Bacterial transferase hexapeptide (Six repeats) family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ20_LEIBR

TriTrypDb:

LbrM.35.5290 , LBRM2903_350063800

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ20

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.467
CLV_NRD_NRD_1	7	9	PF00675	0.566
CLV_PCSK_KEX2_1	303	305	PF00082	0.428
CLV_PCSK_KEX2_1	7	9	PF00082	0.566
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.428
CLV_PCSK_SKI1_1	255	259	PF00082	0.361
DEG_APCC_DBOX_1	72	80	PF00400	0.533
DEG_Nend_Nbox_1	1	3	PF02207	0.571
DOC_CYCLIN_RxL_1	38	47	PF00134	0.561
DOC_MAPK_gen_1	101	111	PF00069	0.581
DOC_PP4_FxxP_1	66	69	PF00568	0.627
DOC_PP4_MxPP_1	393	396	PF00568	0.702
DOC_USP7_MATH_1	103	107	PF00917	0.579
DOC_USP7_MATH_1	14	18	PF00917	0.614
DOC_USP7_UBL2_3	299	303	PF12436	0.434
DOC_WW_Pin1_4	349	354	PF00397	0.497
DOC_WW_Pin1_4	378	383	PF00397	0.567
DOC_WW_Pin1_4	408	413	PF00397	0.757
LIG_APCC_ABBA_1	400	405	PF00400	0.594
LIG_eIF4E_1	206	212	PF01652	0.613
LIG_FHA_1	151	157	PF00498	0.377
LIG_FHA_1	176	182	PF00498	0.368
LIG_FHA_1	199	205	PF00498	0.504
LIG_FHA_1	259	265	PF00498	0.440
LIG_FHA_1	340	346	PF00498	0.484
LIG_FHA_1	350	356	PF00498	0.453
LIG_FHA_2	229	235	PF00498	0.350
LIG_FHA_2	63	69	PF00498	0.589
LIG_IBAR_NPY_1	213	215	PF08397	0.454
LIG_LIR_Apic_2	114	119	PF02991	0.474
LIG_LIR_Apic_2	301	305	PF02991	0.420
LIG_LIR_Apic_2	65	69	PF02991	0.638
LIG_LIR_Gen_1	418	426	PF02991	0.525
LIG_LIR_Gen_1	88	99	PF02991	0.532
LIG_LIR_Nem_3	246	250	PF02991	0.470
LIG_LIR_Nem_3	328	333	PF02991	0.680
LIG_LIR_Nem_3	418	422	PF02991	0.539
LIG_LIR_Nem_3	423	429	PF02991	0.510
LIG_LIR_Nem_3	88	94	PF02991	0.504
LIG_LIR_Nem_3	98	102	PF02991	0.497
LIG_Pex14_1	415	419	PF04695	0.641
LIG_SH2_CRK	132	136	PF00017	0.514
LIG_SH2_CRK	302	306	PF00017	0.460
LIG_SH2_CRK	307	311	PF00017	0.451
LIG_SH2_CRK	31	35	PF00017	0.499
LIG_SH2_CRK	419	423	PF00017	0.612
LIG_SH2_GRB2like	113	116	PF00017	0.482
LIG_SH2_GRB2like	333	336	PF00017	0.470
LIG_SH2_GRB2like	419	422	PF00017	0.581
LIG_SH2_NCK_1	419	423	PF00017	0.609
LIG_SH2_SRC	116	119	PF00017	0.478
LIG_SH2_SRC	238	241	PF00017	0.451
LIG_SH2_SRC	333	336	PF00017	0.624
LIG_SH2_SRC	347	350	PF00017	0.596
LIG_SH2_SRC	419	422	PF00017	0.669
LIG_SH2_STAP1	113	117	PF00017	0.461
LIG_SH2_STAP1	307	311	PF00017	0.524
LIG_SH2_STAP1	347	351	PF00017	0.500
LIG_SH2_STAT3	130	133	PF00017	0.526
LIG_SH2_STAT3	149	152	PF00017	0.298
LIG_SH2_STAT3	326	329	PF00017	0.494
LIG_SH2_STAT5	116	119	PF00017	0.478
LIG_SH2_STAT5	130	133	PF00017	0.509
LIG_SH2_STAT5	149	152	PF00017	0.298
LIG_SH2_STAT5	182	185	PF00017	0.345
LIG_SH2_STAT5	238	241	PF00017	0.451
LIG_SH2_STAT5	333	336	PF00017	0.520
LIG_SH3_3	392	398	PF00018	0.608
LIG_SH3_3	66	72	PF00018	0.507
LIG_TRAF2_2	214	219	PF00917	0.472
LIG_WRC_WIRS_1	244	249	PF05994	0.464
MOD_CDK_SPxxK_3	349	356	PF00069	0.494
MOD_CDK_SPxxK_3	378	385	PF00069	0.565
MOD_CK1_1	243	249	PF00069	0.463
MOD_CK1_1	272	278	PF00069	0.383
MOD_CK1_1	319	325	PF00069	0.397
MOD_CK1_1	410	416	PF00069	0.559
MOD_CK2_1	228	234	PF00069	0.334
MOD_CK2_1	295	301	PF00069	0.391
MOD_CK2_1	312	318	PF00069	0.429
MOD_CK2_1	408	414	PF00069	0.632
MOD_GSK3_1	139	146	PF00069	0.515
MOD_GSK3_1	190	197	PF00069	0.347
MOD_GSK3_1	269	276	PF00069	0.377
MOD_GSK3_1	312	319	PF00069	0.513
MOD_N-GLC_1	415	420	PF02516	0.606
MOD_N-GLC_2	192	194	PF02516	0.339
MOD_NEK2_1	190	195	PF00069	0.363
MOD_NEK2_1	2	7	PF00069	0.553
MOD_NEK2_1	369	374	PF00069	0.688
MOD_NEK2_1	39	44	PF00069	0.544
MOD_NEK2_1	87	92	PF00069	0.506
MOD_NEK2_2	14	19	PF00069	0.613
MOD_OFUCOSY	237	242	PF10250	0.227
MOD_PKA_2	312	318	PF00069	0.510
MOD_Plk_1	190	196	PF00069	0.337
MOD_Plk_4	152	158	PF00069	0.407
MOD_Plk_4	228	234	PF00069	0.331
MOD_Plk_4	269	275	PF00069	0.429
MOD_Plk_4	306	312	PF00069	0.443
MOD_Plk_4	339	345	PF00069	0.481
MOD_Plk_4	62	68	PF00069	0.638
MOD_ProDKin_1	349	355	PF00069	0.493
MOD_ProDKin_1	378	384	PF00069	0.565
MOD_ProDKin_1	408	414	PF00069	0.760
MOD_SUMO_for_1	345	348	PF00179	0.495
MOD_SUMO_rev_2	272	280	PF00179	0.424
MOD_SUMO_rev_2	296	305	PF00179	0.416
MOD_SUMO_rev_2	381	391	PF00179	0.696
TRG_ENDOCYTIC_2	132	135	PF00928	0.516
TRG_ENDOCYTIC_2	307	310	PF00928	0.484
TRG_ENDOCYTIC_2	320	323	PF00928	0.473
TRG_ENDOCYTIC_2	419	422	PF00928	0.537
TRG_ENDOCYTIC_2	96	99	PF00928	0.543
TRG_ER_diArg_1	6	8	PF00400	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P359	Leptomonas seymouri	87%	100%
A0A0S4JP99	Bodo saltans	64%	100%
A0A1X0NE18	Trypanosomatidae	75%	100%
A0A3Q8IKZ8	Leishmania donovani	96%	100%
A4IDS7	Leishmania infantum	96%	100%
D0A8U9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	92%
E9ATT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q0Q8	Leishmania major	97%	100%
V5ATD4	Trypanosoma cruzi	74%	100%