CCHC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ24_LEIBR

TriTrypDb:

LbrM.35.5330 , LBRM2903_350064200

Length:

614

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	67	71	PF00656	0.571
CLV_NRD_NRD_1	210	212	PF00675	0.543
CLV_NRD_NRD_1	344	346	PF00675	0.467
CLV_NRD_NRD_1	38	40	PF00675	0.720
CLV_NRD_NRD_1	418	420	PF00675	0.652
CLV_NRD_NRD_1	579	581	PF00675	0.490
CLV_NRD_NRD_1	84	86	PF00675	0.740
CLV_PCSK_KEX2_1	106	108	PF00082	0.631
CLV_PCSK_KEX2_1	344	346	PF00082	0.467
CLV_PCSK_KEX2_1	38	40	PF00082	0.820
CLV_PCSK_KEX2_1	418	420	PF00082	0.651
CLV_PCSK_KEX2_1	557	559	PF00082	0.444
CLV_PCSK_KEX2_1	579	581	PF00082	0.490
CLV_PCSK_KEX2_1	84	86	PF00082	0.740
CLV_PCSK_KEX2_1	92	94	PF00082	0.704
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.631
CLV_PCSK_PC1ET2_1	557	559	PF00082	0.500
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.724
CLV_PCSK_SKI1_1	145	149	PF00082	0.468
CLV_PCSK_SKI1_1	267	271	PF00082	0.470
CLV_PCSK_SKI1_1	300	304	PF00082	0.513
CLV_PCSK_SKI1_1	459	463	PF00082	0.425
CLV_PCSK_SKI1_1	470	474	PF00082	0.542
CLV_PCSK_SKI1_1	479	483	PF00082	0.515
CLV_PCSK_SKI1_1	579	583	PF00082	0.535
CLV_PCSK_SKI1_1	599	603	PF00082	0.328
DEG_APCC_DBOX_1	266	274	PF00400	0.462
DEG_APCC_DBOX_1	578	586	PF00400	0.476
DEG_Nend_UBRbox_2	1	3	PF02207	0.677
DEG_SPOP_SBC_1	3	7	PF00917	0.549
DOC_ANK_TNKS_1	65	72	PF00023	0.541
DOC_CKS1_1	193	198	PF01111	0.328
DOC_CYCLIN_RxL_1	467	477	PF00134	0.604
DOC_CYCLIN_RxL_1	577	588	PF00134	0.471
DOC_CYCLIN_RxL_1	593	606	PF00134	0.525
DOC_PP1_RVXF_1	460	467	PF00149	0.508
DOC_PP1_RVXF_1	578	585	PF00149	0.473
DOC_PP4_FxxP_1	351	354	PF00568	0.614
DOC_USP7_MATH_1	15	19	PF00917	0.714
DOC_USP7_MATH_1	3	7	PF00917	0.750
DOC_USP7_MATH_2	266	272	PF00917	0.342
DOC_USP7_UBL2_3	106	110	PF12436	0.700
DOC_USP7_UBL2_3	338	342	PF12436	0.440
DOC_USP7_UBL2_3	356	360	PF12436	0.649
DOC_WW_Pin1_4	189	194	PF00397	0.550
DOC_WW_Pin1_4	262	267	PF00397	0.506
DOC_WW_Pin1_4	409	414	PF00397	0.542
DOC_WW_Pin1_4	530	535	PF00397	0.598
LIG_14-3-3_CanoR_1	26	30	PF00244	0.661
LIG_14-3-3_CanoR_1	321	329	PF00244	0.536
LIG_14-3-3_CanoR_1	479	484	PF00244	0.525
LIG_14-3-3_CanoR_1	563	571	PF00244	0.430
LIG_14-3-3_CanoR_1	84	90	PF00244	0.712
LIG_Actin_WH2_2	501	519	PF00022	0.596
LIG_Actin_WH2_2	568	585	PF00022	0.549
LIG_BIR_III_4	277	281	PF00653	0.369
LIG_BRCT_BRCA1_1	140	144	PF00533	0.537
LIG_BRCT_BRCA1_1	434	438	PF00533	0.545
LIG_BRCT_BRCA1_1	79	83	PF00533	0.539
LIG_CaM_IQ_9	330	346	PF13499	0.500
LIG_FHA_1	3	9	PF00498	0.556
LIG_FHA_1	301	307	PF00498	0.579
LIG_FHA_1	410	416	PF00498	0.636
LIG_FHA_1	511	517	PF00498	0.509
LIG_FHA_1	527	533	PF00498	0.536
LIG_FHA_2	128	134	PF00498	0.534
LIG_FHA_2	176	182	PF00498	0.466
LIG_FHA_2	289	295	PF00498	0.342
LIG_FHA_2	320	326	PF00498	0.719
LIG_FHA_2	360	366	PF00498	0.639
LIG_FHA_2	392	398	PF00498	0.775
LIG_FHA_2	421	427	PF00498	0.474
LIG_FHA_2	480	486	PF00498	0.594
LIG_FHA_2	608	614	PF00498	0.604
LIG_Integrin_RGD_1	68	70	PF01839	0.620
LIG_LIR_Apic_2	348	354	PF02991	0.580
LIG_LIR_Gen_1	116	125	PF02991	0.495
LIG_LIR_Gen_1	174	185	PF02991	0.492
LIG_LIR_Gen_1	435	446	PF02991	0.547
LIG_LIR_Gen_1	458	464	PF02991	0.530
LIG_LIR_Gen_1	477	488	PF02991	0.555
LIG_LIR_Nem_3	116	121	PF02991	0.507
LIG_LIR_Nem_3	174	180	PF02991	0.481
LIG_LIR_Nem_3	181	187	PF02991	0.533
LIG_LIR_Nem_3	435	441	PF02991	0.525
LIG_LIR_Nem_3	477	483	PF02991	0.528
LIG_SH2_CRK	122	126	PF00017	0.348
LIG_SH2_STAP1	165	169	PF00017	0.473
LIG_SH2_STAT5	134	137	PF00017	0.517
LIG_SH3_3	190	196	PF00018	0.607
LIG_SH3_3	239	245	PF00018	0.740
LIG_SH3_3	249	255	PF00018	0.644
LIG_SH3_3	343	349	PF00018	0.399
LIG_TRFH_1	351	355	PF08558	0.463
LIG_TYR_ITIM	120	125	PF00017	0.351
LIG_TYR_ITIM	163	168	PF00017	0.336
LIG_UBA3_1	183	191	PF00899	0.524
LIG_UBA3_1	335	342	PF00899	0.489
LIG_WRC_WIRS_1	150	155	PF05994	0.483
MOD_CDK_SPK_2	262	267	PF00069	0.506
MOD_CK1_1	149	155	PF00069	0.456
MOD_CK1_1	213	219	PF00069	0.474
MOD_CK1_1	262	268	PF00069	0.520
MOD_CK1_1	320	326	PF00069	0.613
MOD_CK1_1	392	398	PF00069	0.564
MOD_CK1_1	4	10	PF00069	0.756
MOD_CK1_1	401	407	PF00069	0.807
MOD_CK1_1	46	52	PF00069	0.543
MOD_CK1_1	533	539	PF00069	0.600
MOD_CK2_1	127	133	PF00069	0.546
MOD_CK2_1	175	181	PF00069	0.463
MOD_CK2_1	262	268	PF00069	0.476
MOD_CK2_1	319	325	PF00069	0.693
MOD_CK2_1	391	397	PF00069	0.775
MOD_CK2_1	420	426	PF00069	0.567
MOD_CK2_1	479	485	PF00069	0.526
MOD_CK2_1	603	609	PF00069	0.425
MOD_Cter_Amidation	90	93	PF01082	0.540
MOD_GlcNHglycan	212	215	PF01048	0.659
MOD_GlcNHglycan	233	236	PF01048	0.675
MOD_GlcNHglycan	322	325	PF01048	0.681
MOD_GlcNHglycan	400	403	PF01048	0.815
MOD_GlcNHglycan	540	543	PF01048	0.437
MOD_GlcNHglycan	61	64	PF01048	0.611
MOD_GlcNHglycan	8	11	PF01048	0.803
MOD_GlcNHglycan	89	92	PF01048	0.714
MOD_GSK3_1	2	9	PF00069	0.643
MOD_GSK3_1	255	262	PF00069	0.749
MOD_GSK3_1	268	275	PF00069	0.466
MOD_GSK3_1	300	307	PF00069	0.557
MOD_GSK3_1	334	341	PF00069	0.376
MOD_GSK3_1	355	362	PF00069	0.578
MOD_GSK3_1	389	396	PF00069	0.713
MOD_GSK3_1	397	404	PF00069	0.668
MOD_GSK3_1	526	533	PF00069	0.358
MOD_GSK3_1	603	610	PF00069	0.684
MOD_NEK2_1	120	125	PF00069	0.480
MOD_NEK2_1	319	324	PF00069	0.491
MOD_NEK2_1	391	396	PF00069	0.563
MOD_NEK2_1	564	569	PF00069	0.459
MOD_NEK2_2	25	30	PF00069	0.670
MOD_NEK2_2	372	377	PF00069	0.555
MOD_PIKK_1	155	161	PF00454	0.512
MOD_PIKK_1	389	395	PF00454	0.757
MOD_PIKK_1	450	456	PF00454	0.580
MOD_PIKK_1	533	539	PF00454	0.373
MOD_PIKK_1	564	570	PF00454	0.467
MOD_PK_1	360	366	PF00069	0.521
MOD_PK_1	448	454	PF00069	0.506
MOD_PKA_1	300	306	PF00069	0.508
MOD_PKA_1	92	98	PF00069	0.536
MOD_PKA_2	210	216	PF00069	0.622
MOD_PKA_2	25	31	PF00069	0.741
MOD_PKA_2	32	38	PF00069	0.722
MOD_PKA_2	320	326	PF00069	0.574
MOD_PKA_2	59	65	PF00069	0.601
MOD_PKA_2	92	98	PF00069	0.536
MOD_PKB_1	85	93	PF00069	0.715
MOD_Plk_1	372	378	PF00069	0.810
MOD_Plk_1	468	474	PF00069	0.452
MOD_Plk_2-3	127	133	PF00069	0.565
MOD_Plk_4	120	126	PF00069	0.370
MOD_Plk_4	149	155	PF00069	0.486
MOD_Plk_4	259	265	PF00069	0.586
MOD_Plk_4	440	446	PF00069	0.543
MOD_Plk_4	468	474	PF00069	0.553
MOD_Plk_4	479	485	PF00069	0.536
MOD_Plk_4	498	504	PF00069	0.293
MOD_ProDKin_1	189	195	PF00069	0.542
MOD_ProDKin_1	262	268	PF00069	0.504
MOD_ProDKin_1	409	415	PF00069	0.539
MOD_ProDKin_1	530	536	PF00069	0.596
MOD_SUMO_for_1	105	108	PF00179	0.667
MOD_SUMO_rev_2	108	114	PF00179	0.641
MOD_SUMO_rev_2	140	150	PF00179	0.495
MOD_SUMO_rev_2	550	559	PF00179	0.591
TRG_DiLeu_BaEn_1	259	264	PF01217	0.695
TRG_DiLeu_BaEn_2	73	79	PF01217	0.663
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.493
TRG_DiLeu_BaLyEn_6	560	565	PF01217	0.444
TRG_ENDOCYTIC_2	122	125	PF00928	0.350
TRG_ENDOCYTIC_2	165	168	PF00928	0.484
TRG_ER_diArg_1	344	346	PF00400	0.467
TRG_ER_diArg_1	38	41	PF00400	0.822
TRG_ER_diArg_1	53	56	PF00400	0.592
TRG_ER_diArg_1	578	580	PF00400	0.494
TRG_ER_diArg_1	65	68	PF00400	0.698
TRG_ER_diArg_1	83	85	PF00400	0.684
TRG_Pf-PMV_PEXEL_1	563	568	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHF8	Leptomonas seymouri	58%	97%
A0A3R7LPT3	Trypanosoma rangeli	34%	100%
A0A3S7XBM9	Leishmania donovani	71%	99%
E9AHY2	Leishmania infantum	70%	99%
E9ATU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	99%
Q4Q0Q4	Leishmania major	70%	100%