW_Pin1_4	337	342	PF00397	0.265
DOC_WW_Pin1_4	364	369	PF00397	0.272
DOC_WW_Pin1_4	496	501	PF00397	0.327
LIG_14-3-3_CanoR_1	29	35	PF00244	0.492
LIG_14-3-3_CanoR_1	297	303	PF00244	0.382
LIG_14-3-3_CanoR_1	330	336	PF00244	0.335
LIG_14-3-3_CanoR_1	407	417	PF00244	0.177
LIG_14-3-3_CanoR_1	453	459	PF00244	0.399
LIG_BIR_II_1	1	5	PF00653	0.551
LIG_CSL_BTD_1	194	197	PF09270	0.333
LIG_FHA_1	245	251	PF00498	0.305
LIG_FHA_1	338	344	PF00498	0.304
LIG_FHA_1	368	374	PF00498	0.174
LIG_FHA_2	69	75	PF00498	0.298
LIG_LIR_Apic_2	450	454	PF02991	0.337
LIG_LIR_Gen_1	203	212	PF02991	0.255
LIG_LIR_Gen_1	399	409	PF02991	0.345
LIG_LIR_Nem_3	203	207	PF02991	0.200
LIG_LIR_Nem_3	233	237	PF02991	0.267
LIG_LIR_Nem_3	390	396	PF02991	0.291
LIG_LIR_Nem_3	399	404	PF02991	0.285
LIG_LIR_Nem_3	427	432	PF02991	0.286
LIG_Pex14_2	223	227	PF04695	0.254
LIG_Pex14_2	377	381	PF04695	0.351
LIG_Rb_pABgroove_1	155	163	PF01858	0.386
LIG_SH2_STAP1	369	373	PF00017	0.386
LIG_SH2_STAP1	57	61	PF00017	0.313
LIG_SH2_STAT5	131	134	PF00017	0.272
LIG_SH2_STAT5	366	369	PF00017	0.268
LIG_SH2_STAT5	375	378	PF00017	0.254
LIG_SUMO_SIM_anti_2	247	254	PF11976	0.173
LIG_SUMO_SIM_anti_2	58	63	PF11976	0.294
LIG_SUMO_SIM_par_1	369	374	PF11976	0.173
LIG_SUMO_SIM_par_1	83	88	PF11976	0.272
LIG_TRFH_1	309	313	PF08558	0.293
LIG_UBA3_1	416	423	PF00899	0.381
LIG_WRC_WIRS_1	426	431	PF05994	0.268
LIG_WRC_WIRS_1	45	50	PF05994	0.492
MOD_CDK_SPxK_1	309	315	PF00069	0.330
MOD_CK1_1	196	202	PF00069	0.254
MOD_CK1_1	205	211	PF00069	0.254
MOD_CK1_1	33	39	PF00069	0.428
MOD_CK1_1	388	394	PF00069	0.324
MOD_CK1_1	419	425	PF00069	0.184
MOD_CK1_1	44	50	PF00069	0.342
MOD_CK2_1	68	74	PF00069	0.331
MOD_Cter_Amidation	294	297	PF01082	0.272
MOD_GlcNHglycan	101	104	PF01048	0.258
MOD_GlcNHglycan	114	117	PF01048	0.318
MOD_GlcNHglycan	191	194	PF01048	0.345
MOD_GlcNHglycan	198	201	PF01048	0.271
MOD_GlcNHglycan	21	24	PF01048	0.463
MOD_GlcNHglycan	286	289	PF01048	0.278
MOD_GlcNHglycan	356	359	PF01048	0.297
MOD_GlcNHglycan	475	478	PF01048	0.548
MOD_GlcNHglycan	485	488	PF01048	0.425
MOD_GlcNHglycan	9	12	PF01048	0.518
MOD_GlcNHglycan	97	100	PF01048	0.286
MOD_GSK3_1	189	196	PF00069	0.333
MOD_GSK3_1	235	242	PF00069	0.331
MOD_GSK3_1	309	316	PF00069	0.230
MOD_GSK3_1	33	40	PF00069	0.497
MOD_GSK3_1	454	461	PF00069	0.405
MOD_GSK3_1	496	503	PF00069	0.311
MOD_GSK3_1	95	102	PF00069	0.254
MOD_NEK2_1	298	303	PF00069	0.173
MOD_NEK2_1	402	407	PF00069	0.323
MOD_PIKK_1	149	155	PF00454	0.386
MOD_PK_1	331	337	PF00069	0.272
MOD_PKA_2	454	460	PF00069	0.468
MOD_Plk_1	263	269	PF00069	0.298
MOD_Plk_1	37	43	PF00069	0.300
MOD_Plk_4	263	269	PF00069	0.333
MOD_Plk_4	396	402	PF00069	0.381
MOD_Plk_4	41	47	PF00069	0.452
MOD_ProDKin_1	193	199	PF00069	0.254
MOD_ProDKin_1	239	245	PF00069	0.305
MOD_ProDKin_1	309	315	PF00069	0.330
MOD_ProDKin_1	337	343	PF00069	0.265
MOD_ProDKin_1	364	370	PF00069	0.272
MOD_ProDKin_1	496	502	PF00069	0.325
MOD_SUMO_rev_2	419	425	PF00179	0.381
TRG_DiLeu_BaEn_1	248	253	PF01217	0.369
TRG_DiLeu_BaEn_1	314	319	PF01217	0.190
TRG_DiLeu_BaEn_1	412	417	PF01217	0.249
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.173
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.378
TRG_ENDOCYTIC_2	308	311	PF00928	0.293
TRG_ENDOCYTIC_2	31	34	PF00928	0.413
TRG_ENDOCYTIC_2	401	404	PF00928	0.386
TRG_ER_diArg_1	253	256	PF00400	0.281
TRG_ER_diArg_1	27	29	PF00400	0.523
TRG_ER_diArg_1	304	307	PF00400	0.254
TRG_ER_diArg_1	345	347	PF00400	0.325
TRG_ER_diArg_1	453	456	PF00400	0.409
TRG_NES_CRM1_1	424	439	PF08389	0.268
TRG_NLS_MonoExtC_3	75	80	PF00514	0.173
TRG_NLS_MonoExtN_4	28	33	PF00514	0.328
TRG_NLS_MonoExtN_4	73	80	PF00514	0.390
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.173
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.268

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1P3	Leptomonas seymouri	23%	100%
A0A0N1PEN9	Leptomonas seymouri	76%	100%
A0A0S4JUB7	Bodo saltans	42%	100%
A0A1X0P066	Trypanosomatidae	58%	100%
A0A3Q8IJT1	Leishmania donovani	86%	100%
A0A5Y6MCT2	Salmonella houtenae	31%	100%
A4IDW0	Leishmania infantum	86%	100%
A7MBI3	Bos taurus	32%	100%
A7SMW7	Nematostella vectensis	35%	100%
A8X2R1	Caenorhabditis briggsae	32%	100%
B7N6P4	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	31%	100%
D0A456	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9ATY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
P37339	Escherichia coli (strain K12)	31%	100%
Q4Q0L5	Leishmania major	85%	100%
Q55GI5	Dictyostelium discoideum	33%	100%
Q91YP0	Mus musculus	34%	100%
Q9H9P8	Homo sapiens	31%	100%
Q9LES4	Arabidopsis thaliana	25%	100%
Q9N4Z0	Caenorhabditis elegans	33%	100%
S2DJ52	Indibacter alkaliphilus (strain CCUG 57479 / KCTC 22604 / LW1)	30%	100%
V5DK53	Trypanosoma cruzi	57%	100%