Cilia- and flagella-associated protein 58

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ18_LEIBR

TriTrypDb:

LbrM.35.5270 , LBRM2903_350063600

Length:

845

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005856	cytoskeleton	5	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HQ18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.594
CLV_NRD_NRD_1	196	198	PF00675	0.516
CLV_NRD_NRD_1	347	349	PF00675	0.524
CLV_NRD_NRD_1	361	363	PF00675	0.450
CLV_NRD_NRD_1	474	476	PF00675	0.563
CLV_NRD_NRD_1	482	484	PF00675	0.576
CLV_NRD_NRD_1	503	505	PF00675	0.557
CLV_NRD_NRD_1	537	539	PF00675	0.667
CLV_NRD_NRD_1	619	621	PF00675	0.412
CLV_NRD_NRD_1	714	716	PF00675	0.660
CLV_PCSK_FUR_1	712	716	PF00082	0.672
CLV_PCSK_KEX2_1	156	158	PF00082	0.497
CLV_PCSK_KEX2_1	266	268	PF00082	0.506
CLV_PCSK_KEX2_1	363	365	PF00082	0.486
CLV_PCSK_KEX2_1	372	374	PF00082	0.458
CLV_PCSK_KEX2_1	482	484	PF00082	0.576
CLV_PCSK_KEX2_1	503	505	PF00082	0.589
CLV_PCSK_KEX2_1	619	621	PF00082	0.412
CLV_PCSK_KEX2_1	714	716	PF00082	0.686
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.497
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.442
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.477
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.458
CLV_PCSK_SKI1_1	121	125	PF00082	0.512
CLV_PCSK_SKI1_1	156	160	PF00082	0.557
CLV_PCSK_SKI1_1	179	183	PF00082	0.561
CLV_PCSK_SKI1_1	187	191	PF00082	0.535
CLV_PCSK_SKI1_1	197	201	PF00082	0.330
CLV_PCSK_SKI1_1	226	230	PF00082	0.372
CLV_PCSK_SKI1_1	245	249	PF00082	0.277
CLV_PCSK_SKI1_1	314	318	PF00082	0.609
CLV_PCSK_SKI1_1	392	396	PF00082	0.472
CLV_PCSK_SKI1_1	48	52	PF00082	0.438
CLV_PCSK_SKI1_1	482	486	PF00082	0.615
CLV_PCSK_SKI1_1	553	557	PF00082	0.558
CLV_PCSK_SKI1_1	583	587	PF00082	0.534
CLV_PCSK_SKI1_1	6	10	PF00082	0.534
CLV_PCSK_SKI1_1	601	605	PF00082	0.341
CLV_PCSK_SKI1_1	735	739	PF00082	0.503
CLV_Separin_Metazoa	205	209	PF03568	0.563
DEG_APCC_DBOX_1	225	233	PF00400	0.400
DEG_APCC_DBOX_1	431	439	PF00400	0.584
DEG_APCC_DBOX_1	645	653	PF00400	0.493
DOC_CYCLIN_RxL_1	194	202	PF00134	0.545
DOC_CYCLIN_RxL_1	598	608	PF00134	0.322
DOC_CYCLIN_RxL_1	729	742	PF00134	0.548
DOC_MAPK_gen_1	362	370	PF00069	0.565
DOC_MAPK_gen_1	51	60	PF00069	0.307
DOC_MAPK_gen_1	619	626	PF00069	0.398
DOC_MAPK_gen_1	646	654	PF00069	0.437
DOC_MAPK_gen_1	684	692	PF00069	0.560
DOC_MAPK_gen_1	754	761	PF00069	0.442
DOC_MAPK_gen_1	823	831	PF00069	0.572
DOC_PIKK_1	456	463	PF02985	0.344
DOC_USP7_MATH_1	7	11	PF00917	0.651
DOC_USP7_MATH_1	719	723	PF00917	0.603
DOC_USP7_MATH_1	838	842	PF00917	0.534
DOC_USP7_UBL2_3	152	156	PF12436	0.506
DOC_USP7_UBL2_3	233	237	PF12436	0.544
DOC_USP7_UBL2_3	262	266	PF12436	0.625
DOC_USP7_UBL2_3	391	395	PF12436	0.418
DOC_USP7_UBL2_3	544	548	PF12436	0.629
DOC_USP7_UBL2_3	583	587	PF12436	0.422
DOC_USP7_UBL2_3	782	786	PF12436	0.570
DOC_USP7_UBL2_3	97	101	PF12436	0.434
LIG_14-3-3_CanoR_1	157	165	PF00244	0.555
LIG_14-3-3_CanoR_1	179	184	PF00244	0.616
LIG_14-3-3_CanoR_1	197	207	PF00244	0.299
LIG_14-3-3_CanoR_1	267	271	PF00244	0.439
LIG_14-3-3_CanoR_1	400	407	PF00244	0.488
LIG_14-3-3_CanoR_1	482	491	PF00244	0.587
LIG_14-3-3_CanoR_1	54	61	PF00244	0.539
LIG_14-3-3_CanoR_1	814	820	PF00244	0.455
LIG_Actin_WH2_2	645	662	PF00022	0.529
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_CaM_IQ_9	586	602	PF13499	0.565
LIG_eIF4E_1	223	229	PF01652	0.556
LIG_eIF4E_1	628	634	PF01652	0.534
LIG_FHA_1	103	109	PF00498	0.448
LIG_FHA_1	143	149	PF00498	0.541
LIG_FHA_1	164	170	PF00498	0.475
LIG_FHA_1	178	184	PF00498	0.462
LIG_FHA_1	199	205	PF00498	0.329
LIG_FHA_1	293	299	PF00498	0.524
LIG_FHA_1	401	407	PF00498	0.537
LIG_FHA_1	66	72	PF00498	0.434
LIG_FHA_1	803	809	PF00498	0.455
LIG_FHA_2	15	21	PF00498	0.326
LIG_FHA_2	158	164	PF00498	0.574
LIG_FHA_2	186	192	PF00498	0.512
LIG_FHA_2	249	255	PF00498	0.430
LIG_FHA_2	292	298	PF00498	0.623
LIG_FHA_2	317	323	PF00498	0.608
LIG_FHA_2	325	331	PF00498	0.629
LIG_FHA_2	353	359	PF00498	0.366
LIG_FHA_2	456	462	PF00498	0.404
LIG_FHA_2	569	575	PF00498	0.603
LIG_FHA_2	635	641	PF00498	0.352
LIG_FHA_2	737	743	PF00498	0.565
LIG_LIR_Gen_1	13	24	PF02991	0.407
LIG_LIR_Gen_1	336	344	PF02991	0.598
LIG_LIR_Gen_1	42	50	PF02991	0.405
LIG_LIR_Nem_3	100	106	PF02991	0.426
LIG_LIR_Nem_3	13	19	PF02991	0.528
LIG_LIR_Nem_3	331	337	PF02991	0.501
LIG_LIR_Nem_3	35	41	PF02991	0.413
LIG_LIR_Nem_3	42	46	PF02991	0.400
LIG_LIR_Nem_3	710	716	PF02991	0.578
LIG_LYPXL_yS_3	720	723	PF13949	0.649
LIG_SH2_CRK	628	632	PF00017	0.534
LIG_SH2_STAP1	43	47	PF00017	0.440
LIG_SH2_STAP1	827	831	PF00017	0.474
LIG_SH2_STAT5	38	41	PF00017	0.303
LIG_SH3_3	1	7	PF00018	0.720
LIG_SUMO_SIM_anti_2	201	208	PF11976	0.587
LIG_SUMO_SIM_anti_2	243	251	PF11976	0.583
LIG_SUMO_SIM_par_1	227	234	PF11976	0.549
LIG_TRAF2_1	193	196	PF00917	0.567
LIG_TRAF2_1	238	241	PF00917	0.579
LIG_TRAF2_1	355	358	PF00917	0.584
LIG_TRAF2_1	374	377	PF00917	0.593
LIG_TRAF2_1	459	462	PF00917	0.481
LIG_TRAF2_1	571	574	PF00917	0.581
LIG_TYR_ITIM	36	41	PF00017	0.454
LIG_TYR_ITIM	626	631	PF00017	0.409
LIG_UBA3_1	228	237	PF00899	0.554
LIG_UBA3_1	46	52	PF00899	0.298
LIG_UBA3_1	654	658	PF00899	0.409
MOD_CK1_1	129	135	PF00069	0.590
MOD_CK1_1	139	145	PF00069	0.570
MOD_CK1_1	291	297	PF00069	0.601
MOD_CK1_1	450	456	PF00069	0.460
MOD_CK1_1	53	59	PF00069	0.407
MOD_CK1_1	564	570	PF00069	0.579
MOD_CK2_1	14	20	PF00069	0.462
MOD_CK2_1	143	149	PF00069	0.605
MOD_CK2_1	157	163	PF00069	0.476
MOD_CK2_1	185	191	PF00069	0.537
MOD_CK2_1	199	205	PF00069	0.393
MOD_CK2_1	248	254	PF00069	0.428
MOD_CK2_1	25	31	PF00069	0.409
MOD_CK2_1	291	297	PF00069	0.614
MOD_CK2_1	316	322	PF00069	0.576
MOD_CK2_1	324	330	PF00069	0.584
MOD_CK2_1	352	358	PF00069	0.628
MOD_CK2_1	371	377	PF00069	0.548
MOD_CK2_1	455	461	PF00069	0.592
MOD_CK2_1	53	59	PF00069	0.515
MOD_CK2_1	568	574	PF00069	0.594
MOD_CK2_1	634	640	PF00069	0.332
MOD_CK2_1	719	725	PF00069	0.495
MOD_CK2_1	736	742	PF00069	0.430
MOD_CK2_1	815	821	PF00069	0.496
MOD_CK2_1	87	93	PF00069	0.448
MOD_GlcNHglycan	27	30	PF01048	0.452
MOD_GlcNHglycan	452	455	PF01048	0.567
MOD_GlcNHglycan	596	599	PF01048	0.437
MOD_GlcNHglycan	675	679	PF01048	0.332
MOD_GSK3_1	135	142	PF00069	0.593
MOD_GSK3_1	159	166	PF00069	0.632
MOD_GSK3_1	284	291	PF00069	0.574
MOD_GSK3_1	395	402	PF00069	0.549
MOD_GSK3_1	564	571	PF00069	0.607
MOD_GSK3_1	605	612	PF00069	0.310
MOD_GSK3_1	7	14	PF00069	0.608
MOD_GSK3_1	798	805	PF00069	0.344
MOD_GSK3_1	815	822	PF00069	0.280
MOD_GSK3_1	838	845	PF00069	0.604
MOD_N-GLC_1	288	293	PF02516	0.595
MOD_N-GLC_1	455	460	PF02516	0.562
MOD_N-GLC_1	561	566	PF02516	0.567
MOD_N-GLC_1	594	599	PF02516	0.433
MOD_N-GLC_1	708	713	PF02516	0.594
MOD_N-GLC_1	798	803	PF02516	0.458
MOD_N-GLC_1	832	837	PF02516	0.575
MOD_NEK2_1	119	124	PF00069	0.540
MOD_NEK2_1	199	204	PF00069	0.543
MOD_NEK2_1	228	233	PF00069	0.549
MOD_NEK2_1	248	253	PF00069	0.260
MOD_NEK2_1	281	286	PF00069	0.471
MOD_NEK2_1	399	404	PF00069	0.506
MOD_NEK2_1	50	55	PF00069	0.526
MOD_NEK2_1	633	638	PF00069	0.440
MOD_NEK2_1	798	803	PF00069	0.462
MOD_NEK2_1	819	824	PF00069	0.358
MOD_PIKK_1	248	254	PF00454	0.357
MOD_PIKK_1	400	406	PF00454	0.545
MOD_PIKK_1	447	453	PF00454	0.491
MOD_PIKK_1	482	488	PF00454	0.531
MOD_PIKK_1	59	65	PF00454	0.479
MOD_PKA_1	266	272	PF00069	0.436
MOD_PKA_1	482	488	PF00069	0.584
MOD_PKA_2	266	272	PF00069	0.494
MOD_PKA_2	324	330	PF00069	0.628
MOD_PKA_2	399	405	PF00069	0.355
MOD_PKA_2	436	442	PF00069	0.461
MOD_PKA_2	482	488	PF00069	0.576
MOD_PKA_2	53	59	PF00069	0.450
MOD_PKA_2	609	615	PF00069	0.534
MOD_PKA_2	815	821	PF00069	0.418
MOD_Plk_1	288	294	PF00069	0.595
MOD_Plk_1	32	38	PF00069	0.563
MOD_Plk_1	357	363	PF00069	0.573
MOD_Plk_1	395	401	PF00069	0.469
MOD_Plk_1	447	453	PF00069	0.472
MOD_Plk_1	455	461	PF00069	0.462
MOD_Plk_1	708	714	PF00069	0.617
MOD_Plk_1	832	838	PF00069	0.585
MOD_Plk_1	87	93	PF00069	0.432
MOD_Plk_2-3	371	377	PF00069	0.564
MOD_Plk_2-3	88	94	PF00069	0.434
MOD_Plk_4	11	17	PF00069	0.481
MOD_Plk_4	129	135	PF00069	0.626
MOD_Plk_4	402	408	PF00069	0.475
MOD_Plk_4	663	669	PF00069	0.472
MOD_Plk_4	775	781	PF00069	0.522
MOD_SUMO_for_1	123	126	PF00179	0.486
MOD_SUMO_for_1	368	371	PF00179	0.571
MOD_SUMO_for_1	407	410	PF00179	0.547
MOD_SUMO_for_1	489	492	PF00179	0.594
MOD_SUMO_for_1	529	532	PF00179	0.540
MOD_SUMO_for_1	745	748	PF00179	0.572
MOD_SUMO_for_1	95	98	PF00179	0.438
MOD_SUMO_rev_2	149	158	PF00179	0.496
MOD_SUMO_rev_2	191	200	PF00179	0.533
MOD_SUMO_rev_2	385	394	PF00179	0.550
MOD_SUMO_rev_2	461	466	PF00179	0.434
MOD_SUMO_rev_2	576	585	PF00179	0.510
MOD_SUMO_rev_2	722	730	PF00179	0.533
TRG_AP2beta_CARGO_1	331	341	PF09066	0.377
TRG_AP2beta_CARGO_1	44	54	PF09066	0.292
TRG_DiLeu_BaEn_1	377	382	PF01217	0.531
TRG_DiLeu_BaEn_1	581	586	PF01217	0.545
TRG_DiLeu_BaEn_1	753	758	PF01217	0.460
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.601
TRG_DiLeu_BaLyEn_6	550	555	PF01217	0.385
TRG_DiLeu_BaLyEn_6	650	655	PF01217	0.525
TRG_ENDOCYTIC_2	38	41	PF00928	0.415
TRG_ENDOCYTIC_2	43	46	PF00928	0.385
TRG_ENDOCYTIC_2	491	494	PF00928	0.486
TRG_ENDOCYTIC_2	628	631	PF00928	0.413
TRG_ENDOCYTIC_2	720	723	PF00928	0.637
TRG_ENDOCYTIC_2	826	829	PF00928	0.472
TRG_ER_diArg_1	361	364	PF00400	0.532
TRG_ER_diArg_1	482	484	PF00400	0.576
TRG_ER_diArg_1	503	505	PF00400	0.464
TRG_ER_diArg_1	515	518	PF00400	0.579
TRG_ER_diArg_1	618	620	PF00400	0.302
TRG_ER_diArg_1	713	715	PF00400	0.678
TRG_ER_FFAT_1	18	28	PF00635	0.303
TRG_NES_CRM1_1	622	635	PF08389	0.490
TRG_NES_CRM1_1	647	661	PF08389	0.492
TRG_NLS_Bipartite_1	348	366	PF00514	0.612
TRG_NLS_MonoExtN_4	48	55	PF00514	0.301
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	503	507	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	558	563	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J7	Leptomonas seymouri	73%	99%
A0A0S4JDB4	Bodo saltans	39%	99%
A0A0S4JNC8	Bodo saltans	22%	86%
A0A0S4KGN1	Bodo saltans	27%	89%
A0A1X0NE93	Trypanosomatidae	48%	99%
A0A3Q8IGJ9	Leishmania donovani	84%	100%
A0A3R7L4Y2	Trypanosoma rangeli	25%	88%
A0A3R7NDH9	Trypanosoma rangeli	47%	99%
A4IDS5	Leishmania infantum	84%	100%
A8HUA1	Chlamydomonas reinhardtii	31%	98%
B2RW38	Mus musculus	33%	97%
C9ZJ55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	82%
D0A8V1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ATT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q0R0	Leishmania major	83%	100%
V5A873	Trypanosoma cruzi	47%	99%