Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ37_LEIBR

TriTrypDb:

LbrM.35.5470 , LBRM2903_350066000

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 0
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005788	endoplasmic reticulum lumen	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HQ37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ37

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	7
GO:0006511	ubiquitin-dependent protein catabolic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0007165	signal transduction	2	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009057	macromolecule catabolic process	4	7
GO:0009987	cellular process	1	7
GO:0010033	response to organic substance	3	7
GO:0010243	response to organonitrogen compound	4	7
GO:0010498	proteasomal protein catabolic process	5	7
GO:0019538	protein metabolic process	3	7
GO:0019941	modification-dependent protein catabolic process	6	7
GO:0030163	protein catabolic process	4	7
GO:0030433	ubiquitin-dependent ERAD pathway	6	7
GO:0030968	endoplasmic reticulum unfolded protein response	3	7
GO:0033554	cellular response to stress	3	7
GO:0034976	response to endoplasmic reticulum stress	4	7
GO:0036503	ERAD pathway	5	7
GO:0042221	response to chemical	2	7
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043632	modification-dependent macromolecule catabolic process	5	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044248	cellular catabolic process	3	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0044265	obsolete cellular macromolecule catabolic process	4	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0050896	response to stimulus	1	7
GO:0051603	proteolysis involved in protein catabolic process	5	7
GO:0051716	cellular response to stimulus	2	7
GO:0065007	biological regulation	1	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901565	organonitrogen compound catabolic process	4	7
GO:1901575	organic substance catabolic process	3	7
GO:1901698	response to nitrogen compound	3	7
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0015031	protein transport	4	1
GO:0030970	retrograde protein transport, ER to cytosol	5	1
GO:0032527	protein exit from endoplasmic reticulum	5	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:1903513	endoplasmic reticulum to cytosol transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.473
CLV_NRD_NRD_1	182	184	PF00675	0.549
CLV_NRD_NRD_1	84	86	PF00675	0.676
CLV_PCSK_KEX2_1	146	148	PF00082	0.604
CLV_PCSK_KEX2_1	182	184	PF00082	0.549
CLV_PCSK_KEX2_1	83	85	PF00082	0.680
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.351
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.641
CLV_PCSK_PC7_1	142	148	PF00082	0.488
DEG_Nend_UBRbox_2	1	3	PF02207	0.455
DOC_CYCLIN_yCln2_LP_2	33	39	PF00134	0.682
DOC_MAPK_gen_1	146	154	PF00069	0.369
DOC_MAPK_gen_1	180	190	PF00069	0.546
DOC_PP2B_LxvP_1	44	47	PF13499	0.743
DOC_PP4_FxxP_1	197	200	PF00568	0.609
DOC_USP7_MATH_1	47	51	PF00917	0.557
LIG_14-3-3_CanoR_1	147	155	PF00244	0.616
LIG_14-3-3_CanoR_1	164	170	PF00244	0.403
LIG_14-3-3_CanoR_1	193	201	PF00244	0.591
LIG_14-3-3_CanoR_1	217	226	PF00244	0.441
LIG_14-3-3_CanoR_1	4	11	PF00244	0.549
LIG_BIR_III_4	160	164	PF00653	0.538
LIG_BIR_III_4	57	61	PF00653	0.513
LIG_BRCT_BRCA1_1	158	162	PF00533	0.458
LIG_BRCT_BRCA1_1	219	223	PF00533	0.487
LIG_deltaCOP1_diTrp_1	2	10	PF00928	0.529
LIG_FHA_1	12	18	PF00498	0.490
LIG_LIR_Apic_2	195	200	PF02991	0.602
LIG_LIR_Gen_1	118	125	PF02991	0.441
LIG_LIR_Gen_1	14	23	PF02991	0.440
LIG_LIR_Gen_1	220	229	PF02991	0.414
LIG_LIR_Nem_3	118	124	PF02991	0.429
LIG_LIR_Nem_3	14	19	PF02991	0.431
LIG_LIR_Nem_3	220	226	PF02991	0.413
LIG_LIR_Nem_3	63	69	PF02991	0.536
LIG_SH2_PTP2	121	124	PF00017	0.538
LIG_SH2_PTP2	203	206	PF00017	0.310
LIG_SH2_PTP2	66	69	PF00017	0.570
LIG_SH2_SRC	121	124	PF00017	0.286
LIG_SH2_STAT5	121	124	PF00017	0.538
LIG_SH2_STAT5	125	128	PF00017	0.456
LIG_SH2_STAT5	191	194	PF00017	0.408
LIG_SH2_STAT5	203	206	PF00017	0.400
LIG_SH2_STAT5	214	217	PF00017	0.261
LIG_SH2_STAT5	66	69	PF00017	0.570
LIG_SUMO_SIM_par_1	17	22	PF11976	0.446
LIG_TRAF2_1	232	235	PF00917	0.671
LIG_TYR_ITIM	201	206	PF00017	0.579
LIG_UBA3_1	102	110	PF00899	0.348
MOD_CK1_1	117	123	PF00069	0.353
MOD_CK1_1	210	216	PF00069	0.314
MOD_CK1_1	70	76	PF00069	0.501
MOD_CK2_1	202	208	PF00069	0.441
MOD_Cter_Amidation	144	147	PF01082	0.579
MOD_GlcNHglycan	156	159	PF01048	0.435
MOD_GlcNHglycan	170	173	PF01048	0.296
MOD_GSK3_1	136	143	PF00069	0.417
MOD_GSK3_1	202	209	PF00069	0.476
MOD_GSK3_1	218	225	PF00069	0.371
MOD_N-GLC_1	70	75	PF02516	0.506
MOD_NEK2_1	106	111	PF00069	0.478
MOD_NEK2_1	136	141	PF00069	0.413
MOD_NEK2_1	154	159	PF00069	0.485
MOD_NEK2_1	206	211	PF00069	0.452
MOD_NEK2_1	218	223	PF00069	0.423
MOD_NEK2_1	31	36	PF00069	0.702
MOD_NEK2_1	76	81	PF00069	0.529
MOD_NEK2_1	9	14	PF00069	0.461
MOD_NEK2_2	202	207	PF00069	0.542
MOD_PIKK_1	192	198	PF00454	0.608
MOD_PIKK_1	207	213	PF00454	0.479
MOD_PIKK_1	224	230	PF00454	0.496
MOD_PK_1	222	228	PF00069	0.572
MOD_PKA_1	146	152	PF00069	0.514
MOD_PKA_2	106	112	PF00069	0.600
MOD_PKA_2	146	152	PF00069	0.514
MOD_PKA_2	192	198	PF00069	0.577
MOD_PKA_2	3	9	PF00069	0.693
MOD_Plk_1	234	240	PF00069	0.676
MOD_Plk_4	117	123	PF00069	0.511
MOD_Plk_4	165	171	PF00069	0.456
MOD_Plk_4	210	216	PF00069	0.285
MOD_Plk_4	98	104	PF00069	0.579
TRG_DiLeu_BaEn_2	37	43	PF01217	0.728
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.523
TRG_ENDOCYTIC_2	121	124	PF00928	0.538
TRG_ENDOCYTIC_2	194	197	PF00928	0.598
TRG_ENDOCYTIC_2	203	206	PF00928	0.511
TRG_ENDOCYTIC_2	66	69	PF00928	0.484
TRG_ER_diArg_1	182	184	PF00400	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N4	Leptomonas seymouri	41%	100%
A0A3R7KHI0	Trypanosoma rangeli	26%	98%
A0A3S7XBS9	Leishmania donovani	70%	100%
A4IDU3	Leishmania infantum	69%	100%
E9ATV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q0P0	Leishmania major	70%	100%