Putative tyrosine specific protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosine specific protein phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ52_LEIBR

TriTrypDb:

LbrM.35.5630 , LBRM2903_350067800

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ52

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016311	dephosphorylation	5	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004721	phosphoprotein phosphatase activity	3	9
GO:0004725	protein tyrosine phosphatase activity	4	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016791	phosphatase activity	5	9
GO:0042578	phosphoric ester hydrolase activity	4	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:0004722	protein serine/threonine phosphatase activity	4	1
GO:0017018	myosin phosphatase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.581
CLV_NRD_NRD_1	282	284	PF00675	0.316
CLV_NRD_NRD_1	39	41	PF00675	0.482
CLV_NRD_NRD_1	5	7	PF00675	0.445
CLV_PCSK_FUR_1	484	488	PF00082	0.643
CLV_PCSK_KEX2_1	17	19	PF00082	0.511
CLV_PCSK_KEX2_1	282	284	PF00082	0.307
CLV_PCSK_KEX2_1	3	5	PF00082	0.417
CLV_PCSK_KEX2_1	39	41	PF00082	0.482
CLV_PCSK_KEX2_1	486	488	PF00082	0.608
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.369
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.645
CLV_PCSK_SKI1_1	180	184	PF00082	0.329
CLV_PCSK_SKI1_1	192	196	PF00082	0.329
CLV_PCSK_SKI1_1	299	303	PF00082	0.480
CLV_PCSK_SKI1_1	316	320	PF00082	0.642
CLV_PCSK_SKI1_1	431	435	PF00082	0.501
DEG_SCF_FBW7_1	317	323	PF00400	0.504
DEG_SCF_FBW7_1	327	334	PF00400	0.474
DOC_CKS1_1	317	322	PF01111	0.502
DOC_CKS1_1	372	377	PF01111	0.522
DOC_CYCLIN_RxL_1	177	186	PF00134	0.382
DOC_CYCLIN_yCln2_LP_2	336	342	PF00134	0.648
DOC_CYCLIN_yCln2_LP_2	433	439	PF00134	0.490
DOC_MAPK_DCC_7	99	109	PF00069	0.388
DOC_MAPK_gen_1	226	234	PF00069	0.212
DOC_MAPK_gen_1	282	289	PF00069	0.341
DOC_MAPK_gen_1	99	106	PF00069	0.388
DOC_MAPK_MEF2A_6	101	109	PF00069	0.388
DOC_MAPK_MEF2A_6	242	251	PF00069	0.294
DOC_PP2B_LxvP_1	336	339	PF13499	0.748
DOC_PP2B_LxvP_1	433	436	PF13499	0.600
DOC_PP4_FxxP_1	102	105	PF00568	0.294
DOC_USP7_MATH_1	208	212	PF00917	0.329
DOC_USP7_MATH_1	404	408	PF00917	0.800
DOC_USP7_UBL2_3	3	7	PF12436	0.370
DOC_WW_Pin1_4	110	115	PF00397	0.212
DOC_WW_Pin1_4	221	226	PF00397	0.396
DOC_WW_Pin1_4	227	232	PF00397	0.348
DOC_WW_Pin1_4	316	321	PF00397	0.640
DOC_WW_Pin1_4	327	332	PF00397	0.645
DOC_WW_Pin1_4	371	376	PF00397	0.665
DOC_WW_Pin1_4	394	399	PF00397	0.686
DOC_WW_Pin1_4	400	405	PF00397	0.755
DOC_WW_Pin1_4	411	416	PF00397	0.680
DOC_WW_Pin1_4	460	465	PF00397	0.714
DOC_WW_Pin1_4	486	491	PF00397	0.651
LIG_14-3-3_CanoR_1	299	308	PF00244	0.447
LIG_14-3-3_CanoR_1	357	363	PF00244	0.639
LIG_14-3-3_CanoR_1	424	429	PF00244	0.715
LIG_14-3-3_CanoR_1	467	472	PF00244	0.591
LIG_BRCT_BRCA1_1	102	106	PF00533	0.212
LIG_FHA_1	317	323	PF00498	0.510
LIG_FHA_1	331	337	PF00498	0.673
LIG_FHA_1	460	466	PF00498	0.739
LIG_FHA_1	467	473	PF00498	0.612
LIG_FHA_2	116	122	PF00498	0.267
LIG_FHA_2	199	205	PF00498	0.445
LIG_FHA_2	211	217	PF00498	0.405
LIG_FHA_2	24	30	PF00498	0.346
LIG_FHA_2	321	327	PF00498	0.695
LIG_Integrin_RGD_1	188	190	PF01839	0.349
LIG_LIR_Apic_2	100	105	PF02991	0.388
LIG_LIR_Gen_1	103	114	PF02991	0.345
LIG_LIR_Gen_1	130	140	PF02991	0.294
LIG_LIR_Gen_1	284	293	PF02991	0.294
LIG_LIR_Nem_3	103	109	PF02991	0.340
LIG_LIR_Nem_3	121	126	PF02991	0.304
LIG_LIR_Nem_3	148	154	PF02991	0.409
LIG_LIR_Nem_3	21	27	PF02991	0.457
LIG_LIR_Nem_3	243	249	PF02991	0.329
LIG_LIR_Nem_3	284	289	PF02991	0.294
LIG_LIR_Nem_3	350	356	PF02991	0.656
LIG_LIR_Nem_3	432	437	PF02991	0.544
LIG_LYPXL_S_1	23	27	PF13949	0.523
LIG_LYPXL_yS_3	24	27	PF13949	0.526
LIG_OCRL_FandH_1	245	257	PF00620	0.329
LIG_PCNA_yPIPBox_3	294	305	PF02747	0.419
LIG_Pex14_1	123	127	PF04695	0.294
LIG_Pex14_2	102	106	PF04695	0.294
LIG_PTB_Apo_2	89	96	PF02174	0.294
LIG_PTB_Phospho_1	89	95	PF10480	0.267
LIG_SH2_GRB2like	127	130	PF00017	0.388
LIG_SH2_GRB2like	90	93	PF00017	0.294
LIG_SH2_PTP2	286	289	PF00017	0.329
LIG_SH2_SRC	90	93	PF00017	0.330
LIG_SH2_SRC	95	98	PF00017	0.330
LIG_SH2_STAP1	53	57	PF00017	0.372
LIG_SH2_STAT3	291	294	PF00017	0.329
LIG_SH2_STAT5	108	111	PF00017	0.330
LIG_SH2_STAT5	199	202	PF00017	0.294
LIG_SH2_STAT5	271	274	PF00017	0.340
LIG_SH2_STAT5	286	289	PF00017	0.279
LIG_SH2_STAT5	390	393	PF00017	0.457
LIG_SH2_STAT5	44	47	PF00017	0.411
LIG_SH2_STAT5	90	93	PF00017	0.330
LIG_SH2_STAT5	95	98	PF00017	0.330
LIG_SH3_3	435	441	PF00018	0.632
LIG_SUMO_SIM_anti_2	210	216	PF11976	0.374
LIG_SUMO_SIM_par_1	162	167	PF11976	0.388
LIG_TRAF2_1	139	142	PF00917	0.212
LIG_UBA3_1	214	223	PF00899	0.294
LIG_UBA3_1	352	360	PF00899	0.489
MOD_CDC14_SPxK_1	113	116	PF00782	0.212
MOD_CDK_SPK_2	221	226	PF00069	0.374
MOD_CDK_SPK_2	371	376	PF00069	0.529
MOD_CDK_SPxK_1	110	116	PF00069	0.212
MOD_CDK_SPxxK_3	371	378	PF00069	0.520
MOD_CDK_SPxxK_3	460	467	PF00069	0.660
MOD_CK1_1	210	216	PF00069	0.369
MOD_CK1_1	224	230	PF00069	0.234
MOD_CK1_1	351	357	PF00069	0.654
MOD_CK1_1	358	364	PF00069	0.623
MOD_CK1_1	371	377	PF00069	0.592
MOD_CK1_1	397	403	PF00069	0.729
MOD_CK1_1	427	433	PF00069	0.693
MOD_CK1_1	451	457	PF00069	0.737
MOD_CK1_1	459	465	PF00069	0.701
MOD_CK1_1	56	62	PF00069	0.395
MOD_CK2_1	210	216	PF00069	0.388
MOD_CK2_1	411	417	PF00069	0.533
MOD_Cter_Amidation	280	283	PF01082	0.212
MOD_GlcNHglycan	130	133	PF01048	0.389
MOD_GlcNHglycan	236	239	PF01048	0.326
MOD_GlcNHglycan	276	279	PF01048	0.251
MOD_GlcNHglycan	368	371	PF01048	0.745
MOD_GlcNHglycan	399	402	PF01048	0.583
MOD_GlcNHglycan	53	56	PF01048	0.522
MOD_GSK3_1	217	224	PF00069	0.338
MOD_GSK3_1	316	323	PF00069	0.747
MOD_GSK3_1	327	334	PF00069	0.687
MOD_GSK3_1	347	354	PF00069	0.487
MOD_GSK3_1	358	365	PF00069	0.676
MOD_GSK3_1	393	400	PF00069	0.720
MOD_GSK3_1	406	413	PF00069	0.740
MOD_GSK3_1	423	430	PF00069	0.631
MOD_GSK3_1	447	454	PF00069	0.727
MOD_GSK3_1	455	462	PF00069	0.778
MOD_GSK3_1	53	60	PF00069	0.379
MOD_N-GLC_1	128	133	PF02516	0.449
MOD_N-GLC_1	261	266	PF02516	0.287
MOD_N-GLC_1	404	409	PF02516	0.658
MOD_N-GLC_1	79	84	PF02516	0.287
MOD_NEK2_1	115	120	PF00069	0.308
MOD_NEK2_1	164	169	PF00069	0.415
MOD_NEK2_1	183	188	PF00069	0.366
MOD_NEK2_1	217	222	PF00069	0.401
MOD_NEK2_1	300	305	PF00069	0.454
MOD_NEK2_1	310	315	PF00069	0.603
MOD_NEK2_1	355	360	PF00069	0.636
MOD_NEK2_1	466	471	PF00069	0.747
MOD_NEK2_1	57	62	PF00069	0.428
MOD_NEK2_1	79	84	PF00069	0.429
MOD_NEK2_2	271	276	PF00069	0.212
MOD_PIKK_1	108	114	PF00454	0.294
MOD_PIKK_1	300	306	PF00454	0.510
MOD_PK_1	368	374	PF00069	0.560
MOD_PKA_2	225	231	PF00069	0.374
MOD_PKA_2	348	354	PF00069	0.560
MOD_PKA_2	356	362	PF00069	0.613
MOD_PKA_2	423	429	PF00069	0.659
MOD_PKA_2	451	457	PF00069	0.713
MOD_PKA_2	466	472	PF00069	0.523
MOD_Plk_1	128	134	PF00069	0.449
MOD_Plk_1	261	267	PF00069	0.287
MOD_Plk_1	79	85	PF00069	0.212
MOD_Plk_4	115	121	PF00069	0.345
MOD_Plk_4	147	153	PF00069	0.388
MOD_Plk_4	210	216	PF00069	0.388
MOD_Plk_4	348	354	PF00069	0.515
MOD_Plk_4	429	435	PF00069	0.630
MOD_Plk_4	467	473	PF00069	0.514
MOD_Plk_4	57	63	PF00069	0.311
MOD_Plk_4	72	78	PF00069	0.403
MOD_ProDKin_1	110	116	PF00069	0.212
MOD_ProDKin_1	221	227	PF00069	0.396
MOD_ProDKin_1	316	322	PF00069	0.642
MOD_ProDKin_1	327	333	PF00069	0.645
MOD_ProDKin_1	371	377	PF00069	0.660
MOD_ProDKin_1	394	400	PF00069	0.694
MOD_ProDKin_1	411	417	PF00069	0.680
MOD_ProDKin_1	460	466	PF00069	0.713
MOD_ProDKin_1	486	492	PF00069	0.654
MOD_SUMO_for_1	146	149	PF00179	0.329
MOD_SUMO_rev_2	186	194	PF00179	0.378
TRG_DiLeu_BaEn_4	474	480	PF01217	0.430
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.695
TRG_ENDOCYTIC_2	151	154	PF00928	0.445
TRG_ENDOCYTIC_2	24	27	PF00928	0.526
TRG_ENDOCYTIC_2	286	289	PF00928	0.294
TRG_ENDOCYTIC_2	290	293	PF00928	0.294
TRG_ER_diArg_1	16	18	PF00400	0.507
TRG_ER_diArg_1	314	317	PF00400	0.560
TRG_ER_diArg_1	38	40	PF00400	0.473
TRG_NLS_MonoExtC_3	2	7	PF00514	0.333
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9E1	Leptomonas seymouri	63%	98%
A0A3Q8ILM2	Leishmania donovani	77%	100%
A0A3R7L1Z6	Trypanosoma rangeli	47%	81%
A4IDV1	Leishmania infantum	77%	100%
E9ATX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q0M4	Leishmania major	75%	100%
V5B554	Trypanosoma cruzi	41%	75%