DNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA helicase

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ26_LEIBR

TriTrypDb:

LbrM.35.5350 , LBRM2903_350064400

Length:

977

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ26

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0005488	binding	1	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	272	274	PF00675	0.538
CLV_NRD_NRD_1	505	507	PF00675	0.443
CLV_NRD_NRD_1	625	627	PF00675	0.812
CLV_NRD_NRD_1	707	709	PF00675	0.627
CLV_NRD_NRD_1	769	771	PF00675	0.590
CLV_PCSK_FUR_1	707	711	PF00082	0.557
CLV_PCSK_KEX2_1	485	487	PF00082	0.571
CLV_PCSK_KEX2_1	507	509	PF00082	0.437
CLV_PCSK_KEX2_1	631	633	PF00082	0.706
CLV_PCSK_KEX2_1	707	709	PF00082	0.620
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.571
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.480
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.688
CLV_PCSK_PC1ET2_1	709	711	PF00082	0.634
CLV_PCSK_SKI1_1	274	278	PF00082	0.663
CLV_PCSK_SKI1_1	482	486	PF00082	0.656
CLV_PCSK_SKI1_1	499	503	PF00082	0.472
CLV_PCSK_SKI1_1	508	512	PF00082	0.437
CLV_PCSK_SKI1_1	567	571	PF00082	0.686
CLV_PCSK_SKI1_1	660	664	PF00082	0.565
CLV_PCSK_SKI1_1	680	684	PF00082	0.403
CLV_PCSK_SKI1_1	712	716	PF00082	0.467
CLV_PCSK_SKI1_1	728	732	PF00082	0.497
CLV_PCSK_SKI1_1	807	811	PF00082	0.541
CLV_PCSK_SKI1_1	828	832	PF00082	0.516
DEG_APCC_DBOX_1	806	814	PF00400	0.455
DEG_APCC_DBOX_1	827	835	PF00400	0.473
DEG_COP1_1	661	669	PF00400	0.545
DEG_Nend_UBRbox_3	1	3	PF02207	0.858
DOC_ANK_TNKS_1	633	640	PF00023	0.584
DOC_CDC14_PxL_1	542	550	PF14671	0.488
DOC_CKS1_1	819	824	PF01111	0.482
DOC_CYCLIN_yCln2_LP_2	538	544	PF00134	0.475
DOC_MAPK_gen_1	292	300	PF00069	0.580
DOC_MAPK_gen_1	496	504	PF00069	0.546
DOC_MAPK_gen_1	506	512	PF00069	0.553
DOC_MAPK_gen_1	570	578	PF00069	0.519
DOC_MAPK_gen_1	859	867	PF00069	0.407
DOC_MAPK_MEF2A_6	294	302	PF00069	0.555
DOC_PP1_RVXF_1	527	533	PF00149	0.615
DOC_PP2B_LxvP_1	313	316	PF13499	0.551
DOC_PP4_FxxP_1	373	376	PF00568	0.719
DOC_USP7_MATH_1	288	292	PF00917	0.644
DOC_USP7_MATH_1	416	420	PF00917	0.571
DOC_USP7_MATH_1	473	477	PF00917	0.709
DOC_USP7_MATH_1	50	54	PF00917	0.578
DOC_USP7_MATH_1	6	10	PF00917	0.676
DOC_USP7_MATH_1	612	616	PF00917	0.426
DOC_USP7_MATH_1	621	625	PF00917	0.484
DOC_USP7_MATH_1	912	916	PF00917	0.604
DOC_USP7_MATH_1	965	969	PF00917	0.613
DOC_USP7_UBL2_3	481	485	PF12436	0.753
DOC_USP7_UBL2_3	627	631	PF12436	0.695
DOC_WW_Pin1_4	376	381	PF00397	0.713
DOC_WW_Pin1_4	488	493	PF00397	0.623
DOC_WW_Pin1_4	818	823	PF00397	0.426
DOC_WW_Pin1_4	886	891	PF00397	0.478
DOC_WW_Pin1_4	970	975	PF00397	0.811
LIG_14-3-3_CanoR_1	273	283	PF00244	0.638
LIG_14-3-3_CanoR_1	466	470	PF00244	0.642
LIG_14-3-3_CanoR_1	486	492	PF00244	0.519
LIG_14-3-3_CanoR_1	496	504	PF00244	0.301
LIG_14-3-3_CanoR_1	712	719	PF00244	0.568
LIG_14-3-3_CanoR_1	866	870	PF00244	0.551
LIG_14-3-3_CanoR_1	946	952	PF00244	0.376
LIG_Actin_WH2_2	523	539	PF00022	0.581
LIG_APCC_ABBA_1	753	758	PF00400	0.358
LIG_APCC_ABBAyCdc20_2	507	513	PF00400	0.513
LIG_Clathr_ClatBox_1	429	433	PF01394	0.388
LIG_eIF4E_1	738	744	PF01652	0.480
LIG_FHA_1	119	125	PF00498	0.700
LIG_FHA_1	275	281	PF00498	0.616
LIG_FHA_1	295	301	PF00498	0.344
LIG_FHA_1	400	406	PF00498	0.531
LIG_FHA_1	661	667	PF00498	0.641
LIG_FHA_1	681	687	PF00498	0.382
LIG_FHA_1	709	715	PF00498	0.455
LIG_FHA_1	866	872	PF00498	0.508
LIG_FHA_1	931	937	PF00498	0.482
LIG_FHA_1	954	960	PF00498	0.396
LIG_FHA_2	369	375	PF00498	0.573
LIG_FHA_2	377	383	PF00498	0.609
LIG_FHA_2	391	397	PF00498	0.439
LIG_FHA_2	466	472	PF00498	0.793
LIG_FHA_2	819	825	PF00498	0.606
LIG_FHA_2	827	833	PF00498	0.522
LIG_FHA_2	835	841	PF00498	0.361
LIG_GBD_Chelix_1	895	903	PF00786	0.424
LIG_IBAR_NPY_1	10	12	PF08397	0.756
LIG_Integrin_RGD_1	99	101	PF01839	0.580
LIG_IRF3_LxIS_1	883	889	PF10401	0.476
LIG_LIR_Apic_2	137	141	PF02991	0.622
LIG_LIR_Apic_2	371	376	PF02991	0.715
LIG_LIR_Gen_1	255	265	PF02991	0.557
LIG_LIR_Gen_1	407	416	PF02991	0.585
LIG_LIR_Gen_1	423	432	PF02991	0.500
LIG_LIR_Gen_1	550	561	PF02991	0.517
LIG_LIR_Nem_3	255	260	PF02991	0.493
LIG_LIR_Nem_3	263	268	PF02991	0.458
LIG_LIR_Nem_3	330	335	PF02991	0.575
LIG_LIR_Nem_3	361	366	PF02991	0.620
LIG_LIR_Nem_3	407	411	PF02991	0.609
LIG_LIR_Nem_3	423	429	PF02991	0.495
LIG_LIR_Nem_3	550	556	PF02991	0.498
LIG_LIR_Nem_3	678	682	PF02991	0.452
LIG_LIR_Nem_3	687	691	PF02991	0.348
LIG_LIR_Nem_3	9	15	PF02991	0.720
LIG_LIR_Nem_3	925	931	PF02991	0.542
LIG_LYPXL_yS_3	545	548	PF13949	0.496
LIG_NRBOX	365	371	PF00104	0.543
LIG_NRBOX	826	832	PF00104	0.471
LIG_PAM2_1	784	796	PF00658	0.476
LIG_Pex14_1	688	692	PF04695	0.480
LIG_PTB_Apo_2	155	162	PF02174	0.750
LIG_PTB_Apo_2	221	228	PF02174	0.599
LIG_PTB_Phospho_1	155	161	PF10480	0.750
LIG_PTB_Phospho_1	221	227	PF10480	0.600
LIG_REV1ctd_RIR_1	509	516	PF16727	0.537
LIG_SH2_CRK	109	113	PF00017	0.582
LIG_SH2_CRK	257	261	PF00017	0.546
LIG_SH2_CRK	67	71	PF00017	0.628
LIG_SH2_CRK	679	683	PF00017	0.389
LIG_SH2_CRK	751	755	PF00017	0.443
LIG_SH2_CRK	806	810	PF00017	0.450
LIG_SH2_GRB2like	156	159	PF00017	0.768
LIG_SH2_NCK_1	167	171	PF00017	0.745
LIG_SH2_NCK_1	67	71	PF00017	0.708
LIG_SH2_NCK_1	692	696	PF00017	0.459
LIG_SH2_SRC	167	170	PF00017	0.699
LIG_SH2_STAP1	408	412	PF00017	0.562
LIG_SH2_STAP1	71	75	PF00017	0.694
LIG_SH2_STAT3	139	142	PF00017	0.787
LIG_SH2_STAT3	148	151	PF00017	0.728
LIG_SH2_STAT3	156	159	PF00017	0.651
LIG_SH2_STAT3	19	22	PF00017	0.741
LIG_SH2_STAT3	28	31	PF00017	0.650
LIG_SH2_STAT3	41	44	PF00017	0.601
LIG_SH2_STAT3	586	589	PF00017	0.464
LIG_SH2_STAT3	81	84	PF00017	0.778
LIG_SH2_STAT5	738	741	PF00017	0.475
LIG_SH2_STAT5	846	849	PF00017	0.478
LIG_SH2_STAT5	894	897	PF00017	0.401
LIG_SH2_STAT5	929	932	PF00017	0.402
LIG_SH3_1	514	520	PF00018	0.583
LIG_SH3_3	313	319	PF00018	0.603
LIG_SH3_3	42	48	PF00018	0.716
LIG_SH3_3	514	520	PF00018	0.655
LIG_SH3_3	679	685	PF00018	0.590
LIG_SH3_3	816	822	PF00018	0.480
LIG_SH3_3	968	974	PF00018	0.702
LIG_SH3_4	627	634	PF00018	0.730
LIG_SH3_5	98	102	PF00018	0.574
LIG_SUMO_SIM_anti_2	599	605	PF11976	0.486
LIG_SUMO_SIM_par_1	612	618	PF11976	0.444
LIG_TRAF2_1	445	448	PF00917	0.742
LIG_TRAF2_1	451	454	PF00917	0.673
LIG_TRAF2_1	620	623	PF00917	0.751
LIG_TYR_ITIM	543	548	PF00017	0.494
LIG_UBA3_1	366	375	PF00899	0.560
LIG_WRC_WIRS_1	360	365	PF05994	0.539
LIG_WRC_WIRS_1	370	375	PF05994	0.468
LIG_WRC_WIRS_1	552	557	PF05994	0.371
LIG_WRC_WIRS_1	744	749	PF05994	0.476
LIG_WRC_WIRS_1	928	933	PF05994	0.404
MOD_CDK_SPxxK_3	818	825	PF00069	0.325
MOD_CK1_1	325	331	PF00069	0.597
MOD_CK1_1	419	425	PF00069	0.558
MOD_CK1_1	476	482	PF00069	0.619
MOD_CK1_1	592	598	PF00069	0.607
MOD_CK1_1	697	703	PF00069	0.593
MOD_CK1_1	879	885	PF00069	0.352
MOD_CK1_1	950	956	PF00069	0.525
MOD_CK1_1	969	975	PF00069	0.576
MOD_CK2_1	376	382	PF00069	0.739
MOD_CK2_1	390	396	PF00069	0.452
MOD_CK2_1	454	460	PF00069	0.672
MOD_CK2_1	465	471	PF00069	0.661
MOD_CK2_1	525	531	PF00069	0.717
MOD_CK2_1	612	618	PF00069	0.613
MOD_CK2_1	672	678	PF00069	0.506
MOD_CK2_1	791	797	PF00069	0.358
MOD_CK2_1	838	844	PF00069	0.405
MOD_Cter_Amidation	271	274	PF01082	0.610
MOD_GlcNHglycan	286	289	PF01048	0.647
MOD_GlcNHglycan	475	478	PF01048	0.647
MOD_GlcNHglycan	531	535	PF01048	0.581
MOD_GlcNHglycan	592	595	PF01048	0.563
MOD_GlcNHglycan	644	648	PF01048	0.606
MOD_GlcNHglycan	761	764	PF01048	0.404
MOD_GlcNHglycan	890	893	PF01048	0.567
MOD_GSK3_1	193	200	PF00069	0.598
MOD_GSK3_1	284	291	PF00069	0.608
MOD_GSK3_1	358	365	PF00069	0.621
MOD_GSK3_1	416	423	PF00069	0.538
MOD_GSK3_1	484	491	PF00069	0.547
MOD_GSK3_1	588	595	PF00069	0.422
MOD_GSK3_1	708	715	PF00069	0.642
MOD_GSK3_1	781	788	PF00069	0.542
MOD_GSK3_1	792	799	PF00069	0.394
MOD_GSK3_1	834	841	PF00069	0.470
MOD_GSK3_1	912	919	PF00069	0.503
MOD_GSK3_1	946	953	PF00069	0.405
MOD_GSK3_1	959	966	PF00069	0.629
MOD_N-GLC_1	6	11	PF02516	0.582
MOD_NEK2_1	253	258	PF00069	0.702
MOD_NEK2_1	368	373	PF00069	0.536
MOD_NEK2_1	397	402	PF00069	0.371
MOD_NEK2_1	551	556	PF00069	0.352
MOD_NEK2_1	590	595	PF00069	0.459
MOD_NEK2_1	743	748	PF00069	0.470
MOD_NEK2_1	796	801	PF00069	0.407
MOD_NEK2_1	959	964	PF00069	0.482
MOD_NEK2_2	532	537	PF00069	0.530
MOD_PIKK_1	147	153	PF00454	0.675
MOD_PIKK_1	193	199	PF00454	0.619
MOD_PIKK_1	205	211	PF00454	0.562
MOD_PIKK_1	50	56	PF00454	0.680
MOD_PIKK_1	712	718	PF00454	0.604
MOD_PIKK_1	83	89	PF00454	0.805
MOD_PKA_1	708	714	PF00069	0.619
MOD_PKA_2	293	299	PF00069	0.692
MOD_PKA_2	465	471	PF00069	0.643
MOD_PKA_2	858	864	PF00069	0.513
MOD_PKA_2	865	871	PF00069	0.408
MOD_PKB_1	292	300	PF00069	0.580
MOD_PKB_1	710	718	PF00069	0.598
MOD_Plk_1	319	325	PF00069	0.618
MOD_Plk_1	796	802	PF00069	0.457
MOD_Plk_1	879	885	PF00069	0.510
MOD_Plk_2-3	404	410	PF00069	0.534
MOD_Plk_2-3	454	460	PF00069	0.618
MOD_Plk_2-3	653	659	PF00069	0.573
MOD_Plk_2-3	826	832	PF00069	0.314
MOD_Plk_4	134	140	PF00069	0.644
MOD_Plk_4	152	158	PF00069	0.573
MOD_Plk_4	276	282	PF00069	0.528
MOD_Plk_4	319	325	PF00069	0.573
MOD_Plk_4	328	334	PF00069	0.474
MOD_Plk_4	596	602	PF00069	0.451
MOD_Plk_4	743	749	PF00069	0.420
MOD_Plk_4	781	787	PF00069	0.534
MOD_Plk_4	834	840	PF00069	0.417
MOD_Plk_4	879	885	PF00069	0.566
MOD_Plk_4	927	933	PF00069	0.409
MOD_ProDKin_1	376	382	PF00069	0.721
MOD_ProDKin_1	488	494	PF00069	0.620
MOD_ProDKin_1	818	824	PF00069	0.423
MOD_ProDKin_1	886	892	PF00069	0.473
MOD_ProDKin_1	970	976	PF00069	0.811
MOD_SUMO_for_1	650	653	PF00179	0.679
MOD_SUMO_rev_2	653	662	PF00179	0.572
MOD_SUMO_rev_2	664	672	PF00179	0.531
MOD_SUMO_rev_2	675	682	PF00179	0.605
MOD_SUMO_rev_2	914	924	PF00179	0.548
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.508
TRG_DiLeu_BaLyEn_6	534	539	PF01217	0.491
TRG_DiLeu_BaLyEn_6	543	548	PF01217	0.402
TRG_ENDOCYTIC_2	109	112	PF00928	0.585
TRG_ENDOCYTIC_2	257	260	PF00928	0.501
TRG_ENDOCYTIC_2	265	268	PF00928	0.502
TRG_ENDOCYTIC_2	408	411	PF00928	0.597
TRG_ENDOCYTIC_2	545	548	PF00928	0.536
TRG_ENDOCYTIC_2	679	682	PF00928	0.421
TRG_ENDOCYTIC_2	691	694	PF00928	0.347
TRG_ENDOCYTIC_2	71	74	PF00928	0.565
TRG_ENDOCYTIC_2	806	809	PF00928	0.453
TRG_ENDOCYTIC_2	928	931	PF00928	0.496
TRG_ER_diArg_1	289	292	PF00400	0.734
TRG_ER_diArg_1	706	708	PF00400	0.613
TRG_ER_diArg_1	710	713	PF00400	0.606
TRG_ER_diArg_1	735	738	PF00400	0.454
TRG_NLS_MonoExtC_3	707	712	PF00514	0.633
TRG_NLS_MonoExtN_4	707	713	PF00514	0.627
TRG_Pf-PMV_PEXEL_1	674	678	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	828	832	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	873	877	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	897	902	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NFU9	Trypanosomatidae	26%	100%
A0A3Q8IRM7	Leishmania donovani	77%	100%
A0A422N6K0	Trypanosoma rangeli	27%	100%
A4IDT2	Leishmania infantum	77%	100%
D0A8U2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	100%
E9ATU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4Q0Q2	Leishmania major	76%	97%