Branchpoint-bridging protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

branch point binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ57_LEIBR

TriTrypDb:

LbrM.35.5680 , LBRM2903_350068300

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HQ57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ57

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	12
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	12
GO:0000398	mRNA splicing, via spliceosome	8	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008380	RNA splicing	7	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0010468	regulation of gene expression	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0043484	regulation of RNA splicing	6	1
GO:0048024	regulation of mRNA splicing, via spliceosome	7	1
GO:0050684	regulation of mRNA processing	7	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903311	regulation of mRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0036002	pre-mRNA binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0045131	pre-mRNA branch point binding	6	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.470
CLV_NRD_NRD_1	218	220	PF00675	0.497
CLV_NRD_NRD_1	238	240	PF00675	0.631
CLV_NRD_NRD_1	260	262	PF00675	0.800
CLV_PCSK_KEX2_1	118	120	PF00082	0.451
CLV_PCSK_KEX2_1	217	219	PF00082	0.492
CLV_PCSK_KEX2_1	238	240	PF00082	0.631
CLV_PCSK_KEX2_1	262	264	PF00082	0.678
CLV_PCSK_KEX2_1	87	89	PF00082	0.487
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.616
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.673
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.458
CLV_PCSK_PC7_1	213	219	PF00082	0.517
CLV_PCSK_SKI1_1	159	163	PF00082	0.314
CLV_PCSK_SKI1_1	37	41	PF00082	0.445
CLV_TASPASE1	222	228	PF01112	0.628
DEG_APCC_DBOX_1	36	44	PF00400	0.456
DEG_COP1_1	10	22	PF00400	0.605
DOC_PP1_RVXF_1	116	123	PF00149	0.541
DOC_PP1_RVXF_1	196	202	PF00149	0.507
DOC_PP2B_LxvP_1	17	20	PF13499	0.538
DOC_USP7_MATH_1	110	114	PF00917	0.668
DOC_USP7_MATH_2	2	8	PF00917	0.688
DOC_WW_Pin1_4	76	81	PF00397	0.485
LIG_14-3-3_CanoR_1	119	127	PF00244	0.444
LIG_14-3-3_CanoR_1	183	192	PF00244	0.521
LIG_14-3-3_CanoR_1	8	14	PF00244	0.597
LIG_Actin_WH2_2	150	168	PF00022	0.596
LIG_BIR_III_4	71	75	PF00653	0.648
LIG_FHA_1	160	166	PF00498	0.507
LIG_FHA_2	185	191	PF00498	0.600
LIG_FHA_2	192	198	PF00498	0.604
LIG_FHA_2	232	238	PF00498	0.630
LIG_FHA_2	99	105	PF00498	0.573
LIG_LIR_Gen_1	11	22	PF02991	0.533
LIG_LIR_Nem_3	11	17	PF02991	0.542
LIG_LIR_Nem_3	129	135	PF02991	0.563
LIG_PDZ_Class_3	279	284	PF00595	0.596
LIG_Pex14_2	35	39	PF04695	0.418
LIG_SH2_CRK	14	18	PF00017	0.518
LIG_SH2_GRB2like	14	17	PF00017	0.502
LIG_SH2_SRC	22	25	PF00017	0.496
LIG_SH2_STAT5	102	105	PF00017	0.601
LIG_SH2_STAT5	121	124	PF00017	0.463
LIG_SH2_STAT5	14	17	PF00017	0.509
LIG_SH2_STAT5	22	25	PF00017	0.519
LIG_SH2_STAT5	60	63	PF00017	0.468
LIG_SH3_1	62	68	PF00018	0.574
LIG_SH3_3	62	68	PF00018	0.495
LIG_TRAF2_1	187	190	PF00917	0.558
LIG_TRAF2_1	269	272	PF00917	0.679
MOD_CK1_1	7	13	PF00069	0.544
MOD_CK2_1	184	190	PF00069	0.572
MOD_CK2_1	191	197	PF00069	0.505
MOD_CK2_1	231	237	PF00069	0.507
MOD_CK2_1	98	104	PF00069	0.541
MOD_Cter_Amidation	259	262	PF01082	0.747
MOD_GlcNHglycan	71	75	PF01048	0.577
MOD_GSK3_1	18	25	PF00069	0.604
MOD_GSK3_1	70	77	PF00069	0.698
MOD_N-GLC_1	110	115	PF02516	0.602
MOD_N-GLC_1	74	79	PF02516	0.582
MOD_N-GLC_2	55	57	PF02516	0.534
MOD_NEK2_1	165	170	PF00069	0.520
MOD_NEK2_1	51	56	PF00069	0.490
MOD_NEK2_1	98	103	PF00069	0.587
MOD_PKA_2	182	188	PF00069	0.507
MOD_PKA_2	7	13	PF00069	0.554
MOD_Plk_4	18	24	PF00069	0.574
MOD_ProDKin_1	76	82	PF00069	0.486
TRG_DiLeu_BaEn_2	275	281	PF01217	0.673
TRG_DiLeu_BaEn_2	30	36	PF01217	0.534
TRG_DiLeu_BaEn_4	272	278	PF01217	0.691
TRG_ENDOCYTIC_2	14	17	PF00928	0.518
TRG_ER_diArg_1	118	120	PF00400	0.470
TRG_ER_diArg_1	217	219	PF00400	0.505
TRG_ER_diArg_1	261	264	PF00400	0.573
TRG_ER_diArg_1	88	91	PF00400	0.540
TRG_NLS_MonoExtC_3	260	265	PF00514	0.569
TRG_NLS_MonoExtN_4	238	243	PF00514	0.610
TRG_NLS_MonoExtN_4	259	265	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAH9	Leptomonas seymouri	82%	100%
A0A0S4JQ68	Bodo saltans	45%	97%
A0A1X0P0K4	Trypanosomatidae	54%	100%
A0A3Q8IJ64	Leishmania donovani	93%	98%
A0A3R7MP14	Trypanosoma rangeli	52%	100%
A4IDV6	Leishmania infantum	93%	98%
D0A460	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ATX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	98%
Q4Q0L9	Leishmania major	95%	100%
V5B558	Trypanosoma cruzi	54%	93%