WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ51_LEIBR

TriTrypDb:

LbrM.35.5620

Length:

534

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.703
CLV_C14_Caspase3-7	384	388	PF00656	0.647
CLV_NRD_NRD_1	23	25	PF00675	0.575
CLV_NRD_NRD_1	287	289	PF00675	0.662
CLV_NRD_NRD_1	323	325	PF00675	0.551
CLV_PCSK_KEX2_1	127	129	PF00082	0.311
CLV_PCSK_KEX2_1	21	23	PF00082	0.576
CLV_PCSK_KEX2_1	287	289	PF00082	0.617
CLV_PCSK_KEX2_1	325	327	PF00082	0.633
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.366
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.614
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.633
CLV_PCSK_PC7_1	18	24	PF00082	0.498
CLV_PCSK_SKI1_1	151	155	PF00082	0.602
CLV_PCSK_SKI1_1	18	22	PF00082	0.534
CLV_PCSK_SKI1_1	37	41	PF00082	0.534
CLV_PCSK_SKI1_1	420	424	PF00082	0.383
DEG_Kelch_actinfilin_1	78	82	PF01344	0.366
DEG_Nend_UBRbox_2	1	3	PF02207	0.538
DOC_AGCK_PIF_1	498	503	PF00069	0.332
DOC_CYCLIN_yClb1_LxF_4	418	423	PF00134	0.505
DOC_MAPK_DCC_7	352	360	PF00069	0.343
DOC_MAPK_gen_1	324	332	PF00069	0.492
DOC_MAPK_gen_1	37	46	PF00069	0.514
DOC_MAPK_MEF2A_6	352	360	PF00069	0.536
DOC_MAPK_MEF2A_6	37	46	PF00069	0.514
DOC_MAPK_MEF2A_6	485	494	PF00069	0.637
DOC_MAPK_MEF2A_6	77	84	PF00069	0.371
DOC_PP1_RVXF_1	168	174	PF00149	0.563
DOC_PP1_RVXF_1	217	224	PF00149	0.612
DOC_PP1_RVXF_1	418	424	PF00149	0.286
DOC_PP2B_LxvP_1	397	400	PF13499	0.529
DOC_PP2B_PxIxI_1	399	405	PF00149	0.353
DOC_SPAK_OSR1_1	72	76	PF12202	0.422
DOC_USP7_MATH_1	301	305	PF00917	0.620
DOC_USP7_MATH_1	331	335	PF00917	0.596
DOC_USP7_MATH_1	347	351	PF00917	0.610
DOC_USP7_MATH_1	52	56	PF00917	0.469
DOC_USP7_MATH_1	90	94	PF00917	0.673
DOC_WW_Pin1_4	191	196	PF00397	0.521
DOC_WW_Pin1_4	262	267	PF00397	0.612
DOC_WW_Pin1_4	269	274	PF00397	0.510
DOC_WW_Pin1_4	395	400	PF00397	0.625
DOC_WW_Pin1_4	99	104	PF00397	0.604
LIG_14-3-3_CanoR_1	108	118	PF00244	0.332
LIG_14-3-3_CanoR_1	170	174	PF00244	0.491
LIG_14-3-3_CanoR_1	390	400	PF00244	0.514
LIG_BRCT_BRCA1_1	219	223	PF00533	0.354
LIG_BRCT_BRCA1_1	494	498	PF00533	0.469
LIG_BRCT_BRCA1_1	54	58	PF00533	0.735
LIG_FHA_1	176	182	PF00498	0.441
LIG_FHA_1	192	198	PF00498	0.353
LIG_FHA_1	213	219	PF00498	0.582
LIG_FHA_1	234	240	PF00498	0.450
LIG_FHA_1	243	249	PF00498	0.408
LIG_FHA_1	284	290	PF00498	0.706
LIG_FHA_1	355	361	PF00498	0.491
LIG_FHA_1	485	491	PF00498	0.469
LIG_FHA_1	5	11	PF00498	0.536
LIG_FHA_1	514	520	PF00498	0.335
LIG_FHA_2	112	118	PF00498	0.563
LIG_FHA_2	239	245	PF00498	0.498
LIG_FHA_2	294	300	PF00498	0.448
LIG_LIR_Gen_1	136	146	PF02991	0.585
LIG_LIR_Gen_1	375	383	PF02991	0.612
LIG_LIR_Nem_3	129	134	PF02991	0.441
LIG_LIR_Nem_3	136	142	PF02991	0.539
LIG_LIR_Nem_3	172	176	PF02991	0.502
LIG_LIR_Nem_3	29	35	PF02991	0.513
LIG_LIR_Nem_3	375	380	PF02991	0.549
LIG_LIR_Nem_3	465	470	PF02991	0.605
LIG_LIR_Nem_3	61	66	PF02991	0.704
LIG_LYPXL_S_1	412	416	PF13949	0.454
LIG_LYPXL_yS_3	32	35	PF13949	0.487
LIG_LYPXL_yS_3	413	416	PF13949	0.455
LIG_MLH1_MIPbox_1	54	58	PF16413	0.742
LIG_PDZ_Class_1	529	534	PF00595	0.427
LIG_SH2_CRK	63	67	PF00017	0.717
LIG_SH2_SRC	122	125	PF00017	0.544
LIG_SH2_SRC	424	427	PF00017	0.565
LIG_SH2_STAP1	28	32	PF00017	0.676
LIG_SH2_STAT5	122	125	PF00017	0.532
LIG_SH2_STAT5	28	31	PF00017	0.480
LIG_SH3_3	270	276	PF00018	0.651
LIG_SH3_3	278	284	PF00018	0.544
LIG_SH3_3	30	36	PF00018	0.487
LIG_SH3_3	72	78	PF00018	0.630
LIG_SUMO_SIM_par_1	152	158	PF11976	0.521
LIG_SUMO_SIM_par_1	236	245	PF11976	0.448
LIG_SUMO_SIM_par_1	256	263	PF11976	0.227
LIG_SUMO_SIM_par_1	315	322	PF11976	0.491
LIG_SUMO_SIM_par_1	328	334	PF11976	0.523
LIG_SUMO_SIM_par_1	78	83	PF11976	0.369
LIG_TRAF2_1	376	379	PF00917	0.546
LIG_TRFH_1	32	36	PF08558	0.483
LIG_TYR_ITIM	411	416	PF00017	0.454
LIG_UBA3_1	317	325	PF00899	0.517
LIG_WRC_WIRS_1	104	109	PF05994	0.535
MOD_CDC14_SPxK_1	398	401	PF00782	0.596
MOD_CDK_SPxK_1	395	401	PF00069	0.620
MOD_CK1_1	112	118	PF00069	0.523
MOD_CK1_1	126	132	PF00069	0.254
MOD_CK1_1	135	141	PF00069	0.465
MOD_CK1_1	147	153	PF00069	0.383
MOD_CK1_1	234	240	PF00069	0.571
MOD_CK1_1	388	394	PF00069	0.545
MOD_CK1_1	465	471	PF00069	0.576
MOD_CK1_1	499	505	PF00069	0.512
MOD_CK2_1	293	299	PF00069	0.517
MOD_CK2_1	372	378	PF00069	0.506
MOD_CK2_1	465	471	PF00069	0.586
MOD_GlcNHglycan	128	131	PF01048	0.547
MOD_GlcNHglycan	157	160	PF01048	0.549
MOD_GlcNHglycan	191	194	PF01048	0.469
MOD_GlcNHglycan	232	236	PF01048	0.513
MOD_GlcNHglycan	255	258	PF01048	0.350
MOD_GlcNHglycan	363	366	PF01048	0.577
MOD_GlcNHglycan	393	396	PF01048	0.582
MOD_GlcNHglycan	434	439	PF01048	0.514
MOD_GlcNHglycan	453	456	PF01048	0.540
MOD_GlcNHglycan	508	511	PF01048	0.412
MOD_GlcNHglycan	54	57	PF01048	0.690
MOD_GSK3_1	134	141	PF00069	0.351
MOD_GSK3_1	180	187	PF00069	0.563
MOD_GSK3_1	234	241	PF00069	0.459
MOD_GSK3_1	249	256	PF00069	0.354
MOD_GSK3_1	342	349	PF00069	0.468
MOD_GSK3_1	368	375	PF00069	0.513
MOD_GSK3_1	378	385	PF00069	0.426
MOD_GSK3_1	391	398	PF00069	0.568
MOD_GSK3_1	430	437	PF00069	0.675
MOD_GSK3_1	465	472	PF00069	0.555
MOD_GSK3_1	484	491	PF00069	0.663
MOD_GSK3_1	492	499	PF00069	0.441
MOD_GSK3_1	504	511	PF00069	0.360
MOD_GSK3_1	80	87	PF00069	0.571
MOD_GSK3_1	99	106	PF00069	0.326
MOD_N-GLC_2	253	255	PF02516	0.473
MOD_NEK2_1	1	6	PF00069	0.598
MOD_NEK2_1	123	128	PF00069	0.430
MOD_NEK2_1	133	138	PF00069	0.437
MOD_NEK2_1	146	151	PF00069	0.536
MOD_NEK2_1	175	180	PF00069	0.467
MOD_NEK2_1	181	186	PF00069	0.521
MOD_NEK2_1	393	398	PF00069	0.543
MOD_NEK2_1	460	465	PF00069	0.707
MOD_NEK2_1	483	488	PF00069	0.615
MOD_NEK2_1	492	497	PF00069	0.421
MOD_NEK2_1	529	534	PF00069	0.559
MOD_NEK2_1	58	63	PF00069	0.726
MOD_NEK2_2	103	108	PF00069	0.611
MOD_NEK2_2	16	21	PF00069	0.499
MOD_NEK2_2	347	352	PF00069	0.668
MOD_PIKK_1	175	181	PF00454	0.493
MOD_PIKK_1	385	391	PF00454	0.588
MOD_PIKK_1	445	451	PF00454	0.707
MOD_PKA_2	169	175	PF00069	0.538
MOD_PKA_2	368	374	PF00069	0.384
MOD_PKA_2	381	387	PF00069	0.524
MOD_PKA_2	4	10	PF00069	0.641
MOD_Plk_1	16	22	PF00069	0.501
MOD_Plk_1	378	384	PF00069	0.502
MOD_Plk_1	434	440	PF00069	0.643
MOD_Plk_1	499	505	PF00069	0.322
MOD_Plk_2-3	469	475	PF00069	0.721
MOD_Plk_4	135	141	PF00069	0.556
MOD_Plk_4	354	360	PF00069	0.541
MOD_Plk_4	488	494	PF00069	0.538
MOD_Plk_4	80	86	PF00069	0.369
MOD_ProDKin_1	191	197	PF00069	0.517
MOD_ProDKin_1	262	268	PF00069	0.607
MOD_ProDKin_1	269	275	PF00069	0.522
MOD_ProDKin_1	395	401	PF00069	0.620
MOD_ProDKin_1	99	105	PF00069	0.599
MOD_SUMO_rev_2	150	159	PF00179	0.523
TRG_DiLeu_BaEn_1	95	100	PF01217	0.503
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.490
TRG_DiLeu_BaLyEn_6	417	422	PF01217	0.296
TRG_ENDOCYTIC_2	32	35	PF00928	0.512
TRG_ENDOCYTIC_2	413	416	PF00928	0.455
TRG_ENDOCYTIC_2	63	66	PF00928	0.610
TRG_ER_diArg_1	22	24	PF00400	0.549
TRG_ER_diArg_1	287	289	PF00400	0.722
TRG_ER_diArg_1	323	326	PF00400	0.620
TRG_ER_diArg_1	69	72	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	219	224	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	420	425	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC59	Leptomonas seymouri	42%	82%
A0A1X0P468	Trypanosomatidae	26%	92%
A0A3Q8IGL8	Leishmania donovani	75%	98%
A4IC79	Leishmania infantum	75%	98%
E9ATX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	98%
Q4Q0M5	Leishmania major	75%	100%