LeishMANIAdb
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PRKCSH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
PRKCSH domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HQ60_LEIBR
TriTrypDb:
LbrM.35.5710 , LBRM2903_350068600 *
Length:
433

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 8, no: 2
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ60
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ60

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 284 288 PF00656 0.431
CLV_C14_Caspase3-7 32 36 PF00656 0.629
CLV_NRD_NRD_1 185 187 PF00675 0.564
CLV_PCSK_FUR_1 245 249 PF00082 0.400
CLV_PCSK_KEX2_1 185 187 PF00082 0.520
CLV_PCSK_KEX2_1 247 249 PF00082 0.518
CLV_PCSK_PC1ET2_1 247 249 PF00082 0.416
CLV_PCSK_SKI1_1 221 225 PF00082 0.568
CLV_PCSK_SKI1_1 247 251 PF00082 0.484
DEG_SPOP_SBC_1 79 83 PF00917 0.498
DOC_CYCLIN_RxL_1 243 254 PF00134 0.493
DOC_MAPK_gen_1 245 252 PF00069 0.448
DOC_PP2B_LxvP_1 171 174 PF13499 0.506
DOC_PP2B_LxvP_1 250 253 PF13499 0.433
DOC_PP4_FxxP_1 375 378 PF00568 0.497
DOC_USP7_MATH_1 146 150 PF00917 0.756
DOC_USP7_MATH_1 193 197 PF00917 0.569
DOC_USP7_MATH_1 344 348 PF00917 0.698
DOC_USP7_MATH_1 80 84 PF00917 0.503
DOC_USP7_MATH_1 93 97 PF00917 0.475
DOC_WW_Pin1_4 100 105 PF00397 0.528
DOC_WW_Pin1_4 123 128 PF00397 0.545
DOC_WW_Pin1_4 266 271 PF00397 0.645
DOC_WW_Pin1_4 279 284 PF00397 0.455
LIG_14-3-3_CanoR_1 111 118 PF00244 0.655
LIG_14-3-3_CanoR_1 13 19 PF00244 0.557
LIG_14-3-3_CanoR_1 192 202 PF00244 0.482
LIG_14-3-3_CanoR_1 385 394 PF00244 0.573
LIG_BIR_III_2 159 163 PF00653 0.505
LIG_deltaCOP1_diTrp_1 137 141 PF00928 0.587
LIG_deltaCOP1_diTrp_1 366 375 PF00928 0.397
LIG_FHA_1 15 21 PF00498 0.434
LIG_FHA_1 267 273 PF00498 0.527
LIG_FHA_1 36 42 PF00498 0.458
LIG_FHA_1 45 51 PF00498 0.461
LIG_FHA_2 222 228 PF00498 0.525
LIG_FHA_2 257 263 PF00498 0.669
LIG_FHA_2 391 397 PF00498 0.458
LIG_FXI_DFP_1 42 46 PF00024 0.351
LIG_LIR_Apic_2 53 59 PF02991 0.579
LIG_LIR_Gen_1 17 25 PF02991 0.369
LIG_LIR_Gen_1 261 270 PF02991 0.449
LIG_LIR_Gen_1 333 341 PF02991 0.559
LIG_LIR_Gen_1 34 45 PF02991 0.526
LIG_LIR_Nem_3 17 21 PF02991 0.363
LIG_LIR_Nem_3 226 232 PF02991 0.374
LIG_LIR_Nem_3 293 298 PF02991 0.460
LIG_LIR_Nem_3 333 338 PF02991 0.546
LIG_LIR_Nem_3 34 40 PF02991 0.562
LIG_LIR_Nem_3 366 372 PF02991 0.409
LIG_NRBOX 245 251 PF00104 0.526
LIG_Pex14_1 314 318 PF04695 0.502
LIG_Pex14_1 321 325 PF04695 0.328
LIG_PTB_Apo_2 289 296 PF02174 0.526
LIG_PTB_Phospho_1 289 295 PF10480 0.523
LIG_RPA_C_Fungi 181 193 PF08784 0.552
LIG_SH2_CRK 295 299 PF00017 0.494
LIG_SH2_CRK 335 339 PF00017 0.566
LIG_SH2_CRK 37 41 PF00017 0.570
LIG_SH2_CRK 56 60 PF00017 0.597
LIG_SH2_NCK_1 56 60 PF00017 0.597
LIG_SH2_STAP1 37 41 PF00017 0.570
LIG_SH2_STAT3 239 242 PF00017 0.509
LIG_SH2_STAT5 187 190 PF00017 0.449
LIG_SH2_STAT5 318 321 PF00017 0.489
LIG_SH2_STAT5 335 338 PF00017 0.542
LIG_SH2_STAT5 37 40 PF00017 0.568
LIG_SH3_3 121 127 PF00018 0.657
LIG_SH3_3 2 8 PF00018 0.471
LIG_SH3_3 295 301 PF00018 0.448
LIG_SUMO_SIM_anti_2 38 44 PF11976 0.452
LIG_SUMO_SIM_par_1 38 44 PF11976 0.357
LIG_TRFH_1 230 234 PF08558 0.398
LIG_WRC_WIRS_1 15 20 PF05994 0.358
LIG_WRC_WIRS_1 419 424 PF05994 0.553
LIG_WW_3 3 7 PF00397 0.431
MOD_CDK_SPxxK_3 279 286 PF00069 0.390
MOD_CK1_1 307 313 PF00069 0.417
MOD_CK1_1 339 345 PF00069 0.468
MOD_CK1_1 379 385 PF00069 0.675
MOD_CK1_1 390 396 PF00069 0.514
MOD_CK1_1 83 89 PF00069 0.741
MOD_CK2_1 221 227 PF00069 0.559
MOD_CK2_1 390 396 PF00069 0.403
MOD_CK2_1 93 99 PF00069 0.498
MOD_CMANNOS 138 141 PF00535 0.574
MOD_CMANNOS 321 324 PF00535 0.444
MOD_GlcNHglycan 134 137 PF01048 0.541
MOD_GlcNHglycan 148 151 PF01048 0.579
MOD_GlcNHglycan 195 198 PF01048 0.494
MOD_GlcNHglycan 340 344 PF01048 0.608
MOD_GlcNHglycan 68 71 PF01048 0.645
MOD_GlcNHglycan 8 11 PF01048 0.550
MOD_GlcNHglycan 82 85 PF01048 0.617
MOD_GlcNHglycan 93 96 PF01048 0.679
MOD_GSK3_1 205 212 PF00069 0.527
MOD_GSK3_1 31 38 PF00069 0.462
MOD_GSK3_1 320 327 PF00069 0.408
MOD_GSK3_1 344 351 PF00069 0.530
MOD_GSK3_1 379 386 PF00069 0.608
MOD_GSK3_1 62 69 PF00069 0.625
MOD_GSK3_1 78 85 PF00069 0.508
MOD_GSK3_1 87 94 PF00069 0.696
MOD_N-GLC_1 349 354 PF02516 0.640
MOD_N-GLC_1 59 64 PF02516 0.618
MOD_NEK2_1 290 295 PF00069 0.315
MOD_NEK2_1 87 92 PF00069 0.694
MOD_PIKK_1 251 257 PF00454 0.473
MOD_PIKK_1 290 296 PF00454 0.575
MOD_PKA_2 110 116 PF00069 0.637
MOD_PKA_2 132 138 PF00069 0.494
MOD_PKA_2 146 152 PF00069 0.546
MOD_PKA_2 256 262 PF00069 0.708
MOD_PKA_2 307 313 PF00069 0.351
MOD_PKB_1 374 382 PF00069 0.559
MOD_Plk_4 14 20 PF00069 0.399
MOD_Plk_4 268 274 PF00069 0.474
MOD_Plk_4 320 326 PF00069 0.463
MOD_Plk_4 333 339 PF00069 0.552
MOD_Plk_4 35 41 PF00069 0.583
MOD_Plk_4 368 374 PF00069 0.355
MOD_Plk_4 387 393 PF00069 0.488
MOD_Plk_4 59 65 PF00069 0.549
MOD_ProDKin_1 100 106 PF00069 0.528
MOD_ProDKin_1 123 129 PF00069 0.543
MOD_ProDKin_1 266 272 PF00069 0.625
MOD_ProDKin_1 279 285 PF00069 0.456
TRG_DiLeu_BaLyEn_6 245 250 PF01217 0.402
TRG_ENDOCYTIC_2 118 121 PF00928 0.574
TRG_ENDOCYTIC_2 229 232 PF00928 0.453
TRG_ENDOCYTIC_2 295 298 PF00928 0.500
TRG_ENDOCYTIC_2 335 338 PF00928 0.564
TRG_ENDOCYTIC_2 37 40 PF00928 0.568
TRG_ENDOCYTIC_2 71 74 PF00928 0.609
TRG_ER_diArg_1 130 133 PF00400 0.679
TRG_ER_diArg_1 185 187 PF00400 0.571
TRG_Pf-PMV_PEXEL_1 213 218 PF00026 0.457
TRG_Pf-PMV_PEXEL_1 398 402 PF00026 0.512

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P921 Leptomonas seymouri 57% 100%
A0A0S4JQR0 Bodo saltans 23% 100%
A0A1X0P090 Trypanosomatidae 28% 100%
A0A3Q8IRP6 Leishmania donovani 79% 100%
A0A422NKF7 Trypanosoma rangeli 29% 100%
A4IDV9 Leishmania infantum 79% 100%
D0A457 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9ATY0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
Q4Q0L6 Leishmania major 76% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS