Macrocin O-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Macrocin-O-methyltransferase (TylF), putative

Species:

Leishmania braziliensis

UniProt:

A4HQ58_LEIBR

TriTrypDb:

LbrM.35.5690 , LBRM2903_350068400

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ58

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	3
GO:0032259	methylation	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.223
CLV_NRD_NRD_1	105	107	PF00675	0.525
CLV_NRD_NRD_1	189	191	PF00675	0.319
CLV_NRD_NRD_1	312	314	PF00675	0.449
CLV_PCSK_KEX2_1	189	191	PF00082	0.386
CLV_PCSK_KEX2_1	311	313	PF00082	0.444
CLV_PCSK_SKI1_1	189	193	PF00082	0.413
CLV_PCSK_SKI1_1	300	304	PF00082	0.340
CLV_PCSK_SKI1_1	39	43	PF00082	0.306
CLV_PCSK_SKI1_1	96	100	PF00082	0.515
DEG_APCC_DBOX_1	299	307	PF00400	0.391
DEG_Nend_Nbox_1	1	3	PF02207	0.654
DEG_SPOP_SBC_1	216	220	PF00917	0.399
DOC_CYCLIN_RxL_1	49	59	PF00134	0.423
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.302
DOC_MAPK_MEF2A_6	300	309	PF00069	0.443
DOC_MAPK_NFAT4_5	300	308	PF00069	0.449
DOC_PP1_RVXF_1	50	57	PF00149	0.380
DOC_PP2B_LxvP_1	222	225	PF13499	0.223
DOC_PP2B_LxvP_1	305	308	PF13499	0.449
DOC_PP2B_LxvP_1	98	101	PF13499	0.425
DOC_USP7_MATH_1	177	181	PF00917	0.475
DOC_USP7_MATH_1	193	197	PF00917	0.319
DOC_USP7_MATH_1	216	220	PF00917	0.432
DOC_USP7_MATH_1	231	235	PF00917	0.420
DOC_USP7_MATH_1	67	71	PF00917	0.501
DOC_WW_Pin1_4	183	188	PF00397	0.455
DOC_WW_Pin1_4	199	204	PF00397	0.368
DOC_WW_Pin1_4	224	229	PF00397	0.453
DOC_WW_Pin1_4	239	244	PF00397	0.427
DOC_WW_Pin1_4	320	325	PF00397	0.223
DOC_WW_Pin1_4	353	358	PF00397	0.437
LIG_14-3-3_CanoR_1	241	250	PF00244	0.336
LIG_14-3-3_CanoR_1	311	320	PF00244	0.437
LIG_14-3-3_CanoR_1	68	72	PF00244	0.526
LIG_BRCT_BRCA1_1	112	116	PF00533	0.257
LIG_Clathr_ClatBox_1	260	264	PF01394	0.475
LIG_Clathr_ClatBox_1	288	292	PF01394	0.449
LIG_eIF4E_1	109	115	PF01652	0.311
LIG_FHA_1	183	189	PF00498	0.464
LIG_FHA_1	2	8	PF00498	0.661
LIG_FHA_1	377	383	PF00498	0.438
LIG_FHA_2	13	19	PF00498	0.277
LIG_FHA_2	202	208	PF00498	0.346
LIG_FHA_2	312	318	PF00498	0.461
LIG_LIR_Gen_1	113	124	PF02991	0.324
LIG_LIR_LC3C_4	257	262	PF02991	0.413
LIG_LIR_Nem_3	113	119	PF02991	0.306
LIG_LIR_Nem_3	126	130	PF02991	0.328
LIG_MYND_1	97	101	PF01753	0.400
LIG_PCNA_yPIPBox_3	106	115	PF02747	0.511
LIG_Pex14_2	112	116	PF04695	0.510
LIG_Rb_pABgroove_1	52	60	PF01858	0.486
LIG_SH2_CRK	327	331	PF00017	0.397
LIG_SH2_STAT5	348	351	PF00017	0.463
LIG_SH2_STAT5	8	11	PF00017	0.339
LIG_SH3_3	222	228	PF00018	0.444
LIG_SUMO_SIM_anti_2	257	264	PF11976	0.385
LIG_SUMO_SIM_anti_2	284	290	PF11976	0.449
LIG_SUMO_SIM_par_1	257	264	PF11976	0.475
LIG_TRAF2_1	15	18	PF00917	0.282
LIG_WRC_WIRS_1	194	199	PF05994	0.328
LIG_WW_3	223	227	PF00397	0.223
MOD_CDC14_SPxK_1	186	189	PF00782	0.475
MOD_CDK_SPxK_1	183	189	PF00069	0.475
MOD_CDK_SPxxK_3	183	190	PF00069	0.475
MOD_CDK_SPxxK_3	199	206	PF00069	0.211
MOD_CK1_1	215	221	PF00069	0.430
MOD_CK1_1	234	240	PF00069	0.172
MOD_CK1_1	242	248	PF00069	0.215
MOD_CK2_1	12	18	PF00069	0.362
MOD_CK2_1	224	230	PF00069	0.428
MOD_CK2_1	67	73	PF00069	0.510
MOD_GlcNHglycan	165	168	PF01048	0.268
MOD_GlcNHglycan	214	217	PF01048	0.423
MOD_GSK3_1	119	126	PF00069	0.425
MOD_GSK3_1	195	202	PF00069	0.438
MOD_GSK3_1	208	215	PF00069	0.364
MOD_GSK3_1	376	383	PF00069	0.438
MOD_N-GLC_1	380	385	PF02516	0.481
MOD_N-GLC_1	91	96	PF02516	0.556
MOD_N-GLC_2	179	181	PF02516	0.223
MOD_NEK2_1	1	6	PF00069	0.605
MOD_NEK2_1	119	124	PF00069	0.389
MOD_NEK2_1	145	150	PF00069	0.423
MOD_NEK2_1	267	272	PF00069	0.339
MOD_NEK2_1	7	12	PF00069	0.518
MOD_NEK2_2	236	241	PF00069	0.475
MOD_PIKK_1	217	223	PF00454	0.475
MOD_PKA_1	311	317	PF00069	0.437
MOD_PKA_2	311	317	PF00069	0.437
MOD_PKA_2	67	73	PF00069	0.510
MOD_Plk_1	120	126	PF00069	0.344
MOD_Plk_4	120	126	PF00069	0.324
MOD_Plk_4	67	73	PF00069	0.501
MOD_ProDKin_1	183	189	PF00069	0.455
MOD_ProDKin_1	199	205	PF00069	0.368
MOD_ProDKin_1	224	230	PF00069	0.453
MOD_ProDKin_1	239	245	PF00069	0.427
MOD_ProDKin_1	320	326	PF00069	0.223
MOD_ProDKin_1	353	359	PF00069	0.437
MOD_SUMO_rev_2	138	148	PF00179	0.446
TRG_DiLeu_BaEn_1	83	88	PF01217	0.514
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.451
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.223
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.514
TRG_ENDOCYTIC_2	109	112	PF00928	0.469
TRG_ENDOCYTIC_2	134	137	PF00928	0.223
TRG_ENDOCYTIC_2	327	330	PF00928	0.397
TRG_ER_diArg_1	188	190	PF00400	0.392
TRG_ER_diArg_1	25	28	PF00400	0.318
TRG_ER_diArg_1	310	313	PF00400	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC88	Leptomonas seymouri	57%	99%
A0A0S4JTC1	Bodo saltans	39%	100%
A0A1X0P072	Trypanosomatidae	41%	100%
A0A3S5IRD0	Trypanosoma rangeli	44%	100%
A0A3S7XBX8	Leishmania donovani	81%	100%
A4IDV7	Leishmania infantum	82%	100%
D0A459	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ATX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q0L8	Leishmania major	81%	100%
V5DLQ3	Trypanosoma cruzi	42%	100%