LeishMANIAdb
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DUF4154 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF4154 domain-containing protein
Gene product:
32 kDa ER-associated protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HQ21_LEIBR
TriTrypDb:
LbrM.35.5300 , LBRM2903_350063900
Length:
267

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 1, no: 8
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HQ21
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ21

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 114 118 PF00656 0.443
CLV_NRD_NRD_1 137 139 PF00675 0.433
CLV_NRD_NRD_1 222 224 PF00675 0.393
CLV_NRD_NRD_1 243 245 PF00675 0.626
CLV_NRD_NRD_1 50 52 PF00675 0.650
CLV_PCSK_KEX2_1 137 139 PF00082 0.456
CLV_PCSK_KEX2_1 222 224 PF00082 0.393
CLV_PCSK_KEX2_1 242 244 PF00082 0.349
CLV_PCSK_KEX2_1 52 54 PF00082 0.650
CLV_PCSK_PC1ET2_1 52 54 PF00082 0.646
CLV_PCSK_SKI1_1 243 247 PF00082 0.618
CLV_PCSK_SKI1_1 61 65 PF00082 0.633
CLV_PCSK_SKI1_1 99 103 PF00082 0.430
DEG_SPOP_SBC_1 22 26 PF00917 0.548
DOC_CYCLIN_yCln2_LP_2 86 92 PF00134 0.397
DOC_MAPK_gen_1 150 159 PF00069 0.467
DOC_MAPK_gen_1 71 79 PF00069 0.542
DOC_MAPK_HePTP_8 147 159 PF00069 0.502
DOC_MAPK_MEF2A_6 150 159 PF00069 0.461
DOC_MAPK_MEF2A_6 74 81 PF00069 0.488
DOC_MAPK_NFAT4_5 152 160 PF00069 0.512
DOC_PP2B_LxvP_1 157 160 PF13499 0.518
DOC_PP4_FxxP_1 64 67 PF00568 0.603
DOC_USP7_MATH_1 140 144 PF00917 0.356
DOC_USP7_MATH_1 160 164 PF00917 0.528
DOC_USP7_MATH_1 22 26 PF00917 0.512
DOC_WW_Pin1_4 179 184 PF00397 0.464
DOC_WW_Pin1_4 209 214 PF00397 0.520
DOC_WW_Pin1_4 63 68 PF00397 0.516
DOC_WW_Pin1_4 85 90 PF00397 0.490
DOC_WW_Pin1_4 94 99 PF00397 0.452
LIG_14-3-3_CanoR_1 11 19 PF00244 0.548
LIG_Actin_WH2_2 102 118 PF00022 0.488
LIG_BRCT_BRCA1_1 142 146 PF00533 0.441
LIG_BRCT_BRCA1_1 24 28 PF00533 0.504
LIG_BRCT_BRCA1_1 29 33 PF00533 0.508
LIG_BRCT_BRCA1_1 87 91 PF00533 0.566
LIG_deltaCOP1_diTrp_1 194 203 PF00928 0.284
LIG_deltaCOP1_diTrp_1 58 64 PF00928 0.644
LIG_FHA_1 174 180 PF00498 0.433
LIG_FHA_1 205 211 PF00498 0.582
LIG_FHA_1 22 28 PF00498 0.362
LIG_FHA_1 232 238 PF00498 0.580
LIG_FHA_1 91 97 PF00498 0.497
LIG_FHA_2 149 155 PF00498 0.451
LIG_FHA_2 189 195 PF00498 0.449
LIG_FHA_2 35 41 PF00498 0.331
LIG_LIR_Apic_2 162 167 PF02991 0.538
LIG_LIR_Apic_2 62 67 PF02991 0.580
LIG_LIR_Gen_1 78 86 PF02991 0.529
LIG_LIR_Gen_1 88 98 PF02991 0.407
LIG_LIR_Nem_3 212 217 PF02991 0.468
LIG_LIR_Nem_3 62 68 PF02991 0.598
LIG_LIR_Nem_3 78 83 PF02991 0.464
LIG_LIR_Nem_3 88 94 PF02991 0.528
LIG_PALB2_WD40_1 193 201 PF16756 0.490
LIG_PDZ_Class_2 262 267 PF00595 0.416
LIG_Pex14_1 60 64 PF04695 0.566
LIG_Pex14_2 171 175 PF04695 0.528
LIG_Pex14_2 39 43 PF04695 0.504
LIG_SH2_CRK 164 168 PF00017 0.569
LIG_SH2_CRK 45 49 PF00017 0.548
LIG_SH2_CRK 65 69 PF00017 0.285
LIG_SH2_NCK_1 45 49 PF00017 0.623
LIG_SH2_STAT5 120 123 PF00017 0.443
LIG_SH2_STAT5 132 135 PF00017 0.364
LIG_SH2_STAT5 56 59 PF00017 0.602
LIG_SH3_3 207 213 PF00018 0.581
LIG_SUMO_SIM_par_1 82 88 PF11976 0.541
LIG_TRAF2_1 70 73 PF00917 0.515
MOD_CDK_SPK_2 94 99 PF00069 0.507
MOD_CK1_1 204 210 PF00069 0.448
MOD_CK1_1 46 52 PF00069 0.610
MOD_CK2_1 188 194 PF00069 0.454
MOD_CK2_1 235 241 PF00069 0.571
MOD_CK2_1 34 40 PF00069 0.321
MOD_CK2_1 67 73 PF00069 0.451
MOD_GlcNHglycan 13 16 PF01048 0.408
MOD_GlcNHglycan 198 201 PF01048 0.551
MOD_GlcNHglycan 30 33 PF01048 0.446
MOD_GlcNHglycan 61 64 PF01048 0.581
MOD_GSK3_1 227 234 PF00069 0.534
MOD_GSK3_1 23 30 PF00069 0.345
MOD_GSK3_1 59 66 PF00069 0.558
MOD_GSK3_1 90 97 PF00069 0.474
MOD_LATS_1 148 154 PF00433 0.397
MOD_N-GLC_1 43 48 PF02516 0.600
MOD_NEK2_1 102 107 PF00069 0.324
MOD_NEK2_1 188 193 PF00069 0.471
MOD_NEK2_1 201 206 PF00069 0.385
MOD_NEK2_1 21 26 PF00069 0.368
MOD_NEK2_1 227 232 PF00069 0.448
MOD_NEK2_1 27 32 PF00069 0.411
MOD_NEK2_1 59 64 PF00069 0.568
MOD_NEK2_1 90 95 PF00069 0.488
MOD_PKA_1 235 241 PF00069 0.606
MOD_Plk_4 140 146 PF00069 0.447
MOD_Plk_4 23 29 PF00069 0.444
MOD_Plk_4 79 85 PF00069 0.504
MOD_ProDKin_1 179 185 PF00069 0.472
MOD_ProDKin_1 209 215 PF00069 0.507
MOD_ProDKin_1 63 69 PF00069 0.502
MOD_ProDKin_1 85 91 PF00069 0.497
MOD_ProDKin_1 94 100 PF00069 0.445
TRG_DiLeu_BaEn_4 72 78 PF01217 0.494
TRG_ENDOCYTIC_2 224 227 PF00928 0.457
TRG_ENDOCYTIC_2 56 59 PF00928 0.565
TRG_ENDOCYTIC_2 65 68 PF00928 0.494
TRG_ER_diArg_1 136 138 PF00400 0.442
TRG_ER_diArg_1 222 224 PF00400 0.396
TRG_ER_diArg_1 242 244 PF00400 0.349
TRG_ER_diArg_1 50 53 PF00400 0.611
TRG_NES_CRM1_1 110 123 PF08389 0.409
TRG_NLS_MonoExtN_4 48 55 PF00514 0.524

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZW1 Leptomonas seymouri 65% 100%
A0A0S4JNP4 Bodo saltans 27% 100%
A0A1X0NDW5 Trypanosomatidae 34% 100%
A0A3S7XBV9 Leishmania donovani 83% 100%
A4IDS8 Leishmania infantum 85% 100%
D0A8U8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
E9ATT9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q0Q7 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS