Saposin B-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ17_LEIBR

TriTrypDb:

LbrM.35.5250 , LBRM2903_350063400

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 6
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HQ17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	172	174	PF00675	0.663
CLV_NRD_NRD_1	208	210	PF00675	0.577
CLV_NRD_NRD_1	291	293	PF00675	0.728
CLV_NRD_NRD_1	337	339	PF00675	0.737
CLV_PCSK_FUR_1	335	339	PF00082	0.749
CLV_PCSK_KEX2_1	208	210	PF00082	0.577
CLV_PCSK_KEX2_1	291	293	PF00082	0.728
CLV_PCSK_KEX2_1	335	337	PF00082	0.675
CLV_PCSK_PC7_1	331	337	PF00082	0.753
CLV_PCSK_SKI1_1	123	127	PF00082	0.533
CLV_PCSK_SKI1_1	249	253	PF00082	0.618
CLV_PCSK_SKI1_1	280	284	PF00082	0.524
CLV_PCSK_SKI1_1	291	295	PF00082	0.614
CLV_Separin_Metazoa	236	240	PF03568	0.318
DEG_APCC_DBOX_1	231	239	PF00400	0.320
DEG_MDM2_SWIB_1	135	142	PF02201	0.536
DEG_SPOP_SBC_1	301	305	PF00917	0.730
DOC_CDC14_PxL_1	20	28	PF14671	0.518
DOC_CKS1_1	45	50	PF01111	0.559
DOC_CYCLIN_yCln2_LP_2	21	27	PF00134	0.520
DOC_MAPK_gen_1	254	263	PF00069	0.615
DOC_MAPK_gen_1	335	342	PF00069	0.697
DOC_PP1_RVXF_1	224	230	PF00149	0.539
DOC_PP2B_LxvP_1	21	24	PF13499	0.514
DOC_SPAK_OSR1_1	239	243	PF12202	0.459
DOC_USP7_MATH_1	245	249	PF00917	0.342
DOC_USP7_MATH_1	302	306	PF00917	0.720
DOC_USP7_MATH_1	322	326	PF00917	0.698
DOC_USP7_MATH_1	33	37	PF00917	0.583
DOC_WW_Pin1_4	44	49	PF00397	0.567
DOC_WW_Pin1_4	80	85	PF00397	0.685
LIG_BIR_II_1	1	5	PF00653	0.687
LIG_BRCT_BRCA1_1	269	273	PF00533	0.339
LIG_BRCT_BRCA1_1	324	328	PF00533	0.720
LIG_EH_1	73	77	PF12763	0.693
LIG_EH1_1	272	280	PF00400	0.539
LIG_FHA_1	149	155	PF00498	0.531
LIG_FHA_1	177	183	PF00498	0.536
LIG_FHA_1	186	192	PF00498	0.604
LIG_FHA_1	258	264	PF00498	0.528
LIG_FHA_1	5	11	PF00498	0.631
LIG_FHA_2	45	51	PF00498	0.536
LIG_LIR_Gen_1	40	48	PF02991	0.566
LIG_LIR_Nem_3	228	233	PF02991	0.468
LIG_LIR_Nem_3	40	46	PF02991	0.560
LIG_PCNA_PIPBox_1	234	243	PF02747	0.564
LIG_PCNA_yPIPBox_3	232	241	PF02747	0.545
LIG_PDZ_Class_2	338	343	PF00595	0.648
LIG_Pex14_2	135	139	PF04695	0.532
LIG_Pex14_2	218	222	PF04695	0.306
LIG_REV1ctd_RIR_1	227	236	PF16727	0.314
LIG_SH2_CRK	43	47	PF00017	0.322
LIG_SH2_SRC	41	44	PF00017	0.326
LIG_SH2_STAT5	146	149	PF00017	0.489
LIG_SH2_STAT5	241	244	PF00017	0.473
LIG_SH2_STAT5	41	44	PF00017	0.497
LIG_SH3_3	180	186	PF00018	0.690
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.595
LIG_SUMO_SIM_anti_2	248	254	PF11976	0.573
LIG_SUMO_SIM_par_1	16	22	PF11976	0.623
LIG_SUMO_SIM_par_1	23	28	PF11976	0.535
LIG_SUMO_SIM_par_1	259	265	PF11976	0.643
LIG_TRAF2_1	37	40	PF00917	0.569
LIG_UBA3_1	250	256	PF00899	0.374
LIG_ULM_U2AF65_1	335	340	PF00076	0.746
LIG_WRC_WIRS_1	268	273	PF05994	0.341
MOD_CK1_1	199	205	PF00069	0.547
MOD_CK1_1	300	306	PF00069	0.733
MOD_CK1_1	44	50	PF00069	0.528
MOD_CK2_1	218	224	PF00069	0.333
MOD_Cter_Amidation	333	336	PF01082	0.658
MOD_GlcNHglycan	120	123	PF01048	0.556
MOD_GlcNHglycan	285	288	PF01048	0.761
MOD_GlcNHglycan	299	302	PF01048	0.592
MOD_GlcNHglycan	324	327	PF01048	0.522
MOD_GlcNHglycan	331	334	PF01048	0.472
MOD_GlcNHglycan	34	38	PF01048	0.480
MOD_GSK3_1	148	155	PF00069	0.446
MOD_GSK3_1	281	288	PF00069	0.720
MOD_GSK3_1	297	304	PF00069	0.555
MOD_GSK3_1	6	13	PF00069	0.632
MOD_N-GLC_1	10	15	PF02516	0.622
MOD_N-GLC_1	306	311	PF02516	0.701
MOD_N-GLC_2	56	58	PF02516	0.433
MOD_NEK2_1	148	153	PF00069	0.329
MOD_NEK2_1	19	24	PF00069	0.462
MOD_NEK2_1	218	223	PF00069	0.395
MOD_NEK2_1	27	32	PF00069	0.509
MOD_NEK2_1	283	288	PF00069	0.762
MOD_NEK2_1	4	9	PF00069	0.589
MOD_NEK2_2	225	230	PF00069	0.581
MOD_PIKK_1	158	164	PF00454	0.627
MOD_PKA_1	291	297	PF00069	0.509
MOD_PKA_2	257	263	PF00069	0.609
MOD_PKA_2	291	297	PF00069	0.677
MOD_PKA_2	4	10	PF00069	0.652
MOD_PKB_1	136	144	PF00069	0.325
MOD_Plk_1	10	16	PF00069	0.646
MOD_Plk_1	148	154	PF00069	0.551
MOD_Plk_1	27	33	PF00069	0.303
MOD_Plk_1	306	312	PF00069	0.521
MOD_Plk_2-3	313	319	PF00069	0.511
MOD_Plk_4	10	16	PF00069	0.559
MOD_Plk_4	106	112	PF00069	0.539
MOD_Plk_4	196	202	PF00069	0.517
MOD_Plk_4	225	231	PF00069	0.532
MOD_Plk_4	257	263	PF00069	0.537
MOD_Plk_4	306	312	PF00069	0.521
MOD_Plk_4	41	47	PF00069	0.424
MOD_ProDKin_1	44	50	PF00069	0.564
MOD_ProDKin_1	80	86	PF00069	0.687
MOD_SUMO_rev_2	221	228	PF00179	0.414
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.525
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.600
TRG_ENDOCYTIC_2	43	46	PF00928	0.550
TRG_ER_diArg_1	135	138	PF00400	0.480
TRG_ER_diArg_1	207	209	PF00400	0.552
TRG_ER_diArg_1	213	216	PF00400	0.540
TRG_ER_diArg_1	291	293	PF00400	0.707
TRG_ER_diArg_1	335	338	PF00400	0.711
TRG_NES_CRM1_1	265	276	PF08389	0.556
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVC1	Leptomonas seymouri	47%	98%
A0A1X0P309	Trypanosomatidae	29%	100%
A0A3Q8IJW1	Leishmania donovani	74%	97%
A0A3R7KTI3	Trypanosoma rangeli	23%	100%
A4IDS3	Leishmania infantum	74%	97%
E9ATT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	97%
Q4Q0R2	Leishmania major	70%	100%
V5D4Y6	Trypanosoma cruzi	25%	100%