Putative NADH dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH dehydrogenase, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ53_LEIBR

TriTrypDb:

LbrM.35.5640 , LBRM2903_350067900

Length:

527

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0020023	kinetoplast	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQ53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ53

Function

Biological processes
Term	Name	Level	Count
GO:0006116	NADH oxidation	3	12
GO:0006734	NADH metabolic process	2	12
GO:0008152	metabolic process	1	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003954	NADH dehydrogenase activity	4	12
GO:0016491	oxidoreductase activity	2	12
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	156	158	PF00675	0.268
CLV_NRD_NRD_1	237	239	PF00675	0.326
CLV_NRD_NRD_1	251	253	PF00675	0.188
CLV_PCSK_KEX2_1	158	160	PF00082	0.263
CLV_PCSK_KEX2_1	178	180	PF00082	0.251
CLV_PCSK_KEX2_1	237	239	PF00082	0.293
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.266
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.266
CLV_PCSK_PC7_1	154	160	PF00082	0.251
CLV_PCSK_SKI1_1	143	147	PF00082	0.447
CLV_PCSK_SKI1_1	148	152	PF00082	0.366
CLV_PCSK_SKI1_1	178	182	PF00082	0.251
CLV_PCSK_SKI1_1	262	266	PF00082	0.217
CLV_PCSK_SKI1_1	290	294	PF00082	0.347
CLV_PCSK_SKI1_1	359	363	PF00082	0.331
CLV_PCSK_SKI1_1	431	435	PF00082	0.398
CLV_PCSK_SKI1_1	96	100	PF00082	0.327
DEG_APCC_DBOX_1	413	421	PF00400	0.320
DEG_Nend_Nbox_1	1	3	PF02207	0.531
DEG_SPOP_SBC_1	53	57	PF00917	0.266
DOC_CKS1_1	47	52	PF01111	0.251
DOC_CKS1_1	520	525	PF01111	0.473
DOC_MAPK_gen_1	178	186	PF00069	0.251
DOC_MAPK_gen_1	237	244	PF00069	0.295
DOC_MAPK_gen_1	252	259	PF00069	0.182
DOC_MAPK_gen_1	414	421	PF00069	0.314
DOC_MAPK_gen_1	96	105	PF00069	0.394
DOC_MAPK_MEF2A_6	243	251	PF00069	0.255
DOC_MAPK_MEF2A_6	414	421	PF00069	0.314
DOC_MAPK_MEF2A_6	8	16	PF00069	0.429
DOC_MAPK_MEF2A_6	96	105	PF00069	0.285
DOC_PP4_FxxP_1	135	138	PF00568	0.251
DOC_USP7_MATH_1	170	174	PF00917	0.379
DOC_USP7_MATH_1	339	343	PF00917	0.251
DOC_USP7_MATH_1	381	385	PF00917	0.429
DOC_USP7_UBL2_3	359	363	PF12436	0.386
DOC_WW_Pin1_4	46	51	PF00397	0.251
DOC_WW_Pin1_4	497	502	PF00397	0.675
DOC_WW_Pin1_4	516	521	PF00397	0.664
LIG_14-3-3_CanoR_1	179	185	PF00244	0.341
LIG_14-3-3_CanoR_1	252	259	PF00244	0.375
LIG_14-3-3_CanoR_1	3	7	PF00244	0.636
LIG_14-3-3_CanoR_1	443	450	PF00244	0.431
LIG_14-3-3_CanoR_1	82	88	PF00244	0.345
LIG_Actin_WH2_2	72	87	PF00022	0.200
LIG_BRCT_BRCA1_1	425	429	PF00533	0.335
LIG_FHA_1	114	120	PF00498	0.285
LIG_FHA_1	132	138	PF00498	0.251
LIG_FHA_1	169	175	PF00498	0.248
LIG_FHA_1	181	187	PF00498	0.310
LIG_FHA_1	210	216	PF00498	0.375
LIG_FHA_1	252	258	PF00498	0.466
LIG_FHA_1	272	278	PF00498	0.124
LIG_FHA_1	287	293	PF00498	0.278
LIG_FHA_1	47	53	PF00498	0.251
LIG_FHA_1	55	61	PF00498	0.251
LIG_FHA_2	170	176	PF00498	0.241
LIG_FHA_2	189	195	PF00498	0.256
LIG_FHA_2	219	225	PF00498	0.277
LIG_FHA_2	458	464	PF00498	0.485
LIG_FHA_2	503	509	PF00498	0.658
LIG_FHA_2	520	526	PF00498	0.732
LIG_LIR_Apic_2	134	138	PF02991	0.251
LIG_LIR_Gen_1	118	127	PF02991	0.285
LIG_LIR_Gen_1	404	413	PF02991	0.336
LIG_LIR_Gen_1	415	424	PF02991	0.310
LIG_LIR_Gen_1	442	453	PF02991	0.473
LIG_LIR_LC3C_4	274	278	PF02991	0.252
LIG_LIR_Nem_3	118	124	PF02991	0.285
LIG_LIR_Nem_3	404	409	PF02991	0.369
LIG_LIR_Nem_3	415	421	PF02991	0.357
LIG_LIR_Nem_3	442	448	PF02991	0.374
LIG_LIR_Nem_3	59	65	PF02991	0.251
LIG_PDZ_Class_3	522	527	PF00595	0.479
LIG_Pex14_1	21	25	PF04695	0.251
LIG_Pex14_1	402	406	PF04695	0.293
LIG_REV1ctd_RIR_1	143	152	PF16727	0.266
LIG_REV1ctd_RIR_1	200	208	PF16727	0.310
LIG_SH2_CRK	121	125	PF00017	0.251
LIG_SH2_CRK	239	243	PF00017	0.327
LIG_SH2_CRK	367	371	PF00017	0.391
LIG_SH2_CRK	445	449	PF00017	0.520
LIG_SH2_PTP2	418	421	PF00017	0.318
LIG_SH2_SRC	418	421	PF00017	0.412
LIG_SH2_STAP1	121	125	PF00017	0.251
LIG_SH2_STAP1	396	400	PF00017	0.228
LIG_SH2_STAP1	445	449	PF00017	0.520
LIG_SH2_STAP1	475	479	PF00017	0.562
LIG_SH2_STAP1	89	93	PF00017	0.345
LIG_SH2_STAT5	123	126	PF00017	0.394
LIG_SH2_STAT5	347	350	PF00017	0.313
LIG_SH2_STAT5	406	409	PF00017	0.335
LIG_SH2_STAT5	418	421	PF00017	0.346
LIG_SH2_STAT5	435	438	PF00017	0.354
LIG_SH2_STAT5	475	478	PF00017	0.669
LIG_SH3_3	44	50	PF00018	0.251
LIG_SH3_3	517	523	PF00018	0.684
LIG_SH3_3	62	68	PF00018	0.251
LIG_SUMO_SIM_par_1	13	19	PF11976	0.251
LIG_SUMO_SIM_par_1	380	387	PF11976	0.360
LIG_TRAF2_1	173	176	PF00917	0.224
LIG_TRAF2_1	449	452	PF00917	0.400
LIG_TRAF2_1	522	525	PF00917	0.722
LIG_TYR_ITIM	119	124	PF00017	0.251
LIG_UBA3_1	409	416	PF00899	0.466
LIG_WRC_WIRS_1	114	119	PF05994	0.266
LIG_WRC_WIRS_1	229	234	PF05994	0.285
MOD_CDK_SPxxK_3	519	526	PF00069	0.739
MOD_CK1_1	369	375	PF00069	0.359
MOD_CK1_1	412	418	PF00069	0.439
MOD_CK2_1	169	175	PF00069	0.299
MOD_CK2_1	188	194	PF00069	0.266
MOD_CK2_1	218	224	PF00069	0.251
MOD_CK2_1	381	387	PF00069	0.245
MOD_CK2_1	455	461	PF00069	0.321
MOD_CK2_1	519	525	PF00069	0.685
MOD_CK2_1	61	67	PF00069	0.310
MOD_GlcNHglycan	267	270	PF01048	0.377
MOD_GlcNHglycan	284	287	PF01048	0.345
MOD_GlcNHglycan	379	382	PF01048	0.307
MOD_GlcNHglycan	403	406	PF01048	0.301
MOD_GlcNHglycan	445	448	PF01048	0.480
MOD_GlcNHglycan	476	479	PF01048	0.556
MOD_GlcNHglycan	482	485	PF01048	0.537
MOD_GSK3_1	113	120	PF00069	0.319
MOD_GSK3_1	228	235	PF00069	0.280
MOD_GSK3_1	278	285	PF00069	0.440
MOD_GSK3_1	377	384	PF00069	0.380
MOD_GSK3_1	401	408	PF00069	0.345
MOD_GSK3_1	437	444	PF00069	0.442
MOD_GSK3_1	451	458	PF00069	0.491
MOD_GSK3_1	470	477	PF00069	0.583
MOD_GSK3_1	493	500	PF00069	0.586
MOD_GSK3_1	502	509	PF00069	0.561
MOD_GSK3_1	52	59	PF00069	0.254
MOD_N-GLC_1	210	215	PF02516	0.363
MOD_N-GLC_1	257	262	PF02516	0.170
MOD_NEK2_1	180	185	PF00069	0.309
MOD_NEK2_1	2	7	PF00069	0.585
MOD_NEK2_1	232	237	PF00069	0.345
MOD_NEK2_1	311	316	PF00069	0.450
MOD_NEK2_1	493	498	PF00069	0.619
MOD_NEK2_1	83	88	PF00069	0.369
MOD_PIKK_1	423	429	PF00454	0.469
MOD_PKA_2	2	8	PF00069	0.539
MOD_PKA_2	251	257	PF00069	0.332
MOD_PKA_2	300	306	PF00069	0.308
MOD_PKA_2	311	317	PF00069	0.358
MOD_Plk_1	210	216	PF00069	0.363
MOD_Plk_1	232	238	PF00069	0.280
MOD_Plk_1	431	437	PF00069	0.345
MOD_Plk_1	441	447	PF00069	0.370
MOD_Plk_1	471	477	PF00069	0.594
MOD_Plk_1	494	500	PF00069	0.489
MOD_Plk_2-3	61	67	PF00069	0.310
MOD_Plk_4	180	186	PF00069	0.310
MOD_Plk_4	2	8	PF00069	0.443
MOD_Plk_4	210	216	PF00069	0.310
MOD_Plk_4	218	224	PF00069	0.194
MOD_Plk_4	405	411	PF00069	0.337
MOD_ProDKin_1	46	52	PF00069	0.251
MOD_ProDKin_1	497	503	PF00069	0.675
MOD_ProDKin_1	516	522	PF00069	0.663
MOD_SUMO_rev_2	173	180	PF00179	0.266
MOD_SUMO_rev_2	201	210	PF00179	0.345
MOD_SUMO_rev_2	90	98	PF00179	0.345
TRG_DiLeu_BaEn_1	176	181	PF01217	0.251
TRG_DiLeu_BaEn_1	351	356	PF01217	0.444
TRG_DiLeu_BaEn_3	141	147	PF01217	0.371
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.251
TRG_DiLeu_LyEn_5	176	181	PF01217	0.251
TRG_ENDOCYTIC_2	121	124	PF00928	0.251
TRG_ENDOCYTIC_2	239	242	PF00928	0.381
TRG_ENDOCYTIC_2	367	370	PF00928	0.378
TRG_ENDOCYTIC_2	396	399	PF00928	0.308
TRG_ENDOCYTIC_2	406	409	PF00928	0.315
TRG_ENDOCYTIC_2	418	421	PF00928	0.318
TRG_ENDOCYTIC_2	445	448	PF00928	0.518
TRG_ER_diArg_1	156	159	PF00400	0.266
TRG_ER_diArg_1	236	238	PF00400	0.301
TRG_NLS_MonoExtN_4	154	161	PF00514	0.266
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P920	Leptomonas seymouri	78%	99%
A0A0S4IWQ4	Bodo saltans	59%	100%
A0A1X0P0A4	Trypanosomatidae	61%	100%
A0A3Q8IL33	Leishmania donovani	85%	100%
A0A3R7KGC5	Trypanosoma rangeli	59%	100%
A4IDV2	Leishmania infantum	85%	100%
D0A465	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9ATX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
F2Z699	Yarrowia lipolytica (strain CLIB 122 / E 150)	32%	91%
M0ZYF3	Solanum tuberosum	42%	100%
O05267	Bacillus subtilis (strain 168)	29%	100%
O14121	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	96%
O43090	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	96%
O80874	Arabidopsis thaliana	42%	100%
P00393	Escherichia coli (strain K12)	27%	100%
P32340	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P40215	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	94%
P73735	Synechocystis sp. (strain PCC 6803 / Kazusa)	25%	100%
P80861	Bacillus subtilis (strain 168)	23%	100%
P95160	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
P95200	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	100%
Q07500	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	97%
Q2FID4	Staphylococcus aureus (strain USA300)	28%	100%
Q2FZV7	Staphylococcus aureus (strain NCTC 8325 / PS 47)	28%	100%
Q2YWP9	Staphylococcus aureus (strain bovine RF122 / ET3-1)	28%	100%
Q49W80	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	26%	100%
Q4L4V6	Staphylococcus haemolyticus (strain JCSC1435)	27%	100%
Q4Q0M3	Leishmania major	85%	100%
Q55CD9	Dictyostelium discoideum	39%	100%
Q5HHE4	Staphylococcus aureus (strain COL)	28%	100%
Q5HQM1	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	27%	100%
Q6GAY5	Staphylococcus aureus (strain MSSA476)	28%	100%
Q6GIE7	Staphylococcus aureus (strain MRSA252)	28%	100%
Q7A6J4	Staphylococcus aureus (strain N315)	28%	100%
Q8CPV5	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	28%	100%
Q8GWA1	Arabidopsis thaliana	41%	100%
Q8GXR9	Arabidopsis thaliana	24%	100%
Q8NXG0	Staphylococcus aureus (strain MW2)	28%	100%
Q99VE0	Staphylococcus aureus (strain Mu50 / ATCC 700699)	28%	100%
Q9SKT7	Arabidopsis thaliana	37%	91%
Q9ST63	Solanum tuberosum	42%	100%
V5DLP7	Trypanosoma cruzi	60%	100%