Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ43_LEIBR

TriTrypDb:

LbrM.35.5540 , LBRM2903_350066800

Length:

195

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQ43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	153	155	PF00675	0.330
CLV_NRD_NRD_1	64	66	PF00675	0.459
CLV_PCSK_KEX2_1	112	114	PF00082	0.545
CLV_PCSK_KEX2_1	12	14	PF00082	0.564
CLV_PCSK_KEX2_1	52	54	PF00082	0.494
CLV_PCSK_KEX2_1	64	66	PF00082	0.433
CLV_PCSK_KEX2_1	81	83	PF00082	0.553
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.537
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.564
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.505
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.554
CLV_PCSK_SKI1_1	12	16	PF00082	0.536
CLV_PCSK_SKI1_1	47	51	PF00082	0.443
CLV_PCSK_SKI1_1	82	86	PF00082	0.584
DEG_Nend_Nbox_1	1	3	PF02207	0.658
DEG_SCF_FBW7_2	91	96	PF00400	0.391
DOC_MAPK_gen_1	152	160	PF00069	0.411
DOC_MAPK_gen_1	81	88	PF00069	0.629
DOC_MAPK_MEF2A_6	128	135	PF00069	0.485
DOC_MAPK_RevD_3	98	112	PF00069	0.533
DOC_USP7_UBL2_3	132	136	PF12436	0.547
DOC_WW_Pin1_4	127	132	PF00397	0.521
DOC_WW_Pin1_4	89	94	PF00397	0.655
LIG_14-3-3_CanoR_1	25	34	PF00244	0.484
LIG_FHA_1	128	134	PF00498	0.590
LIG_FHA_1	140	146	PF00498	0.456
LIG_FHA_1	83	89	PF00498	0.582
LIG_FHA_2	1	7	PF00498	0.619
LIG_FHA_2	13	19	PF00498	0.483
LIG_FHA_2	186	192	PF00498	0.565
LIG_FHA_2	90	96	PF00498	0.516
LIG_MYND_1	172	176	PF01753	0.365
LIG_Rb_pABgroove_1	52	60	PF01858	0.503
LIG_Rb_pABgroove_1	98	106	PF01858	0.464
LIG_SH2_SRC	104	107	PF00017	0.369
LIG_SH2_SRC	58	61	PF00017	0.418
LIG_SH2_STAP1	104	108	PF00017	0.402
LIG_SH2_STAP1	161	165	PF00017	0.497
LIG_SH2_STAP1	58	62	PF00017	0.473
LIG_SH2_STAT5	164	167	PF00017	0.473
LIG_SH2_STAT5	2	5	PF00017	0.494
LIG_SH3_3	35	41	PF00018	0.493
LIG_SUMO_SIM_par_1	83	89	PF11976	0.496
LIG_TRAF2_1	15	18	PF00917	0.488
LIG_TRAF2_1	93	96	PF00917	0.486
MOD_CDK_SPK_2	127	132	PF00069	0.563
MOD_CDK_SPK_2	89	94	PF00069	0.577
MOD_CK1_1	43	49	PF00069	0.600
MOD_CK2_1	12	18	PF00069	0.479
MOD_CK2_1	121	127	PF00069	0.652
MOD_CK2_1	185	191	PF00069	0.521
MOD_CK2_1	89	95	PF00069	0.500
MOD_GlcNHglycan	139	142	PF01048	0.360
MOD_GlcNHglycan	182	185	PF01048	0.524
MOD_GSK3_1	127	134	PF00069	0.565
MOD_GSK3_1	82	89	PF00069	0.543
MOD_NEK2_1	26	31	PF00069	0.564
MOD_NEK2_2	131	136	PF00069	0.379
MOD_PKA_1	12	18	PF00069	0.432
MOD_PKA_2	12	18	PF00069	0.498
MOD_PKA_2	24	30	PF00069	0.518
MOD_PKA_2	41	47	PF00069	0.327
MOD_Plk_1	121	127	PF00069	0.502
MOD_Plk_1	58	64	PF00069	0.459
MOD_Plk_1	82	88	PF00069	0.620
MOD_ProDKin_1	127	133	PF00069	0.515
MOD_ProDKin_1	89	95	PF00069	0.650
MOD_SUMO_rev_2	29	39	PF00179	0.700
TRG_DiLeu_BaEn_1	95	100	PF01217	0.431
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.398
TRG_ER_diArg_1	64	67	PF00400	0.534
TRG_NLS_MonoExtC_3	110	116	PF00514	0.554
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS21	Leptomonas seymouri	25%	99%
A0A0N1PAU2	Leptomonas seymouri	68%	100%
A0A0S4ITG8	Bodo saltans	28%	94%
A0A0S4KH12	Bodo saltans	33%	98%
A0A1X0P384	Trypanosomatidae	44%	100%
A0A1X0P828	Trypanosomatidae	29%	100%
A0A3Q8IJ52	Leishmania donovani	78%	100%
A0A3R7K1K7	Trypanosoma rangeli	29%	100%
A0A3S7XAJ8	Leishmania donovani	26%	100%
A0A422NMA5	Trypanosoma rangeli	42%	100%
A4ICK7	Leishmania infantum	27%	100%
A4IDV0	Leishmania infantum	78%	100%
D0A8S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AIX6	Leishmania braziliensis	29%	100%
E9ASP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ATW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q0N3	Leishmania major	76%	100%