Kinesin motor domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin-D

Species:

Leishmania braziliensis

UniProt:

A4HQ31_LEIBR

TriTrypDb:

LbrM.35.5400 , LBRM2903_350065000

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	4
GO:0005875	microtubule associated complex	2	1
GO:0015630	microtubule cytoskeleton	6	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0099080	supramolecular complex	2	4
GO:0099081	supramolecular polymer	3	4
GO:0099512	supramolecular fiber	4	4
GO:0099513	polymeric cytoskeletal fiber	5	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HQ31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ31

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	15
GO:0007018	microtubule-based movement	3	15
GO:0009987	cellular process	1	15
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000902	cell morphogenesis	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0009653	anatomical structure morphogenesis	2	1
GO:0016043	cellular component organization	3	1
GO:0030865	cortical cytoskeleton organization	6	1
GO:0031122	cytoplasmic microtubule organization	4	1
GO:0032502	developmental process	1	1
GO:0043622	cortical microtubule organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0003774	cytoskeletal motor activity	1	15
GO:0003777	microtubule motor activity	2	15
GO:0005488	binding	1	15
GO:0005515	protein binding	2	15
GO:0005524	ATP binding	5	15
GO:0008017	microtubule binding	5	15
GO:0008092	cytoskeletal protein binding	3	15
GO:0015631	tubulin binding	4	15
GO:0017076	purine nucleotide binding	4	15
GO:0030554	adenyl nucleotide binding	5	15
GO:0032553	ribonucleotide binding	3	15
GO:0032555	purine ribonucleotide binding	4	15
GO:0032559	adenyl ribonucleotide binding	5	15
GO:0035639	purine ribonucleoside triphosphate binding	4	15
GO:0036094	small molecule binding	2	15
GO:0043167	ion binding	2	15
GO:0043168	anion binding	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:0097367	carbohydrate derivative binding	2	15
GO:0140657	ATP-dependent activity	1	15
GO:1901265	nucleoside phosphate binding	3	15
GO:1901363	heterocyclic compound binding	2	15
GO:0003824	catalytic activity	1	2
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	348	350	PF00675	0.538
CLV_NRD_NRD_1	367	369	PF00675	0.510
CLV_NRD_NRD_1	439	441	PF00675	0.580
CLV_NRD_NRD_1	584	586	PF00675	0.503
CLV_PCSK_KEX2_1	234	236	PF00082	0.451
CLV_PCSK_KEX2_1	367	369	PF00082	0.521
CLV_PCSK_KEX2_1	450	452	PF00082	0.555
CLV_PCSK_KEX2_1	501	503	PF00082	0.666
CLV_PCSK_KEX2_1	538	540	PF00082	0.633
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.466
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.608
CLV_PCSK_PC1ET2_1	501	503	PF00082	0.626
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.690
CLV_PCSK_PC7_1	497	503	PF00082	0.511
CLV_PCSK_SKI1_1	138	142	PF00082	0.331
CLV_PCSK_SKI1_1	17	21	PF00082	0.457
CLV_PCSK_SKI1_1	349	353	PF00082	0.446
CLV_PCSK_SKI1_1	35	39	PF00082	0.454
CLV_PCSK_SKI1_1	410	414	PF00082	0.579
CLV_PCSK_SKI1_1	420	424	PF00082	0.576
CLV_PCSK_SKI1_1	621	625	PF00082	0.432
CLV_PCSK_SKI1_1	87	91	PF00082	0.373
CLV_Separin_Metazoa	605	609	PF03568	0.391
DEG_APCC_DBOX_1	335	343	PF00400	0.294
DEG_APCC_KENBOX_2	492	496	PF00400	0.425
DEG_Kelch_Keap1_1	290	295	PF01344	0.321
DEG_Nend_UBRbox_1	1	4	PF02207	0.440
DOC_CKS1_1	18	23	PF01111	0.540
DOC_MAPK_gen_1	263	272	PF00069	0.390
DOC_MAPK_gen_1	381	389	PF00069	0.602
DOC_MAPK_MEF2A_6	263	271	PF00069	0.401
DOC_MAPK_MEF2A_6	97	105	PF00069	0.214
DOC_MAPK_RevD_3	487	502	PF00069	0.428
DOC_PP2B_LxvP_1	578	581	PF13499	0.434
DOC_PP2B_PxIxI_1	100	106	PF00149	0.214
DOC_PP4_FxxP_1	251	254	PF00568	0.495
DOC_PP4_FxxP_1	72	75	PF00568	0.607
DOC_USP7_MATH_1	117	121	PF00917	0.396
DOC_USP7_MATH_1	257	261	PF00917	0.401
DOC_USP7_MATH_1	433	437	PF00917	0.591
DOC_USP7_MATH_1	462	466	PF00917	0.621
DOC_USP7_MATH_1	555	559	PF00917	0.750
DOC_USP7_UBL2_3	2	6	PF12436	0.400
DOC_USP7_UBL2_3	223	227	PF12436	0.214
DOC_USP7_UBL2_3	441	445	PF12436	0.518
DOC_USP7_UBL2_3	511	515	PF12436	0.588
DOC_USP7_UBL2_3	617	621	PF12436	0.669
DOC_USP7_UBL2_3	81	85	PF12436	0.623
DOC_WW_Pin1_4	17	22	PF00397	0.454
DOC_WW_Pin1_4	198	203	PF00397	0.459
DOC_WW_Pin1_4	24	29	PF00397	0.423
DOC_WW_Pin1_4	326	331	PF00397	0.383
LIG_14-3-3_CanoR_1	124	129	PF00244	0.325
LIG_14-3-3_CanoR_1	235	243	PF00244	0.428
LIG_14-3-3_CanoR_1	244	251	PF00244	0.449
LIG_14-3-3_CanoR_1	552	559	PF00244	0.704
LIG_14-3-3_CanoR_1	87	95	PF00244	0.469
LIG_APCC_ABBA_1	328	333	PF00400	0.387
LIG_APCC_ABBAyCdc20_2	440	446	PF00400	0.380
LIG_BRCT_BRCA1_1	110	114	PF00533	0.306
LIG_BRCT_BRCA1_1	121	125	PF00533	0.348
LIG_BRCT_BRCA1_1	241	245	PF00533	0.476
LIG_CaM_IQ_9	339	354	PF13499	0.543
LIG_deltaCOP1_diTrp_1	67	72	PF00928	0.451
LIG_FHA_1	159	165	PF00498	0.302
LIG_FHA_1	236	242	PF00498	0.307
LIG_FHA_1	244	250	PF00498	0.438
LIG_FHA_1	511	517	PF00498	0.609
LIG_FHA_2	173	179	PF00498	0.371
LIG_FHA_2	18	24	PF00498	0.447
LIG_FHA_2	88	94	PF00498	0.383
LIG_KLC1_Yacidic_2	174	178	PF13176	0.385
LIG_LIR_Apic_2	248	254	PF02991	0.472
LIG_LIR_Apic_2	71	75	PF02991	0.613
LIG_LIR_Gen_1	12	21	PF02991	0.464
LIG_LIR_Gen_1	174	182	PF02991	0.340
LIG_LIR_Gen_1	305	316	PF02991	0.375
LIG_LIR_Gen_1	329	339	PF02991	0.479
LIG_LIR_Gen_1	360	370	PF02991	0.614
LIG_LIR_Gen_1	93	103	PF02991	0.374
LIG_LIR_Nem_3	12	16	PF02991	0.465
LIG_LIR_Nem_3	122	128	PF02991	0.434
LIG_LIR_Nem_3	146	152	PF02991	0.358
LIG_LIR_Nem_3	174	179	PF02991	0.340
LIG_LIR_Nem_3	305	311	PF02991	0.377
LIG_LIR_Nem_3	93	98	PF02991	0.373
LIG_NRBOX	269	275	PF00104	0.369
LIG_Pex14_2	308	312	PF04695	0.457
LIG_SH2_CRK	95	99	PF00017	0.393
LIG_SH2_NCK_1	110	114	PF00017	0.348
LIG_SH2_NCK_1	572	576	PF00017	0.559
LIG_SH2_PTP2	176	179	PF00017	0.349
LIG_SH2_STAP1	110	114	PF00017	0.335
LIG_SH2_STAP1	499	503	PF00017	0.693
LIG_SH2_STAP1	572	576	PF00017	0.559
LIG_SH2_STAP1	595	599	PF00017	0.530
LIG_SH2_STAT5	126	129	PF00017	0.453
LIG_SH2_STAT5	151	154	PF00017	0.214
LIG_SH2_STAT5	176	179	PF00017	0.349
LIG_SH3_1	15	21	PF00018	0.517
LIG_SH3_3	15	21	PF00018	0.517
LIG_SH3_3	199	205	PF00018	0.386
LIG_SH3_3	45	51	PF00018	0.524
LIG_SH3_3	95	101	PF00018	0.340
LIG_SUMO_SIM_anti_2	174	181	PF11976	0.346
LIG_SUMO_SIM_anti_2	385	391	PF11976	0.623
LIG_SUMO_SIM_anti_2	398	403	PF11976	0.473
LIG_SUMO_SIM_par_1	44	50	PF11976	0.454
LIG_TRAF2_1	567	570	PF00917	0.586
LIG_UBA3_1	221	227	PF00899	0.214
LIG_WRC_WIRS_1	69	74	PF05994	0.449
MOD_CAAXbox	622	625	PF01239	0.468
MOD_CK1_1	172	178	PF00069	0.364
MOD_CK1_1	200	206	PF00069	0.447
MOD_CK1_1	290	296	PF00069	0.522
MOD_CK1_1	323	329	PF00069	0.428
MOD_CK2_1	17	23	PF00069	0.430
MOD_CK2_1	214	220	PF00069	0.421
MOD_CK2_1	359	365	PF00069	0.556
MOD_CK2_1	597	603	PF00069	0.574
MOD_CK2_1	61	67	PF00069	0.476
MOD_CK2_1	68	74	PF00069	0.469
MOD_DYRK1A_RPxSP_1	17	21	PF00069	0.533
MOD_GlcNHglycan	121	124	PF01048	0.389
MOD_GlcNHglycan	170	174	PF01048	0.356
MOD_GlcNHglycan	202	205	PF01048	0.445
MOD_GlcNHglycan	216	219	PF01048	0.411
MOD_GlcNHglycan	278	281	PF01048	0.503
MOD_GlcNHglycan	292	295	PF01048	0.315
MOD_GlcNHglycan	462	465	PF01048	0.536
MOD_GlcNHglycan	553	556	PF01048	0.591
MOD_GlcNHglycan	81	84	PF01048	0.547
MOD_GSK3_1	153	160	PF00069	0.400
MOD_GSK3_1	235	242	PF00069	0.398
MOD_GSK3_1	257	264	PF00069	0.554
MOD_GSK3_1	338	345	PF00069	0.503
MOD_GSK3_1	460	467	PF00069	0.542
MOD_GSK3_1	5	12	PF00069	0.587
MOD_GSK3_1	551	558	PF00069	0.468
MOD_N-GLC_1	158	163	PF02516	0.368
MOD_N-GLC_1	184	189	PF02516	0.467
MOD_N-GLC_1	235	240	PF02516	0.530
MOD_N-GLC_1	24	29	PF02516	0.480
MOD_N-GLC_1	257	262	PF02516	0.621
MOD_N-GLC_1	413	418	PF02516	0.352
MOD_N-GLC_1	532	537	PF02516	0.492
MOD_N-GLC_2	577	579	PF02516	0.429
MOD_NEK2_1	320	325	PF00069	0.452
MOD_NEK2_1	342	347	PF00069	0.499
MOD_NEK2_1	5	10	PF00069	0.564
MOD_NEK2_1	550	555	PF00069	0.465
MOD_NEK2_2	192	197	PF00069	0.214
MOD_NEK2_2	76	81	PF00069	0.541
MOD_PIKK_1	153	159	PF00454	0.214
MOD_PIKK_1	415	421	PF00454	0.495
MOD_PIKK_1	87	93	PF00454	0.389
MOD_PKA_1	153	159	PF00069	0.214
MOD_PKA_2	243	249	PF00069	0.423
MOD_PKA_2	551	557	PF00069	0.689
MOD_Plk_1	158	164	PF00069	0.375
MOD_Plk_1	257	263	PF00069	0.612
MOD_Plk_1	359	365	PF00069	0.576
MOD_Plk_1	76	82	PF00069	0.576
MOD_Plk_4	124	130	PF00069	0.349
MOD_Plk_4	172	178	PF00069	0.376
MOD_Plk_4	311	317	PF00069	0.450
MOD_Plk_4	320	326	PF00069	0.409
MOD_Plk_4	359	365	PF00069	0.599
MOD_ProDKin_1	17	23	PF00069	0.448
MOD_ProDKin_1	198	204	PF00069	0.459
MOD_ProDKin_1	24	30	PF00069	0.434
MOD_ProDKin_1	326	332	PF00069	0.392
MOD_SUMO_for_1	402	405	PF00179	0.524
MOD_SUMO_for_1	514	517	PF00179	0.516
MOD_SUMO_for_1	593	596	PF00179	0.596
MOD_SUMO_rev_2	371	376	PF00179	0.481
MOD_SUMO_rev_2	474	480	PF00179	0.601
MOD_SUMO_rev_2	505	513	PF00179	0.659
MOD_SUMO_rev_2	542	548	PF00179	0.557
TRG_DiLeu_BaEn_4	604	610	PF01217	0.533
TRG_ENDOCYTIC_2	176	179	PF00928	0.317
TRG_ENDOCYTIC_2	332	335	PF00928	0.518
TRG_ENDOCYTIC_2	95	98	PF00928	0.349
TRG_ER_diArg_1	14	17	PF00400	0.386
TRG_ER_diArg_1	366	368	PF00400	0.545
TRG_ER_diArg_1	488	491	PF00400	0.431
TRG_NLS_MonoExtN_4	347	353	PF00514	0.540
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	586	590	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K9	Leptomonas seymouri	66%	100%
A0A0S4JFN9	Bodo saltans	22%	73%
A0A0S4JPE8	Bodo saltans	32%	69%
A0A0S4JRN9	Bodo saltans	23%	95%
A0A1X0NNI2	Trypanosomatidae	23%	68%
A0A1X0P435	Trypanosomatidae	42%	100%
A0A3S7XBW9	Leishmania donovani	75%	100%
A0A422NMD1	Trypanosoma rangeli	41%	100%
A4HCT2	Leishmania braziliensis	23%	87%
A4IDT7	Leishmania infantum	75%	100%
D0A8T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ATU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
P46873	Caenorhabditis elegans	23%	89%
Q4Q0P7	Leishmania major	74%	100%
V5B6Q5	Trypanosoma cruzi	43%	100%