Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ19_LEIBR

TriTrypDb:

LbrM.35.5280 , LBRM2903_350063700

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.500
CLV_NRD_NRD_1	199	201	PF00675	0.539
CLV_NRD_NRD_1	308	310	PF00675	0.360
CLV_NRD_NRD_1	370	372	PF00675	0.718
CLV_NRD_NRD_1	87	89	PF00675	0.444
CLV_PCSK_FUR_1	75	79	PF00082	0.514
CLV_PCSK_KEX2_1	12	14	PF00082	0.500
CLV_PCSK_KEX2_1	199	201	PF00082	0.454
CLV_PCSK_KEX2_1	347	349	PF00082	0.481
CLV_PCSK_KEX2_1	370	372	PF00082	0.718
CLV_PCSK_KEX2_1	77	79	PF00082	0.504
CLV_PCSK_KEX2_1	87	89	PF00082	0.422
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.481
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.402
CLV_PCSK_PC7_1	8	14	PF00082	0.494
CLV_PCSK_SKI1_1	13	17	PF00082	0.540
CLV_PCSK_SKI1_1	302	306	PF00082	0.642
CLV_PCSK_SKI1_1	370	374	PF00082	0.593
DEG_APCC_DBOX_1	12	20	PF00400	0.504
DEG_SPOP_SBC_1	133	137	PF00917	0.510
DOC_CKS1_1	26	31	PF01111	0.520
DOC_CYCLIN_RxL_1	299	306	PF00134	0.481
DOC_MAPK_gen_1	309	317	PF00069	0.360
DOC_MAPK_gen_1	84	93	PF00069	0.368
DOC_PP1_RVXF_1	249	255	PF00149	0.360
DOC_PP2B_LxvP_1	123	126	PF13499	0.475
DOC_USP7_MATH_1	133	137	PF00917	0.568
DOC_USP7_MATH_1	257	261	PF00917	0.356
DOC_USP7_UBL2_3	116	120	PF12436	0.487
DOC_USP7_UBL2_3	267	271	PF12436	0.542
DOC_WW_Pin1_4	135	140	PF00397	0.611
DOC_WW_Pin1_4	149	154	PF00397	0.483
DOC_WW_Pin1_4	25	30	PF00397	0.515
LIG_14-3-3_CanoR_1	221	229	PF00244	0.358
LIG_14-3-3_CanoR_1	251	255	PF00244	0.440
LIG_14-3-3_CanoR_1	370	377	PF00244	0.488
LIG_14-3-3_CanoR_1	8	16	PF00244	0.637
LIG_BIR_II_1	1	5	PF00653	0.663
LIG_BIR_III_4	255	259	PF00653	0.378
LIG_BRCT_BRCA1_1	137	141	PF00533	0.491
LIG_BRCT_BRCA1_1	29	33	PF00533	0.499
LIG_CaM_IQ_9	208	223	PF13499	0.357
LIG_CaM_IQ_9	79	94	PF13499	0.373
LIG_FHA_1	281	287	PF00498	0.406
LIG_FHA_1	312	318	PF00498	0.360
LIG_FHA_1	357	363	PF00498	0.462
LIG_FHA_2	107	113	PF00498	0.433
LIG_FHA_2	143	149	PF00498	0.714
LIG_FHA_2	222	228	PF00498	0.415
LIG_LIR_Gen_1	109	118	PF02991	0.438
LIG_LIR_Gen_1	138	148	PF02991	0.493
LIG_LIR_Gen_1	177	186	PF02991	0.411
LIG_LIR_Gen_1	332	342	PF02991	0.468
LIG_LIR_Nem_3	109	114	PF02991	0.588
LIG_LIR_Nem_3	138	144	PF02991	0.495
LIG_LIR_Nem_3	177	183	PF02991	0.410
LIG_LIR_Nem_3	332	338	PF02991	0.475
LIG_LIR_Nem_3	52	58	PF02991	0.688
LIG_PCNA_yPIPBox_3	174	183	PF02747	0.499
LIG_Pex14_2	51	55	PF04695	0.617
LIG_SH2_STAP1	180	184	PF00017	0.414
LIG_SH2_STAT3	186	189	PF00017	0.425
LIG_SUMO_SIM_par_1	312	319	PF11976	0.361
LIG_TRAF2_1	245	248	PF00917	0.434
LIG_TRAF2_1	63	66	PF00917	0.623
LIG_UBA3_1	140	149	PF00899	0.495
MOD_CK1_1	135	141	PF00069	0.654
MOD_CK1_1	155	161	PF00069	0.542
MOD_CK1_1	195	201	PF00069	0.462
MOD_CK1_1	260	266	PF00069	0.422
MOD_CK1_1	303	309	PF00069	0.476
MOD_CK1_1	361	367	PF00069	0.528
MOD_CK1_1	60	66	PF00069	0.759
MOD_CK1_1	7	13	PF00069	0.632
MOD_CK2_1	106	112	PF00069	0.528
MOD_CK2_1	142	148	PF00069	0.755
MOD_CK2_1	221	227	PF00069	0.415
MOD_CK2_1	290	296	PF00069	0.420
MOD_CK2_1	348	354	PF00069	0.526
MOD_CK2_1	58	64	PF00069	0.651
MOD_CK2_1	70	76	PF00069	0.555
MOD_GlcNHglycan	1	4	PF01048	0.640
MOD_GlcNHglycan	305	308	PF01048	0.416
MOD_GlcNHglycan	318	321	PF01048	0.406
MOD_GlcNHglycan	373	376	PF01048	0.489
MOD_GlcNHglycan	40	43	PF01048	0.543
MOD_GSK3_1	149	156	PF00069	0.605
MOD_GSK3_1	206	213	PF00069	0.406
MOD_GSK3_1	263	270	PF00069	0.369
MOD_GSK3_1	380	387	PF00069	0.579
MOD_GSK3_1	4	11	PF00069	0.564
MOD_N-GLC_1	4	9	PF02516	0.580
MOD_NEK2_1	160	165	PF00069	0.531
MOD_NEK2_1	4	9	PF00069	0.562
MOD_NEK2_1	58	63	PF00069	0.624
MOD_PIKK_1	17	23	PF00454	0.503
MOD_PIKK_1	206	212	PF00454	0.354
MOD_PIKK_1	221	227	PF00454	0.313
MOD_PIKK_1	384	390	PF00454	0.501
MOD_PKA_1	370	376	PF00069	0.604
MOD_PKA_1	77	83	PF00069	0.390
MOD_PKA_2	220	226	PF00069	0.439
MOD_PKA_2	250	256	PF00069	0.362
MOD_PKA_2	260	266	PF00069	0.509
MOD_PKA_2	370	376	PF00069	0.604
MOD_PKA_2	7	13	PF00069	0.632
MOD_PKA_2	77	83	PF00069	0.397
MOD_PKB_1	278	286	PF00069	0.350
MOD_Plk_1	204	210	PF00069	0.361
MOD_Plk_1	311	317	PF00069	0.358
MOD_Plk_4	106	112	PF00069	0.369
MOD_Plk_4	28	34	PF00069	0.665
MOD_Plk_4	318	324	PF00069	0.370
MOD_ProDKin_1	135	141	PF00069	0.615
MOD_ProDKin_1	149	155	PF00069	0.481
MOD_ProDKin_1	25	31	PF00069	0.514
MOD_SUMO_rev_2	259	266	PF00179	0.510
TRG_AP2beta_CARGO_1	52	62	PF09066	0.595
TRG_ENDOCYTIC_2	111	114	PF00928	0.424
TRG_ENDOCYTIC_2	180	183	PF00928	0.417
TRG_ER_diArg_1	199	202	PF00400	0.450
TRG_ER_diArg_1	369	371	PF00400	0.711
TRG_ER_diArg_1	86	88	PF00400	0.433
TRG_NES_CRM1_1	112	124	PF08389	0.387
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBK9	Leptomonas seymouri	38%	100%
A0A3Q8ILJ1	Leishmania donovani	69%	100%
A4IDS6	Leishmania infantum	68%	100%
E9ATT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q0Q9	Leishmania major	66%	99%