HU-CCDC81_euk_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4496), putative

Species:

Leishmania braziliensis

UniProt:

A4HQ27_LEIBR

TriTrypDb:

LbrM.35.5360 , LBRM2903_350064500

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HQ27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.406
CLV_C14_Caspase3-7	249	253	PF00656	0.568
CLV_NRD_NRD_1	260	262	PF00675	0.621
CLV_PCSK_KEX2_1	260	262	PF00082	0.656
CLV_PCSK_KEX2_1	35	37	PF00082	0.366
CLV_PCSK_KEX2_1	61	63	PF00082	0.308
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.366
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.308
CLV_PCSK_SKI1_1	107	111	PF00082	0.571
DOC_CKS1_1	201	206	PF01111	0.601
DOC_MAPK_gen_1	60	69	PF00069	0.400
DOC_MAPK_MEF2A_6	60	69	PF00069	0.400
DOC_MAPK_NFAT4_5	62	70	PF00069	0.400
DOC_SPAK_OSR1_1	138	142	PF12202	0.308
DOC_USP7_UBL2_3	103	107	PF12436	0.390
DOC_WW_Pin1_4	200	205	PF00397	0.554
LIG_14-3-3_CanoR_1	158	168	PF00244	0.344
LIG_14-3-3_CanoR_1	181	189	PF00244	0.310
LIG_14-3-3_CanoR_1	191	197	PF00244	0.385
LIG_14-3-3_CanoR_1	230	239	PF00244	0.575
LIG_14-3-3_CanoR_1	244	250	PF00244	0.562
LIG_BRCT_BRCA1_1	184	188	PF00533	0.344
LIG_CtBP_PxDLS_1	207	211	PF00389	0.425
LIG_FHA_1	161	167	PF00498	0.365
LIG_FHA_2	201	207	PF00498	0.576
LIG_FHA_2	22	28	PF00498	0.373
LIG_FHA_2	244	250	PF00498	0.501
LIG_LIR_Apic_2	203	208	PF02991	0.464
LIG_LIR_Gen_1	126	134	PF02991	0.305
LIG_LIR_Nem_3	126	130	PF02991	0.280
LIG_LIR_Nem_3	256	262	PF02991	0.462
LIG_Pex14_1	184	188	PF04695	0.284
LIG_Pex14_2	100	104	PF04695	0.308
LIG_PTAP_UEV_1	214	219	PF05743	0.488
LIG_RPA_C_Fungi	133	145	PF08784	0.203
LIG_SH2_CRK	205	209	PF00017	0.473
LIG_SH2_CRK	259	263	PF00017	0.471
LIG_SH2_NCK_1	205	209	PF00017	0.473
LIG_SH2_SRC	205	208	PF00017	0.455
LIG_SH2_STAT3	30	33	PF00017	0.284
LIG_SH2_STAT5	127	130	PF00017	0.412
LIG_SH2_STAT5	155	158	PF00017	0.324
LIG_SH2_STAT5	30	33	PF00017	0.231
LIG_SH3_2	215	220	PF14604	0.569
LIG_SH3_3	198	204	PF00018	0.539
LIG_SH3_3	209	215	PF00018	0.516
LIG_SUMO_SIM_par_1	162	167	PF11976	0.344
LIG_TYR_ITIM	125	130	PF00017	0.308
MOD_CK1_1	126	132	PF00069	0.339
MOD_CK1_1	162	168	PF00069	0.360
MOD_CK1_1	243	249	PF00069	0.631
MOD_CK1_1	5	11	PF00069	0.576
MOD_CK2_1	145	151	PF00069	0.284
MOD_CK2_1	243	249	PF00069	0.589
MOD_GlcNHglycan	62	65	PF01048	0.400
MOD_GlcNHglycan	7	10	PF01048	0.641
MOD_GSK3_1	1	8	PF00069	0.728
MOD_GSK3_1	129	136	PF00069	0.335
MOD_N-GLC_1	82	87	PF02516	0.203
MOD_NEK2_1	1	6	PF00069	0.618
MOD_NEK2_1	192	197	PF00069	0.360
MOD_NEK2_1	240	245	PF00069	0.494
MOD_NEK2_1	254	259	PF00069	0.480
MOD_NEK2_1	70	75	PF00069	0.284
MOD_NEK2_1	82	87	PF00069	0.284
MOD_PIKK_1	230	236	PF00454	0.555
MOD_PKA_1	60	66	PF00069	0.344
MOD_PKA_2	235	241	PF00069	0.497
MOD_PKA_2	243	249	PF00069	0.534
MOD_Plk_1	176	182	PF00069	0.360
MOD_Plk_1	83	89	PF00069	0.401
MOD_Plk_4	123	129	PF00069	0.360
MOD_Plk_4	235	241	PF00069	0.534
MOD_ProDKin_1	200	206	PF00069	0.551
TRG_ENDOCYTIC_2	127	130	PF00928	0.308
TRG_ENDOCYTIC_2	16	19	PF00928	0.362
TRG_ENDOCYTIC_2	259	262	PF00928	0.469
TRG_ER_diArg_1	259	261	PF00400	0.667
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P360	Leptomonas seymouri	77%	100%
A0A1X0NFH5	Trypanosomatidae	53%	100%
A0A3Q8IJR1	Leishmania donovani	86%	100%
A0A422N6F8	Trypanosoma rangeli	55%	83%
A4IDT3	Leishmania infantum	86%	100%
D0A8U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9ATU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q0Q1	Leishmania major	86%	100%