SEP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SEP domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ59_LEIBR

TriTrypDb:

LbrM.35.5700 , LBRM2903_350068500

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

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Expansion

Sequence features

A4HQ59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ59

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	413	415	PF00675	0.731
CLV_NRD_NRD_1	45	47	PF00675	0.556
CLV_NRD_NRD_1	556	558	PF00675	0.410
CLV_NRD_NRD_1	56	58	PF00675	0.621
CLV_PCSK_FUR_1	54	58	PF00082	0.691
CLV_PCSK_KEX2_1	413	415	PF00082	0.731
CLV_PCSK_KEX2_1	45	47	PF00082	0.556
CLV_PCSK_KEX2_1	56	58	PF00082	0.624
CLV_PCSK_SKI1_1	159	163	PF00082	0.555
CLV_PCSK_SKI1_1	211	215	PF00082	0.702

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMT0	Leptomonas seymouri	53%	97%
A0A0S4JTW8	Bodo saltans	35%	100%
A0A1X0P060	Trypanosomatidae	35%	100%
A0A3R7LYT2	Trypanosoma rangeli	33%	100%
A0A3S7XBW1	Leishmania donovani	76%	99%
A4IDV8	Leishmania infantum	76%	99%
D0A458	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ATX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q0L7	Leishmania major	77%	100%
V5BQB1	Trypanosoma cruzi	32%	100%

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