Mitochondrial chaperone bcs1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial chaperone BCS1, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ55_LEIBR

TriTrypDb:

LbrM.35.5660 , LBRM2903_350068100

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	11
GO:0016020	membrane	2	11
GO:0019866	organelle inner membrane	4	11
GO:0031090	organelle membrane	3	11
GO:0031966	mitochondrial membrane	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HQ55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ55

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	229	231	PF00675	0.364
CLV_NRD_NRD_1	272	274	PF00675	0.336
CLV_NRD_NRD_1	309	311	PF00675	0.374
CLV_NRD_NRD_1	361	363	PF00675	0.431
CLV_NRD_NRD_1	38	40	PF00675	0.592
CLV_NRD_NRD_1	466	468	PF00675	0.401
CLV_NRD_NRD_1	6	8	PF00675	0.465
CLV_NRD_NRD_1	62	64	PF00675	0.492
CLV_PCSK_FUR_1	270	274	PF00082	0.355
CLV_PCSK_FUR_1	35	39	PF00082	0.571
CLV_PCSK_KEX2_1	228	230	PF00082	0.368
CLV_PCSK_KEX2_1	272	274	PF00082	0.318
CLV_PCSK_KEX2_1	309	311	PF00082	0.374
CLV_PCSK_KEX2_1	361	363	PF00082	0.431
CLV_PCSK_KEX2_1	37	39	PF00082	0.599
CLV_PCSK_KEX2_1	466	468	PF00082	0.401
CLV_PCSK_KEX2_1	6	8	PF00082	0.465
CLV_PCSK_SKI1_1	144	148	PF00082	0.414
CLV_PCSK_SKI1_1	176	180	PF00082	0.363
CLV_PCSK_SKI1_1	292	296	PF00082	0.377
CLV_PCSK_SKI1_1	362	366	PF00082	0.283
CLV_PCSK_SKI1_1	440	444	PF00082	0.493
DEG_APCC_DBOX_1	271	279	PF00400	0.317
DEG_MDM2_SWIB_1	190	197	PF02201	0.402
DEG_SPOP_SBC_1	115	119	PF00917	0.380
DEG_SPOP_SBC_1	399	403	PF00917	0.578
DOC_ANK_TNKS_1	56	63	PF00023	0.753
DOC_CYCLIN_RxL_1	134	147	PF00134	0.402
DOC_CYCLIN_yCln2_LP_2	333	339	PF00134	0.319
DOC_MAPK_DCC_7	139	148	PF00069	0.294
DOC_MAPK_gen_1	134	143	PF00069	0.391
DOC_MAPK_gen_1	213	223	PF00069	0.319
DOC_MAPK_gen_1	270	280	PF00069	0.315
DOC_MAPK_gen_1	361	367	PF00069	0.405
DOC_MAPK_gen_1	460	470	PF00069	0.424
DOC_MAPK_gen_1	6	14	PF00069	0.437
DOC_MAPK_MEF2A_6	216	225	PF00069	0.294
DOC_MAPK_MEF2A_6	249	256	PF00069	0.296
DOC_PP1_RVXF_1	464	471	PF00149	0.400
DOC_PP1_RVXF_1	8	15	PF00149	0.441
DOC_PP2B_LxvP_1	278	281	PF13499	0.374
DOC_PP2B_LxvP_1	304	307	PF13499	0.418
DOC_PP2B_LxvP_1	333	336	PF13499	0.294
DOC_PP4_FxxP_1	18	21	PF00568	0.461
DOC_USP7_MATH_1	167	171	PF00917	0.303
DOC_USP7_MATH_1	200	204	PF00917	0.177
DOC_USP7_MATH_1	360	364	PF00917	0.418
DOC_USP7_MATH_1	387	391	PF00917	0.639
DOC_USP7_MATH_1	65	69	PF00917	0.703
DOC_USP7_MATH_1	96	100	PF00917	0.374
DOC_WW_Pin1_4	17	22	PF00397	0.648
DOC_WW_Pin1_4	383	388	PF00397	0.636
DOC_WW_Pin1_4	405	410	PF00397	0.689
DOC_WW_Pin1_4	516	521	PF00397	0.434
LIG_14-3-3_CanoR_1	116	125	PF00244	0.406
LIG_14-3-3_CanoR_1	189	195	PF00244	0.346
LIG_14-3-3_CanoR_1	249	253	PF00244	0.303
LIG_14-3-3_CanoR_1	272	281	PF00244	0.322
LIG_14-3-3_CanoR_1	419	425	PF00244	0.549
LIG_14-3-3_CanoR_1	47	53	PF00244	0.481
LIG_14-3-3_CanoR_1	538	547	PF00244	0.526
LIG_Actin_WH2_2	173	191	PF00022	0.315
LIG_BIR_II_1	1	5	PF00653	0.427
LIG_BRCT_BRCA1_1	118	122	PF00533	0.380
LIG_FHA_1	110	116	PF00498	0.289
LIG_FHA_1	249	255	PF00498	0.294
LIG_FHA_1	275	281	PF00498	0.365
LIG_FHA_1	282	288	PF00498	0.360
LIG_FHA_1	321	327	PF00498	0.355
LIG_FHA_1	354	360	PF00498	0.442
LIG_FHA_1	447	453	PF00498	0.499
LIG_FHA_2	109	115	PF00498	0.335
LIG_FHA_2	145	151	PF00498	0.364
LIG_FHA_2	196	202	PF00498	0.402
LIG_FHA_2	443	449	PF00498	0.361
LIG_GBD_Chelix_1	82	90	PF00786	0.451
LIG_Integrin_RGD_1	44	46	PF01839	0.489
LIG_LIR_Gen_1	119	129	PF02991	0.310
LIG_LIR_Gen_1	192	200	PF02991	0.396
LIG_LIR_Gen_1	300	307	PF02991	0.371
LIG_LIR_Gen_1	529	536	PF02991	0.502
LIG_LIR_Gen_1	88	96	PF02991	0.289
LIG_LIR_Gen_1	99	110	PF02991	0.185
LIG_LIR_Nem_3	119	125	PF02991	0.288
LIG_LIR_Nem_3	192	197	PF02991	0.396
LIG_LIR_Nem_3	300	304	PF02991	0.398
LIG_LIR_Nem_3	529	535	PF02991	0.527
LIG_LIR_Nem_3	88	94	PF02991	0.240
LIG_LIR_Nem_3	99	105	PF02991	0.185
LIG_NRBOX	423	429	PF00104	0.386
LIG_Pex14_1	308	312	PF04695	0.336
LIG_Pex14_2	14	18	PF04695	0.470
LIG_Pex14_2	190	194	PF04695	0.346
LIG_REV1ctd_RIR_1	223	234	PF16727	0.319
LIG_SH2_CRK	301	305	PF00017	0.426
LIG_SH2_CRK	5	9	PF00017	0.427
LIG_SH2_STAP1	410	414	PF00017	0.619
LIG_SH2_STAP1	532	536	PF00017	0.455
LIG_SH2_STAT5	196	199	PF00017	0.402
LIG_SH2_STAT5	255	258	PF00017	0.294
LIG_SH2_STAT5	279	282	PF00017	0.419
LIG_SH2_STAT5	312	315	PF00017	0.326
LIG_SH3_3	403	409	PF00018	0.627
LIG_SUMO_SIM_anti_2	363	369	PF11976	0.330
LIG_SUMO_SIM_par_1	111	119	PF11976	0.305
LIG_SUMO_SIM_par_1	144	151	PF11976	0.294
LIG_SUMO_SIM_par_1	338	345	PF11976	0.306
LIG_SUMO_SIM_par_1	348	358	PF11976	0.299
LIG_SUMO_SIM_par_1	363	369	PF11976	0.288
LIG_SUMO_SIM_par_1	440	446	PF11976	0.360
LIG_TRAF2_1	118	121	PF00917	0.289
LIG_UBA3_1	293	298	PF00899	0.477
LIG_UBA3_1	366	375	PF00899	0.340
LIG_WRC_WIRS_1	532	537	PF05994	0.344
MOD_CDK_SPK_2	383	388	PF00069	0.473
MOD_CK1_1	108	114	PF00069	0.303
MOD_CK1_1	161	167	PF00069	0.402
MOD_CK1_1	341	347	PF00069	0.350
MOD_CK1_1	354	360	PF00069	0.364
MOD_CK1_1	383	389	PF00069	0.634
MOD_CK1_1	408	414	PF00069	0.531
MOD_CK1_1	420	426	PF00069	0.289
MOD_CK1_1	534	540	PF00069	0.497
MOD_CK2_1	108	114	PF00069	0.371
MOD_CK2_1	115	121	PF00069	0.252
MOD_CK2_1	195	201	PF00069	0.402
MOD_CK2_1	432	438	PF00069	0.503
MOD_CK2_1	492	498	PF00069	0.552
MOD_CK2_1	536	542	PF00069	0.352
MOD_Cter_Amidation	61	64	PF01082	0.494
MOD_GlcNHglycan	169	172	PF01048	0.379
MOD_GlcNHglycan	377	380	PF01048	0.346
MOD_GlcNHglycan	382	385	PF01048	0.657
MOD_GlcNHglycan	419	422	PF01048	0.384
MOD_GlcNHglycan	424	427	PF01048	0.452
MOD_GlcNHglycan	494	497	PF01048	0.513
MOD_GlcNHglycan	503	506	PF01048	0.506
MOD_GlcNHglycan	68	71	PF01048	0.540
MOD_GlcNHglycan	87	90	PF01048	0.222
MOD_GlcNHglycan	98	101	PF01048	0.194
MOD_GSK3_1	105	112	PF00069	0.457
MOD_GSK3_1	317	324	PF00069	0.260
MOD_GSK3_1	351	358	PF00069	0.468
MOD_GSK3_1	383	390	PF00069	0.639
MOD_GSK3_1	401	408	PF00069	0.693
MOD_GSK3_1	442	449	PF00069	0.376
MOD_GSK3_1	512	519	PF00069	0.533
MOD_GSK3_1	534	541	PF00069	0.573
MOD_GSK3_1	92	99	PF00069	0.374
MOD_N-GLC_1	24	29	PF02516	0.589
MOD_N-GLC_1	446	451	PF02516	0.460
MOD_NEK2_1	190	195	PF00069	0.282
MOD_NEK2_1	221	226	PF00069	0.386
MOD_NEK2_1	297	302	PF00069	0.406
MOD_NEK2_1	353	358	PF00069	0.335
MOD_NEK2_1	422	427	PF00069	0.509
MOD_NEK2_1	442	447	PF00069	0.378
MOD_NEK2_1	481	486	PF00069	0.412
MOD_NEK2_1	536	541	PF00069	0.603
MOD_NEK2_1	85	90	PF00069	0.332
MOD_NEK2_2	274	279	PF00069	0.319
MOD_PIKK_1	116	122	PF00454	0.380
MOD_PIKK_1	373	379	PF00454	0.233
MOD_PKA_2	115	121	PF00069	0.315
MOD_PKA_2	248	254	PF00069	0.317
MOD_PKA_2	360	366	PF00069	0.340
MOD_PKA_2	46	52	PF00069	0.617
MOD_PKB_1	538	546	PF00069	0.384
MOD_Plk_1	447	453	PF00069	0.438
MOD_Plk_1	481	487	PF00069	0.517
MOD_Plk_1	512	518	PF00069	0.570
MOD_Plk_4	105	111	PF00069	0.427
MOD_Plk_4	190	196	PF00069	0.452
MOD_Plk_4	221	227	PF00069	0.415
MOD_Plk_4	274	280	PF00069	0.347
MOD_Plk_4	321	327	PF00069	0.312
MOD_Plk_4	531	537	PF00069	0.468
MOD_ProDKin_1	17	23	PF00069	0.647
MOD_ProDKin_1	383	389	PF00069	0.635
MOD_ProDKin_1	405	411	PF00069	0.682
MOD_ProDKin_1	516	522	PF00069	0.431
TRG_DiLeu_BaEn_1	438	443	PF01217	0.357
TRG_DiLeu_BaEn_1	498	503	PF01217	0.352
TRG_DiLeu_BaEn_3	289	295	PF01217	0.420
TRG_DiLeu_BaLyEn_6	437	442	PF01217	0.411
TRG_DiLeu_LyEn_5	498	503	PF01217	0.352
TRG_ENDOCYTIC_2	301	304	PF00928	0.401
TRG_ENDOCYTIC_2	532	535	PF00928	0.478
TRG_ER_diArg_1	228	230	PF00400	0.368
TRG_ER_diArg_1	270	273	PF00400	0.333
TRG_ER_diArg_1	308	310	PF00400	0.383
TRG_ER_diArg_1	360	362	PF00400	0.431
TRG_ER_diArg_1	37	39	PF00400	0.590
TRG_ER_diArg_1	466	469	PF00400	0.410
TRG_ER_diArg_1	5	7	PF00400	0.475
TRG_ER_FFAT_2	88	99	PF00635	0.227
TRG_NES_CRM1_1	269	283	PF08389	0.402
TRG_NES_CRM1_1	332	345	PF08389	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFP5	Leptomonas seymouri	70%	100%
A0A0S4IXD9	Bodo saltans	32%	100%
A0A1X0P1R2	Trypanosomatidae	45%	99%
A0A3Q8IUI9	Leishmania donovani	32%	100%
A0A3S7XBS4	Leishmania donovani	88%	100%
A4IDV4	Leishmania infantum	85%	94%
C9ZVE3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A462	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ATX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	91%
P32839	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q4Q0M1	Leishmania major	86%	98%
Q54DY9	Dictyostelium discoideum	29%	100%
Q54HY8	Dictyostelium discoideum	26%	100%
Q5E9H5	Bos taurus	28%	100%
Q7ZTL7	Xenopus laevis	28%	100%
Q7ZV60	Danio rerio	27%	100%
Q9CZP5	Mus musculus	27%	100%
Q9P6Q3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
V5BUW7	Trypanosoma cruzi	46%	99%