Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ45_LEIBR

TriTrypDb:

LbrM.35.5560 , LBRM2903_350067100

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.370
CLV_NRD_NRD_1	181	183	PF00675	0.375
CLV_NRD_NRD_1	209	211	PF00675	0.359
CLV_NRD_NRD_1	327	329	PF00675	0.481
CLV_NRD_NRD_1	339	341	PF00675	0.398
CLV_PCSK_KEX2_1	11	13	PF00082	0.503
CLV_PCSK_KEX2_1	181	183	PF00082	0.377
CLV_PCSK_KEX2_1	209	211	PF00082	0.359
CLV_PCSK_KEX2_1	327	329	PF00082	0.504
CLV_PCSK_KEX2_1	339	341	PF00082	0.403
CLV_PCSK_KEX2_1	344	346	PF00082	0.360
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.569
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.389
CLV_PCSK_PC7_1	340	346	PF00082	0.369
CLV_PCSK_SKI1_1	107	111	PF00082	0.426
CLV_PCSK_SKI1_1	12	16	PF00082	0.540
CLV_PCSK_SKI1_1	182	186	PF00082	0.375
CLV_PCSK_SKI1_1	294	298	PF00082	0.457
CLV_PCSK_SKI1_1	44	48	PF00082	0.544
CLV_Separin_Metazoa	94	98	PF03568	0.389
DEG_APCC_DBOX_1	209	217	PF00400	0.489
DEG_Nend_Nbox_1	1	3	PF02207	0.565
DOC_ANK_TNKS_1	133	140	PF00023	0.529
DOC_MAPK_gen_1	209	216	PF00069	0.339
DOC_MAPK_gen_1	23	32	PF00069	0.438
DOC_MAPK_gen_1	73	81	PF00069	0.403
DOC_MAPK_MEF2A_6	120	128	PF00069	0.426
DOC_PP4_FxxP_1	24	27	PF00568	0.479
DOC_USP7_MATH_1	127	131	PF00917	0.459
DOC_USP7_MATH_1	255	259	PF00917	0.295
DOC_USP7_MATH_1	280	284	PF00917	0.539
DOC_USP7_MATH_1	55	59	PF00917	0.573
DOC_USP7_MATH_1	7	11	PF00917	0.551
DOC_USP7_UBL2_3	11	15	PF12436	0.460
DOC_WW_Pin1_4	163	168	PF00397	0.398
LIG_14-3-3_CanoR_1	181	185	PF00244	0.402
LIG_14-3-3_CanoR_1	66	74	PF00244	0.525
LIG_14-3-3_CanoR_1	97	103	PF00244	0.462
LIG_Actin_WH2_2	83	99	PF00022	0.405
LIG_BRCT_BRCA1_1	98	102	PF00533	0.411
LIG_EH1_1	237	245	PF00400	0.356
LIG_EVH1_2	124	128	PF00568	0.431
LIG_FHA_1	218	224	PF00498	0.263
LIG_FHA_1	82	88	PF00498	0.441
LIG_FHA_2	169	175	PF00498	0.480
LIG_GBD_Chelix_1	176	184	PF00786	0.366
LIG_LIR_Gen_1	196	205	PF02991	0.348
LIG_LIR_Nem_3	196	200	PF02991	0.357
LIG_LIR_Nem_3	58	63	PF02991	0.438
LIG_PCNA_yPIPBox_3	199	212	PF02747	0.351
LIG_Pex14_1	311	315	PF04695	0.383
LIG_PTAP_UEV_1	142	147	PF05743	0.400
LIG_SH2_CRK	112	116	PF00017	0.558
LIG_SH2_NCK_1	121	125	PF00017	0.422
LIG_SH2_STAT3	62	65	PF00017	0.410
LIG_SH2_STAT3	85	88	PF00017	0.386
LIG_SH2_STAT5	158	161	PF00017	0.519
LIG_SH2_STAT5	215	218	PF00017	0.304
LIG_SH2_STAT5	295	298	PF00017	0.438
LIG_SH2_STAT5	315	318	PF00017	0.392
LIG_SH2_STAT5	62	65	PF00017	0.390
LIG_SH3_1	121	127	PF00018	0.410
LIG_SH3_1	140	146	PF00018	0.553
LIG_SH3_1	249	255	PF00018	0.386
LIG_SH3_3	121	127	PF00018	0.435
LIG_SH3_3	140	146	PF00018	0.413
LIG_SH3_3	249	255	PF00018	0.386
LIG_TRAF2_1	114	117	PF00917	0.361
LIG_TYR_ITIM	110	115	PF00017	0.555
LIG_WW_1	366	369	PF00397	0.628
MOD_CK1_1	10	16	PF00069	0.572
MOD_CK1_1	168	174	PF00069	0.419
MOD_CK1_1	208	214	PF00069	0.360
MOD_CK1_1	283	289	PF00069	0.521
MOD_CK1_1	355	361	PF00069	0.630
MOD_CK1_1	69	75	PF00069	0.394
MOD_CK2_1	102	108	PF00069	0.441
MOD_CK2_1	111	117	PF00069	0.423
MOD_CK2_1	141	147	PF00069	0.417
MOD_CK2_1	168	174	PF00069	0.412
MOD_CK2_1	284	290	PF00069	0.435
MOD_GlcNHglycan	143	146	PF01048	0.423
MOD_GlcNHglycan	167	170	PF01048	0.397
MOD_GlcNHglycan	353	357	PF01048	0.657
MOD_GSK3_1	280	287	PF00069	0.473
MOD_GSK3_1	98	105	PF00069	0.514
MOD_N-GLC_1	163	168	PF02516	0.397
MOD_N-GLC_1	284	289	PF02516	0.564
MOD_N-GLC_1	55	60	PF02516	0.501
MOD_N-GLC_1	81	86	PF02516	0.416
MOD_NEK2_1	1	6	PF00069	0.573
MOD_NEK2_1	180	185	PF00069	0.378
MOD_NEK2_1	32	37	PF00069	0.536
MOD_NEK2_1	67	72	PF00069	0.508
MOD_NEK2_1	81	86	PF00069	0.478
MOD_NEK2_1	96	101	PF00069	0.382
MOD_PK_1	25	31	PF00069	0.501
MOD_PKA_2	180	186	PF00069	0.385
MOD_PKA_2	208	214	PF00069	0.344
MOD_PKA_2	7	13	PF00069	0.494
MOD_PKA_2	96	102	PF00069	0.432
MOD_PKB_1	23	31	PF00069	0.525
MOD_Plk_1	284	290	PF00069	0.567
MOD_Plk_1	39	45	PF00069	0.525
MOD_Plk_1	55	61	PF00069	0.552
MOD_Plk_1	81	87	PF00069	0.434
MOD_Plk_4	25	31	PF00069	0.481
MOD_Plk_4	255	261	PF00069	0.274
MOD_ProDKin_1	163	169	PF00069	0.391
MOD_SUMO_for_1	119	122	PF00179	0.480
MOD_SUMO_for_1	274	277	PF00179	0.430
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.393
TRG_ENDOCYTIC_2	112	115	PF00928	0.553
TRG_ENDOCYTIC_2	60	63	PF00928	0.392
TRG_ER_diArg_1	159	162	PF00400	0.523
TRG_ER_diArg_1	180	182	PF00400	0.366
TRG_ER_diArg_1	20	23	PF00400	0.466
TRG_ER_diArg_1	248	251	PF00400	0.489
TRG_ER_diArg_1	327	330	PF00400	0.599
TRG_ER_diArg_1	339	341	PF00400	0.442
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2J5	Leptomonas seymouri	85%	100%
A0A0S4KDW2	Bodo saltans	54%	100%
A0A1X0P3G7	Trypanosomatidae	71%	100%
A0A3Q8IJS4	Leishmania donovani	92%	100%
A0A3R7KL34	Trypanosoma rangeli	68%	100%
A4IC81	Leishmania infantum	92%	100%
D0A8R9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9ATW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q0N1	Leishmania major	94%	100%
V5BMB9	Trypanosoma cruzi	67%	100%