VHS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

VHS domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ30_LEIBR

TriTrypDb:

LbrM.35.5390 , LBRM2903_350064900

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQ30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ30

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0006886	intracellular protein transport	4	9
GO:0007034	vacuolar transport	4	9
GO:0008104	protein localization	4	9
GO:0009987	cellular process	1	9
GO:0015031	protein transport	4	9
GO:0016192	vesicle-mediated transport	4	9
GO:0016197	endosomal transport	4	9
GO:0032509	endosome transport via multivesicular body sorting pathway	5	9
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	9
GO:0033036	macromolecule localization	2	9
GO:0033365	protein localization to organelle	5	9
GO:0043328	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	5	9
GO:0045184	establishment of protein localization	3	9
GO:0045324	late endosome to vacuole transport	5	9
GO:0046907	intracellular transport	3	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0051641	cellular localization	2	9
GO:0051649	establishment of localization in cell	3	9
GO:0070727	cellular macromolecule localization	3	9
GO:0071702	organic substance transport	4	9
GO:0071705	nitrogen compound transport	4	9
GO:0071985	multivesicular body sorting pathway	5	9
GO:0072594	establishment of protein localization to organelle	4	9
GO:0072665	protein localization to vacuole	6	9
GO:0072666	establishment of protein localization to vacuole	5	9

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0005515	protein binding	2	9
GO:0005543	phospholipid binding	3	9
GO:0008289	lipid binding	2	9
GO:0032182	ubiquitin-like protein binding	3	9
GO:0035091	phosphatidylinositol binding	4	9
GO:0043130	ubiquitin binding	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.400
CLV_NRD_NRD_1	209	211	PF00675	0.777
CLV_NRD_NRD_1	65	67	PF00675	0.291
CLV_PCSK_KEX2_1	209	211	PF00082	0.784
CLV_PCSK_KEX2_1	64	66	PF00082	0.291
CLV_PCSK_PC7_1	61	67	PF00082	0.291
CLV_PCSK_SKI1_1	101	105	PF00082	0.291
CLV_PCSK_SKI1_1	286	290	PF00082	0.512
DEG_APCC_DBOX_1	285	293	PF00400	0.450
DEG_SCF_FBW7_2	17	24	PF00400	0.356
DEG_SPOP_SBC_1	370	374	PF00917	0.537
DEG_SPOP_SBC_1	410	414	PF00917	0.535
DOC_CKS1_1	18	23	PF01111	0.313
DOC_MAPK_gen_1	51	59	PF00069	0.367
DOC_MAPK_MEF2A_6	124	132	PF00069	0.370
DOC_MAPK_MEF2A_6	268	276	PF00069	0.465
DOC_MAPK_MEF2A_6	65	74	PF00069	0.305
DOC_PP1_RVXF_1	1	7	PF00149	0.320
DOC_PP2B_LxvP_1	34	37	PF13499	0.325
DOC_PP2B_LxvP_1	356	359	PF13499	0.548
DOC_USP7_MATH_1	143	147	PF00917	0.309
DOC_USP7_MATH_1	235	239	PF00917	0.469
DOC_USP7_MATH_1	382	386	PF00917	0.549
DOC_USP7_MATH_1	410	414	PF00917	0.582
DOC_USP7_MATH_1	440	444	PF00917	0.630
DOC_USP7_MATH_1	457	461	PF00917	0.621
DOC_USP7_MATH_2	409	415	PF00917	0.633
DOC_WW_Pin1_4	17	22	PF00397	0.329
DOC_WW_Pin1_4	354	359	PF00397	0.581
DOC_WW_Pin1_4	371	376	PF00397	0.700
DOC_WW_Pin1_4	445	450	PF00397	0.779
LIG_14-3-3_CterR_2	507	510	PF00244	0.505
LIG_Actin_WH2_2	275	292	PF00022	0.474
LIG_AP_GAE_1	497	503	PF02883	0.495
LIG_BH_BH3_1	141	157	PF00452	0.462
LIG_BIR_III_2	217	221	PF00653	0.494
LIG_BRCT_BRCA1_1	134	138	PF00533	0.335
LIG_BRCT_BRCA1_1	89	93	PF00533	0.415
LIG_EVH1_1	322	326	PF00568	0.490
LIG_FHA_1	129	135	PF00498	0.356
LIG_FHA_1	13	19	PF00498	0.490
LIG_FHA_1	273	279	PF00498	0.492
LIG_FHA_1	413	419	PF00498	0.734
LIG_FHA_1	431	437	PF00498	0.760
LIG_FHA_1	76	82	PF00498	0.291
LIG_FHA_2	149	155	PF00498	0.396
LIG_FHA_2	289	295	PF00498	0.441
LIG_FHA_2	53	59	PF00498	0.351
LIG_HCF-1_HBM_1	270	273	PF13415	0.466
LIG_LIR_Apic_2	404	410	PF02991	0.684
LIG_LIR_Gen_1	20	26	PF02991	0.328
LIG_LIR_Gen_1	270	278	PF02991	0.474
LIG_LIR_Gen_1	38	45	PF02991	0.369
LIG_LIR_Gen_1	497	504	PF02991	0.562
LIG_LIR_Nem_3	20	25	PF02991	0.340
LIG_LIR_Nem_3	238	242	PF02991	0.490
LIG_LIR_Nem_3	270	276	PF02991	0.458
LIG_LIR_Nem_3	38	42	PF02991	0.390
LIG_LIR_Nem_3	497	503	PF02991	0.562
LIG_MYND_1	354	358	PF01753	0.525
LIG_SH2_GRB2like	242	245	PF00017	0.446
LIG_SH2_GRB2like	341	344	PF00017	0.522
LIG_SH2_PTP2	273	276	PF00017	0.463
LIG_SH2_PTP2	407	410	PF00017	0.518
LIG_SH2_SRC	39	42	PF00017	0.285
LIG_SH2_SRC	407	410	PF00017	0.518
LIG_SH2_STAT3	263	266	PF00017	0.482
LIG_SH2_STAT5	147	150	PF00017	0.411
LIG_SH2_STAT5	242	245	PF00017	0.462
LIG_SH2_STAT5	263	266	PF00017	0.549
LIG_SH2_STAT5	273	276	PF00017	0.448
LIG_SH2_STAT5	407	410	PF00017	0.518
LIG_SH3_3	320	326	PF00018	0.562
LIG_SH3_3	375	381	PF00018	0.654
LIG_SH3_3	420	426	PF00018	0.656
LIG_SH3_3	433	439	PF00018	0.605
LIG_SUMO_SIM_anti_2	54	61	PF11976	0.363
LIG_SUMO_SIM_par_1	219	227	PF11976	0.436
LIG_SUMO_SIM_par_1	274	280	PF11976	0.430
LIG_SxIP_EBH_1	345	355	PF03271	0.528
LIG_TRAF2_1	142	145	PF00917	0.466
LIG_TYR_ITSM	18	25	PF00017	0.356
LIG_UBA3_1	81	87	PF00899	0.385
LIG_WW_3	352	356	PF00397	0.624
MOD_CK1_1	262	268	PF00069	0.573
MOD_CK1_1	342	348	PF00069	0.687
MOD_CK1_1	365	371	PF00069	0.539
MOD_CK1_1	385	391	PF00069	0.617
MOD_CK1_1	412	418	PF00069	0.563
MOD_CK1_1	477	483	PF00069	0.571
MOD_CK1_1	88	94	PF00069	0.440
MOD_CK2_1	2	8	PF00069	0.485
MOD_CK2_1	235	241	PF00069	0.323
MOD_CK2_1	250	256	PF00069	0.493
MOD_CK2_1	410	416	PF00069	0.670
MOD_CK2_1	440	446	PF00069	0.746
MOD_GlcNHglycan	194	197	PF01048	0.627
MOD_GlcNHglycan	229	232	PF01048	0.424
MOD_GlcNHglycan	296	299	PF01048	0.505
MOD_GlcNHglycan	332	335	PF01048	0.659
MOD_GlcNHglycan	384	387	PF01048	0.612
MOD_GlcNHglycan	418	421	PF01048	0.704
MOD_GlcNHglycan	476	479	PF01048	0.606
MOD_GlcNHglycan	484	487	PF01048	0.773
MOD_GSK3_1	128	135	PF00069	0.438
MOD_GSK3_1	143	150	PF00069	0.352
MOD_GSK3_1	223	230	PF00069	0.511
MOD_GSK3_1	272	279	PF00069	0.482
MOD_GSK3_1	288	295	PF00069	0.364
MOD_GSK3_1	326	333	PF00069	0.625
MOD_GSK3_1	339	346	PF00069	0.676
MOD_GSK3_1	365	372	PF00069	0.614
MOD_GSK3_1	381	388	PF00069	0.604
MOD_GSK3_1	412	419	PF00069	0.635
MOD_GSK3_1	441	448	PF00069	0.678
MOD_GSK3_1	477	484	PF00069	0.710
MOD_GSK3_1	81	88	PF00069	0.431
MOD_LATS_1	360	366	PF00433	0.543
MOD_N-GLC_1	132	137	PF02516	0.332
MOD_N-GLC_1	243	248	PF02516	0.432
MOD_N-GLC_1	342	347	PF02516	0.586
MOD_N-GLC_1	368	373	PF02516	0.538
MOD_NEK2_1	128	133	PF00069	0.356
MOD_NEK2_1	277	282	PF00069	0.470
MOD_NEK2_1	288	293	PF00069	0.485
MOD_NEK2_1	330	335	PF00069	0.767
MOD_NEK2_1	45	50	PF00069	0.294
MOD_NEK2_1	81	86	PF00069	0.388
MOD_NEK2_2	89	94	PF00069	0.307
MOD_PIKK_1	202	208	PF00454	0.515
MOD_PIKK_1	262	268	PF00454	0.485
MOD_PIKK_1	292	298	PF00454	0.398
MOD_PIKK_1	96	102	PF00454	0.325
MOD_PKA_1	318	324	PF00069	0.505
MOD_PKA_2	192	198	PF00069	0.538
MOD_PKA_2	227	233	PF00069	0.489
MOD_Plk_1	132	138	PF00069	0.330
MOD_Plk_1	143	149	PF00069	0.378
MOD_Plk_1	250	256	PF00069	0.422
MOD_Plk_1	342	348	PF00069	0.611
MOD_Plk_1	441	447	PF00069	0.527
MOD_Plk_4	132	138	PF00069	0.361
MOD_Plk_4	143	149	PF00069	0.421
MOD_Plk_4	2	8	PF00069	0.426
MOD_Plk_4	259	265	PF00069	0.578
MOD_Plk_4	272	278	PF00069	0.391
MOD_Plk_4	326	332	PF00069	0.615
MOD_Plk_4	402	408	PF00069	0.536
MOD_Plk_4	52	58	PF00069	0.210
MOD_Plk_4	81	87	PF00069	0.300
MOD_ProDKin_1	17	23	PF00069	0.321
MOD_ProDKin_1	354	360	PF00069	0.585
MOD_ProDKin_1	371	377	PF00069	0.695
MOD_ProDKin_1	445	451	PF00069	0.782
MOD_SUMO_for_1	168	171	PF00179	0.436
MOD_SUMO_for_1	176	179	PF00179	0.500
MOD_SUMO_for_1	301	304	PF00179	0.562
MOD_SUMO_for_1	469	472	PF00179	0.528
MOD_SUMO_rev_2	191	200	PF00179	0.593
MOD_SUMO_rev_2	313	321	PF00179	0.514
TRG_AP2beta_CARGO_1	497	507	PF09066	0.480
TRG_DiLeu_BaEn_1	125	130	PF01217	0.432
TRG_DiLeu_BaEn_2	39	45	PF01217	0.385
TRG_DiLeu_BaEn_4	144	150	PF01217	0.458
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.349
TRG_ENDOCYTIC_2	22	25	PF00928	0.382
TRG_ENDOCYTIC_2	273	276	PF00928	0.481
TRG_ENDOCYTIC_2	39	42	PF00928	0.460
TRG_ER_diArg_1	63	66	PF00400	0.291
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB53	Leptomonas seymouri	63%	94%
A0A0S4JSH6	Bodo saltans	34%	100%
A0A3Q8IJX3	Leishmania donovani	65%	98%
A4IDT6	Leishmania infantum	65%	98%
E9ATU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q0P8	Leishmania major	62%	100%
V5BM99	Trypanosoma cruzi	36%	100%