Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ38_LEIBR

TriTrypDb:

LbrM.35.5480 , LBRM2903_350066100

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HQ38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ38

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	325	329	PF00656	0.400
CLV_C14_Caspase3-7	400	404	PF00656	0.279
CLV_NRD_NRD_1	157	159	PF00675	0.644
CLV_NRD_NRD_1	35	37	PF00675	0.548
CLV_NRD_NRD_1	75	77	PF00675	0.768
CLV_PCSK_FUR_1	33	37	PF00082	0.476
CLV_PCSK_KEX2_1	157	159	PF00082	0.610
CLV_PCSK_KEX2_1	265	267	PF00082	0.707
CLV_PCSK_KEX2_1	35	37	PF00082	0.519
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.571
CLV_PCSK_SKI1_1	168	172	PF00082	0.587
CLV_PCSK_SKI1_1	266	270	PF00082	0.588
CLV_PCSK_SKI1_1	343	347	PF00082	0.622
CLV_PCSK_SKI1_1	434	438	PF00082	0.498
DEG_APCC_DBOX_1	265	273	PF00400	0.488
DEG_Nend_UBRbox_1	1	4	PF02207	0.700
DOC_CDC14_PxL_1	99	107	PF14671	0.467
DOC_CKS1_1	376	381	PF01111	0.397
DOC_CYCLIN_RxL_1	263	270	PF00134	0.389
DOC_CYCLIN_RxL_1	72	85	PF00134	0.361
DOC_MAPK_MEF2A_6	84	91	PF00069	0.403
DOC_MAPK_NFAT4_5	84	92	PF00069	0.389
DOC_PP4_FxxP_1	376	379	PF00568	0.453
DOC_USP7_MATH_1	160	164	PF00917	0.339
DOC_USP7_MATH_1	20	24	PF00917	0.666
DOC_USP7_MATH_1	397	401	PF00917	0.297
DOC_WW_Pin1_4	212	217	PF00397	0.322
DOC_WW_Pin1_4	229	234	PF00397	0.432
DOC_WW_Pin1_4	237	242	PF00397	0.484
DOC_WW_Pin1_4	333	338	PF00397	0.401
DOC_WW_Pin1_4	375	380	PF00397	0.383
LIG_14-3-3_CanoR_1	266	276	PF00244	0.297
LIG_14-3-3_CanoR_1	292	298	PF00244	0.450
LIG_BRCT_BRCA1_1	283	287	PF00533	0.298
LIG_BRCT_BRCA1_1	316	320	PF00533	0.396
LIG_BRCT_BRCA1_1	57	61	PF00533	0.493
LIG_Clathr_ClatBox_1	370	374	PF01394	0.273
LIG_eIF4E_2	423	429	PF01652	0.296
LIG_FHA_1	182	188	PF00498	0.424
LIG_FHA_1	250	256	PF00498	0.542
LIG_FHA_1	91	97	PF00498	0.387
LIG_FHA_2	102	108	PF00498	0.448
LIG_FHA_2	294	300	PF00498	0.446
LIG_FHA_2	323	329	PF00498	0.551
LIG_FHA_2	80	86	PF00498	0.336
LIG_Integrin_RGD_1	349	351	PF01839	0.493
LIG_Integrin_RGD_1	4	6	PF01839	0.443
LIG_LIR_Apic_2	374	379	PF02991	0.374
LIG_LIR_Apic_2	422	426	PF02991	0.407
LIG_LIR_Gen_1	161	172	PF02991	0.380
LIG_LIR_Gen_1	296	305	PF02991	0.343
LIG_LIR_Gen_1	317	327	PF02991	0.494
LIG_LIR_Nem_3	161	167	PF02991	0.375
LIG_LIR_Nem_3	207	211	PF02991	0.458
LIG_LIR_Nem_3	252	256	PF02991	0.461
LIG_LIR_Nem_3	284	289	PF02991	0.446
LIG_LIR_Nem_3	296	300	PF02991	0.302
LIG_LIR_Nem_3	306	310	PF02991	0.317
LIG_LIR_Nem_3	317	321	PF02991	0.317
LIG_NRBOX	432	438	PF00104	0.401
LIG_PDZ_Class_2	453	458	PF00595	0.491
LIG_Pex14_2	283	287	PF04695	0.298
LIG_SH2_CRK	119	123	PF00017	0.375
LIG_SH2_CRK	164	168	PF00017	0.380
LIG_SH2_CRK	201	205	PF00017	0.359
LIG_SH2_CRK	307	311	PF00017	0.359
LIG_SH2_CRK	423	427	PF00017	0.382
LIG_SH2_CRK	52	56	PF00017	0.290
LIG_SH2_SRC	199	202	PF00017	0.429
LIG_SH2_SRC	314	317	PF00017	0.365
LIG_SH2_STAP1	119	123	PF00017	0.375
LIG_SH2_STAP1	201	205	PF00017	0.418
LIG_SH2_STAP1	297	301	PF00017	0.372
LIG_SH2_STAP1	314	318	PF00017	0.366
LIG_SH2_STAT3	209	212	PF00017	0.308
LIG_SH2_STAT5	148	151	PF00017	0.301
LIG_SH2_STAT5	199	202	PF00017	0.390
LIG_SH2_STAT5	209	212	PF00017	0.346
LIG_SH2_STAT5	383	386	PF00017	0.297
LIG_SH3_3	235	241	PF00018	0.375
LIG_SH3_3	299	305	PF00018	0.383
LIG_SUMO_SIM_anti_2	298	304	PF11976	0.380
LIG_SUMO_SIM_par_1	368	374	PF11976	0.361
LIG_SUMO_SIM_par_1	77	83	PF11976	0.394
LIG_TRAF2_1	128	131	PF00917	0.424
LIG_TRAF2_1	296	299	PF00917	0.447
LIG_TYR_ITIM	162	167	PF00017	0.451
LIG_TYR_ITIM	50	55	PF00017	0.411
MOD_CK1_1	240	246	PF00069	0.588
MOD_CK1_1	281	287	PF00069	0.496
MOD_CK2_1	236	242	PF00069	0.475
MOD_CK2_1	293	299	PF00069	0.556
MOD_CK2_1	333	339	PF00069	0.479
MOD_CK2_1	350	356	PF00069	0.516
MOD_GlcNHglycan	10	13	PF01048	0.551
MOD_GlcNHglycan	201	204	PF01048	0.534
MOD_GlcNHglycan	22	25	PF01048	0.516
MOD_GlcNHglycan	258	261	PF01048	0.667
MOD_GlcNHglycan	63	66	PF01048	0.657
MOD_GSK3_1	148	155	PF00069	0.534
MOD_GSK3_1	236	243	PF00069	0.640
MOD_GSK3_1	278	285	PF00069	0.479
MOD_N-GLC_1	256	261	PF02516	0.562
MOD_NEK2_1	142	147	PF00069	0.512
MOD_NEK2_1	222	227	PF00069	0.436
MOD_NEK2_1	256	261	PF00069	0.664
MOD_NEK2_1	278	283	PF00069	0.470
MOD_NEK2_1	355	360	PF00069	0.646
MOD_NEK2_1	408	413	PF00069	0.519
MOD_NEK2_1	55	60	PF00069	0.716
MOD_NEK2_1	61	66	PF00069	0.639
MOD_PIKK_1	142	148	PF00454	0.506
MOD_PIKK_1	331	337	PF00454	0.755
MOD_PIKK_1	91	97	PF00454	0.473
MOD_PKA_2	20	26	PF00069	0.621
MOD_PKA_2	27	33	PF00069	0.595
MOD_Plk_1	160	166	PF00069	0.412
MOD_Plk_1	279	285	PF00069	0.482
MOD_Plk_1	355	361	PF00069	0.527
MOD_Plk_4	182	188	PF00069	0.521
MOD_Plk_4	282	288	PF00069	0.334
MOD_Plk_4	55	61	PF00069	0.646
MOD_ProDKin_1	212	218	PF00069	0.369
MOD_ProDKin_1	229	235	PF00069	0.532
MOD_ProDKin_1	237	243	PF00069	0.604
MOD_ProDKin_1	333	339	PF00069	0.479
MOD_ProDKin_1	375	381	PF00069	0.475
TRG_DiLeu_BaEn_4	298	304	PF01217	0.459
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.485
TRG_ENDOCYTIC_2	119	122	PF00928	0.419
TRG_ENDOCYTIC_2	164	167	PF00928	0.458
TRG_ENDOCYTIC_2	191	194	PF00928	0.445
TRG_ENDOCYTIC_2	201	204	PF00928	0.432
TRG_ENDOCYTIC_2	208	211	PF00928	0.457
TRG_ENDOCYTIC_2	253	256	PF00928	0.555
TRG_ENDOCYTIC_2	297	300	PF00928	0.450
TRG_ENDOCYTIC_2	307	310	PF00928	0.424
TRG_ENDOCYTIC_2	52	55	PF00928	0.411
TRG_ER_diArg_1	1	4	PF00400	0.716
TRG_ER_diArg_1	156	158	PF00400	0.549
TRG_ER_diArg_1	33	36	PF00400	0.701
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P492	Leptomonas seymouri	52%	97%
A0A3S7XBP8	Leishmania donovani	77%	94%
A4IDU4	Leishmania infantum	77%	94%
E9ATV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	94%
Q4Q0N9	Leishmania major	76%	100%