Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ48_LEIBR

TriTrypDb:

LbrM.35.5590 , LBRM2903_350067500

Length:

852

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	471	475	PF00656	0.555
CLV_C14_Caspase3-7	482	486	PF00656	0.492
CLV_C14_Caspase3-7	834	838	PF00656	0.489
CLV_NRD_NRD_1	124	126	PF00675	0.480
CLV_NRD_NRD_1	158	160	PF00675	0.623
CLV_NRD_NRD_1	246	248	PF00675	0.518
CLV_NRD_NRD_1	292	294	PF00675	0.560
CLV_NRD_NRD_1	380	382	PF00675	0.636
CLV_NRD_NRD_1	424	426	PF00675	0.607
CLV_NRD_NRD_1	452	454	PF00675	0.493
CLV_NRD_NRD_1	489	491	PF00675	0.501
CLV_NRD_NRD_1	520	522	PF00675	0.632
CLV_NRD_NRD_1	53	55	PF00675	0.552
CLV_NRD_NRD_1	555	557	PF00675	0.577
CLV_NRD_NRD_1	715	717	PF00675	0.546
CLV_NRD_NRD_1	722	724	PF00675	0.557
CLV_NRD_NRD_1	75	77	PF00675	0.545
CLV_NRD_NRD_1	809	811	PF00675	0.735
CLV_PCSK_KEX2_1	124	126	PF00082	0.480
CLV_PCSK_KEX2_1	272	274	PF00082	0.494
CLV_PCSK_KEX2_1	280	282	PF00082	0.490
CLV_PCSK_KEX2_1	292	294	PF00082	0.300
CLV_PCSK_KEX2_1	452	454	PF00082	0.436
CLV_PCSK_KEX2_1	488	490	PF00082	0.599
CLV_PCSK_KEX2_1	555	557	PF00082	0.584
CLV_PCSK_KEX2_1	644	646	PF00082	0.480
CLV_PCSK_KEX2_1	715	717	PF00082	0.531
CLV_PCSK_KEX2_1	722	724	PF00082	0.536
CLV_PCSK_KEX2_1	809	811	PF00082	0.572
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.513
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.509
CLV_PCSK_PC1ET2_1	644	646	PF00082	0.480
CLV_PCSK_PC7_1	268	274	PF00082	0.508
CLV_PCSK_SKI1_1	125	129	PF00082	0.490
CLV_PCSK_SKI1_1	178	182	PF00082	0.440
CLV_PCSK_SKI1_1	402	406	PF00082	0.555
CLV_PCSK_SKI1_1	428	432	PF00082	0.608
CLV_PCSK_SKI1_1	477	481	PF00082	0.575
CLV_PCSK_SKI1_1	54	58	PF00082	0.522
CLV_PCSK_SKI1_1	641	645	PF00082	0.577
CLV_PCSK_SKI1_1	661	665	PF00082	0.606
CLV_PCSK_SKI1_1	820	824	PF00082	0.606
CLV_PCSK_SKI1_1	831	835	PF00082	0.556
CLV_Separin_Metazoa	27	31	PF03568	0.641
DEG_APCC_DBOX_1	476	484	PF00400	0.634
DEG_APCC_DBOX_1	67	75	PF00400	0.625
DEG_ODPH_VHL_1	727	738	PF01847	0.390
DOC_CYCLIN_RxL_1	15	25	PF00134	0.424
DOC_CYCLIN_RxL_1	315	325	PF00134	0.588
DOC_MAPK_gen_1	203	212	PF00069	0.503
DOC_MAPK_gen_1	280	287	PF00069	0.541
DOC_MAPK_gen_1	381	388	PF00069	0.603
DOC_MAPK_gen_1	634	642	PF00069	0.583
DOC_MAPK_gen_1	685	693	PF00069	0.670
DOC_MAPK_MEF2A_6	252	259	PF00069	0.470
DOC_MAPK_MEF2A_6	318	326	PF00069	0.498
DOC_MAPK_MEF2A_6	381	388	PF00069	0.601
DOC_MAPK_MEF2A_6	685	693	PF00069	0.670
DOC_MAPK_NFAT4_5	381	389	PF00069	0.505
DOC_MIT_MIM_1	410	419	PF04212	0.516
DOC_PP2B_LxvP_1	726	729	PF13499	0.644
DOC_USP7_MATH_1	295	299	PF00917	0.624
DOC_USP7_MATH_1	479	483	PF00917	0.396
DOC_USP7_MATH_1	812	816	PF00917	0.678
DOC_USP7_UBL2_3	248	252	PF12436	0.629
DOC_USP7_UBL2_3	349	353	PF12436	0.380
DOC_WW_Pin1_4	810	815	PF00397	0.735
DOC_WW_Pin1_4	9	14	PF00397	0.500
LIG_14-3-3_CanoR_1	223	232	PF00244	0.530
LIG_14-3-3_CanoR_1	299	306	PF00244	0.641
LIG_14-3-3_CanoR_1	504	512	PF00244	0.514
LIG_14-3-3_CanoR_1	575	582	PF00244	0.382
LIG_14-3-3_CanoR_1	661	670	PF00244	0.614
LIG_14-3-3_CanoR_1	679	685	PF00244	0.455
LIG_14-3-3_CanoR_1	68	72	PF00244	0.522
LIG_14-3-3_CanoR_1	759	764	PF00244	0.725
LIG_14-3-3_CanoR_1	8	13	PF00244	0.764
LIG_Actin_WH2_2	126	141	PF00022	0.640
LIG_CaM_IQ_9	671	687	PF13499	0.622
LIG_FHA_1	102	108	PF00498	0.623
LIG_FHA_1	128	134	PF00498	0.584
LIG_FHA_1	193	199	PF00498	0.709
LIG_FHA_1	216	222	PF00498	0.590
LIG_FHA_1	333	339	PF00498	0.438
LIG_FHA_1	431	437	PF00498	0.535
LIG_FHA_1	457	463	PF00498	0.607
LIG_FHA_1	528	534	PF00498	0.563
LIG_FHA_1	669	675	PF00498	0.599
LIG_FHA_1	686	692	PF00498	0.502
LIG_FHA_1	784	790	PF00498	0.715
LIG_FHA_2	161	167	PF00498	0.532
LIG_FHA_2	225	231	PF00498	0.533
LIG_FHA_2	260	266	PF00498	0.539
LIG_FHA_2	327	333	PF00498	0.590
LIG_FHA_2	391	397	PF00498	0.570
LIG_FHA_2	403	409	PF00498	0.628
LIG_FHA_2	467	473	PF00498	0.636
LIG_FHA_2	506	512	PF00498	0.563
LIG_FHA_2	619	625	PF00498	0.599
LIG_FHA_2	68	74	PF00498	0.529
LIG_FHA_2	681	687	PF00498	0.603
LIG_FHA_2	751	757	PF00498	0.533
LIG_FHA_2	832	838	PF00498	0.731
LIG_LIR_Apic_2	744	748	PF02991	0.690
LIG_LIR_Gen_1	162	171	PF02991	0.553
LIG_LIR_Gen_1	176	187	PF02991	0.552
LIG_LIR_Gen_1	429	439	PF02991	0.536
LIG_LIR_Gen_1	493	503	PF02991	0.500
LIG_LIR_Gen_1	840	849	PF02991	0.725
LIG_LIR_Nem_3	162	168	PF02991	0.556
LIG_LIR_Nem_3	176	182	PF02991	0.496
LIG_LIR_Nem_3	429	434	PF02991	0.534
LIG_LIR_Nem_3	493	498	PF02991	0.501
LIG_LIR_Nem_3	721	727	PF02991	0.619
LIG_LIR_Nem_3	840	846	PF02991	0.756
LIG_PDZ_Class_1	847	852	PF00595	0.690
LIG_Pex14_1	161	165	PF04695	0.597
LIG_SH2_CRK	165	169	PF00017	0.592
LIG_SH2_CRK	660	664	PF00017	0.523
LIG_SH2_CRK	724	728	PF00017	0.651
LIG_SH2_SRC	154	157	PF00017	0.356
LIG_SH2_STAT3	757	760	PF00017	0.715
LIG_SH2_STAT5	505	508	PF00017	0.366
LIG_SH2_STAT5	526	529	PF00017	0.596
LIG_SH3_3	762	768	PF00018	0.653
LIG_SH3_3	802	808	PF00018	0.664
LIG_SH3_3	841	847	PF00018	0.616
LIG_SUMO_SIM_anti_2	432	438	PF11976	0.523
LIG_SUMO_SIM_par_1	334	340	PF11976	0.356
LIG_TRAF2_1	153	156	PF00917	0.622
LIG_TRAF2_1	171	174	PF00917	0.526
LIG_TRAF2_1	341	344	PF00917	0.579
LIG_TRAF2_1	442	445	PF00917	0.646
LIG_TRAF2_1	508	511	PF00917	0.582
LIG_TRAF2_1	706	709	PF00917	0.642
LIG_TRAF2_1	793	796	PF00917	0.727
LIG_TYR_ITAM	162	182	PF00017	0.502
MOD_CK1_1	298	304	PF00069	0.605
MOD_CK1_1	411	417	PF00069	0.601
MOD_CK1_1	475	481	PF00069	0.555
MOD_CK1_1	545	551	PF00069	0.614
MOD_CK1_1	813	819	PF00069	0.704
MOD_CK1_1	826	832	PF00069	0.719
MOD_CK2_1	188	194	PF00069	0.655
MOD_CK2_1	199	205	PF00069	0.653
MOD_CK2_1	224	230	PF00069	0.591
MOD_CK2_1	259	265	PF00069	0.470
MOD_CK2_1	326	332	PF00069	0.546
MOD_CK2_1	402	408	PF00069	0.599
MOD_CK2_1	466	472	PF00069	0.595
MOD_CK2_1	475	481	PF00069	0.536
MOD_CK2_1	505	511	PF00069	0.555
MOD_CK2_1	618	624	PF00069	0.491
MOD_CK2_1	67	73	PF00069	0.522
MOD_DYRK1A_RPxSP_1	810	814	PF00069	0.515
MOD_GlcNHglycan	120	123	PF01048	0.510
MOD_GlcNHglycan	190	193	PF01048	0.751
MOD_GlcNHglycan	212	215	PF01048	0.679
MOD_GlcNHglycan	286	290	PF01048	0.444
MOD_GlcNHglycan	300	303	PF01048	0.572
MOD_GlcNHglycan	310	313	PF01048	0.456
MOD_GlcNHglycan	477	480	PF01048	0.572
MOD_GlcNHglycan	86	90	PF01048	0.376
MOD_GSK3_1	188	195	PF00069	0.619
MOD_GSK3_1	259	266	PF00069	0.514
MOD_GSK3_1	353	360	PF00069	0.580
MOD_GSK3_1	362	369	PF00069	0.617
MOD_GSK3_1	4	11	PF00069	0.673
MOD_GSK3_1	464	471	PF00069	0.655
MOD_GSK3_1	475	482	PF00069	0.429
MOD_GSK3_1	499	506	PF00069	0.610
MOD_GSK3_1	737	744	PF00069	0.571
MOD_GSK3_1	759	766	PF00069	0.602
MOD_GSK3_1	823	830	PF00069	0.666
MOD_N-GLC_1	679	684	PF02516	0.513
MOD_N-GLC_2	600	602	PF02516	0.370
MOD_NEK2_1	133	138	PF00069	0.599
MOD_NEK2_1	285	290	PF00069	0.555
MOD_NEK2_1	466	471	PF00069	0.580
MOD_NEK2_1	483	488	PF00069	0.603
MOD_NEK2_1	547	552	PF00069	0.641
MOD_NEK2_1	582	587	PF00069	0.385
MOD_NEK2_1	737	742	PF00069	0.474
MOD_PIKK_1	133	139	PF00454	0.602
MOD_PIKK_1	140	146	PF00454	0.608
MOD_PIKK_1	234	240	PF00454	0.520
MOD_PIKK_1	259	265	PF00454	0.467
MOD_PIKK_1	30	36	PF00454	0.579
MOD_PIKK_1	357	363	PF00454	0.551
MOD_PIKK_1	496	502	PF00454	0.372
MOD_PIKK_1	729	735	PF00454	0.393
MOD_PK_1	443	449	PF00069	0.548
MOD_PK_1	823	829	PF00069	0.737
MOD_PKA_1	4	10	PF00069	0.605
MOD_PKA_1	521	527	PF00069	0.628
MOD_PKA_2	138	144	PF00069	0.622
MOD_PKA_2	298	304	PF00069	0.633
MOD_PKA_2	472	478	PF00069	0.425
MOD_PKA_2	503	509	PF00069	0.490
MOD_PKA_2	554	560	PF00069	0.611
MOD_PKA_2	574	580	PF00069	0.638
MOD_PKA_2	67	73	PF00069	0.599
MOD_PKA_2	758	764	PF00069	0.628
MOD_PKA_2	827	833	PF00069	0.734
MOD_Plk_1	133	139	PF00069	0.602
MOD_Plk_1	199	205	PF00069	0.654
MOD_Plk_1	215	221	PF00069	0.618
MOD_Plk_1	241	247	PF00069	0.563
MOD_Plk_1	306	312	PF00069	0.430
MOD_Plk_1	443	449	PF00069	0.451
MOD_Plk_1	679	685	PF00069	0.539
MOD_Plk_1	823	829	PF00069	0.737
MOD_Plk_2-3	332	338	PF00069	0.519
MOD_Plk_4	741	747	PF00069	0.687
MOD_Plk_4	759	765	PF00069	0.452
MOD_Plk_4	801	807	PF00069	0.654
MOD_ProDKin_1	810	816	PF00069	0.737
MOD_ProDKin_1	9	15	PF00069	0.494
MOD_SUMO_for_1	348	351	PF00179	0.627
MOD_SUMO_for_1	442	445	PF00179	0.684
MOD_SUMO_rev_2	174	180	PF00179	0.651
MOD_SUMO_rev_2	265	274	PF00179	0.502
MOD_SUMO_rev_2	350	355	PF00179	0.384
MOD_SUMO_rev_2	50	57	PF00179	0.377
MOD_SUMO_rev_2	73	78	PF00179	0.574
TRG_DiLeu_BaEn_1	217	222	PF01217	0.553
TRG_DiLeu_BaEn_1	251	256	PF01217	0.570
TRG_DiLeu_BaEn_1	52	57	PF01217	0.532
TRG_DiLeu_BaEn_1	708	713	PF01217	0.670
TRG_DiLeu_BaEn_4	510	516	PF01217	0.565
TRG_DiLeu_BaEn_4	52	58	PF01217	0.617
TRG_DiLeu_BaLyEn_6	722	727	PF01217	0.656
TRG_ENDOCYTIC_2	165	168	PF00928	0.570
TRG_ENDOCYTIC_2	179	182	PF00928	0.465
TRG_ENDOCYTIC_2	495	498	PF00928	0.557
TRG_ENDOCYTIC_2	660	663	PF00928	0.529
TRG_ENDOCYTIC_2	724	727	PF00928	0.587
TRG_ER_diArg_1	123	125	PF00400	0.502
TRG_ER_diArg_1	291	293	PF00400	0.584
TRG_ER_diArg_1	45	48	PF00400	0.408
TRG_ER_diArg_1	451	453	PF00400	0.446
TRG_ER_diArg_1	488	490	PF00400	0.379
TRG_ER_diArg_1	715	717	PF00400	0.548
TRG_ER_diArg_1	722	724	PF00400	0.559
TRG_ER_diArg_1	808	810	PF00400	0.731
TRG_NES_CRM1_1	665	678	PF08389	0.591
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	318	323	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	634	639	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	661	665	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	715	719	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	735	739	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ64	Leptomonas seymouri	52%	99%
A0A0S4IKB4	Bodo saltans	26%	100%
A0A1X0P393	Trypanosomatidae	34%	99%
A0A3S7XBY8	Leishmania donovani	78%	99%
A0A422NT20	Trypanosoma rangeli	33%	100%
A4IC76	Leishmania infantum	78%	99%
D0A8R1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ATW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%
Q4Q0M8	Leishmania major	77%	100%