Bacterial transferase hexapeptide (Six repeats) family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ20_LEIBR

TriTrypDb:

LbrM.35.5290 , LBRM2903_350063800

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ20

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.467
CLV_NRD_NRD_1	7	9	PF00675	0.566
CLV_PCSK_KEX2_1	303	305	PF00082	0.428
CLV_PCSK_KEX2_1	7	9	PF00082	0.566
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.428
CLV_PCSK_SKI1_1	255	259	PF00082	0.361
DEG_APCC_DBOX_1	72	80	PF00400	0.533
DEG_Nend_Nbox_1	1	3	PF02207	0.571
DOC_CYCLIN_RxL_1	38	47	PF00134	0.561
DOC_MAPK_gen_1	101	111	PF00069	0.581

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P359	Leptomonas seymouri	87%	100%
A0A0S4JP99	Bodo saltans	64%	100%
A0A1X0NE18	Trypanosomatidae	75%	100%
A0A3Q8IKZ8	Leishmania donovani	96%	100%
A4IDS7	Leishmania infantum	96%	100%
D0A8U9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	92%
E9ATT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q0Q8	Leishmania major	97%	100%
V5ATD4	Trypanosoma cruzi	74%	100%

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