Nin one binding Zn-ribbon like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nin one binding (NOB1) Zn-ribbon like, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ22_LEIBR

TriTrypDb:

LbrM.35.5310 , LBRM2903_350064000

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0030684	preribosome	3	1
GO:0030688	preribosome, small subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HQ22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ22

Function

Biological processes
Term	Name	Level	Count
GO:0000469	cleavage involved in rRNA processing	7	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0022613	ribonucleoprotein complex biogenesis	4	11
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0042274	ribosomal small subunit biogenesis	5	11
GO:0043170	macromolecule metabolic process	3	12
GO:0044085	cellular component biogenesis	3	11
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090304	nucleic acid metabolic process	4	12
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	12
GO:0090501	RNA phosphodiester bond hydrolysis	6	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004519	endonuclease activity	5	12
GO:0004521	RNA endonuclease activity	5	12
GO:0004540	RNA nuclease activity	4	12
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	76	80	PF00656	0.386
CLV_NRD_NRD_1	323	325	PF00675	0.301
CLV_NRD_NRD_1	341	343	PF00675	0.301
CLV_NRD_NRD_1	38	40	PF00675	0.658
CLV_NRD_NRD_1	438	440	PF00675	0.629
CLV_PCSK_KEX2_1	323	325	PF00082	0.301
CLV_PCSK_KEX2_1	343	345	PF00082	0.118
CLV_PCSK_KEX2_1	38	40	PF00082	0.484
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.382
CLV_PCSK_SKI1_1	57	61	PF00082	0.380
CLV_PCSK_SKI1_1	8	12	PF00082	0.560
CLV_PCSK_SKI1_1	89	93	PF00082	0.286
CLV_PCSK_SKI1_1	97	101	PF00082	0.259
DEG_APCC_DBOX_1	96	104	PF00400	0.287
DOC_CKS1_1	236	241	PF01111	0.486
DOC_CKS1_1	82	87	PF01111	0.422
DOC_CYCLIN_RxL_1	362	373	PF00134	0.441
DOC_CYCLIN_RxL_1	51	63	PF00134	0.433
DOC_CYCLIN_RxL_1	92	101	PF00134	0.271
DOC_CYCLIN_yCln2_LP_2	154	160	PF00134	0.480
DOC_PP1_RVXF_1	170	176	PF00149	0.501
DOC_PP2B_LxvP_1	276	279	PF13499	0.397
DOC_PP2B_LxvP_1	50	53	PF13499	0.336
DOC_USP7_MATH_1	189	193	PF00917	0.540
DOC_USP7_MATH_1	28	32	PF00917	0.472
DOC_USP7_MATH_1	419	423	PF00917	0.551
DOC_USP7_UBL2_3	17	21	PF12436	0.573
DOC_USP7_UBL2_3	408	412	PF12436	0.671
DOC_WW_Pin1_4	235	240	PF00397	0.499
DOC_WW_Pin1_4	403	408	PF00397	0.439
DOC_WW_Pin1_4	81	86	PF00397	0.422
LIG_14-3-3_CanoR_1	297	305	PF00244	0.306
LIG_14-3-3_CanoR_1	342	352	PF00244	0.361
LIG_14-3-3_CanoR_1	380	387	PF00244	0.524
LIG_14-3-3_CanoR_1	418	424	PF00244	0.461
LIG_BIR_II_1	1	5	PF00653	0.556
LIG_Clathr_ClatBox_1	59	63	PF01394	0.336
LIG_FHA_1	175	181	PF00498	0.526
LIG_FHA_1	281	287	PF00498	0.525
LIG_FHA_1	301	307	PF00498	0.118
LIG_FHA_1	45	51	PF00498	0.657
LIG_FHA_1	82	88	PF00498	0.319
LIG_FHA_2	106	112	PF00498	0.420
LIG_FHA_2	216	222	PF00498	0.783
LIG_FHA_2	400	406	PF00498	0.684
LIG_LIR_Apic_2	233	239	PF02991	0.509
LIG_LIR_Apic_2	350	355	PF02991	0.301
LIG_LIR_Gen_1	2	10	PF02991	0.570
LIG_LIR_Gen_1	299	306	PF02991	0.422
LIG_LIR_Gen_1	335	345	PF02991	0.335
LIG_LIR_LC3C_4	303	306	PF02991	0.409
LIG_LIR_Nem_3	2	6	PF02991	0.575
LIG_LIR_Nem_3	299	305	PF02991	0.422
LIG_LIR_Nem_3	335	341	PF02991	0.335
LIG_LIR_Nem_3	421	426	PF02991	0.454
LIG_MYND_1	163	167	PF01753	0.515
LIG_SH2_CRK	352	356	PF00017	0.301
LIG_SH2_GRB2like	338	341	PF00017	0.422
LIG_SH2_STAT3	267	270	PF00017	0.383
LIG_SH2_STAT5	327	330	PF00017	0.301
LIG_SH2_STAT5	338	341	PF00017	0.301
LIG_SH3_3	106	112	PF00018	0.317
LIG_SH3_3	154	160	PF00018	0.466
LIG_SH3_3	79	85	PF00018	0.386
LIG_SUMO_SIM_par_1	302	309	PF11976	0.456
LIG_SUMO_SIM_par_1	58	63	PF11976	0.336
LIG_UBA3_1	99	106	PF00899	0.356
LIG_WRC_WIRS_1	400	405	PF05994	0.682
LIG_WRC_WIRS_1	52	57	PF05994	0.513
MOD_CDK_SPK_2	403	408	PF00069	0.439
MOD_CDK_SPxxK_3	403	410	PF00069	0.441
MOD_CK1_1	318	324	PF00069	0.301
MOD_CK2_1	215	221	PF00069	0.780
MOD_CK2_1	399	405	PF00069	0.682
MOD_CMANNOS	208	211	PF00535	0.717
MOD_GlcNHglycan	221	225	PF01048	0.569
MOD_GlcNHglycan	317	320	PF01048	0.291
MOD_GSK3_1	296	303	PF00069	0.356
MOD_GSK3_1	343	350	PF00069	0.304
MOD_GSK3_1	399	406	PF00069	0.431
MOD_NEK2_1	269	274	PF00069	0.358
MOD_NEK2_1	296	301	PF00069	0.322
MOD_NEK2_1	6	11	PF00069	0.655
MOD_NEK2_2	22	27	PF00069	0.723
MOD_PIKK_1	29	35	PF00454	0.692
MOD_PKA_1	343	349	PF00069	0.351
MOD_PKA_2	249	255	PF00069	0.610
MOD_PKA_2	296	302	PF00069	0.317
MOD_PKA_2	343	349	PF00069	0.314
MOD_PKA_2	361	367	PF00069	0.391
MOD_PKA_2	379	385	PF00069	0.602
MOD_PKA_2	93	99	PF00069	0.400
MOD_PKB_1	342	350	PF00069	0.422
MOD_Plk_4	105	111	PF00069	0.422
MOD_Plk_4	22	28	PF00069	0.724
MOD_Plk_4	269	275	PF00069	0.380
MOD_Plk_4	347	353	PF00069	0.301
MOD_ProDKin_1	235	241	PF00069	0.489
MOD_ProDKin_1	403	409	PF00069	0.440
MOD_ProDKin_1	81	87	PF00069	0.422
MOD_SUMO_for_1	10	13	PF00179	0.638
MOD_SUMO_rev_2	210	218	PF00179	0.762
MOD_SUMO_rev_2	331	337	PF00179	0.448
MOD_SUMO_rev_2	46	53	PF00179	0.616
TRG_DiLeu_BaEn_2	170	176	PF01217	0.501
TRG_ENDOCYTIC_2	338	341	PF00928	0.422
TRG_ER_diArg_1	322	324	PF00400	0.301
TRG_ER_diArg_1	341	344	PF00400	0.301
TRG_ER_diArg_1	38	40	PF00400	0.484
TRG_NLS_MonoExtN_4	407	414	PF00514	0.664
TRG_NLS_MonoExtN_4	431	436	PF00514	0.566
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAE9	Leptomonas seymouri	78%	98%
A0A0S4JQ15	Bodo saltans	53%	100%
A0A1X0NEQ4	Trypanosomatidae	52%	100%
A0A3S7XBT5	Leishmania donovani	88%	100%
A0A422N6K6	Trypanosoma rangeli	53%	100%
A4IDS9	Leishmania infantum	88%	100%
D0A8U7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ATU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q3T042	Bos taurus	28%	100%
Q4Q0Q6	Leishmania major	88%	100%
Q4R537	Macaca fascicularis	27%	100%
Q5RBB3	Pongo abelii	28%	100%
Q6VEU1	Rattus norvegicus	30%	100%
Q8BW10	Mus musculus	28%	100%
Q9ULX3	Homo sapiens	27%	100%
Q9UTK0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
V5AXR8	Trypanosoma cruzi	55%	100%