SEP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SEP domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ59_LEIBR

TriTrypDb:

LbrM.35.5700 , LBRM2903_350068500

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HQ59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ59

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	413	415	PF00675	0.731
CLV_NRD_NRD_1	45	47	PF00675	0.556
CLV_NRD_NRD_1	556	558	PF00675	0.410
CLV_NRD_NRD_1	56	58	PF00675	0.621
CLV_PCSK_FUR_1	54	58	PF00082	0.691
CLV_PCSK_KEX2_1	413	415	PF00082	0.731
CLV_PCSK_KEX2_1	45	47	PF00082	0.556
CLV_PCSK_KEX2_1	56	58	PF00082	0.624
CLV_PCSK_SKI1_1	159	163	PF00082	0.555
CLV_PCSK_SKI1_1	211	215	PF00082	0.702
CLV_PCSK_SKI1_1	46	50	PF00082	0.574
CLV_PCSK_SKI1_1	489	493	PF00082	0.494
DEG_APCC_DBOX_1	45	53	PF00400	0.611
DEG_APCC_DBOX_1	56	64	PF00400	0.692
DEG_Nend_UBRbox_2	1	3	PF02207	0.637
DEG_SPOP_SBC_1	478	482	PF00917	0.468
DEG_SPOP_SBC_1	520	524	PF00917	0.682
DOC_AGCK_PIF_2	359	364	PF00069	0.517
DOC_ANK_TNKS_1	64	71	PF00023	0.527
DOC_CKS1_1	206	211	PF01111	0.720
DOC_CYCLIN_RxL_1	43	51	PF00134	0.641
DOC_CYCLIN_yClb5_NLxxxL_5	525	534	PF00134	0.571
DOC_MAPK_gen_1	319	328	PF00069	0.465
DOC_MAPK_gen_1	597	604	PF00069	0.477
DOC_MAPK_HePTP_8	594	606	PF00069	0.300
DOC_MAPK_MEF2A_6	319	328	PF00069	0.427
DOC_MAPK_MEF2A_6	597	606	PF00069	0.527
DOC_USP7_MATH_1	174	178	PF00917	0.694
DOC_USP7_MATH_1	200	204	PF00917	0.787
DOC_USP7_MATH_1	392	396	PF00917	0.708
DOC_USP7_MATH_1	478	482	PF00917	0.566
DOC_USP7_MATH_1	521	525	PF00917	0.710
DOC_USP7_MATH_1	93	97	PF00917	0.456
DOC_USP7_UBL2_3	232	236	PF12436	0.812
DOC_WW_Pin1_4	11	16	PF00397	0.742
DOC_WW_Pin1_4	198	203	PF00397	0.637
DOC_WW_Pin1_4	205	210	PF00397	0.632
DOC_WW_Pin1_4	251	256	PF00397	0.758
DOC_WW_Pin1_4	272	277	PF00397	0.679
DOC_WW_Pin1_4	33	38	PF00397	0.713
DOC_WW_Pin1_4	58	63	PF00397	0.701
LIG_14-3-3_CanoR_1	282	286	PF00244	0.637
LIG_14-3-3_CanoR_1	298	306	PF00244	0.398
LIG_14-3-3_CanoR_1	428	433	PF00244	0.726
LIG_14-3-3_CanoR_1	510	515	PF00244	0.464
LIG_14-3-3_CanoR_1	56	61	PF00244	0.581
LIG_14-3-3_CanoR_1	92	102	PF00244	0.542
LIG_APCC_ABBA_1	153	158	PF00400	0.478
LIG_BRCT_BRCA1_1	218	222	PF00533	0.661
LIG_BRCT_BRCA1_1	522	526	PF00533	0.679
LIG_deltaCOP1_diTrp_1	583	591	PF00928	0.549
LIG_eIF4E_1	156	162	PF01652	0.609
LIG_FHA_1	148	154	PF00498	0.507
LIG_FHA_1	238	244	PF00498	0.785
LIG_FHA_1	248	254	PF00498	0.731
LIG_FHA_1	285	291	PF00498	0.443
LIG_FHA_1	384	390	PF00498	0.589
LIG_FHA_1	599	605	PF00498	0.417
LIG_FHA_2	152	158	PF00498	0.582
LIG_FHA_2	42	48	PF00498	0.625
LIG_FHA_2	429	435	PF00498	0.710
LIG_FHA_2	76	82	PF00498	0.732
LIG_Integrin_isoDGR_2	3	5	PF01839	0.804
LIG_LIR_Gen_1	573	580	PF02991	0.366
LIG_LIR_Gen_1	590	596	PF02991	0.494
LIG_LIR_Nem_3	357	362	PF02991	0.476
LIG_LIR_Nem_3	440	444	PF02991	0.524
LIG_LIR_Nem_3	569	575	PF02991	0.474
LIG_LIR_Nem_3	590	594	PF02991	0.504
LIG_Pex14_2	218	222	PF04695	0.731
LIG_Rb_pABgroove_1	150	158	PF01858	0.581
LIG_SH2_CRK	131	135	PF00017	0.597
LIG_SH2_CRK	441	445	PF00017	0.580
LIG_SH2_NCK_1	441	445	PF00017	0.638
LIG_SH2_SRC	441	444	PF00017	0.567
LIG_SH2_STAT5	303	306	PF00017	0.560
LIG_SH2_STAT5	501	504	PF00017	0.382
LIG_SH3_2	206	211	PF14604	0.780
LIG_SH3_3	181	187	PF00018	0.777
LIG_SH3_3	203	209	PF00018	0.763
LIG_SH3_3	273	279	PF00018	0.740
LIG_SH3_3	336	342	PF00018	0.476
LIG_SH3_3	402	408	PF00018	0.714
LIG_SH3_3	9	15	PF00018	0.636
LIG_SUMO_SIM_anti_2	289	294	PF11976	0.363
LIG_SUMO_SIM_par_1	149	158	PF11976	0.501
LIG_SUMO_SIM_par_1	286	291	PF11976	0.466
LIG_SUMO_SIM_par_1	372	378	PF11976	0.476
LIG_TRAF2_1	445	448	PF00917	0.407
LIG_TYR_ITIM	439	444	PF00017	0.667
LIG_UBA3_1	534	542	PF00899	0.560
LIG_UBA3_1	602	608	PF00899	0.497
LIG_WRPW_2	340	343	PF00400	0.476
MOD_CDK_SPK_2	272	277	PF00069	0.537
MOD_CDK_SPxK_1	205	211	PF00069	0.664
MOD_CDK_SPxK_1	251	257	PF00069	0.768
MOD_CDK_SPxxK_3	58	65	PF00069	0.509
MOD_CK1_1	177	183	PF00069	0.686
MOD_CK1_1	281	287	PF00069	0.625
MOD_CK1_1	482	488	PF00069	0.692
MOD_CK1_1	96	102	PF00069	0.428
MOD_CK2_1	41	47	PF00069	0.599
MOD_CK2_1	428	434	PF00069	0.679
MOD_CK2_1	442	448	PF00069	0.427
MOD_CK2_1	492	498	PF00069	0.479
MOD_CK2_1	75	81	PF00069	0.717
MOD_Cter_Amidation	411	414	PF01082	0.742
MOD_GlcNHglycan	218	221	PF01048	0.703
MOD_GlcNHglycan	268	271	PF01048	0.774
MOD_GlcNHglycan	394	397	PF01048	0.663
MOD_GlcNHglycan	421	424	PF01048	0.531
MOD_GlcNHglycan	444	447	PF01048	0.536
MOD_GlcNHglycan	482	485	PF01048	0.648
MOD_GlcNHglycan	494	497	PF01048	0.369
MOD_GlcNHglycan	510	513	PF01048	0.380
MOD_GlcNHglycan	66	69	PF01048	0.687
MOD_GlcNHglycan	95	98	PF01048	0.604
MOD_GSK3_1	147	154	PF00069	0.566
MOD_GSK3_1	194	201	PF00069	0.759
MOD_GSK3_1	247	254	PF00069	0.678
MOD_GSK3_1	392	399	PF00069	0.685
MOD_GSK3_1	478	485	PF00069	0.650
MOD_GSK3_1	516	523	PF00069	0.651
MOD_GSK3_1	92	99	PF00069	0.661
MOD_N-GLC_1	177	182	PF02516	0.487
MOD_NEK2_2	151	156	PF00069	0.580
MOD_NEK2_2	521	526	PF00069	0.588
MOD_PIKK_1	195	201	PF00454	0.773
MOD_PIKK_1	482	488	PF00454	0.472
MOD_PIKK_1	503	509	PF00454	0.566
MOD_PKA_1	56	62	PF00069	0.495
MOD_PKA_2	174	180	PF00069	0.455
MOD_PKA_2	281	287	PF00069	0.671
MOD_PKA_2	378	384	PF00069	0.497
MOD_PKA_2	56	62	PF00069	0.634
MOD_PKA_2	6	12	PF00069	0.809
MOD_PKA_2	64	70	PF00069	0.651
MOD_PKB_1	54	62	PF00069	0.485
MOD_PKB_1	90	98	PF00069	0.655
MOD_Plk_1	549	555	PF00069	0.423
MOD_Plk_2-3	224	230	PF00069	0.634
MOD_Plk_2-3	75	81	PF00069	0.713
MOD_Plk_4	151	157	PF00069	0.538
MOD_Plk_4	510	516	PF00069	0.478
MOD_Plk_4	521	527	PF00069	0.645
MOD_Plk_4	598	604	PF00069	0.406
MOD_ProDKin_1	11	17	PF00069	0.744
MOD_ProDKin_1	198	204	PF00069	0.639
MOD_ProDKin_1	205	211	PF00069	0.631
MOD_ProDKin_1	251	257	PF00069	0.759
MOD_ProDKin_1	272	278	PF00069	0.675
MOD_ProDKin_1	33	39	PF00069	0.707
MOD_ProDKin_1	58	64	PF00069	0.703
MOD_SUMO_for_1	580	583	PF00179	0.609
TRG_ENDOCYTIC_2	131	134	PF00928	0.602
TRG_ENDOCYTIC_2	441	444	PF00928	0.594
TRG_ENDOCYTIC_2	575	578	PF00928	0.331
TRG_ER_diArg_1	413	415	PF00400	0.752
TRG_ER_diArg_1	53	56	PF00400	0.600
TRG_ER_diArg_1	87	90	PF00400	0.667
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMT0	Leptomonas seymouri	53%	97%
A0A0S4JTW8	Bodo saltans	35%	100%
A0A1X0P060	Trypanosomatidae	35%	100%
A0A3R7LYT2	Trypanosoma rangeli	33%	100%
A0A3S7XBW1	Leishmania donovani	76%	99%
A4IDV8	Leishmania infantum	76%	99%
D0A458	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ATX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q0L7	Leishmania major	77%	100%
V5BQB1	Trypanosoma cruzi	32%	100%