GST_C_6 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glutathione S-transferase, C-terminal domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ46_LEIBR

TriTrypDb:

LbrM.35.5570 , LBRM2903_350067200

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ46

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.651
CLV_C14_Caspase3-7	291	295	PF00656	0.678
CLV_NRD_NRD_1	126	128	PF00675	0.441
CLV_NRD_NRD_1	195	197	PF00675	0.392
CLV_NRD_NRD_1	371	373	PF00675	0.525
CLV_NRD_NRD_1	433	435	PF00675	0.580
CLV_NRD_NRD_1	606	608	PF00675	0.426
CLV_NRD_NRD_1	621	623	PF00675	0.410
CLV_NRD_NRD_1	628	630	PF00675	0.428
CLV_PCSK_KEX2_1	195	197	PF00082	0.298
CLV_PCSK_KEX2_1	371	373	PF00082	0.462
CLV_PCSK_KEX2_1	433	435	PF00082	0.580
CLV_PCSK_KEX2_1	507	509	PF00082	0.553
CLV_PCSK_KEX2_1	606	608	PF00082	0.441
CLV_PCSK_KEX2_1	630	632	PF00082	0.413
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.500
CLV_PCSK_PC1ET2_1	630	632	PF00082	0.397
CLV_PCSK_PC7_1	191	197	PF00082	0.286
CLV_PCSK_SKI1_1	172	176	PF00082	0.369
CLV_PCSK_SKI1_1	233	237	PF00082	0.289
CLV_PCSK_SKI1_1	284	288	PF00082	0.502
CLV_PCSK_SKI1_1	421	425	PF00082	0.420
CLV_PCSK_SKI1_1	55	59	PF00082	0.495
CLV_PCSK_SKI1_1	89	93	PF00082	0.562
CLV_Separin_Metazoa	192	196	PF03568	0.489
DEG_SCF_FBW7_1	235	242	PF00400	0.563
DEG_SCF_FBW7_1	61	66	PF00400	0.628
DEG_SCF_FBW7_2	337	342	PF00400	0.443
DOC_CKS1_1	236	241	PF01111	0.569
DOC_CKS1_1	451	456	PF01111	0.630
DOC_MAPK_DCC_7	172	182	PF00069	0.444
DOC_MAPK_gen_1	157	166	PF00069	0.419
DOC_MAPK_HePTP_8	124	136	PF00069	0.653
DOC_MAPK_MEF2A_6	127	136	PF00069	0.548
DOC_MAPK_MEF2A_6	409	417	PF00069	0.572
DOC_PP4_FxxP_1	13	16	PF00568	0.672
DOC_PP4_FxxP_1	175	178	PF00568	0.444
DOC_PP4_FxxP_1	519	522	PF00568	0.733
DOC_USP7_MATH_1	456	460	PF00917	0.743
DOC_USP7_MATH_1	494	498	PF00917	0.750
DOC_USP7_MATH_1	590	594	PF00917	0.640
DOC_USP7_MATH_1	63	67	PF00917	0.666
DOC_USP7_UBL2_3	468	472	PF12436	0.595
DOC_WW_Pin1_4	12	17	PF00397	0.614
DOC_WW_Pin1_4	235	240	PF00397	0.571
DOC_WW_Pin1_4	335	340	PF00397	0.456
DOC_WW_Pin1_4	439	444	PF00397	0.749
DOC_WW_Pin1_4	450	455	PF00397	0.715
DOC_WW_Pin1_4	5	10	PF00397	0.704
DOC_WW_Pin1_4	59	64	PF00397	0.604
LIG_14-3-3_CanoR_1	217	226	PF00244	0.565
LIG_14-3-3_CanoR_1	284	289	PF00244	0.704
LIG_14-3-3_CanoR_1	325	333	PF00244	0.710
LIG_14-3-3_CanoR_1	36	46	PF00244	0.653
LIG_14-3-3_CanoR_1	537	545	PF00244	0.613
LIG_14-3-3_CanoR_1	562	572	PF00244	0.729
LIG_14-3-3_CanoR_1	581	586	PF00244	0.584
LIG_14-3-3_CanoR_1	629	635	PF00244	0.707
LIG_Actin_WH2_2	18	33	PF00022	0.505
LIG_BIR_II_1	1	5	PF00653	0.766
LIG_BRCT_BRCA1_1	230	234	PF00533	0.518
LIG_BRCT_BRCA1_1	248	252	PF00533	0.537
LIG_Clathr_ClatBox_1	396	400	PF01394	0.621
LIG_CtBP_PxDLS_1	334	338	PF00389	0.582
LIG_CtBP_PxDLS_1	522	526	PF00389	0.590
LIG_eIF4E_1	385	391	PF01652	0.526
LIG_FHA_1	119	125	PF00498	0.691
LIG_FHA_1	16	22	PF00498	0.657
LIG_FHA_1	272	278	PF00498	0.645
LIG_FHA_1	381	387	PF00498	0.712
LIG_FHA_1	42	48	PF00498	0.646
LIG_FHA_1	459	465	PF00498	0.673
LIG_FHA_2	218	224	PF00498	0.449
LIG_FHA_2	240	246	PF00498	0.546
LIG_FHA_2	289	295	PF00498	0.732
LIG_FHA_2	330	336	PF00498	0.646
LIG_FHA_2	440	446	PF00498	0.702
LIG_FHA_2	497	503	PF00498	0.773
LIG_Integrin_RGD_1	160	162	PF01839	0.661
LIG_LIR_Apic_2	383	388	PF02991	0.654
LIG_LIR_Gen_1	138	145	PF02991	0.369
LIG_LIR_Gen_1	212	222	PF02991	0.549
LIG_LIR_Gen_1	26	35	PF02991	0.648
LIG_LIR_Gen_1	338	349	PF02991	0.508
LIG_LIR_Gen_1	357	363	PF02991	0.640
LIG_LIR_Gen_1	56	63	PF02991	0.633
LIG_LIR_Gen_1	584	592	PF02991	0.613
LIG_LIR_Nem_3	138	142	PF02991	0.369
LIG_LIR_Nem_3	168	173	PF02991	0.290
LIG_LIR_Nem_3	212	218	PF02991	0.533
LIG_LIR_Nem_3	249	255	PF02991	0.509
LIG_LIR_Nem_3	26	30	PF02991	0.551
LIG_LIR_Nem_3	268	273	PF02991	0.612
LIG_LIR_Nem_3	338	344	PF02991	0.482
LIG_LIR_Nem_3	357	361	PF02991	0.610
LIG_LIR_Nem_3	45	51	PF02991	0.607
LIG_LIR_Nem_3	534	539	PF02991	0.659
LIG_LIR_Nem_3	56	61	PF02991	0.588
LIG_LIR_Nem_3	584	589	PF02991	0.610
LIG_LIR_Nem_3	8	13	PF02991	0.691
LIG_MLH1_MIPbox_1	252	256	PF16413	0.492
LIG_PCNA_PIPBox_1	596	605	PF02747	0.497
LIG_PCNA_yPIPBox_3	591	603	PF02747	0.556
LIG_PDZ_Class_1	630	635	PF00595	0.574
LIG_Pex14_2	252	256	PF04695	0.541
LIG_Pex14_2	42	46	PF04695	0.603
LIG_SH2_CRK	586	590	PF00017	0.546
LIG_SH2_NCK_1	539	543	PF00017	0.710
LIG_SH2_STAP1	144	148	PF00017	0.369
LIG_SH2_STAP1	17	21	PF00017	0.602
LIG_SH2_STAP1	48	52	PF00017	0.627
LIG_SH2_STAP1	539	543	PF00017	0.559
LIG_SH2_STAP1	586	590	PF00017	0.643
LIG_SH2_STAT5	158	161	PF00017	0.315
LIG_SH2_STAT5	17	20	PF00017	0.618
LIG_SH2_STAT5	170	173	PF00017	0.263
LIG_SH2_STAT5	27	30	PF00017	0.555
LIG_SH2_STAT5	276	279	PF00017	0.556
LIG_SH2_STAT5	38	41	PF00017	0.621
LIG_SH2_STAT5	385	388	PF00017	0.622
LIG_SH2_STAT5	539	542	PF00017	0.746
LIG_SH2_STAT5	597	600	PF00017	0.578
LIG_SH2_STAT5	609	612	PF00017	0.551
LIG_SH3_3	105	111	PF00018	0.612
LIG_SH3_3	448	454	PF00018	0.792
LIG_SH3_3	554	560	PF00018	0.705
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.398
LIG_SUMO_SIM_anti_2	395	401	PF11976	0.614
LIG_SUMO_SIM_par_1	457	465	PF11976	0.595
LIG_TRAF2_1	624	627	PF00917	0.691
LIG_TYR_ITIM	25	30	PF00017	0.473
MOD_CDK_SPxK_1	5	11	PF00069	0.718
MOD_CK1_1	15	21	PF00069	0.544
MOD_CK1_1	204	210	PF00069	0.421
MOD_CK1_1	41	47	PF00069	0.656
MOD_CK1_1	438	444	PF00069	0.623
MOD_CK1_1	566	572	PF00069	0.703
MOD_CK1_1	64	70	PF00069	0.615
MOD_CK2_1	217	223	PF00069	0.282
MOD_CK2_1	329	335	PF00069	0.603
MOD_CK2_1	496	502	PF00069	0.733
MOD_CK2_1	574	580	PF00069	0.585
MOD_Cter_Amidation	431	434	PF01082	0.730
MOD_Cter_Amidation	604	607	PF01082	0.550
MOD_DYRK1A_RPxSP_1	450	454	PF00069	0.554
MOD_GlcNHglycan	1	4	PF01048	0.660
MOD_GlcNHglycan	198	201	PF01048	0.601
MOD_GlcNHglycan	248	251	PF01048	0.323
MOD_GlcNHglycan	252	255	PF01048	0.309
MOD_GlcNHglycan	320	323	PF01048	0.722
MOD_GlcNHglycan	457	461	PF01048	0.718
MOD_GlcNHglycan	472	475	PF01048	0.557
MOD_GlcNHglycan	496	499	PF01048	0.621
MOD_GlcNHglycan	565	568	PF01048	0.658
MOD_GlcNHglycan	63	66	PF01048	0.612
MOD_GlcNHglycan	89	92	PF01048	0.560
MOD_GSK3_1	114	121	PF00069	0.697
MOD_GSK3_1	235	242	PF00069	0.456
MOD_GSK3_1	246	253	PF00069	0.409
MOD_GSK3_1	284	291	PF00069	0.601
MOD_GSK3_1	329	336	PF00069	0.555
MOD_GSK3_1	350	357	PF00069	0.501
MOD_GSK3_1	37	44	PF00069	0.519
MOD_GSK3_1	435	442	PF00069	0.683
MOD_GSK3_1	464	471	PF00069	0.623
MOD_GSK3_1	53	60	PF00069	0.462
MOD_GSK3_1	563	570	PF00069	0.668
MOD_N-GLC_1	401	406	PF02516	0.649
MOD_N-GLC_1	438	443	PF02516	0.692
MOD_N-GLC_1	494	499	PF02516	0.530
MOD_N-GLC_1	523	528	PF02516	0.471
MOD_NEK2_1	149	154	PF00069	0.380
MOD_NEK2_1	182	187	PF00069	0.444
MOD_NEK2_1	288	293	PF00069	0.550
MOD_NEK2_1	318	323	PF00069	0.534
MOD_NEK2_1	350	355	PF00069	0.433
MOD_NEK2_1	42	47	PF00069	0.509
MOD_NEK2_1	464	469	PF00069	0.484
MOD_NEK2_1	523	528	PF00069	0.690
MOD_NEK2_2	17	22	PF00069	0.613
MOD_NEK2_2	366	371	PF00069	0.643
MOD_PIKK_1	118	124	PF00454	0.652
MOD_PIKK_1	350	356	PF00454	0.442
MOD_PIKK_1	407	413	PF00454	0.552
MOD_PKA_1	127	133	PF00069	0.543
MOD_PKA_1	629	635	PF00069	0.686
MOD_PKA_2	278	284	PF00069	0.530
MOD_PKA_2	3	9	PF00069	0.775
MOD_PKA_2	324	330	PF00069	0.691
MOD_PKA_2	561	567	PF00069	0.586
MOD_PKA_2	574	580	PF00069	0.491
MOD_Plk_1	244	250	PF00069	0.463
MOD_Plk_1	401	407	PF00069	0.603
MOD_Plk_1	489	495	PF00069	0.508
MOD_Plk_1	523	529	PF00069	0.578
MOD_Plk_1	93	99	PF00069	0.693
MOD_Plk_4	23	29	PF00069	0.585
MOD_Plk_4	261	267	PF00069	0.452
MOD_Plk_4	284	290	PF00069	0.623
MOD_Plk_4	42	48	PF00069	0.491
MOD_Plk_4	581	587	PF00069	0.466
MOD_Plk_4	598	604	PF00069	0.329
MOD_ProDKin_1	12	18	PF00069	0.511
MOD_ProDKin_1	235	241	PF00069	0.457
MOD_ProDKin_1	335	341	PF00069	0.291
MOD_ProDKin_1	439	445	PF00069	0.709
MOD_ProDKin_1	450	456	PF00069	0.654
MOD_ProDKin_1	5	11	PF00069	0.645
MOD_ProDKin_1	59	65	PF00069	0.508
MOD_SUMO_for_1	91	94	PF00179	0.697
MOD_SUMO_rev_2	422	428	PF00179	0.353
TRG_DiLeu_BaEn_2	345	351	PF01217	0.491
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.608
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.341
TRG_ENDOCYTIC_2	27	30	PF00928	0.569
TRG_ENDOCYTIC_2	586	589	PF00928	0.514
TRG_ER_diArg_1	194	196	PF00400	0.493
TRG_ER_diArg_1	370	372	PF00400	0.661
TRG_ER_diArg_1	606	608	PF00400	0.569
TRG_NES_CRM1_1	389	401	PF08389	0.569
TRG_NLS_Bipartite_1	606	626	PF00514	0.498
TRG_NLS_MonoExtC_3	621	627	PF00514	0.567
TRG_NLS_MonoExtN_4	620	626	PF00514	0.570
TRG_Pf-PMV_PEXEL_1	368	373	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3U3	Leptomonas seymouri	60%	98%
A0A0S4ITV1	Bodo saltans	32%	100%
A0A3Q8IPN5	Leishmania donovani	80%	98%
A4IC82	Leishmania infantum	80%	98%
D0A8R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ATW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%
Q4Q0N0	Leishmania major	80%	100%
V5B6S7	Trypanosoma cruzi	44%	100%