Expansin-like EG45 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ29_LEIBR

TriTrypDb:

LbrM.35.5380 , LBRM2903_350064800

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQ29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.374
CLV_C14_Caspase3-7	196	200	PF00656	0.360
CLV_MEL_PAP_1	133	139	PF00089	0.334
CLV_NRD_NRD_1	206	208	PF00675	0.487
CLV_PCSK_KEX2_1	152	154	PF00082	0.564
CLV_PCSK_KEX2_1	206	208	PF00082	0.503
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.564
CLV_PCSK_SKI1_1	157	161	PF00082	0.473
CLV_PCSK_SKI1_1	222	226	PF00082	0.474
DEG_APCC_DBOX_1	77	85	PF00400	0.485
DOC_PP2B_LxvP_1	190	193	PF13499	0.377
DOC_PP2B_LxvP_1	252	255	PF13499	0.235
DOC_PP4_FxxP_1	45	48	PF00568	0.368
DOC_USP7_MATH_1	143	147	PF00917	0.367
DOC_USP7_MATH_1	151	155	PF00917	0.357
DOC_USP7_MATH_1	227	231	PF00917	0.525
DOC_USP7_MATH_1	255	259	PF00917	0.482
DOC_USP7_MATH_1	73	77	PF00917	0.485
DOC_USP7_UBL2_3	107	111	PF12436	0.515
DOC_WW_Pin1_4	214	219	PF00397	0.384
DOC_WW_Pin1_4	44	49	PF00397	0.529
LIG_14-3-3_CanoR_1	69	77	PF00244	0.393
LIG_APCC_ABBA_1	53	58	PF00400	0.252
LIG_BIR_II_1	1	5	PF00653	0.436
LIG_BRCT_BRCA1_1	70	74	PF00533	0.511
LIG_FHA_1	103	109	PF00498	0.295
LIG_FHA_1	119	125	PF00498	0.378
LIG_FHA_1	247	253	PF00498	0.358
LIG_FHA_2	194	200	PF00498	0.524
LIG_LIR_Gen_1	158	167	PF02991	0.377
LIG_LIR_Gen_1	6	14	PF02991	0.345
LIG_LIR_Nem_3	158	162	PF02991	0.404
LIG_LIR_Nem_3	6	10	PF02991	0.346
LIG_LIR_Nem_3	76	80	PF02991	0.365
LIG_Pex14_2	267	271	PF04695	0.278
LIG_PTB_Apo_2	136	143	PF02174	0.270
LIG_SH2_CRK	166	170	PF00017	0.459
LIG_SH2_NCK_1	166	170	PF00017	0.426
LIG_SH2_NCK_1	57	61	PF00017	0.408
LIG_SH2_SRC	197	200	PF00017	0.467
LIG_SH2_STAP1	234	238	PF00017	0.542
LIG_SH2_STAP1	7	11	PF00017	0.437
LIG_SH2_STAT3	180	183	PF00017	0.265
LIG_SH2_STAT5	17	20	PF00017	0.433
LIG_SH2_STAT5	197	200	PF00017	0.372
LIG_SH2_STAT5	234	237	PF00017	0.461
LIG_SH2_STAT5	80	83	PF00017	0.477
LIG_WW_1	4	7	PF00397	0.472
MOD_CK1_1	118	124	PF00069	0.402
MOD_CK1_1	22	28	PF00069	0.452
MOD_CK1_1	230	236	PF00069	0.466
MOD_CK1_1	68	74	PF00069	0.484
MOD_CK2_1	73	79	PF00069	0.515
MOD_GlcNHglycan	1	4	PF01048	0.571
MOD_GlcNHglycan	153	156	PF01048	0.403
MOD_GlcNHglycan	257	260	PF01048	0.489
MOD_GlcNHglycan	70	73	PF01048	0.430
MOD_GSK3_1	115	122	PF00069	0.447
MOD_GSK3_1	230	237	PF00069	0.419
MOD_GSK3_1	246	253	PF00069	0.286
MOD_GSK3_1	61	68	PF00069	0.353
MOD_N-GLC_1	115	120	PF02516	0.470
MOD_N-GLC_1	227	232	PF02516	0.474
MOD_NEK2_1	115	120	PF00069	0.422
MOD_NEK2_1	269	274	PF00069	0.492
MOD_NEK2_2	102	107	PF00069	0.486
MOD_NEK2_2	62	67	PF00069	0.486
MOD_PKA_2	135	141	PF00069	0.375
MOD_PKA_2	68	74	PF00069	0.530
MOD_Plk_1	157	163	PF00069	0.387
MOD_Plk_4	119	125	PF00069	0.392
MOD_Plk_4	193	199	PF00069	0.503
MOD_Plk_4	80	86	PF00069	0.414
MOD_ProDKin_1	214	220	PF00069	0.388
MOD_ProDKin_1	44	50	PF00069	0.524
MOD_SUMO_rev_2	146	154	PF00179	0.509
TRG_DiLeu_BaEn_2	204	210	PF01217	0.426
TRG_ENDOCYTIC_2	7	10	PF00928	0.435
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P495	Leptomonas seymouri	60%	100%
A0A0S4JKK5	Bodo saltans	25%	98%
A0A1X0P327	Trypanosomatidae	35%	96%
A0A3Q8IPM4	Leishmania donovani	77%	100%
A0A422NMF9	Trypanosoma rangeli	35%	100%
A4IDT5	Leishmania infantum	77%	100%
D0A8T8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ATU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q0P9	Leishmania major	74%	100%
V5BWK1	Trypanosoma cruzi	35%	100%